Dll1 (delta like canonical Notch ligand 1) - Rat Genome Database

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Gene: Dll1 (delta like canonical Notch ligand 1) Rattus norvegicus
Analyze
Symbol: Dll1
Name: delta like canonical Notch ligand 1
RGD ID: 70949
Description: Enables Notch binding activity. Involved in clathrin-dependent endocytosis and positive regulation of Notch signaling pathway. Predicted to be located in several cellular components, including adherens junction; apical plasma membrane; and membrane raft. Predicted to be active in plasma membrane. Orthologous to human DLL1 (delta like canonical Notch ligand 1); PARTICIPATES IN altered Notch signaling pathway; Notch signaling pathway; Notch signaling pathway; INTERACTS WITH 3-methylcholanthrene; 3H-1,2-dithiole-3-thione; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: delta (Drosophila)-like 1; delta-like 1 (Drosophila); delta-like protein 1; delta1; drosophila Delta homolog 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8164,985,161 - 64,993,274 (-)NCBIGRCr8
mRatBN7.2156,312,062 - 56,320,177 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl156,312,066 - 56,320,179 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx161,164,063 - 61,172,170 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0169,827,568 - 69,835,693 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0163,074,034 - 63,082,141 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0157,318,621 - 57,326,732 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl157,318,708 - 57,327,379 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01242,107,684 - 242,115,795 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4154,240,395 - 54,248,183 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1154,243,339 - 54,251,125 (-)NCBI
Celera152,521,212 - 52,529,325 (-)NCBICelera
Cytogenetic Map1q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-methylcholanthrene  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetohydrazide  (ISO)
acrylamide  (EXP)
all-trans-retinoic acid  (ISO)
alpha-naphthoflavone  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
antimycin A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP,ISO)
azoxystrobin  (EXP)
benzene  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
calciol  (EXP)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (EXP,ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
dioxygen  (EXP,ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
furan  (EXP,ISO)
genistein  (ISO)
glycidol  (EXP)
glyphosate  (EXP,ISO)
hydrazine  (ISO)
imidacloprid  (EXP)
linuron  (EXP)
lipopolysaccharide  (EXP,ISO)
maneb  (ISO)
mercury dibromide  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP,ISO)
mono(2-ethylhexyl) phthalate  (EXP)
N,N-diethyl-m-toluamide  (EXP)
naphthalene  (ISO)
nitrofen  (EXP)
orphenadrine  (EXP)
p-chloromercuribenzoic acid  (ISO)
paraquat  (ISO)
pentachlorophenol  (ISO)
pentanal  (ISO)
permethrin  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propanal  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
thiabendazole  (EXP)
titanium dioxide  (EXP,ISO)
triadimefon  (EXP)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
astrocyte development  (IEA,ISO,ISS)
auditory receptor cell fate commitment  (NAS)
cell fate determination  (TAS)
cell-cell signaling  (ISO)
cerebellar molecular layer formation  (IEA,ISO,ISS)
cerebellar Purkinje cell layer structural organization  (IEA,ISO,ISS)
clathrin-dependent endocytosis  (IDA)
compartment pattern specification  (IEA,ISO)
determination of left/right symmetry  (ISO)
developmental process  (IEA)
endothelial tip cell fate specification  (IEA,ISO,ISS)
energy homeostasis  (IEA,ISO,ISS)
heart looping  (IEA,ISO)
inhibition of neuroepithelial cell differentiation  (IEA,ISO)
inner ear auditory receptor cell differentiation  (IEA,ISO)
inner ear development  (ISO)
lateral inhibition  (IEA,ISO,ISS)
left/right axis specification  (IEA,ISO)
loop of Henle development  (IEA,ISO)
marginal zone B cell differentiation  (IEA,ISO,ISS)
myeloid cell differentiation  (IEA,ISO)
negative regulation of cardiac muscle cell differentiation  (IEA,ISO)
negative regulation of cell differentiation  (ISO,ISS)
negative regulation of cell population proliferation  (IEA,ISO,ISS)
negative regulation of epidermal cell differentiation  (ISO,ISS)
negative regulation of epithelial cell differentiation  (ISO,ISS)
negative regulation of glial cell apoptotic process  (IEA,ISO,ISS)
negative regulation of inner ear auditory receptor cell differentiation  (IEA,ISO)
negative regulation of interleukin-10 production  (IEA,ISO)
negative regulation of myeloid cell differentiation  (IEA,ISO)
negative regulation of myoblast differentiation  (IEA,ISO,ISS)
negative regulation of neuron differentiation  (ISO,ISS)
negative regulation of Notch signaling pathway  (IBA,IEA)
nephron development  (ISO,ISS)
nervous system development  (NAS)
neuroepithelial cell differentiation  (IEA,ISO)
neuron differentiation  (ISO)
neuron fate specification  (IEA,ISO,ISS)
neuronal stem cell population maintenance  (IEA,ISO,ISS)
Notch signaling pathway  (IBA,IEA,ISO,ISS,NAS)
Notch signaling pathway involved in arterial endothelial cell fate commitment  (IEA,ISO,ISS)
organ growth  (IEA,ISO,ISS)
positive regulation of cell population proliferation  (IEA,ISO,ISS)
positive regulation of endocytosis  (IEA,ISO,ISS)
positive regulation of gene expression  (IEA,ISO)
positive regulation of Notch signaling pathway  (IDA,IEA,ISO,ISS)
positive regulation of skeletal muscle tissue growth  (IEA,ISO,ISS)
positive regulation of sprouting angiogenesis  (IEA,ISO,ISS)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
proximal tubule development  (IEA,ISO)
proximal/distal pattern formation  (IEA,ISO,ISS)
regulation of blood pressure  (IEA,ISO,ISS)
regulation of cell adhesion  (IEA,ISO)
regulation of cell division  (IEA,ISO,ISS)
regulation of growth  (ISO,ISS)
regulation of neurogenesis  (IEA,ISO,ISS)
regulation of skeletal muscle tissue growth  (ISO,ISS)
regulation of somitogenesis  (IEA,ISO,ISS)
regulation of vascular endothelial growth factor receptor signaling pathway  (IEA,ISO)
regulation of vascular endothelial growth factor signaling pathway  (IEA,ISO,ISS)
retina development in camera-type eye  (ISO,ISS)
retina morphogenesis in camera-type eye  (IEA,ISO,ISS)
skeletal muscle tissue growth  (IEA,ISO,ISS)
skin epidermis development  (IEA,ISO,ISS)
somite specification  (IEA,ISO)
somitogenesis  (ISO,ISS)
spinal cord development  (IEA,ISO,ISS)
type B pancreatic cell development  (IEA,ISO,ISS)

Cellular Component
adherens junction  (IEA,ISO,ISS)
apical plasma membrane  (IEA,ISO,ISS)
cytoplasmic vesicle  (IEA,ISO)
membrane  (IEA)
membrane raft  (IEA,ISO,ISS)
plasma membrane  (IBA,IEA,ISO,TAS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. JAGGED1 and delta1 differentially regulate the outcome of experimental autoimmune encephalomyelitis. Elyaman W, etal., J Immunol. 2007 Nov 1;179(9):5990-8.
2. Localisation of members of the notch system and the differentiation of vibrissa hair follicles: receptors, ligands, and fringe modulators. Favier B, etal., Dev Dyn. 2000 Jul;218(3):426-37.
3. Cell and molecular biology of Notch. Fiuza UM and Arias AM, J Endocrinol. 2007 Sep;194(3):459-74.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Human ligands of the Notch receptor. Gray GE, etal., Am J Pathol 1999 Mar;154(3):785-94.
7. Patterns of Jagged1, Jagged2, Delta-like 1 and Delta-like 3 expression during late embryonic and postnatal brain development suggest multiple functional roles in progenitors and differentiated cells. Irvin DK, etal., J Neurosci Res 2004 Feb 1;75(3):330-43.
8. Deciphering the Fringe-Mediated Notch Code: Identification of Activating and Inhibiting Sites Allowing Discrimination between Ligands. Kakuda S and Haltiwanger RS, Dev Cell. 2017 Jan 23;40(2):193-201. doi: 10.1016/j.devcel.2016.12.013. Epub 2017 Jan 12.
9. Expression patterns of Jagged, Delta1, Notch1, Notch2, and Notch3 genes identify ligand-receptor pairs that may function in neural development. Lindsell CE, etal., Mol Cell Neurosci. 1996;8(1):14-27.
10. Notch ligand endocytosis generates mechanical pulling force dependent on dynamin, epsins, and actin. Meloty-Kapella L, etal., Dev Cell. 2012 Jun 12;22(6):1299-312. doi: 10.1016/j.devcel.2012.04.005. Epub 2012 May 31.
11. Gene Data Set MGD Curation, June 12, 2002
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Reactivation of Delta-Notch signaling after injury: complementary expression patterns of ligand and receptor in dental pulp. Mitsiadis TA, etal., Exp Cell Res. 1999 Feb 1;246(2):312-8.
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. Blocking the NOTCH pathway inhibits vascular inflammation in large-vessel vasculitis. Piggott K, etal., Circulation. 2011 Jan 25;123(3):309-18. Epub 2011 Jan 10.
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
18. GOA pipeline RGD automated data pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Information Derived from GenBank Report RGD, Sept. 2003
22. Integrity of intracellular domain of Notch ligand is indispensable for cleavage required for release of the Notch2 intracellular domain. Shimizu K, etal., EMBO J. 2002 Feb 1;21(3):294-302.
23. Pancreatic regeneration in chronic pancreatitis requires activation of the notch signaling pathway. Su Y, etal., J Gastrointest Surg. 2006 Nov;10(9):1230-41; discussion 1242.
24. Cloning of a cDNA encoding a rat DNase II-like acid DNase. Tanuma S and Shiokawa D, Biochem Biophys Res Commun 1999 Nov 19;265(2):395-9.
Additional References at PubMed
PMID:9858718   PMID:9882480   PMID:10473134   PMID:10476967   PMID:10958687   PMID:11006133   PMID:11076679   PMID:11581320   PMID:11912004   PMID:12001066   PMID:12730124   PMID:14960495  
PMID:15146182   PMID:15509766   PMID:15574878   PMID:15821257   PMID:15902259   PMID:15908431   PMID:16000382   PMID:16495313   PMID:16621992   PMID:17194759   PMID:17960184   PMID:18371447  
PMID:18418349   PMID:18449946   PMID:18676613   PMID:18997111   PMID:19144989   PMID:19217325   PMID:19389377   PMID:19481784   PMID:19562077   PMID:19682396   PMID:20081190   PMID:21238454  
PMID:21915337   PMID:21985982   PMID:22096075   PMID:22282195   PMID:22529374   PMID:22940113   PMID:23072809   PMID:23086448   PMID:23688253   PMID:23695674   PMID:23806616   PMID:24715457  
PMID:25220152   PMID:26114479   PMID:26355680   PMID:29181775   PMID:32703409  


Genomics

Comparative Map Data
Dll1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8164,985,161 - 64,993,274 (-)NCBIGRCr8
mRatBN7.2156,312,062 - 56,320,177 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl156,312,066 - 56,320,179 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx161,164,063 - 61,172,170 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0169,827,568 - 69,835,693 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0163,074,034 - 63,082,141 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0157,318,621 - 57,326,732 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl157,318,708 - 57,327,379 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01242,107,684 - 242,115,795 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4154,240,395 - 54,248,183 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1154,243,339 - 54,251,125 (-)NCBI
Celera152,521,212 - 52,529,325 (-)NCBICelera
Cytogenetic Map1q12NCBI
DLL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386170,282,206 - 170,291,078 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6170,282,206 - 170,306,565 (-)EnsemblGRCh38hg38GRCh38
GRCh376170,591,294 - 170,600,166 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366170,433,219 - 170,441,622 (-)NCBINCBI36Build 36hg18NCBI36
Build 346170,508,932 - 170,517,112NCBI
Celera6171,388,861 - 171,397,261 (-)NCBICelera
Cytogenetic Map6q27NCBI
HuRef6168,098,039 - 168,106,439 (-)NCBIHuRef
CHM1_16170,851,870 - 170,860,273 (-)NCBICHM1_1
T2T-CHM13v2.06171,640,900 - 171,649,769 (-)NCBIT2T-CHM13v2.0
Dll1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391715,587,616 - 15,597,275 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1715,587,616 - 15,597,134 (-)EnsemblGRCm39 Ensembl
GRCm381715,367,354 - 15,376,932 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1715,367,354 - 15,376,872 (-)EnsemblGRCm38mm10GRCm38
MGSCv371715,504,318 - 15,512,787 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361715,072,317 - 15,080,550 (-)NCBIMGSCv36mm8
Celera1716,154,981 - 16,163,462 (-)NCBICelera
Cytogenetic Map17A2NCBI
cM Map178.95NCBI
Dll1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554113,478,033 - 3,486,604 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554113,478,943 - 3,486,541 (+)NCBIChiLan1.0ChiLan1.0
DLL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25190,554,039 - 190,562,923 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16188,458,574 - 188,466,578 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06168,440,192 - 168,449,071 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16173,535,941 - 173,545,362 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6173,534,292 - 173,544,759 (-)Ensemblpanpan1.1panPan2
DLL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11272,265,078 - 72,272,347 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1272,265,682 - 72,272,348 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1272,029,118 - 72,036,680 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01273,251,013 - 73,258,571 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11272,524,902 - 72,532,408 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01272,346,638 - 72,354,211 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01272,737,393 - 72,744,967 (-)NCBIUU_Cfam_GSD_1.0
Dll1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946151,369,680 - 151,377,618 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004937098213,227 - 220,427 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004937098212,704 - 220,589 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DLL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1199,358 - 211,346 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11198,815 - 211,346 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21280,640 - 291,729 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DLL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11397,928,480 - 97,936,594 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1397,928,634 - 97,936,589 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604069,934,302 - 69,943,226 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dll1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248506,134,908 - 6,143,404 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248506,135,214 - 6,142,975 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dll1
20 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:89
Count of miRNA genes:72
Interacting mature miRNAs:75
Transcripts:ENSRNOT00000019934
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)11183518156835181Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)11933357156983283Rat
724520Bp145Blood pressure QTL 1452.10.0024arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12078482865784828Rat
1357400Bw62Body weight QTL624.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)12234064767340647Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)12887978078430678Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)13344984878449848Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)13344984878449848Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)13483685879836858Rat
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)13523959878430678Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)13523959878430678Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14580314078430678Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14936146582174945Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)15389511782174945Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15389511782174945Rat

Markers in Region
UniSTS:465448  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2156,313,301 - 56,313,409 (+)MAPPERmRatBN7.2
Rnor_6.0157,319,861 - 57,319,968NCBIRnor6.0
Rnor_5.01242,108,924 - 242,109,031UniSTSRnor5.0
RGSC_v3.4154,241,310 - 54,241,417UniSTSRGSC3.4
Celera152,522,452 - 52,522,559UniSTS
Cytogenetic Map1q12UniSTS
Dll1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2156,312,413 - 56,313,211 (+)MAPPERmRatBN7.2
Rnor_6.0157,318,973 - 57,319,770NCBIRnor6.0
Rnor_5.01242,108,036 - 242,108,833UniSTSRnor5.0
RGSC_v3.4154,240,422 - 54,241,219UniSTSRGSC3.4
Celera152,521,564 - 52,522,361UniSTS
Cytogenetic Map1q12UniSTS
Dll1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2156,312,588 - 56,313,318 (+)MAPPERmRatBN7.2
Rnor_6.0157,319,148 - 57,319,877NCBIRnor6.0
Rnor_5.01242,108,211 - 242,108,940UniSTSRnor5.0
RGSC_v3.4154,240,597 - 54,241,326UniSTSRGSC3.4
Celera152,521,739 - 52,522,468UniSTS
Cytogenetic Map1q12UniSTS
Dll1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2156,312,188 - 56,313,417 (+)MAPPERmRatBN7.2
Rnor_6.0157,318,748 - 57,319,976NCBIRnor6.0
Rnor_5.01242,107,811 - 242,109,039UniSTSRnor5.0
Celera152,521,339 - 52,522,567UniSTS
Cytogenetic Map1q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 11 49 10 2 11
Low 3 43 57 41 8 41 8 11 25 25 35 8
Below cutoff 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000080429   ⟹   ENSRNOP00000073159
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl156,312,066 - 56,320,179 (-)Ensembl
Rnor_6.0 Ensembl157,318,708 - 57,327,379 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000113128   ⟹   ENSRNOP00000089438
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl156,312,678 - 56,320,179 (-)Ensembl
RefSeq Acc Id: NM_032063   ⟹   NP_114452
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8164,985,161 - 64,993,274 (-)NCBI
mRatBN7.2156,312,062 - 56,320,177 (-)NCBI
Rnor_6.0157,318,621 - 57,326,732 (-)NCBI
Rnor_5.01242,107,684 - 242,115,795 (-)NCBI
RGSC_v3.4154,240,395 - 54,248,183 (-)RGD
Celera152,521,212 - 52,529,325 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_114452 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB37343 (Get FASTA)   NCBI Sequence Viewer  
  EDL99825 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000073159
  ENSRNOP00000073159.1
  ENSRNOP00000089438.1
GenBank Protein P97677 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_114452   ⟸   NM_032063
- Peptide Label: precursor
- UniProtKB: P97677 (UniProtKB/Swiss-Prot),   G3V7W6 (UniProtKB/TrEMBL),   A6KB40 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000073159   ⟸   ENSRNOT00000080429
RefSeq Acc Id: ENSRNOP00000089438   ⟸   ENSRNOT00000113128
Protein Domains
DSL   EGF-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97677-F1-model_v2 AlphaFold P97677 1-714 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689642
Promoter ID:EPDNEW_R167
Type:single initiation site
Name:Dll1_1
Description:delta like canonical Notch ligand 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0157,327,192 - 57,327,252EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70949 AgrOrtholog
BioCyc Gene G2FUF-61314 BioCyc
Ensembl Genes ENSRNOG00000059984 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000080429 ENTREZGENE
  ENSRNOT00000080429.2 UniProtKB/TrEMBL
  ENSRNOT00000113128.1 UniProtKB/TrEMBL
Gene3D-CATH 2.10.25.140 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.3510 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro DSL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Notch_ligand_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:84010 UniProtKB/Swiss-Prot
NCBI Gene 84010 ENTREZGENE
PANTHER DELTA-LIKE PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOTCH LIGAND FAMILY MEMBER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DL-JAG_EGF-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DSL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MNNL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dll1 PhenoGen
PRINTS EGFBLOOD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DSL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000059984 RatGTEx
SMART DSL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A9U8_RAT UniProtKB/TrEMBL
  A6KB40 ENTREZGENE, UniProtKB/TrEMBL
  DLL1_RAT UniProtKB/Swiss-Prot
  G3V7W6 ENTREZGENE, UniProtKB/TrEMBL
  P97677 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-20 Dll1  delta like canonical Notch ligand 1  Dll1  delta-like 1 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Dll1  delta-like 1 (Drosophila)      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in neurons and glia of the brain during late embryonic and early postnatal development; in embryonic stages, present in cells lining the ventricles and in the germinal center in astrocyte precursors; during the first 2 weeks postnatal, found in white matter tracts of the brain 1304491