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Gene: Lpar4 (lysophosphatidic acid receptor 4) Rattus norvegicus

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Symbol:

Lpar4

Name:

lysophosphatidic acid receptor 4

RGD ID:

1563686

Description:

Predicted to enable lysophosphatidic acid binding activity and lysophosphatidic acid receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in nuclear body. Predicted to be active in plasma membrane. Orthologous to human LPAR4 (lysophosphatidic acid receptor 4); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 3,4-methylenedioxymethamphetamine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

G protein-coupled receptor 23; Gpr23; LOC302378; RGD1563686; similar to G protein-coupled receptor 23

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	LPAR4 (lysophosphatidic acid receptor 4)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Lpar4 (lysophosphatidic acid receptor 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	LPAR4 (lysophosphatidic acid receptor 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	LPAR4 (lysophosphatidic acid receptor 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Lpar4 (lysophosphatidic acid receptor 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	LPAR4 (lysophosphatidic acid receptor 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	LOC103232244 (lysophosphatidic acid receptor 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	LPAR4 (lysophosphatidic acid receptor 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Lpar4 (lysophosphatidic acid receptor 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	lpar4 (lysophosphatidic acid receptor 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	gnrr-4	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	lpar4	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	76,106,319 - 76,119,807 (+)	NCBI		GRCr8
mRatBN7.2	X	72,033,486 - 72,046,978 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	72,033,486 - 72,046,977 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	73,537,790 - 73,551,269 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	77,049,652 - 77,063,140 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	74,617,950 - 74,631,433 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	78,042,859 - 78,056,347 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	78,042,859 - 78,056,347 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	78,237,912 - 78,251,631 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	95,180,476 - 95,194,380 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	X	73,333,463 - 73,346,943 (+)	NCBI		Celera
Cytogenetic Map	X	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

autosomal hemophilia A (ISO)

factor VIII deficiency (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

(2,4,5-trichlorophenoxy)acetic acid (ISO)

(S)-nicotine (ISO)

1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane (ISO)

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (ISO)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

3,3',5,5'-tetrabromobisphenol A (ISO)

3,4-methylenedioxymethamphetamine (EXP)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

aldrin (ISO)

all-trans-retinoic acid (ISO)

amitrole (EXP)

arsenous acid (ISO)

Azoxymethane (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

caffeine (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chloroethene (ISO)

copper(II) sulfate (ISO)

dextran sulfate (ISO)

diarsenic trioxide (ISO)

diclofenac (ISO)

diethylstilbestrol (ISO)

diquat (ISO)

dorsomorphin (ISO)

endosulfan (EXP)

estriol (ISO)

inulin (ISO)

methimazole (EXP)

methylmercury chloride (ISO)

miconazole (ISO)

nickel atom (ISO)

nicotine (ISO)

paracetamol (EXP)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

SB 431542 (ISO)

silver atom (ISO)

silver(0) (ISO)

titanium dioxide (ISO)

trichostatin A (ISO)

triticonazole (EXP)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

G protein-coupled receptor signaling pathway (IBA)

Cellular Component

intracellular membrane-bounded organelle (ISO)

nuclear body (IEA,ISO)

plasma membrane (IBA,ISO)

Molecular Function

lysophosphatidic acid binding (ISO)

lysophosphatidic acid receptor activity (IBA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:17166850

Genomics

Comparative Map Data

Lpar4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	76,106,319 - 76,119,807 (+)	NCBI		GRCr8
mRatBN7.2	X	72,033,486 - 72,046,978 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	72,033,486 - 72,046,977 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	73,537,790 - 73,551,269 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	77,049,652 - 77,063,140 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	74,617,950 - 74,631,433 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	78,042,859 - 78,056,347 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	78,042,859 - 78,056,347 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	78,237,912 - 78,251,631 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	95,180,476 - 95,194,380 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	X	73,333,463 - 73,346,943 (+)	NCBI		Celera
Cytogenetic Map	X	q22	NCBI

LPAR4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	78,747,720 - 78,758,714 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	78,747,709 - 78,758,714 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	78,003,217 - 78,014,211 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	77,896,957 - 77,899,249 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	77,816,445 - 77,818,733	NCBI
Celera	X	78,243,611 - 78,252,993 (+)	NCBI		Celera
Cytogenetic Map	X	q21.1	NCBI
HuRef	X	71,584,019 - 71,593,185 (+)	NCBI		HuRef
CHM1_1	X	77,896,235 - 77,905,616 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	X	77,184,471 - 77,195,526 (+)	NCBI		T2T-CHM13v2.0

Lpar4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	105,964,231 - 105,977,505 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	105,964,231 - 105,977,506 (+)	Ensembl		GRCm39 Ensembl
GRCm38	X	106,920,625 - 106,933,899 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	106,920,625 - 106,933,900 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	104,115,964 - 104,129,238 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	103,123,375 - 103,135,151 (+)	NCBI		MGSCv36	mm8
Celera	X	93,766,647 - 93,780,135 (+)	NCBI		Celera
Cytogenetic Map	X	D	NCBI
cM Map	X	47.39	NCBI

LPAR4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	78,287,373 - 78,298,731 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	78,290,990 - 78,302,342 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	67,887,929 - 67,899,287 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	77,997,762 - 78,007,810 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

LPAR4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	60,828,462 - 60,840,053 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	60,838,170 - 60,839,282 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	51,840,269 - 51,852,543 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	62,081,200 - 62,093,456 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	62,091,097 - 62,092,209 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	59,772,817 - 59,785,084 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	61,377,993 - 61,390,257 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	60,976,943 - 60,989,213 (+)	NCBI		UU_Cfam_GSD_1.0

Lpar4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	54,501,599 - 54,514,883 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936547	750,947 - 834,069 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936547	821,950 - 834,069 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LPAR4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	62,870,984 - 62,874,422 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	62,862,158 - 62,876,184 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	71,950,203 - 71,962,681 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LOC103232244
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	67,755,081 - 67,770,690 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	67,764,914 - 67,766,026 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023667909	4,274 - 10,125 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Variants

Variants in Lpar4
23 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	1201
Count of miRNA genes:	353
Interacting mature miRNAs:	495
Transcripts:	ENSRNOT00000003286
Prediction methods:	Microtar, Miranda, Pita, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61430	Cia18	Collagen induced arthritis QTL 18	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	X	14843113	120568734	Rat
61431	Cia19	Collagen induced arthritis QTL 19	4.4		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	X	65612192	120568734	Rat
738035	Stresp1	Stress response QTL 1	4.96	0.000011	stress-related behavior trait (VT:0010451)	defensive burying - coping	X	41304447	112935181	Rat
1598837	Memor13	Memory QTL 13	3.2		exploratory behavior trait (VT:0010471)	difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)	X	41052407	146860749	Rat

Markers in Region

RH131472

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	72,045,017 - 72,045,179 (+)	MAPPER	mRatBN7.2
Rnor_6.0	X	78,054,389 - 78,054,550	NCBI	Rnor6.0
Rnor_5.0	X	78,249,672 - 78,249,833	UniSTS	Rnor5.0
RGSC_v3.4	X	95,192,422 - 95,192,583	UniSTS	RGSC3.4
Celera	X	73,344,985 - 73,345,146	UniSTS
Cytogenetic Map	X	q31	UniSTS

BI294122

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	72,046,815 - 72,046,912 (+)	MAPPER	mRatBN7.2
Rnor_6.0	X	78,056,186 - 78,056,282	NCBI	Rnor6.0
Rnor_5.0	X	78,251,469 - 78,251,565	UniSTS	Rnor5.0
RGSC_v3.4	X	95,194,219 - 95,194,315	UniSTS	RGSC3.4
Celera	X	73,346,782 - 73,346,878	UniSTS
RH 3.4 Map	14	153.87	UniSTS
Cytogenetic Map	X	q31	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	10	49	113	89	88	57	25	57	6	215	96	93	45	55	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106940	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473969	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000003286 ⟹ ENSRNOP00000003286

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	72,033,486 - 72,046,977 (+)	Ensembl
Rnor_6.0 Ensembl	X	78,042,859 - 78,056,347 (+)	Ensembl

RefSeq Acc Id:

NM_001106940 ⟹ NP_001100410

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	76,106,319 - 76,119,807 (+)	NCBI
mRatBN7.2	X	72,033,486 - 72,046,977 (+)	NCBI
Rnor_6.0	X	78,042,859 - 78,056,347 (+)	NCBI
Rnor_5.0	X	78,237,912 - 78,251,631 (+)	NCBI
RGSC_v3.4	X	95,180,476 - 95,194,380 (+)	RGD
Celera	X	73,333,463 - 73,346,943 (+)	RGD

Sequence:

show sequence

AGAGTTCCCCCGGCGGCCCTCGGCTCCAGCAAGGACTTTGGGCCTTTTCTTGTGTCCTGTTTGT
TAAAGGCATGCGGGCTACAGCATTCAAGAGGGCCAGTCCTTAACAAAGGGAAGGAGATAAATGT
AAATAAGCTCACATTTTCAGAATGAGCGGTTTGCAGTAAGGAGCTGCGGCAGCCCAGAGTCTGC
TCCTTTTGGGCTGGACTAACCTTTCCCTTTTTTTTTTTTGTTTTTCTTTTTGTTTTTGTTTTTT
TTTTTTAATGGATAAAAATATGCTCTTCCAAAGTGCGAGTTGCCCGTTTACATGATTATTAGCT
AACTATCTACAGGCATGAGCACATTCTCTCATCTAGCACACTCTTTTTTGGGCACTCATTCGAG
GAATTCTTTGAACACCTGTCTCCAGAGAACTCATTGATTATCCACATTTCAGATAAATCTGGTG
TCAGAGTTTGGTTTGAACTAACTAATGAAGAAAACACCCTCTACTGGTCCCTAGTCTCAAGAGT
GGTGAACCCCTGCACCTAGCAGGCTCTCTGGGAAAATCCATGGGTGACAGAAGATTTATTGACT
TCCAATTCCAAGATTTAAATTCAAGTCTCAGACCCAGGTTGGGAAATGCAACTGCCAATAATAC
TTGCATTGTTGACGACTCCTTCAAGTATAATCTGAATGGTGCTGTCTATAGTGTTGTATTTATC
CTGGGCTTAATAACCAACAGTGCTTCCCTGTTTGTCTTCTGCTTCCGCATGAAAATGAGAAGTG
AGACCGCTATTTTCATCACCAATCTGGCCCTCTCTGACTTGCTTTTTGTCTGTACCCTACCTTT
CAAAATATTTTACAACTTTAACCGCCACTGGCCGTTTGGTGACACCCTCTGTAAGATCTCAGGG
ACTGCATTCCTCACCAACATCTATGGGAGCATGCTCTTCCTCACCTGCATTAGTGTGGATCGTT
TCCTAGCCATTGTCTATCCCTTCCGATCTCGTACCATCAGGACCAGGAGGAATTCCGCCATTGT
GTGCGCTGGAGTCTGGATCCTAGTCCTCAGTGGTGGTATTTCAGCGTCTTTGTTTTCCACCACT
AACGTCAACAATGCGACCACCACTTGCTTTGAAGGCTTCTCCAAACGTGTCTGGAAGACTTACC
TGTCCAAGATCACCATATTCATTGAAGTTGTTGGGTTCATCATTCCTCTGATATTGAATGTTTC
CTGCTCTTCTGTGGTGCTTAGAACCCTCCGCAAGCCTGCAACATTGTCTCAAATTGGGACCAAT
AAGAAAAAAGTGTTGAAGATGATCACAGTGCATATGGCAGTTTTTGTGGTATGCTTCGTACCAT
ATAACTCTGTTCTCTTTTTATATGCCTTGGTACGTTCCCAAGCCATTACTAATTGCTTATTGGA
AAGGTTTGCAAAGATAATGTACCCGATTACCTTGTGCCTTGCAACTCTGAATTGTTGCTTTGAC
CCTTTTATCTATTACTTCACTCTTGAATCTTTTCAGAAATCCTTTTATATCAACACACACATAA
GGATGGAGTCGCTGTTTAAGACTGAGACACCTCTGACCCCCAAACCTTCCCTTCCAGCTATCCA
AGAGGAAGTTAGTGATCAAACAACAAATAATGGTGGTGAACTAATGCTGGAATCCACCTTCTAG
GCACAGGAATTGTCTTTCAGGTTCAGCTACAGTGTCTCTTATGATTTTTTCTTCCTATGCTATA
AATAAGAGAAACAAATTGAAGCTAATGATACTGAGAATAGATTAATGTACCAAATGCAGTCAGA
TACATTTGTTTGAACACTATTGTACATATTGTTTTGTTCAGTAATTATAGGTCAAGTCTAATTA
CAACAACCAAAACAGATCAGACTCTTCTGTTGAGTTGACTTTTCATTACATAAATGACCAGTGG
TCTTGACTTTTAGTGATGTGGGGTTATTTTAAAACTTAAAAAAAGCATTCCAGTAATTTTGGTA
ATTGGGTTGGGCCTATAAATATAGAACAAATTCAGGGATTATTTAAAAATGTCTGTGTTACTAC
TGATATATGCTAGTATTTTTTTTCCTTTTTTGAATTATCATTGAATTTATTTTACAAAAAGAAC
TATTTTTAGCTAATGTTAGTAAGACATTTTGAGAAATAGAAATATGTTGAATTTTAAAGAATTG
GCAAATTTTATCTAGATTTTAACAACATAAATGAAGTGTTTGAATGAATATGGGTGGGAAAATT
TGGAATTTAGACATTTTCACATATATAGTAACTACAATTAGTGTCAGCTTTTAAAACTTTAAAA
TAATTTTAGAATTTTCATATGAAATTGTTAATCCTCAAAGCTGCTGCAGATGTGCCTGGCAGGT
ATCAAATGGAAAACTCATAAAATTAACAGTGTCAATTAAACTTTAAGCAACACTACAATATTTC
TTAAGATTTTCACTTATCTTTTATGGGGGTGGGGACTGACTTGTATAAAATATTTATTCTTCAT
GTTAAATGTTGGGGACACAGTATAGCCAGAGAGCTCTATAGTATTTGTGTCCAGGTCAGGAGCA
AGTTGAAAAGGTAAGTGAACAGAGTAATAGCAGCAAGATATCTTAGAGTAGTTTTTGAGGTGGG
GGTTAGATAGCTGTAACTTTGAAATACGTACTCTTTTCTATAAATTTTGGAGCACATTGTAGCC
AAGGTGCTGCTAAATTTGTGCTCGGGTTGGGAGCATATTGAAAAAGATGTGTACATTAATAAAA
AACAAAAAACAAAAAAACCAAAAAGAAAAATTAATAAAAAACCCACAAAACTAGAAAAGAAAAA
AAATCAAATAAGAAAAAAATAGTTCCTAACACTTGCATCACTGTTTTACTATTTTTAAAGTTCT
ATAAACTTAAAAGTACTATGCCACTTTAATAAACATTTTAGTATAATTCAATTCAAAATCTGCT
AAAATTGTGTCTGGGACAGGATTGAATACATACATGTAGAAAAATACATAATTTATAAAACTCC
CAAGTGCTACAGCTTGCAGATGATGCCTTGGATCAAAATGCATCTAGGCAACTGCACAATTGGC
ACCAAGTTTGAGAGGGAATTAATAAAAACATCATTTTGAAATTTATAAAAGAATCTTTTTGGAA
CTCACTTAAACAACAAATAAGAATCTTTACAATATTATTTTTCTGATGTATATAGTAGATATAC
CTTAAATATGCATCAGTCAGTTTAAATAATATGCACAAAATGTGACAATTAAAAAATATCCGAA
AATTTCAAGTAAACATCCAGTAATAACACATGTTGTATACTGCTGAACTTGTGCCAGAGAGTGG
TTAAATTAAAAACCACAAAACAATGATGAAATGGTAAAAAATTCCAAAACAATGAGAAAATTCT
TGAAATTCCTTAACCTGTGACTTGTAGGCTTAAAAATAATTTTTAAAAAAAGTAAAAATTTGTG
TGCACAATGCAGTGTTAAAGGCTGCTGATTTGGGGCTTGGGTTAGGAACTAGCTGAAAAAAAAG
TTGCTAAAACAATAGAACAATAGTAAAAATGAATTCATGATTTAAACTCCTAAAAATAACTATG
CATTATATTGTCTTGCAGAGAATGGTGACTGTTGGAGTACATAAGGCTTGTAGGCTCAGTTAGA
CAAAAGTAGGTTAAGTTAGATGGAGTTCAGTTGTTAGTTAACACTACAAGTTCAAACTAGTAAT
CAAAGTAGGAAAAACTTGCTTGTTTCCTTCAGTATTTTTTTGTGTTTTTTTTTTTTTTTTGGTA
ATATTGAACTATATGTGAACTCTCTGTACTCTTAGCTGTTAAAATTATGGAATTTTAGCATTAT
GGTATCAAATTATTGAATTGGATGTTAACTGAATTCACATGAAATACATTTAAGAAATCGTTTG
CATTTTGCATAATCTCCATGTTTAATGTTGCTTACTCTTTCATATTTTCCTTTATTTTGGTTAA
TTTTCATTTTTATATTTAATATAACTCGATAGTAATAAAAATGGTGGTGTGAATAATGTAACCA
ACAAATTGTAATGTATACCTAATTGTAAAGTTGAATTTATTTTACATTTATAAGCACAGGTAAT
CCTTCAGCTGTAATTACAACTTTCATTTAAATGTTTATTAAATGTAATAAAACATATTTGGATT
ATTAAGGTATT

hide sequence

Protein Sequences


Protein RefSeqs	NP_001100410	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM07123	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000003286.5

RefSeq Acc Id:

NP_001100410 ⟸ NM_001106940

- UniProtKB:

D3ZHA3 (UniProtKB/TrEMBL), A6IV57 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MGDRRFIDFQFQDLNSSLRPRLGNATANNTCIVDDSFKYNLNGAVYSVVFILGLITNSASLFVF
CFRMKMRSETAIFITNLALSDLLFVCTLPFKIFYNFNRHWPFGDTLCKISGTAFLTNIYGSMLF
LTCISVDRFLAIVYPFRSRTIRTRRNSAIVCAGVWILVLSGGISASLFSTTNVNNATTTCFEGF
SKRVWKTYLSKITIFIEVVGFIIPLILNVSCSSVVLRTLRKPATLSQIGTNKKKVLKMITVHMA
VFVVCFVPYNSVLFLYALVRSQAITNCLLERFAKIMYPITLCLATLNCCFDPFIYYFTLESFQK
SFYINTHIRMESLFKTETPLTPKPSLPAIQEEVSDQTTNNGGELMLESTF

hide sequence

Ensembl Acc Id:

ENSRNOP00000003286 ⟸ ENSRNOT00000003286

Protein Domains

G-protein coupled receptors family 1 profile

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZHA3-F1-model_v2	AlphaFold	D3ZHA3	1-370	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1563686	AgrOrtholog
BioCyc Gene	G2FUF-1899	BioCyc
Ensembl Genes	ENSRNOG00000002428	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000003286.7	UniProtKB/TrEMBL
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/TrEMBL
InterPro	7TM_GPCR_Rhodpsn	UniProtKB/TrEMBL
	GPCR_Rhodpsn_supfam	UniProtKB/TrEMBL
KEGG Report	rno:302378	UniProtKB/TrEMBL
NCBI Gene	302378	ENTREZGENE
PANTHER	G-PROTEIN COUPLED RECEPTOR	UniProtKB/TrEMBL
	LYSOPHOSPHATIDIC ACID RECEPTOR 4	UniProtKB/TrEMBL
Pfam	7tm_1	UniProtKB/TrEMBL
PhenoGen	Lpar4	PhenoGen
PRINTS	GPCRRHODOPSN	UniProtKB/TrEMBL
	P2Y5ORPHANR	UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F1_1	UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F1_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000002428	RatGTEx
SMART	7TM_GPCR_Srsx	UniProtKB/TrEMBL
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/TrEMBL
UniProt	A6IV57	ENTREZGENE, UniProtKB/TrEMBL
	D3ZHA3	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-25	Lpar4	lysophosphatidic acid receptor 4	Gpr23_predicted	G protein-coupled receptor 23 (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Gpr23_predicted	G protein-coupled receptor 23 (predicted)	RGD1563686_predicted	similar to G protein-coupled receptor 23 (predicted)	Symbol and Name updated	1299863	APPROVED
2006-03-07	RGD1563686_predicted	similar to G protein-coupled receptor 23 (predicted)	LOC302378	similar to G protein-coupled receptor 23	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC302378	similar to G protein-coupled receptor 23			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar