Gene: Serpina1 (serpin family A member 1) Rattus norvegicus
Symbol: Serpina1
Name: serpin family A member 1
Description: ENCODES a protein that exhibits endopeptidase inhibitor activity; serine-type endopeptidase inhibitor activity; identical protein binding (ortholog); INVOLVED IN inflammatory response; negative regulation of serine-type endopeptidase activity; response to chromate; PARTICIPATES IN forkhead class A signaling pathway; coagulation cascade pathway; complement system pathway; ASSOCIATED WITH asthma; Burns; Chemical and Drug Induced Liver Injury; FOUND IN extracellular space; endoplasmic reticulum (ortholog); Golgi apparatus (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol
Type: protein-coding
Also known as: AAT; alpha-1-antiproteinase; alpha-1-antitrypsin (protease inhibitor); alpha-1-protease inhibitor; alpha-1-proteinase inhibitor; Pi; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1; serine (or cysteine) proteinase inhibitor, clade A, member 1; serine protease inhibitor alpha 1; serpin A1; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1; Spi1
Homo sapiens (human) : SERPINA1 (serpin family A member 1)  HGNC  Alliance
Chinchilla lanigera (long-tailed chinchilla) : LOC102021597 (alpha-1-antiproteinase S-like)
Pan paniscus (bonobo/pygmy chimpanzee) : SERPINA1 (serpin family A member 1)
Canis lupus familiaris (dog) : SERPINA1 (serpin family A member 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.06127,610,241 - 127,632,265 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.06136,828,856 - 136,850,880 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46127,998,617 - 128,021,719 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.16128,002,364 - 128,025,466 (-)NCBI
Celera6120,346,394 - 120,368,519 (-)NCBICelera
Cytogenetic Map6q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Serpina1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3326
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2018-03-20
Status: ACTIVE