Serpina1 (serpin family A member 1) - Rat Genome Database

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Gene: Serpina1 (serpin family A member 1) Rattus norvegicus
Analyze
Symbol: Serpina1
Name: serpin family A member 1
RGD ID: 3326
Description: Enables serine-type endopeptidase inhibitor activity. Involved in several processes, including response to estradiol; response to methanol; and response to triglyceride. Located in extracellular space. Used to study pulmonary hypertension. Biomarker of asthma; osteoarthritis; pancreatitis (multiple); primary hyperaldosteronism; and proteinuria. Human ortholog(s) of this gene implicated in several diseases, including alpha 1-antitrypsin deficiency; chronic obstructive pulmonary disease (multiple); human immunodeficiency virus infectious disease; inflammatory bowel disease (multiple); and liver disease (multiple). Orthologous to human SERPINA1 (serpin family A member 1); PARTICIPATES IN forkhead class A signaling pathway; coagulation cascade pathway; complement system pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: AAT; alpha-1-antiproteinase; alpha-1-antitrypsin (protease inhibitor); alpha-1-protease inhibitor; alpha-1-proteinase inhibitor; Pi; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1; serine (or cysteine) proteinase inhibitor, clade A, member 1; serine protease inhibitor alpha 1; serpin A1; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1; Spi1
RGD Orthologs
Human
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86128,631,101 - 128,653,125 (-)NCBIGRCr8
mRatBN7.26122,866,314 - 122,888,339 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6122,866,312 - 122,888,339 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6123,007,214 - 123,029,250 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06123,302,499 - 123,324,535 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06122,639,411 - 122,661,452 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06127,610,241 - 127,632,265 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6127,610,243 - 127,632,265 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06136,828,856 - 136,850,880 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46127,998,617 - 128,021,719 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16128,002,364 - 128,025,466 (-)NCBI
Celera6120,346,394 - 120,368,519 (-)NCBICelera
Cytogenetic Map6q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
achondrogenesis type IA  (ISO)
acute kidney failure  (ISO)
acute pancreatitis  (IEP,ISO)
adenocarcinoma  (ISO)
alpha 1-antitrypsin deficiency  (ISO)
anxiety disorder  (ISO)
arteriosclerosis  (ISO)
asbestosis  (ISO)
asthma  (IEP)
bipolar disorder  (ISO)
Bronchial Hyperreactivity  (ISO)
bronchiectasis  (ISO)
Burns  (IEP)
Chemical and Drug Induced Liver Injury  (IEP,ISO)
chemical colitis  (ISO)
cholestasis  (ISO)
chronic obstructive pulmonary disease  (ISO)
colorectal cancer  (ISO)
coronary artery disease  (ISO)
COVID-19  (ISO)
cystic fibrosis  (ISO)
DICER1 syndrome  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Emphysema  (ISO)
Experimental Autoimmune Orchitis  (IEP)
Experimental Liver Neoplasms  (IEP)
Gastro-Enteropancreatic Neuroendocrine Tumor  (ISO)
genetic disease  (ISO)
Hemorrhage  (ISO)
hepatocellular carcinoma  (ISO)
human immunodeficiency virus infectious disease  (ISO)
hypertension  (ISO)
hypoglycemia  (ISO)
ileitis  (ISO)
Insulin Resistance  (ISO)
Kidney Reperfusion Injury  (ISO)
liver cirrhosis  (ISO)
liver disease  (ISO)
lung disease  (ISO)
Lung Neoplasms  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Myocardial Ischemia  (ISO)
Neoplasm Metastasis  (ISO)
neurodegenerative disease  (ISO)
Neurodevelopmental Disorders  (ISO)
nodular nonsuppurative panniculitis  (ISO)
osteoarthritis  (IEP)
otitis media  (ISO)
Otitis Media with Effusion  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
pancreatitis  (IEP)
pleuropulmonary blastoma  (ISO)
pre-eclampsia  (ISO)
primary hyperaldosteronism  (IEP)
proteinuria  (IEP)
pulmonary emphysema  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (IDA,ISO)
squamous cell carcinoma  (ISO)
Stomach Neoplasms  (ISO)
thiamine deficiency disease  (ISO)
vasculitis  (ISO)
X-linked intellectual developmental disorder 109  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3-chloropropane-1,2-diol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acetylsalicylic acid  (ISO)
afimoxifene  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amiodarone  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arotinoid acid  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
atrazine  (ISO)
azathioprine  (EXP)
azoxystrobin  (EXP)
belinostat  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
bexarotene  (EXP)
bisphenol A  (EXP,ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
CHIR 99021  (ISO)
chlorpyrifos  (EXP)
chromium(3+) trichloride  (EXP,ISO)
chromium(6+)  (ISO)
clofibrate  (EXP)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
cortisol  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
doxorubicin  (EXP)
elemental selenium  (ISO)
entinostat  (ISO)
flutamide  (EXP)
folic acid  (ISO)
furan  (EXP)
genistein  (EXP,ISO)
gentamycin  (EXP)
glyphosate  (EXP)
hydrogen peroxide  (ISO)
imidacloprid  (EXP)
indometacin  (ISO)
ketoconazole  (EXP)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-ethionine  (EXP)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
N-nitrosomorpholine  (EXP)
nickel atom  (ISO)
nitrofen  (EXP)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
omeprazole  (EXP)
ozone  (EXP)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
propanal  (ISO)
propiconazole  (EXP)
resveratrol  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (EXP,ISO)
sirolimus  (ISO)
sodium dichromate  (EXP,ISO)
succimer  (ISO)
tauroursodeoxycholic acid  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
theophylline  (ISO)
thiabendazole  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
triadimefon  (EXP)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
valproic acid  (EXP,ISO)
XAV939  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. FDG PET imaging of Ela1-myc mice reveals major biological differences between pancreatic acinar and ductal tumours. Abasolo I, etal., Eur J Nucl Med Mol Imaging. 2009 Jul;36(7):1156-66. Epub 2009 Feb 28.
2. Hepatic expression of acute-phase protein genes during carcinogenesis induced by peroxisome proliferators. Anderson SP, etal., Mol Carcinog. 1999 Dec;26(4):226-38.
3. Genetic modifiers of liver disease in cystic fibrosis. Bartlett JR, etal., JAMA. 2009 Sep 9;302(10):1076-83.
4. Rat and hamster species differences in susceptibility to elastase-induced pulmonary emphysema relate to differences in elastase inhibitory capacity. Borzone G, etal., Am J Physiol Regul Integr Comp Physiol. 2007 Sep;293(3):R1342-9. Epub 2007 Jul 18.
5. Oncostatin M is a potent stimulator of alpha1-antitrypsin secretion in lung epithelial cells: modulation by transforming growth factor-beta and interferon-gamma. Boutten A, etal., Am J Respir Cell Mol Biol. 1998 Apr;18(4):511-20.
6. Genetic influences on asthma susceptibility in the developing lung. Carpe N, etal., Am J Respir Cell Mol Biol. 2010 Dec;43(6):720-30. Epub 2010 Jan 29.
7. [Influence of escharectomy and skin grafting during early burn stage on acute-phase response in severely burned rats and its significance] Chai J, etal., Zhonghua Yi Xue Za Zhi. 2002 Oct 25;82(20):1420-3.
8. Expression of kallikrein-binding protein and alpha 1-antitrypsin genes in response to sex hormones, growth, inflammation and hypertension. Chao J, etal., Agents Actions Suppl. 1992;38 ( Pt 1):174-81.
9. Regulation of kininogen gene expression and localization in the lung after monocrotaline-induced pulmonary hypertension in rats. Chao J, etal., Proc Soc Exp Biol Med. 1993 Jun;203(2):243-50.
10. Loss of bone minerals and strength in rats with aldosteronism. Chhokar VS, etal., Am J Physiol Heart Circ Physiol. 2004 Nov;287(5):H2023-6.
11. Rapid communication: effect of inhaled chromium on pulmonary A1AT. Cohen MD, etal., Inhal Toxicol. 2002 Jul;14(7):765-71.
12. Alpha-1-antitrypsin therapy ameliorates acute colitis and chronic murine ileitis. Collins CB, etal., Inflamm Bowel Dis. 2013 Aug;19(9):1964-73. doi: 10.1097/MIB.0b013e31829292aa.
13. Genetic and biochemical markers of obstructive lung disease in the general population. Dahl M Clin Respir J. 2009 Apr;3(2):121-2.
14. Is there a relationship between abdominal aortic aneurysms and alpha1-antitrypsin deficiency (PiZ)? Elzouki AN, etal., Eur J Vasc Endovasc Surg. 1999 Feb;17(2):149-54.
15. Complexes of activated protein C with alpha 1-antitrypsin in normal pregnancy and in severe preeclampsia. Espana F, etal., Am J Obstet Gynecol. 1991 May;164(5 Pt 1):1310-6.
16. Apolipoprotein B: a predictor of inflammatory status in postmenopausal overweight and obese women. Faraj M, etal., Diabetologia. 2006 Jul;49(7):1637-46. Epub 2006 May 3.
17. Increased prevalence of the alpha-1-antitrypsin (A1AT) deficiency-related S gene in patients infected with human immunodeficiency virus type 1. Ferreira TC, etal., J Med Virol. 2014 Jan;86(1):23-9. doi: 10.1002/jmv.23759. Epub 2013 Oct 12.
18. Identification of immunodominant autoantigens in rat autoimmune orchitis. Fijak M, etal., J Pathol. 2005 Oct;207(2):127-38.
19. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
20. Mechanism of kinin release during experimental acute pancreatitis in rats: evidence for pro- as well as anti-inflammatory roles of oedema formation. Griesbacher T, etal., Br J Pharmacol. 2003 May;139(2):299-308.
21. Identification of a new defective SERPINA1 allele (PI*Zla palma) encoding an alpha-1-antitrypsin with altered glycosylation pattern. Hernández-Pérez JM, etal., Respir Med. 2017 Oct;131:114-117. doi: 10.1016/j.rmed.2017.08.015. Epub 2017 Aug 16.
22. An autophagy-enhancing drug promotes degradation of mutant alpha1-antitrypsin Z and reduces hepatic fibrosis. Hidvegi T, etal., Science. 2010 Jul 9;329(5988):229-32. doi: 10.1126/science.1190354. Epub 2010 Jun 3.
23. Prevalence of genetic polymorphisms in the promoter region of the alpha-1 antitrypsin (SERPINA1) gene in chronic liver disease: a case control study. Kok KF, etal., BMC Gastroenterol. 2010 Feb 20;10:22. doi: 10.1186/1471-230X-10-22.
24. Ukrainskii biokhimicheskii zhurnal Likholat EA, etal., Ukr Biokhim Zh. 2000 Nov-Dec;72(6):84-7.
25. Comparison of urinary excretion of albumin and alpha-1-antitrypsin in patients with arterial hypertension. Lisowska-Myjak B, etal., Scand J Clin Lab Invest. 1999 Apr;59(2):93-7.
26. Human Alpha-1-Antitrypsin (hAAT) therapy reduces renal dysfunction and acute tubular necrosis in a murine model of bilateral kidney ischemia-reperfusion injury. Maicas N, etal., PLoS One. 2017 Feb 24;12(2):e0168981. doi: 10.1371/journal.pone.0168981. eCollection 2017.
27. Chronic hypoxic pulmonary hypertension in rats and increased elastolytic activity. Maruyama K, etal., Am J Physiol. 1991 Dec;261(6 Pt 2):H1716-26.
28. Serum glycoproteins and severity of coronary atherosclerosis. Mori T, etal., Am Heart J. 1995 Feb;129(2):234-8.
29. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
30. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
31. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
32. Serum concentration of alpha-1 antitrypsin is significantly higher in colorectal cancer patients than in healthy controls. Pérez-Holanda S, etal., BMC Cancer. 2014 May 21;14:355. doi: 10.1186/1471-2407-14-355.
33. GOA pipeline RGD automated data pipeline
34. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
35. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
36. Comprehensive gene review and curation RGD comprehensive gene curation
37. Amelioration of Alpha-1 Antitrypsin Deficiency Diseases with Genome Editing in Transgenic Mice. Shen S, etal., Hum Gene Ther. 2018 Aug;29(8):861-873. doi: 10.1089/hum.2017.227. Epub 2018 Jun 22.
38. Acute-phase proteins before cerebral ischemia in stroke-prone rats: identification by proteomics. Sironi L, etal., Stroke. 2001 Mar;32(3):753-60.
39. Activity of cathepsin G, elastase, and their inhibitors in plasma during methanol intoxication. Skrzydlewska E, etal., J Toxicol Environ Health A. 1999 Jul 23;57(6):431-42.
40. Role of nitric oxide in the regulation of activity of proteinase inhibitors alpha(1)-antitrypsin and alpha(2)-macroglobulin by capsaicin-sensitive nerves. Spiridonov VK and Tolochko ZS, Bull Exp Biol Med. 2008 Sep;146(3):375-8.
41. Progression of atherosclerosis is associated with variation in the alpha1-antitrypsin gene. Talmud PJ, etal., Arterioscler Thromb Vasc Biol. 2003 Apr 1;23(4):644-9. Epub 2003 Mar 6.
42. Gene expression profiles in primary pancreatic tumors and metastatic lesions of Ela-c-myc transgenic mice. Thakur A, etal., Mol Cancer. 2008 Jan 24;7:11.
43. Proteomic analysis reveals alterations in the renal kallikrein pathway during hypoxia-induced hypertension. Thongboonkerd V, etal., J Biol Chem. 2002 Sep 20;277(38):34708-16. Epub 2002 Jul 16.
44. Alpha-1-antitrypsin phenotypes in adult liver disease patients. Topic A, etal., Ups J Med Sci. 2009;114(4):228-34. doi: 10.3109/03009730903243472.
45. Increased expression of alpha-1-antitrypsin, glutathione S-transferase pi and vascular endothelial growth factor in human pancreatic adenocarcinoma. Trachte AL, etal., Am J Surg. 2002 Dec;184(6):642-7; discussion 647-8.
46. Alpha 1-antitrypsin and survival in pancreatic cancer. Trichopoulos D, etal., Int J Cancer. 1990 Apr 15;45(4):685-6.
47. Development of selectivity of alpha1-antitrypsin variant by mutagenesis in its reactive site loop against proprotein convertase. A crucial role of the P4 arginine in PACE4 inhibition. Tsuji A, etal., Protein Eng. 2002 Feb;15(2):123-30.
48. Lung disease associated with alpha1-antitrypsin deficiency. Tuder RM, etal., Proc Am Thorac Soc. 2010 Nov;7(6):381-6.
49. Role of alpha1-antitrypsin and detoxification functions of the liver in the pathogenesis of endotoxin-induced fever. Vismont FI and Shust OG, Bull Exp Biol Med. 2000 Jul;130(7):645-6.
50. [Update: Alpha-1-antitrypsin deficiency. Summary of a scientific symposium at the conference of the Swiss Pneumologic Society on April 16th, 2009]. Vogelmeier C, etal., Pneumologie. 2009 Dec;63(12):718-25. Epub 2009 Nov 25.
51. Hepatic steatosis depresses alpha-1-antitrypsin levels in human and rat acute pancreatitis. Wang Q, etal., Sci Rep. 2015 Dec 4;5:17833. doi: 10.1038/srep17833.
52. Analysis of early changes in the articular cartilage transcriptisome in the rat meniscal tear model of osteoarthritis: pathway comparisons with the rat anterior cruciate transection model and with human osteoarthritic cartilage. Wei T, etal., Osteoarthritis Cartilage. 2010 Apr 29.
53. Rat intestinal alpha1-antitrypsin secretion is regulated by triacylglycerol feeding. Xie QM, etal., Am J Physiol. 1999 Jun;276(6 Pt 1):G1452-60.
54. Proteomic analysis of the serum in patients with idiopathic pulmonary arterial hypertension. Yu M, etal., J Zhejiang Univ Sci B. 2007 Apr;8(4):221-7.
55. Role of neutrophils and alpha1-antitrypsin in coal- and silica-induced connective tissue breakdown. Zay K, etal., Am J Physiol. 1999 Feb;276(2 Pt 1):L269-79.
56. SERPINA1 gene variants in individuals from the general population with reduced alpha1-antitrypsin concentrations. Zorzetto M, etal., Clin Chem. 2008 Aug;54(8):1331-8. doi: 10.1373/clinchem.2007.102798. Epub 2008 May 29.
Additional References at PubMed
PMID:2229024   PMID:2302382   PMID:6980881   PMID:11057674   PMID:12477932   PMID:15489334   PMID:15795238   PMID:15853774   PMID:16192646   PMID:16502470   PMID:16981704   PMID:18923394  
PMID:19056867   PMID:20477988   PMID:21909074   PMID:22405009   PMID:23376485   PMID:23533145   PMID:23580065   PMID:23826168   PMID:24743137   PMID:25645918   PMID:27301375   PMID:35196590  
PMID:36517050  


Genomics

Comparative Map Data
Serpina1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86128,631,101 - 128,653,125 (-)NCBIGRCr8
mRatBN7.26122,866,314 - 122,888,339 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6122,866,312 - 122,888,339 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6123,007,214 - 123,029,250 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06123,302,499 - 123,324,535 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06122,639,411 - 122,661,452 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06127,610,241 - 127,632,265 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6127,610,243 - 127,632,265 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06136,828,856 - 136,850,880 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46127,998,617 - 128,021,719 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16128,002,364 - 128,025,466 (-)NCBI
Celera6120,346,394 - 120,368,519 (-)NCBICelera
Cytogenetic Map6q32NCBI
SERPINA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381494,376,747 - 94,390,635 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1494,376,747 - 94,390,693 (-)EnsemblGRCh38hg38GRCh38
GRCh371494,843,084 - 94,856,972 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361493,914,451 - 93,926,782 (-)NCBINCBI36Build 36hg18NCBI36
Build 341493,914,450 - 93,926,782NCBI
Celera1474,898,987 - 74,912,932 (-)NCBICelera
Cytogenetic Map14q32.13NCBI
HuRef1475,022,652 - 75,036,601 (-)NCBIHuRef
CHM1_11494,780,885 - 94,794,830 (-)NCBICHM1_1
T2T-CHM13v2.01488,606,265 - 88,620,155 (-)NCBIT2T-CHM13v2.0
LOC102021597
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495543817,920,200 - 17,929,105 (+)NCBIChiLan1.0ChiLan1.0
SERPINA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21595,525,119 - 95,539,108 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11494,741,624 - 94,755,614 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01475,001,714 - 75,014,214 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11494,334,258 - 94,347,085 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1494,334,258 - 94,345,419 (-)Ensemblpanpan1.1panPan2
SERPINA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1863,388,498 - 63,400,377 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl863,376,945 - 63,398,435 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha862,965,044 - 62,974,971 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0863,654,807 - 63,666,723 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl863,654,816 - 63,664,785 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1863,330,666 - 63,340,582 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0863,382,963 - 63,392,890 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0863,713,659 - 63,723,574 (-)NCBIUU_Cfam_GSD_1.0
SERPINA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7115,583,043 - 115,614,645 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17115,604,282 - 115,616,915 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27122,616,080 - 122,628,726 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap7q24-q26NCBI
SERPINA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12472,158,521 - 72,171,139 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2472,156,784 - 72,163,500 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605359,387,764 - 59,400,148 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Serpina1
180 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:46
Count of miRNA genes:45
Interacting mature miRNAs:46
Transcripts:ENSRNOT00000012577
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6104085867128713626Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6105156861140994061Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)6122549046140994061Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6100671796132340886Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)693701310128713626Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6106752656132339866Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)6122549046137801795Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)685140138130140138Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6112636280140994061Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6116506292130245370Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)684130881129130881Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
1300076Glom8Glomerulus QTL 879e-09kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6122549046140286318Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 37 37 37
Medium 1 8 4 4 2 2 3 15 10 2
Low 2 11 12 17 6 7 27 21 24 1 6
Below cutoff 18 1 1 35 11 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_022519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240456 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC094636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC078824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D00675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209479 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209492 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209494 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209677 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218241 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218411 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218467 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218492 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219303 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219407 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219621 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219647 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219652 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M32247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X16273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000012577   ⟹   ENSRNOP00000012577
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6122,866,312 - 122,871,787 (-)Ensembl
Rnor_6.0 Ensembl6127,610,243 - 127,620,296 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000084157   ⟹   ENSRNOP00000070499
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6122,866,316 - 122,888,339 (-)Ensembl
Rnor_6.0 Ensembl6127,610,243 - 127,632,265 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000089931   ⟹   ENSRNOP00000070937
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6122,866,316 - 122,883,668 (-)Ensembl
Rnor_6.0 Ensembl6127,610,243 - 127,630,734 (-)Ensembl
RefSeq Acc Id: NM_022519   ⟹   NP_071964
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86128,631,101 - 128,653,125 (-)NCBI
mRatBN7.26122,866,314 - 122,888,339 (-)NCBI
Rnor_6.06127,610,241 - 127,632,265 (-)NCBI
Rnor_5.06136,828,856 - 136,850,880 (-)NCBI
RGSC_v3.46127,998,617 - 128,021,719 (-)RGD
Celera6120,346,394 - 120,368,519 (-)RGD
Sequence:
RefSeq Acc Id: XM_006240456   ⟹   XP_006240518
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86128,631,101 - 128,641,243 (-)NCBI
mRatBN7.26122,866,314 - 122,876,457 (-)NCBI
Rnor_6.06127,610,241 - 127,620,350 (-)NCBI
Rnor_5.06136,828,856 - 136,850,880 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017594032   ⟹   XP_017449521
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86128,631,101 - 128,643,252 (-)NCBI
mRatBN7.26122,866,314 - 122,878,401 (-)NCBI
Rnor_6.06127,610,241 - 127,622,327 (-)NCBI
Sequence:
RefSeq Acc Id: NP_071964   ⟸   NM_022519
- Peptide Label: precursor
- UniProtKB: Q6AYZ5 (UniProtKB/Swiss-Prot),   P17475 (UniProtKB/Swiss-Prot),   A0A0G2JY31 (UniProtKB/TrEMBL),   A6JEP4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240518   ⟸   XM_006240456
- Peptide Label: isoform X1
- UniProtKB: Q6AYZ5 (UniProtKB/Swiss-Prot),   P17475 (UniProtKB/Swiss-Prot),   A0A0G2JY31 (UniProtKB/TrEMBL),   A6JEP4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017449521   ⟸   XM_017594032
- Peptide Label: isoform X1
- UniProtKB: Q6AYZ5 (UniProtKB/Swiss-Prot),   P17475 (UniProtKB/Swiss-Prot),   A0A0G2JY31 (UniProtKB/TrEMBL),   A6JEP4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000012577   ⟸   ENSRNOT00000012577
Ensembl Acc Id: ENSRNOP00000070937   ⟸   ENSRNOT00000089931
Ensembl Acc Id: ENSRNOP00000070499   ⟸   ENSRNOT00000084157
Protein Domains
SERPIN

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P17475-F1-model_v2 AlphaFold P17475 1-411 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694805
Promoter ID:EPDNEW_R5325
Type:initiation region
Name:Serpina1_1
Description:serpin family A member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06127,620,287 - 127,620,347EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3326 AgrOrtholog
BioCyc Gene G2FUF-36401 BioCyc
Ensembl Genes ENSRNOG00000032669 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000012577.7 UniProtKB/TrEMBL
  ENSRNOT00000084157.2 UniProtKB/TrEMBL
  ENSRNOT00000089931.2 UniProtKB/TrEMBL
Gene3D-CATH 2.30.39.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.497.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpins superfamily UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7131535 IMAGE-MGC_LOAD
InterPro Serpin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_sf_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_sf_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24648 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93438 IMAGE-MGC_LOAD
NCBI Gene 24648 ENTREZGENE
PANTHER ALPHA-1-ANTITRYPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11461 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Serpin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Serpina1 PhenoGen
PROSITE SERPIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000032669 RatGTEx
SMART SERPIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56574 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JSJ9_RAT UniProtKB/TrEMBL
  A0A0G2JY31 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2JZ73_RAT UniProtKB/TrEMBL
  A1AT_RAT UniProtKB/Swiss-Prot
  A6JEP4 ENTREZGENE, UniProtKB/TrEMBL
  P17475 ENTREZGENE
  Q6AYZ5 ENTREZGENE
UniProt Secondary Q6AYZ5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-13 Serpina1  serpin family A member 1  Serpina1  serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-02-26 Serpina1  serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1  Serpina1  serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Serpina1  serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1    serine (or cysteine) proteinase inhibitor, clade A, member 1  Name updated 1299863 APPROVED
2002-11-06 Serpina1  serine (or cysteine) proteinase inhibitor, clade A, member 1    serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1  Name updated 625702 APPROVED
2002-01-14 Serpina1  serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1      Correction to spelling of name 67952 APPROVED
2001-06-22 Serpina1  serine (or cysteine) proteinase inhibitor, clade 1 (alpha-1 antiproteinase, antitrypsin), member 1      Symbol and Name updated to reflect Human and Mouse nomenclature 67952 APPROVED
2001-06-22 Pi  Alpha-1-antitrypsin (protease inhibitor)      Symbol and Name withdrawn 67952 WITHDRAWN

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expressed in submandibular gland and lung 1334489