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Gene: Serpina1 (serpin family A member 1) Rattus norvegicus
Symbol: Serpina1
Name: serpin family A member 1
RGD ID: 3326
Description: Exhibits serine-type endopeptidase inhibitor activity. Involved in several processes, including negative regulation of serine-type endopeptidase activity; response to estradiol; and response to methanol. Localizes to extracellular space. Used to study pulmonary hypertension. Biomarker of asthma; osteoarthritis; pancreatitis (multiple); primary hyperaldosteronism; and proteinuria. Human ortholog(s) of this gene implicated in several diseases, including alpha 1-antitrypsin deficiency; chronic obstructive pulmonary disease (multiple); human immunodeficiency virus infectious disease; inflammatory bowel disease (multiple); and liver disease (multiple). Orthologous to human SERPINA1 (serpin family A member 1); PARTICIPATES IN forkhead class A signaling pathway; coagulation cascade pathway; complement system pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.
Type: protein-coding
Also known as: AAT; alpha-1-antiproteinase; alpha-1-antitrypsin (protease inhibitor); alpha-1-protease inhibitor; alpha-1-proteinase inhibitor; Pi; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1; serine (or cysteine) proteinase inhibitor, clade A, member 1; serine protease inhibitor alpha 1; serpin A1; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1; Spi1
Homo sapiens (human) : SERPINA1 (serpin family A member 1)  HGNC  Alliance
Chinchilla lanigera (long-tailed chinchilla) : LOC102021597 (alpha-1-antiproteinase S-like)
Pan paniscus (bonobo/pygmy chimpanzee) : SERPINA1 (serpin family A member 1)
Canis lupus familiaris (dog) : SERPINA1 (serpin family A member 1)
Sus scrofa (pig) : SERPINA1 (serpin family A member 1)
Chlorocebus sabaeus (African green monkey) : SERPINA1 (serpin family A member 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.06127,610,241 - 127,632,265 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6127,610,243 - 127,632,265 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06136,828,856 - 136,850,880 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46127,998,617 - 128,021,719 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.16128,002,364 - 128,025,466 (-)NCBI
Celera6120,346,394 - 120,368,519 (-)NCBICelera
Cytogenetic Map6q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Serpina1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3326
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.