Serpina1 (serpin family A member 1) - Rat Genome Database

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Gene: Serpina1 (serpin family A member 1) Rattus norvegicus
Analyze
Symbol: Serpina1
Name: serpin family A member 1
RGD ID: 3326
Description: Exhibits serine-type endopeptidase inhibitor activity. Involved in several processes, including negative regulation of serine-type endopeptidase activity; response to estradiol; and response to methanol. Localizes to extracellular space. Used to study pulmonary hypertension. Biomarker of asthma; osteoarthritis; pancreatitis (multiple); primary hyperaldosteronism; and proteinuria. Human ortholog(s) of this gene implicated in several diseases, including alpha 1-antitrypsin deficiency; chronic obstructive pulmonary disease (multiple); human immunodeficiency virus infectious disease; inflammatory bowel disease (multiple); and liver disease (multiple). Orthologous to human SERPINA1 (serpin family A member 1); PARTICIPATES IN forkhead class A signaling pathway; coagulation cascade pathway; complement system pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: AAT; alpha-1-antiproteinase; alpha-1-antitrypsin (protease inhibitor); alpha-1-protease inhibitor; alpha-1-proteinase inhibitor; Pi; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1; serine (or cysteine) proteinase inhibitor, clade A, member 1; serine protease inhibitor alpha 1; serpin A1; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1; Spi1
RGD Orthologs
Human
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.26122,866,314 - 122,888,339 (-)NCBI
Rnor_6.0 Ensembl6127,610,243 - 127,632,265 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.06127,610,241 - 127,632,265 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.06136,828,856 - 136,850,880 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46127,998,617 - 128,021,719 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.16128,002,364 - 128,025,466 (-)NCBI
Celera6120,346,394 - 120,368,519 (-)NCBICelera
Cytogenetic Map6q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
acute pancreatitis  (IEP,ISO)
adenocarcinoma  (ISO)
alpha 1-antitrypsin deficiency  (ISO)
anxiety disorder  (ISO)
arteriosclerosis  (ISO)
asbestosis  (ISO)
asthma  (IEP)
bipolar disorder  (ISO)
Bronchial Hyperreactivity  (ISO)
bronchiectasis  (ISO)
Burns  (IEP)
Chemical and Drug Induced Liver Injury  (IEP,ISO)
chemical colitis  (ISO)
cholestasis  (ISO)
chronic obstructive pulmonary disease  (ISO)
colorectal cancer  (ISO)
coronary artery disease  (ISO)
cystic fibrosis  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Emphysema  (ISO)
Experimental Autoimmune Orchitis  (IEP)
Experimental Liver Neoplasms  (IEP)
Gastro-Enteropancreatic Neuroendocrine Tumor  (ISO)
genetic disease  (ISO)
Hemorrhage  (ISO)
hepatocellular carcinoma  (ISO)
human immunodeficiency virus infectious disease  (ISO)
hypertension  (ISO)
hypoglycemia  (ISO)
ileitis  (ISO)
Insulin Resistance  (ISO)
Kidney Reperfusion Injury  (ISO)
liver cirrhosis  (ISO)
liver disease  (ISO)
lung disease  (ISO)
Lung Neoplasms  (ISO)
Myocardial Ischemia  (ISO)
Neoplasm Metastasis  (ISO)
neurodegenerative disease  (ISO)
nodular nonsuppurative panniculitis  (ISO)
osteoarthritis  (IEP)
otitis media  (ISO)
Otitis Media with Effusion  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
pancreatitis  (IEP)
pre-eclampsia  (ISO)
primary hyperaldosteronism  (IEP)
proteinuria  (IEP)
pulmonary emphysema  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (IDA,ISO)
Stomach Neoplasms  (ISO)
thiamine deficiency disease  (ISO)
vasculitis  (ISO)
X-linked intellectual developmental disorder 109  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3-chloropropane-1,2-diol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acetylsalicylic acid  (ISO)
afimoxifene  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
atrazine  (ISO)
azathioprine  (EXP)
belinostat  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
bexarotene  (EXP)
bisphenol A  (EXP,ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chromium(3+) trichloride  (EXP,ISO)
chromium(6+)  (ISO)
clofibrate  (EXP)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP)
doxorubicin  (EXP)
elemental selenium  (ISO)
entinostat  (ISO)
flutamide  (EXP)
furan  (EXP)
genistein  (EXP,ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
L-ethionine  (EXP)
lead(0)  (ISO)
lead(2+)  (ISO)
lipopolysaccharide  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
N-nitrosomorpholine  (EXP)
nickel atom  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
omeprazole  (EXP)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
propanal  (ISO)
propiconazole  (EXP)
resveratrol  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium dichromate  (EXP,ISO)
succimer  (ISO)
tauroursodeoxycholic acid  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
theophylline  (ISO)
thioacetamide  (EXP)
triadimefon  (EXP)
trichloroethene  (EXP)
Triptolide  (EXP)
valproic acid  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Abasolo I, etal., Eur J Nucl Med Mol Imaging. 2009 Jul;36(7):1156-66. Epub 2009 Feb 28.
2. Anderson SP, etal., Mol Carcinog. 1999 Dec;26(4):226-38.
3. Bartlett JR, etal., JAMA. 2009 Sep 9;302(10):1076-83.
4. Borzone G, etal., Am J Physiol Regul Integr Comp Physiol. 2007 Sep;293(3):R1342-9. Epub 2007 Jul 18.
5. Boutten A, etal., Am J Respir Cell Mol Biol. 1998 Apr;18(4):511-20.
6. Carpe N, etal., Am J Respir Cell Mol Biol. 2010 Dec;43(6):720-30. Epub 2010 Jan 29.
7. Chai J, etal., Zhonghua Yi Xue Za Zhi. 2002 Oct 25;82(20):1420-3.
8. Chao J, etal., Agents Actions Suppl. 1992;38 ( Pt 1):174-81.
9. Chao J, etal., Proc Soc Exp Biol Med. 1993 Jun;203(2):243-50.
10. Chhokar VS, etal., Am J Physiol Heart Circ Physiol. 2004 Nov;287(5):H2023-6.
11. Cohen MD, etal., Inhal Toxicol. 2002 Jul;14(7):765-71.
12. Collins CB, etal., Inflamm Bowel Dis. 2013 Aug;19(9):1964-73. doi: 10.1097/MIB.0b013e31829292aa.
13. Dahl M Clin Respir J. 2009 Apr;3(2):121-2.
14. Elzouki AN, etal., Eur J Vasc Endovasc Surg. 1999 Feb;17(2):149-54.
15. Espana F, etal., Am J Obstet Gynecol. 1991 May;164(5 Pt 1):1310-6.
16. Faraj M, etal., Diabetologia. 2006 Jul;49(7):1637-46. Epub 2006 May 3.
17. Ferreira TC, etal., J Med Virol. 2014 Jan;86(1):23-9. doi: 10.1002/jmv.23759. Epub 2013 Oct 12.
18. Fijak M, etal., J Pathol. 2005 Oct;207(2):127-38.
19. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
20. Griesbacher T, etal., Br J Pharmacol. 2003 May;139(2):299-308.
21. Hernández-Pérez JM, etal., Respir Med. 2017 Oct;131:114-117. doi: 10.1016/j.rmed.2017.08.015. Epub 2017 Aug 16.
22. Hidvegi T, etal., Science. 2010 Jul 9;329(5988):229-32. doi: 10.1126/science.1190354. Epub 2010 Jun 3.
23. Kok KF, etal., BMC Gastroenterol. 2010 Feb 20;10:22. doi: 10.1186/1471-230X-10-22.
24. Likholat EA, etal., Ukr Biokhim Zh. 2000 Nov-Dec;72(6):84-7.
25. Lisowska-Myjak B, etal., Scand J Clin Lab Invest. 1999 Apr;59(2):93-7.
26. Maicas N, etal., PLoS One. 2017 Feb 24;12(2):e0168981. doi: 10.1371/journal.pone.0168981. eCollection 2017.
27. Maruyama K, etal., Am J Physiol. 1991 Dec;261(6 Pt 2):H1716-26.
28. Mori T, etal., Am Heart J. 1995 Feb;129(2):234-8.
29. OMIM Disease Annotation Pipeline
30. Pipeline to import KEGG annotations from KEGG into RGD
31. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
32. Pérez-Holanda S, etal., BMC Cancer. 2014 May 21;14:355. doi: 10.1186/1471-2407-14-355.
33. RGD automated data pipeline
34. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
35. RGD automated import pipeline for gene-chemical interactions
36. RGD comprehensive gene curation
37. Shen S, etal., Hum Gene Ther. 2018 Aug;29(8):861-873. doi: 10.1089/hum.2017.227. Epub 2018 Jun 22.
38. Sironi L, etal., Stroke. 2001 Mar;32(3):753-60.
39. Skrzydlewska E, etal., J Toxicol Environ Health A. 1999 Jul 23;57(6):431-42.
40. Spiridonov VK and Tolochko ZS, Bull Exp Biol Med. 2008 Sep;146(3):375-8.
41. Talmud PJ, etal., Arterioscler Thromb Vasc Biol. 2003 Apr 1;23(4):644-9. Epub 2003 Mar 6.
42. Thakur A, etal., Mol Cancer. 2008 Jan 24;7:11.
43. Thongboonkerd V, etal., J Biol Chem. 2002 Sep 20;277(38):34708-16. Epub 2002 Jul 16.
44. Topic A, etal., Ups J Med Sci. 2009;114(4):228-34. doi: 10.3109/03009730903243472.
45. Trachte AL, etal., Am J Surg. 2002 Dec;184(6):642-7; discussion 647-8.
46. Trichopoulos D, etal., Int J Cancer. 1990 Apr 15;45(4):685-6.
47. Tsuji A, etal., Protein Eng. 2002 Feb;15(2):123-30.
48. Tuder RM, etal., Proc Am Thorac Soc. 2010 Nov;7(6):381-6.
49. Vismont FI and Shust OG, Bull Exp Biol Med. 2000 Jul;130(7):645-6.
50. Vogelmeier C, etal., Pneumologie. 2009 Dec;63(12):718-25. Epub 2009 Nov 25.
51. Wang Q, etal., Sci Rep. 2015 Dec 4;5:17833. doi: 10.1038/srep17833.
52. Wei T, etal., Osteoarthritis Cartilage. 2010 Apr 29.
53. Xie QM, etal., Am J Physiol. 1999 Jun;276(6 Pt 1):G1452-60.
54. Yu M, etal., J Zhejiang Univ Sci B. 2007 Apr;8(4):221-7.
55. Zay K, etal., Am J Physiol. 1999 Feb;276(2 Pt 1):L269-79.
56. Zorzetto M, etal., Clin Chem. 2008 Aug;54(8):1331-8. doi: 10.1373/clinchem.2007.102798. Epub 2008 May 29.
Additional References at PubMed
PMID:2229024   PMID:2302382   PMID:6980881   PMID:11057674   PMID:12477932   PMID:15489334   PMID:15795238   PMID:15853774   PMID:16192646   PMID:16502470   PMID:16981704   PMID:18923394  
PMID:19056867   PMID:20477988   PMID:21909074   PMID:22405009   PMID:23376485   PMID:23533145   PMID:23580065   PMID:23826168   PMID:24743137   PMID:25645918   PMID:27301375  


Genomics

Comparative Map Data
Serpina1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.26122,866,314 - 122,888,339 (-)NCBI
Rnor_6.0 Ensembl6127,610,243 - 127,632,265 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.06127,610,241 - 127,632,265 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.06136,828,856 - 136,850,880 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46127,998,617 - 128,021,719 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.16128,002,364 - 128,025,466 (-)NCBI
Celera6120,346,394 - 120,368,519 (-)NCBICelera
Cytogenetic Map6q32NCBI
SERPINA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1494,376,747 - 94,390,693 (-)EnsemblGRCh38hg38GRCh38
GRCh381494,376,747 - 94,390,654 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371494,843,084 - 94,856,972 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361493,914,451 - 93,926,782 (-)NCBINCBI36hg18NCBI36
Build 341493,914,450 - 93,926,782NCBI
Celera1474,898,987 - 74,912,932 (-)NCBI
Cytogenetic Map14q32.13NCBI
HuRef1475,022,652 - 75,036,601 (-)NCBIHuRef
CHM1_11494,780,885 - 94,794,830 (-)NCBICHM1_1
LOC102021597
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495543817,920,200 - 17,929,105 (+)NCBIChiLan1.0ChiLan1.0
SERPINA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11494,334,258 - 94,347,085 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1494,334,258 - 94,345,419 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01475,001,714 - 75,014,214 (-)NCBIMhudiblu_PPA_v0panPan3
SERPINA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1863,388,498 - 63,400,377 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl863,376,945 - 63,398,435 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha862,965,044 - 62,974,971 (-)NCBI
ROS_Cfam_1.0863,654,807 - 63,666,723 (-)NCBI
UMICH_Zoey_3.1863,330,666 - 63,340,582 (-)NCBI
UNSW_CanFamBas_1.0863,382,963 - 63,392,890 (-)NCBI
UU_Cfam_GSD_1.0863,713,659 - 63,723,574 (-)NCBI
SERPINA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7115,604,285 - 115,614,633 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17115,604,282 - 115,616,915 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27122,616,080 - 122,628,726 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap7q24-q26NCBI
SERPINA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12472,158,521 - 72,171,139 (-)NCBI
ChlSab1.1 Ensembl2472,156,784 - 72,163,500 (-)Ensembl
Vero_WHO_p1.0NW_02366605359,387,764 - 59,400,148 (-)NCBI


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)668781170147991367Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)668781170147991367Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)675623277136143011Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)675623277136426962Rat
1581550Pur8Proteinuria QTL 8total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)675623393136142742Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)675623393136142742Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)688507712133507712Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)688996335139410483Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)689631358134631358Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)689631358134631358Rat
1300076Glom8Glomerulus QTL 870.000000009kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)691703409136703409Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)692879510137879510Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)697949772133849286Rat
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)699273921144273921Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)699273921144792678Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)6101207574147991367Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6104363890147991367Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6104381930138066274Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6108154445133849286Rat
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6111134524138065254Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6117355600147991367Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6121224054135658578Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)6127286494144745573Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6127286494147249902Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)6127286494147991367Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:46
Count of miRNA genes:45
Interacting mature miRNAs:46
Transcripts:ENSRNOT00000012577
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 43 37 37
Medium 1 8 4 4 2 2 3 15 10 2
Low 2 11 12 17 6 7 27 21 24 1 6
Below cutoff 18 1 1 35 11 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_022519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240456 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC094636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC078824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D00675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209479 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209492 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209494 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209677 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218241 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218411 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218467 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218492 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219303 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219407 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219621 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219647 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219652 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M32247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X16273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000012577   ⟹   ENSRNOP00000012577
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl6127,610,243 - 127,620,296 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000084157   ⟹   ENSRNOP00000070499
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl6127,610,243 - 127,632,265 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000089931   ⟹   ENSRNOP00000070937
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl6127,610,243 - 127,630,734 (-)Ensembl
RefSeq Acc Id: NM_022519   ⟹   NP_071964
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26122,866,314 - 122,888,339 (-)NCBI
Rnor_6.06127,610,241 - 127,632,265 (-)NCBI
Rnor_5.06136,828,856 - 136,850,880 (-)NCBI
RGSC_v3.46127,998,617 - 128,021,719 (-)RGD
Celera6120,346,394 - 120,368,519 (-)RGD
Sequence:
RefSeq Acc Id: XM_006240456   ⟹   XP_006240518
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26122,866,314 - 122,876,457 (-)NCBI
Rnor_6.06127,610,241 - 127,620,350 (-)NCBI
Rnor_5.06136,828,856 - 136,850,880 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017594032   ⟹   XP_017449521
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26122,866,314 - 122,878,401 (-)NCBI
Rnor_6.06127,610,241 - 127,622,327 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_071964   ⟸   NM_022519
- Peptide Label: precursor
- UniProtKB: P17475 (UniProtKB/Swiss-Prot),   A0A0G2JY31 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240518   ⟸   XM_006240456
- Peptide Label: isoform X1
- UniProtKB: P17475 (UniProtKB/Swiss-Prot),   A0A0G2JY31 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017449521   ⟸   XM_017594032
- Peptide Label: isoform X1
- UniProtKB: P17475 (UniProtKB/Swiss-Prot),   A0A0G2JY31 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000012577   ⟸   ENSRNOT00000012577
RefSeq Acc Id: ENSRNOP00000070937   ⟸   ENSRNOT00000089931
RefSeq Acc Id: ENSRNOP00000070499   ⟸   ENSRNOT00000084157
Protein Domains
SERPIN

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694805
Promoter ID:EPDNEW_R5325
Type:initiation region
Name:Serpina1_1
Description:serpin family A member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06127,620,287 - 127,620,347EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3326 AgrOrtholog
Ensembl Genes ENSRNOG00000032669 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000012577 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000070499 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000070937 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000012577 UniProtKB/TrEMBL
  ENSRNOT00000084157 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000089931 UniProtKB/TrEMBL
Gene3D-CATH 2.30.39.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.497.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7131535 IMAGE-MGC_LOAD
InterPro Serpin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_sf_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_sf_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24648 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93438 IMAGE-MGC_LOAD
NCBI Gene 24648 ENTREZGENE
PANTHER PTHR11461 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Serpin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Serpina1 PhenoGen
PROSITE SERPIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SERPIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56574 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JY31 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2JZ73_RAT UniProtKB/TrEMBL
  A1AT_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q6AYZ5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-13 Serpina1  serpin family A member 1  Serpina1  serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-02-26 Serpina1  serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1  Serpina1  serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Serpina1  serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1    serine (or cysteine) proteinase inhibitor, clade A, member 1  Name updated 1299863 APPROVED
2002-11-06 Serpina1  serine (or cysteine) proteinase inhibitor, clade A, member 1    serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1  Name updated 625702 APPROVED
2002-01-14 Serpina1  serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1      Correction to spelling of name 67952 APPROVED
2001-06-22 Serpina1  serine (or cysteine) proteinase inhibitor, clade 1 (alpha-1 antiproteinase, antitrypsin), member 1      Symbol and Name updated to reflect Human and Mouse nomenclature 67952 APPROVED
2001-06-22 Pi  Alpha-1-antitrypsin (protease inhibitor)      Symbol and Name withdrawn 67952 WITHDRAWN

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expressed in submandibular gland and lung 1334489