RGD Reference Report - Activity of cathepsin G, elastase, and their inhibitors in plasma during methanol intoxication. - Rat Genome Database

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Activity of cathepsin G, elastase, and their inhibitors in plasma during methanol intoxication.

Authors: Skrzydlewska, E  Szmitkowski, M  Farbiszewski, R 
Citation: Skrzydlewska E, etal., J Toxicol Environ Health A. 1999 Jul 23;57(6):431-42.
RGD ID: 2292013
Pubmed: PMID:10478824   (View Abstract at PubMed)

Methanol oxidation in the liver is accompanied by formation of formaldehyde and free radicals. These compounds can react with biologically active proteins, including proteolytic enzymes and their inhibitors. The activity of cathepsin G and elastase and their inhibitors such as alpha-1-antitrypsin and alpha-2-macroglobulin in plasma of rats given methanol orally in doses of 1.5, 3, and 6 g/kg was investigated for 7 days. The activity of cathepsin G and elastase was increased from 12 h to 5 d, proportionally to methanol dose. At the same time, activity of their inhibitors was reduced. Methanol ingestion in humans caused changes in activities of proteases and their inhibitors with similar direction as in rats. These changes in activity of proteases and their inhibitors produce significant disturbances in proteolytic-antiproteolytic balance after methanol administration.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Serpina1Ratresponse to methanol  IDA  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Serpina1  (serpin family A member 1)


Additional Information