LOC102021597 (alpha-1-antiproteinase S-like) - Rat Genome Database

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Gene: LOC102021597 (alpha-1-antiproteinase S-like) Chinchilla lanigera
Analyze
Symbol: LOC102021597
Name: alpha-1-antiproteinase S-like
RGD ID: 9014073
Description: ENCODES a protein that exhibits endopeptidase inhibitor activity (ortholog); identical protein binding (ortholog); protease binding (ortholog); INVOLVED IN negative regulation of serine-type endopeptidase activity (ortholog); response to chromate (ortholog); response to cytokine (ortholog); PARTICIPATES IN forkhead class A signaling pathway; ASSOCIATED WITH otitis media; Otitis Media with Effusion; achondrogenesis type IA (ortholog); FOUND IN extracellular space; endoplasmic reticulum (ortholog); Golgi apparatus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: alpha-1 antitrypsin; alpha1-AT; serpin family A member 1; Serpina1
RGD Orthologs
Human
Rat
Bonobo
Dog
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495543817,920,200 - 17,929,105 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
achondrogenesis type IA  (ISO)
acute kidney failure  (ISO)
acute pancreatitis  (ISO)
adenocarcinoma  (ISO)
alpha 1-antitrypsin deficiency  (ISO)
anxiety disorder  (ISO)
arteriosclerosis  (ISO)
asbestosis  (ISO)
asthma  (ISO)
bipolar disorder  (ISO)
Bronchial Hyperreactivity  (ISO)
bronchiectasis  (ISO)
Burns  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
chemical colitis  (ISO)
cholestasis  (ISO)
chronic obstructive pulmonary disease  (ISO)
colorectal cancer  (ISO)
coronary artery disease  (ISO)
COVID-19  (ISO)
cystic fibrosis  (ISO)
DICER1 syndrome  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Emphysema  (ISO)
Experimental Autoimmune Orchitis  (ISO)
Experimental Liver Neoplasms  (ISO)
Gastro-Enteropancreatic Neuroendocrine Tumor  (ISO)
genetic disease  (ISO)
Hemorrhage  (ISO)
hepatocellular carcinoma  (ISO)
human immunodeficiency virus infectious disease  (ISO)
hypertension  (ISO)
hypoglycemia  (ISO)
ileitis  (ISO)
Insulin Resistance  (ISO)
Kidney Reperfusion Injury  (ISO)
liver cirrhosis  (ISO)
liver disease  (ISO)
lung disease  (ISO)
Lung Neoplasms  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Myocardial Ischemia  (ISO)
Neoplasm Metastasis  (ISO)
neurodegenerative disease  (ISO)
Neurodevelopmental Disorders  (ISO)
nodular nonsuppurative panniculitis  (ISO)
osteoarthritis  (ISO)
otitis media  (IEP)
Otitis Media with Effusion  (IEP)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
pancreatitis  (ISO)
pleuropulmonary blastoma  (ISO)
pre-eclampsia  (ISO)
primary hyperaldosteronism  (ISO)
proteinuria  (ISO)
pulmonary emphysema  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
squamous cell carcinoma  (ISO)
Stomach Neoplasms  (ISO)
thiamine deficiency disease  (ISO)
vasculitis  (ISO)
X-linked intellectual developmental disorder 109  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Antiinflammatory effects of a corticosteroid and protease inhibitor agents on antigen-induced otitis media in chinchillas. Hamaguchi Y, etal., Am J Otolaryngol. 1988 May-Jun;9(3):142-8.
2. Proteases and protease inhibitors in immune complex otitis media in chinchillas. Hamaguchi Y, etal., Ann Otol Rhinol Laryngol. 1989 Jul;98(7 Pt 1):563-8.
3. Biochemical study of protease inhibitors in experimental otitis media with effusion. Juhn SK and Hamaguchi Y, Ann Otol Rhinol Laryngol Suppl. 1988 May-Jun;132:10-3.
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
LOC102021597
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495543817,920,200 - 17,929,105 (+)NCBIChiLan1.0ChiLan1.0
SERPINA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381494,376,747 - 94,390,635 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1494,376,747 - 94,390,693 (-)EnsemblGRCh38hg38GRCh38
GRCh371494,843,084 - 94,856,972 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361493,914,451 - 93,926,782 (-)NCBINCBI36Build 36hg18NCBI36
Build 341493,914,450 - 93,926,782NCBI
Celera1474,898,987 - 74,912,932 (-)NCBICelera
Cytogenetic Map14q32.13NCBI
HuRef1475,022,652 - 75,036,601 (-)NCBIHuRef
CHM1_11494,780,885 - 94,794,830 (-)NCBICHM1_1
T2T-CHM13v2.01488,606,265 - 88,620,155 (-)NCBIT2T-CHM13v2.0
Serpina1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86128,631,101 - 128,653,125 (-)NCBIGRCr8
mRatBN7.26122,866,314 - 122,888,339 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6122,866,312 - 122,888,339 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6123,007,214 - 123,029,250 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06123,302,499 - 123,324,535 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06122,639,411 - 122,661,452 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06127,610,241 - 127,632,265 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6127,610,243 - 127,632,265 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06136,828,856 - 136,850,880 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46127,998,617 - 128,021,719 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16128,002,364 - 128,025,466 (-)NCBI
Celera6120,346,394 - 120,368,519 (-)NCBICelera
Cytogenetic Map6q32NCBI
SERPINA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21595,525,119 - 95,539,108 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11494,741,624 - 94,755,614 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01475,001,714 - 75,014,214 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11494,334,258 - 94,347,085 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1494,334,258 - 94,345,419 (-)Ensemblpanpan1.1panPan2
SERPINA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1863,388,498 - 63,400,377 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl863,376,945 - 63,398,435 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha862,965,044 - 62,974,971 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0863,654,807 - 63,666,723 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl863,654,816 - 63,664,785 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1863,330,666 - 63,340,582 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0863,382,963 - 63,392,890 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0863,713,659 - 63,723,574 (-)NCBIUU_Cfam_GSD_1.0
SERPINA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7115,583,043 - 115,614,645 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17115,604,282 - 115,616,915 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27122,616,080 - 122,628,726 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap7q24-q26NCBI
SERPINA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12472,158,521 - 72,171,139 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2472,156,784 - 72,163,500 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605359,387,764 - 59,400,148 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


RefSeq Acc Id: XM_005390393   ⟹   XP_005390450
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495543817,920,200 - 17,929,105 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005390450 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000021720
  ENSCLAP00000021720.1
RefSeq Acc Id: XP_005390450   ⟸   XM_005390393
- UniProtKB: A0A8C2VZD9 (UniProtKB/TrEMBL)
- Sequence:
Protein Domains
SERPIN


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000014868 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000021923 ENTREZGENE
  ENSCLAT00000021923.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.39.10 UniProtKB/TrEMBL
  3.30.497.10 UniProtKB/TrEMBL
  Serpins superfamily UniProtKB/TrEMBL
InterPro Serpin_CS UniProtKB/TrEMBL
  Serpin_dom UniProtKB/TrEMBL
  Serpin_fam UniProtKB/TrEMBL
  Serpin_sf UniProtKB/TrEMBL
  Serpin_sf_1 UniProtKB/TrEMBL
  Serpin_sf_2 UniProtKB/TrEMBL
NCBI Gene LOC102021597 ENTREZGENE
PANTHER ALPHA-1-ANTITRYPSIN UniProtKB/TrEMBL
  PTHR11461 UniProtKB/TrEMBL
Pfam Serpin UniProtKB/TrEMBL
PROSITE PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
  SERPIN UniProtKB/TrEMBL
SMART SERPIN UniProtKB/TrEMBL
Superfamily-SCOP SSF56574 UniProtKB/TrEMBL
UniProt A0A8C2VZD9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-02-07 LOC102021597  alpha-1-antiproteinase S-like  Serpina1  serpin family A member 1  Symbol and/or name change 5135510 APPROVED
2016-10-17 Serpina1  serpin family A member 1  LOC102021597  alpha-1-antiproteinase S-like  Name and Symbol changed 629549 APPROVED