Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | PKN2 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PKN2 mRNA | CTD | PMID:22079256 | (S)-nicotine | increases expression | ISO | PKN2 (Homo sapiens) | 6480464 | Nicotine results in increased expression of PKN2 mRNA | CTD | PMID:16949557 | 1,2-dimethylhydrazine | decreases expression | ISO | Pkn2 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of PKN2 mRNA | CTD | PMID:22206623 | 17alpha-ethynylestradiol | affects expression | ISO | Pkn2 (Mus musculus) | 6480464 | Ethinyl Estradiol affects the expression of PKN2 mRNA | CTD | PMID:17555576 | 17alpha-ethynylestradiol | multiple interactions | ISO | Pkn2 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PKN2 mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | increases expression | ISO | Pkn2 (Mus musculus) | 6480464 | Ethinyl Estradiol results in increased expression of PKN2 mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Pkn2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of PKN2 mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PKN2 mRNA | CTD | PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Pkn2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of PKN2 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | PKN2 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin affects the expression of PKN2 mRNA | CTD | PMID:22298810 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Pkn2 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PKN2 mRNA | CTD | PMID:17942748 | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 6-dinitrotoluene affects the expression of PKN2 mRNA | CTD | PMID:21346803 | 2-butoxyethanol | increases expression | ISO | Pkn2 (Mus musculus) | 6480464 | n-butoxyethanol results in increased expression of PKN2 mRNA | CTD | PMID:19812364 | 3,4-methylenedioxymethamphetamine | decreases expression | ISO | Pkn2 (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of PKN2 mRNA | CTD | PMID:26251327 | aflatoxin B1 | decreases methylation | ISO | PKN2 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of PKN2 gene | CTD | PMID:27153756 | all-trans-retinoic acid | increases expression | ISO | PKN2 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of PKN2 mRNA | CTD | PMID:33167477 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of PKN2 mRNA | CTD | PMID:16483693 | aristolochic acid A | decreases expression | ISO | PKN2 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of PKN2 mRNA | CTD | PMID:33212167 | arsenite(3-) | affects expression | ISO | PKN2 (Homo sapiens) | 6480464 | arsenite affects the expression of PKN2 mRNA | CTD | PMID:22959463 | arsenite(3-) | multiple interactions | ISO | PKN2 (Homo sapiens) | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to PKN2 mRNA] | CTD | PMID:32406909 | benzo[a]pyrene | increases expression | ISO | Pkn2 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of PKN2 mRNA | CTD | PMID:22228805 | benzo[a]pyrene diol epoxide I | decreases expression | ISO | PKN2 (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:19150397 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of PKN2 mRNA | CTD | PMID:25181051 | bisphenol A | decreases expression | ISO | Pkn2 (Mus musculus) | 6480464 | bisphenol A results in decreased expression of PKN2 mRNA | CTD | PMID:33221593 | cadmium dichloride | increases expression | ISO | PKN2 (Homo sapiens) | 6480464 | Cadmium Chloride results in increased expression of PKN2 mRNA | CTD | PMID:26472689 | caffeine | affects phosphorylation | ISO | PKN2 (Homo sapiens) | 6480464 | Caffeine affects the phosphorylation of PKN2 protein | CTD | PMID:35688186 | cisplatin | increases expression | ISO | Pkn2 (Mus musculus) | 6480464 | Cisplatin results in increased expression of PKN2 mRNA | CTD | PMID:21151649 | copper atom | multiple interactions | ISO | PKN2 (Homo sapiens) | 6480464 | [Chelating Agents binds to Copper] which results in increased expression of PKN2 mRNA | CTD | PMID:30911355 | copper(0) | multiple interactions | ISO | PKN2 (Homo sapiens) | 6480464 | [Chelating Agents binds to Copper] which results in increased expression of PKN2 mRNA | CTD | PMID:30911355 | copper(II) sulfate | increases expression | ISO | PKN2 (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of PKN2 mRNA | CTD | PMID:19549813 | coumarin | decreases phosphorylation | ISO | PKN2 (Homo sapiens) | 6480464 | coumarin results in decreased phosphorylation of PKN2 protein | CTD | PMID:35688186 | dexamethasone | decreases expression | ISO | Pkn2 (Mus musculus) | 6480464 | Dexamethasone results in decreased expression of PKN2 mRNA | CTD | PMID:21041162 | doxorubicin | decreases expression | ISO | Pkn2 (Mus musculus) | 6480464 | Doxorubicin results in decreased expression of PKN2 mRNA | CTD | PMID:17888722 | elemental selenium | decreases expression | ISO | PKN2 (Homo sapiens) | 6480464 | Selenium results in decreased expression of PKN2 mRNA | CTD | PMID:19244175 | epoxiconazole | increases expression | ISO | Pkn2 (Mus musculus) | 6480464 | epoxiconazole results in increased expression of PKN2 mRNA | CTD | PMID:35436446 | fasudil | decreases activity | ISO | PKN2 (Homo sapiens) | 6480464 | fasudil results in decreased activity of PKN2 protein | CTD | PMID:10998351 | folic acid | decreases expression | ISO | PKN2 (Homo sapiens) | 6480464 | Folic Acid results in decreased expression of PKN2 mRNA | CTD | PMID:21867686 | folic acid | decreases expression | ISO | Pkn2 (Mus musculus) | 6480464 | Folic Acid results in decreased expression of PKN2 mRNA | CTD | PMID:25629700 | FR900359 | affects phosphorylation | ISO | PKN2 (Homo sapiens) | 6480464 | FR900359 affects the phosphorylation of PKN2 protein | CTD | PMID:37730182 | glafenine | decreases expression | EXP | | 6480464 | Glafenine results in decreased expression of PKN2 mRNA | CTD | PMID:24136188 | glyphosate | decreases expression | ISO | PKN2 (Homo sapiens) | 6480464 | Glyphosate results in decreased expression of PKN2 mRNA | CTD | PMID:31295307 | ivermectin | decreases expression | ISO | PKN2 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of PKN2 protein | CTD | PMID:32959892 | methyl methanesulfonate | increases expression | ISO | PKN2 (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in increased expression of PKN2 mRNA | CTD | PMID:23649840 | miconazole | decreases expression | ISO | Pkn2 (Mus musculus) | 6480464 | Miconazole results in decreased expression of PKN2 mRNA | CTD | PMID:27462272 | nicotine | increases expression | ISO | PKN2 (Homo sapiens) | 6480464 | Nicotine results in increased expression of PKN2 mRNA | CTD | PMID:16949557 | oxaliplatin | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of PKN2 mRNA | CTD | PMID:25729387 | paracetamol | affects expression | ISO | Pkn2 (Mus musculus) | 6480464 | Acetaminophen affects the expression of PKN2 mRNA | CTD | PMID:17562736 | phenobarbital | affects expression | ISO | Pkn2 (Mus musculus) | 6480464 | Phenobarbital affects the expression of PKN2 mRNA | CTD | PMID:23091169 | potassium chromate | decreases expression | ISO | PKN2 (Homo sapiens) | 6480464 | potassium chromate(VI) results in decreased expression of PKN2 mRNA | CTD | PMID:22079256 | potassium chromate | multiple interactions | ISO | PKN2 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PKN2 mRNA | CTD | PMID:22079256 | quercetin | decreases phosphorylation | ISO | PKN2 (Homo sapiens) | 6480464 | Quercetin results in decreased phosphorylation of PKN2 protein | CTD | PMID:35688186 | resveratrol | decreases expression | ISO | PKN2 (Homo sapiens) | 6480464 | resveratrol results in decreased expression of PKN2 mRNA | CTD | PMID:18089832 | selenium atom | decreases expression | ISO | PKN2 (Homo sapiens) | 6480464 | Selenium results in decreased expression of PKN2 mRNA | CTD | PMID:19244175 | tamoxifen | affects expression | ISO | Pkn2 (Mus musculus) | 6480464 | Tamoxifen affects the expression of PKN2 mRNA | CTD | PMID:17555576 | temozolomide | increases expression | ISO | PKN2 (Homo sapiens) | 6480464 | Temozolomide results in increased expression of PKN2 mRNA | CTD | PMID:31758290 | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of PKN2 mRNA | CTD | PMID:23411599 | topotecan | decreases expression | EXP | | 6480464 | Topotecan results in decreased expression of PKN2 mRNA | CTD | PMID:25729387 | topotecan | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of PKN2 mRNA | CTD | PMID:25729387 | trichloroethene | increases methylation | EXP | | 6480464 | Trichloroethylene results in increased methylation of PKN2 gene | CTD | PMID:27618143 | triptonide | increases expression | ISO | Pkn2 (Mus musculus) | 6480464 | triptonide results in increased expression of PKN2 mRNA | CTD | PMID:33045310 | valproic acid | decreases expression | ISO | PKN2 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of PKN2 mRNA | CTD | PMID:23179753 | vitamin E | decreases expression | ISO | PKN2 (Homo sapiens) | 6480464 | Vitamin E results in decreased expression of PKN2 mRNA | CTD | PMID:19244175 | Y-27632 | decreases activity | ISO | PKN2 (Homo sapiens) | 6480464 | Y 27632 results in decreased activity of PKN2 protein | CTD | PMID:10998351 | |