Pkn2 (protein kinase N2) - Rat Genome Database

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Gene: Pkn2 (protein kinase N2) Rattus norvegicus
Analyze
Symbol: Pkn2
Name: protein kinase N2
RGD ID: 620146
Description: Enables protein serine/threonine kinase activity. Predicted to be involved in several processes, including peptidyl-serine phosphorylation; positive regulation of cell cycle; and positive regulation of viral genome replication. Predicted to be located in several cellular components, including cleavage furrow; cytoskeleton; and midbody. Predicted to be part of protein-containing complex. Orthologous to human PKN2 (protein kinase N2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cardiolipin-activated protein kinase Pak2; p140 kinase; Pak-2; PKN gamma; Prkcl2; protease-activated kinase 2; protein kinase C-like 2; protein-kinase C-related kinase 2; serine/threonine-protein kinase N2; similar to human PRKCL2 (protein kinase C-like 2)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22231,793,584 - 231,898,953 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2231,793,584 - 231,898,953 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2239,572,538 - 239,677,842 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02237,466,818 - 237,572,120 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02232,330,191 - 232,435,493 (-)NCBIRnor_WKY
Rnor_6.02248,735,699 - 248,840,735 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2248,735,699 - 248,840,735 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02267,265,825 - 267,370,861 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42240,903,608 - 241,009,063 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12240,892,652 - 240,944,091 (-)NCBI
Celera2223,803,766 - 223,906,746 (-)NCBICelera
Cytogenetic Map2q44NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
apical junction complex  (IEA,ISO,ISS)
centrosome  (IEA,ISO)
cleavage furrow  (IEA,ISO,ISS)
cytoplasm  (IEA,ISO,ISS)
cytoskeleton  (IEA)
cytosol  (IEA,ISO)
intermediate filament cytoskeleton  (IEA,ISO)
lamellipodium  (IEA,ISO,ISS)
midbody  (IEA,ISO,ISS)
nuclear body  (IEA,ISO)
nucleoplasm  (ISO)
nucleus  (IEA,ISO,ISS)
perinuclear region of cytoplasm  (IEA,ISO)
plasma membrane  (ISO)
protein-containing complex  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. A cardiolipin-activated protein kinase from rat liver structurally distinct from the protein kinases C. Morrice NA, etal., J Biol Chem 1994 Aug 5;269(31):20040-6.
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9092545   PMID:11356191   PMID:12783890   PMID:15057822   PMID:15364941   PMID:17332740   PMID:20188095   PMID:20974804   PMID:21754995   PMID:22658674   PMID:25468996  


Genomics

Comparative Map Data
Pkn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22231,793,584 - 231,898,953 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2231,793,584 - 231,898,953 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2239,572,538 - 239,677,842 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02237,466,818 - 237,572,120 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02232,330,191 - 232,435,493 (-)NCBIRnor_WKY
Rnor_6.02248,735,699 - 248,840,735 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2248,735,699 - 248,840,735 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02267,265,825 - 267,370,861 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42240,903,608 - 241,009,063 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12240,892,652 - 240,944,091 (-)NCBI
Celera2223,803,766 - 223,906,746 (-)NCBICelera
Cytogenetic Map2q44NCBI
PKN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38188,684,273 - 88,836,255 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl188,684,222 - 88,836,255 (+)EnsemblGRCh38hg38GRCh38
GRCh37189,149,956 - 89,301,938 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36188,922,510 - 89,074,526 (+)NCBINCBI36Build 36hg18NCBI36
Build 34188,862,276 - 89,011,443NCBI
Celera187,395,729 - 87,547,728 (+)NCBICelera
Cytogenetic Map1p22.2NCBI
HuRef187,267,203 - 87,419,414 (+)NCBIHuRef
CHM1_1189,265,019 - 89,416,992 (+)NCBICHM1_1
T2T-CHM13v2.0188,527,688 - 88,679,643 (+)NCBIT2T-CHM13v2.0
Pkn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393142,496,663 - 142,587,765 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3142,496,663 - 142,587,765 (-)EnsemblGRCm39 Ensembl
GRCm383142,790,902 - 142,882,004 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3142,790,902 - 142,882,004 (-)EnsemblGRCm38mm10GRCm38
MGSCv373142,453,866 - 142,544,968 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363142,730,845 - 142,819,376 (-)NCBIMGSCv36mm8
Celera3149,222,971 - 149,314,408 (-)NCBICelera
Cytogenetic Map3H1NCBI
cM Map366.69NCBI
Pkn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554235,467,017 - 5,575,620 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554235,467,017 - 5,575,435 (-)NCBIChiLan1.0ChiLan1.0
PKN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1190,147,949 - 90,302,741 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl190,202,299 - 90,302,741 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0191,395,885 - 91,551,347 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PKN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1659,556,668 - 59,638,626 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl659,559,124 - 59,709,926 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha662,264,725 - 62,394,692 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0660,067,704 - 60,197,746 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl660,067,567 - 60,220,888 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1659,633,009 - 59,762,681 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0659,588,332 - 59,718,360 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0660,074,127 - 60,204,202 (-)NCBIUU_Cfam_GSD_1.0
Pkn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505899,124,068 - 99,240,257 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936732198,647 - 314,947 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936732199,208 - 315,094 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PKN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4127,573,703 - 127,709,942 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14127,579,097 - 127,709,982 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24139,804,474 - 139,934,537 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PKN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12044,582,227 - 44,739,892 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2044,584,576 - 44,739,761 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603373,164,387 - 73,324,100 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pkn2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247428,742,473 - 8,865,281 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247428,740,102 - 8,865,483 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pkn2
248 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:544
Count of miRNA genes:268
Interacting mature miRNAs:344
Transcripts:ENSRNOT00000031748
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2189599258234599258Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189599258234599258Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2193452645245889826Rat
1598813Memor9Memory QTL 92.7exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2199341726234244620Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2200990457245990457Rat
2298479Eau5Experimental allergic uveoretinitis QTL 50.0021uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)2202446871237938339Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2211744537249053267Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2211744537249053267Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2211744537249053267Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2211744537249053267Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2211744537249053267Rat
2317885Alcrsp28Alcohol response QTL 282.10.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2212828222249053267Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2214226044247136170Rat
2313073Bmd75Bone mineral density QTL 754.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)2215377404237938339Rat
1331767Hrtrt12Heart rate QTL 123.373heart pumping trait (VT:2000009)heart rate (CMO:0000002)2218414747240841241Rat
2293833Kiddil8Kidney dilation QTL 82.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
2293844Kiddil7Kidney dilation QTL 73.5kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
9587428Epfw6Epididymal fat weight QTL 67.470.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)2223389739249053267Rat
7411555Bw132Body weight QTL 1320.001body mass (VT:0001259)body weight gain (CMO:0000420)2223389739249053267Rat
631563Hcuc3Hepatic copper content QTL 33.87liver copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)2229059610249053267Rat

Markers in Region
D2Rat103  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22231,871,034 - 231,871,243 (+)MAPPERmRatBN7.2
Rnor_6.02248,812,081 - 248,812,289NCBIRnor6.0
Rnor_5.02267,342,207 - 267,342,415UniSTSRnor5.0
RGSC_v3.42240,981,145 - 240,981,354RGDRGSC3.4
RGSC_v3.42240,981,146 - 240,981,354UniSTSRGSC3.4
RGSC_v3.12240,967,886 - 240,968,094RGD
Celera2223,878,766 - 223,878,974UniSTS
RH 3.4 Map21580.1RGD
RH 3.4 Map21580.1UniSTS
SHRSP x BN Map298.7698UniSTS
SHRSP x BN Map298.7698RGD
FHH x ACI Map2112.9599RGD
Cytogenetic Map2q44UniSTS
BB448270  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22231,794,764 - 231,794,850 (+)MAPPERmRatBN7.2
Rnor_6.02248,736,880 - 248,736,965NCBIRnor6.0
Rnor_5.02267,267,006 - 267,267,091UniSTSRnor5.0
RGSC_v3.42240,904,789 - 240,904,874UniSTSRGSC3.4
Celera2223,804,947 - 223,805,032UniSTS
Cytogenetic Map2q44UniSTS
RH134039  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22231,793,678 - 231,793,887 (+)MAPPERmRatBN7.2
Rnor_6.02248,735,794 - 248,736,002NCBIRnor6.0
Rnor_5.02267,265,920 - 267,266,128UniSTSRnor5.0
RGSC_v3.42240,903,703 - 240,903,911UniSTSRGSC3.4
Celera2223,803,861 - 223,804,069UniSTS
RH 3.4 Map21580.5UniSTS
Cytogenetic Map2q44UniSTS
BI290487  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22231,827,639 - 231,827,829 (+)MAPPERmRatBN7.2
Rnor_6.02248,769,753 - 248,769,942NCBIRnor6.0
Rnor_5.02267,299,879 - 267,300,068UniSTSRnor5.0
RGSC_v3.42240,937,662 - 240,937,851UniSTSRGSC3.4
Celera2223,837,820 - 223,838,009UniSTS
RH 3.4 Map21581.2UniSTS
Cytogenetic Map2q44UniSTS
AA996831  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22231,795,477 - 231,795,692 (+)MAPPERmRatBN7.2
mRatBN7.21715,677,457 - 15,677,671 (+)MAPPERmRatBN7.2
Rnor_6.01716,099,171 - 16,099,384NCBIRnor6.0
Rnor_6.02248,737,593 - 248,737,807NCBIRnor6.0
Rnor_5.01718,161,378 - 18,161,591UniSTSRnor5.0
Rnor_5.02267,267,719 - 267,267,933UniSTSRnor5.0
RGSC_v3.42240,905,502 - 240,905,716UniSTSRGSC3.4
RGSC_v3.41721,666,726 - 21,666,939UniSTSRGSC3.4
Celera1715,406,860 - 15,407,073UniSTS
Celera2223,805,660 - 223,805,874UniSTS
RH 3.4 Map17180.5UniSTS
Cytogenetic Map2q44UniSTS
AI507382  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22231,795,904 - 231,796,020 (+)MAPPERmRatBN7.2
Rnor_6.02248,738,020 - 248,738,135NCBIRnor6.0
Rnor_5.02267,268,146 - 267,268,261UniSTSRnor5.0
RGSC_v3.42240,905,929 - 240,906,044UniSTSRGSC3.4
Celera2223,806,087 - 223,806,202UniSTS
Cytogenetic Map2q44UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 40 52 36 19 36 8 10 74 35 41 11 8
Low 3 5 5 5 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000031748   ⟹   ENSRNOP00000034133
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2231,793,584 - 231,898,953 (-)Ensembl
Rnor_6.0 Ensembl2248,735,699 - 248,840,735 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000090705   ⟹   ENSRNOP00000073835
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2231,793,584 - 231,847,446 (-)Ensembl
Rnor_6.0 Ensembl2248,737,983 - 248,789,508 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000094293   ⟹   ENSRNOP00000080575
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2231,793,584 - 231,898,953 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000107422   ⟹   ENSRNOP00000076880
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2231,793,584 - 231,898,953 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000114434   ⟹   ENSRNOP00000082937
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2231,793,584 - 231,898,953 (-)Ensembl
RefSeq Acc Id: NM_001105755   ⟹   NP_001099225
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22231,793,584 - 231,898,953 (-)NCBI
Rnor_6.02248,735,699 - 248,840,735 (-)NCBI
Rnor_5.02267,265,825 - 267,370,861 (-)NCBI
RGSC_v3.42240,903,608 - 241,009,063 (-)RGD
Celera2223,803,766 - 223,906,746 (-)RGD
Sequence:
RefSeq Acc Id: XM_017590603   ⟹   XP_017446092
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22231,793,592 - 231,873,575 (-)NCBI
Rnor_6.02248,735,707 - 248,811,031 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039101684   ⟹   XP_038957612
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22231,793,592 - 231,873,575 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001099225   ⟸   NM_001105755
- UniProtKB: F1LPA4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017446092   ⟸   XM_017590603
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000034133   ⟸   ENSRNOT00000031748
RefSeq Acc Id: ENSRNOP00000073835   ⟸   ENSRNOT00000090705
RefSeq Acc Id: XP_038957612   ⟸   XM_039101684
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000080575   ⟸   ENSRNOT00000094293
RefSeq Acc Id: ENSRNOP00000082937   ⟸   ENSRNOT00000114434
RefSeq Acc Id: ENSRNOP00000076880   ⟸   ENSRNOT00000107422
Protein Domains
AGC-kinase C-terminal   C2   Protein kinase   REM-1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O08874-F1-model_v2 AlphaFold O08874 1-985 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691797
Promoter ID:EPDNEW_R2321
Type:initiation region
Name:Pkn2_1
Description:protein kinase N2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02248,840,686 - 248,840,746EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620146 AgrOrtholog
BioCyc Gene G2FUF-50975 BioCyc
Ensembl Genes ENSRNOG00000011317 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000034133 ENTREZGENE
  ENSRNOP00000034133.4 UniProtKB/TrEMBL
  ENSRNOP00000073835 ENTREZGENE
  ENSRNOP00000073835.1 UniProtKB/TrEMBL
  ENSRNOP00000076880.1 UniProtKB/TrEMBL
  ENSRNOP00000080575.1 UniProtKB/TrEMBL
  ENSRNOP00000082937.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000031748 ENTREZGENE
  ENSRNOT00000031748.6 UniProtKB/TrEMBL
  ENSRNOT00000090705 ENTREZGENE
  ENSRNOT00000090705.2 UniProtKB/TrEMBL
  ENSRNOT00000094293.1 UniProtKB/TrEMBL
  ENSRNOT00000107422.1 UniProtKB/TrEMBL
  ENSRNOT00000114434.1 UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2_PKN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HR1_rho-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HR1_rpt_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PKN_HR1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:207122 UniProtKB/TrEMBL
NCBI Gene 207122 ENTREZGENE
Pfam HR1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pkn2 PhenoGen
PROSITE AGC_KINASE_CTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50004 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  REM_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Hr1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TK_X UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00239 UniProtKB/TrEMBL
Superfamily-SCOP SSF46585 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49562 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K6J2_RAT UniProtKB/TrEMBL
  A0A8I5ZK64_RAT UniProtKB/TrEMBL
  A0A8I5ZQ41_RAT UniProtKB/TrEMBL
  A0A8I5ZV08_RAT UniProtKB/TrEMBL
  F1LPA4 ENTREZGENE, UniProtKB/TrEMBL
  O08874 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-11-17 Pkn2  protein kinase N2  Prkcl2  protein kinase C-like 2  Symbol and Name updated 1299863 APPROVED
2004-02-11 Prkcl2  protein kinase C-like 2  Pak-2  cardiolipin-activated protein kinase Pak2  Symbol and Name updated to reflect Human and Mouse nomenclature 625702 APPROVED
2002-08-07 Pak-2  cardiolipin-activated protein kinase Pak2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression enriched in liver 633689
gene_protein 116 kDa 633689