Il1a (interleukin 1 alpha) - Rat Genome Database

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Gene: Il1a (interleukin 1 alpha) Rattus norvegicus
Analyze
Symbol: Il1a
Name: interleukin 1 alpha
RGD ID: 2890
Description: Predicted to enable copper ion binding activity and cytokine activity. Involved in several processes, including negative regulation of establishment of Sertoli cell barrier; positive regulation of intracellular signal transduction; and response to benzene. Located in cell surface and extracellular space. Used to study interstitial lung disease. Biomarker of several diseases, including endometritis; lung disease (multiple); urinary tract infection; uveitis; and varicocele. Human ortholog(s) of this gene implicated in several diseases, including Fabry disease; Schnitzler syndrome; autoimmune disease (multiple); hematologic cancer (multiple); and lung disease (multiple). Orthologous to human IL1A (interleukin 1 alpha); PARTICIPATES IN interleukin-1 signaling pathway; apoptotic cell death pathway; cytokine mediated signaling pathway; INTERACTS WITH (+)-taxifolin; (R)-lipoic acid; (R,R,R)-alpha-tocopherol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: IL-1 alpha; IL-1F1; interleukin-1 alpha
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83136,979,804 - 136,990,236 (-)NCBIGRCr8
mRatBN7.23116,526,601 - 116,537,055 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3116,526,604 - 116,536,822 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3120,424,348 - 120,434,552 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03129,019,955 - 129,030,165 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03126,680,432 - 126,690,642 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03121,824,712 - 121,836,122 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3121,825,412 - 121,836,086 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03128,180,475 - 128,190,980 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43116,913,612 - 116,924,114 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13116,819,184 - 116,829,687 (-)NCBI
Celera3115,352,857 - 115,362,929 (-)NCBICelera
Cytogenetic Map3q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
Il1aRatacute kidney failure  ISOIl1a (Mus musculus)6907069 RGD 
Il1aRatacute myeloid leukemia treatmentISOIL1A (Homo sapiens)11051965 RGD 
Il1aRatallergic bronchopulmonary aspergillosis  ISOIl1a (Mus musculus)7794730 RGD 
Il1aRatAlzheimer's disease no_associationISOIL1A (Homo sapiens)10045945DNA:SNP:5'UTR:rs1800587(human)RGD 
Il1aRatAlzheimer's disease  ISOIL1A (Homo sapiens)10046059protein:increased expression:microglial cell and cortical layer:RGD 
Il1aRatAlzheimer's disease susceptibilityISOIL1A (Homo sapiens)1358667 RGD 
Il1aRatAlzheimer's disease disease_progressionISOIL1A (Homo sapiens)10045947DNA:SNP:5'UTR:rs1800587(human)RGD 
Il1aRatAnorexia  IEP 7794755associated with Sarcoma more ...RGD 
Il1aRataspiration pneumonia  IEP 4142854protein:increased expression:Bronchoalveolar Lavage FluidRGD 
Il1aRatasthma  ISOIL1A (Homo sapiens)4142802DNA:polymorphisms: :RGD 
Il1aRatautoimmune thrombocytopenic purpura  ISOIL1A (Homo sapiens)11051966DNA:SNP:promoter:-899C>T (human)RGD 
Il1aRatB-Cell Chronic Lymphocytic Leukemia  ISOIL1A (Homo sapiens)11051968 RGD 
Il1aRatbeta thalassemia  ISOIL1A (Homo sapiens)11051969mRNA:decreased expression:blood and mononuclear cellRGD 
Il1aRatBrain Injuries  IEP 2311098mRNA and protein:increased expression:cerebral cortexRGD 
Il1aRatcholestasis  IEP 2311076protein:increased expression:liverRGD 
Il1aRatcholesteatoma  ISOIL1A (Homo sapiens)7401205 RGD 
Il1aRatcholesteatoma of middle ear  ISOIL1A (Homo sapiens)7794712 RGD 
Il1aRatcholesteatoma of middle ear  ISOIL1A (Homo sapiens)11059515 RGD 
Il1aRatcommon cold  ISOIL1A (Homo sapiens)4143183protein:increased expression:nasal mucusRGD 
Il1aRatcorneal edema  ISOIL1A (Homo sapiens)7794733mRNA:increased expression:corneaRGD 
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Original Reference(s)
Il1aRatallergic contact dermatitis  ISOIL1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23178550
Il1aRatamnestic disorder  ISOIL1A (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:8003924
Il1aRatanthracosis  ISOIL1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20005085
Il1aRatArsenic Poisoning  ISOIL1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16835338
Il1aRatBrain Injuries  ISOIL1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21549006
Il1aRatbrain ischemia  ISOIL1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15829914
Il1aRatBurns  ISOIL1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:10431976
Il1aRatcardiomyopathy  ISOIL1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:7979221
Il1aRatChemical and Drug Induced Liver Injury  ISOIL1A (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:8218930
Il1aRatChemical Burns  ISOIL1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22533443
Il1aRatchorioamnionitis  ISOIL1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21493953
Il1aRatchronic progressive external ophthalmoplegia  ISOIL1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:7979221
Il1aRatdermatomyositis  ISOIL1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19035492
Il1aRatdiarrhea  ISOIL1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:9278552
Il1aRatDisease Progression  ISOIL1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:27738319
Il1aRatFever  ISOIL1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15384034
Il1aRathead and neck squamous cell carcinoma  ISOIL1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:27738319
Il1aRatHeat Stroke  ISOIL1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:24039931
Il1aRathemolytic-uremic syndrome  ISOIL1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15384034
Il1aRatHIV Wasting Syndrome  ISOIL1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:7979221
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Original Reference(s)
Il1aRat(+)-epicatechin-3-O-gallate multiple interactionsISOIl1a (Mus musculus)6480464epicatechin gallate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL1A mRNA]CTDPMID:7665919
Il1aRat(+)-taxifolin multiple interactionsEXP 6480464alogliptin promotes the reaction [taxifolin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of IL1A protein]] more ...CTDPMID:33840231
Il1aRat(-)-epigallocatechin 3-gallate multiple interactionsISOIl1a (Mus musculus)6480464epigallocatechin gallate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL1A mRNA]CTDPMID:7665919
Il1aRat(-)-epigallocatechin 3-gallate decreases expressionISOIL1A (Homo sapiens)6480464epigallocatechin gallate results in decreased expression of IL1A mRNACTDPMID:20706672
Il1aRat(-)-epigallocatechin 3-gallate multiple interactionsISOIL1A (Homo sapiens)6480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of IL1A mRNACTDPMID:22079256
Il1aRat(E)-cinnamyl alcohol increases expressionISOIL1A (Homo sapiens)6480464cinnamyl alcohol results in increased expression of IL1A mRNACTDPMID:33715048
Il1aRat(R)-lipoic acid multiple interactionsEXP 6480464[Thioctic Acid co-treated with Propylthiouracil] results in increased expression of IL1A mRNACTDPMID:31068541
Il1aRat(R,R,R)-alpha-tocopherol multiple interactionsEXP 6480464alpha-Tocopherol inhibits the reaction [Hexachlorocyclohexane results in increased expression of IL1A mRNA] and alpha-Tocopherol inhibits the reaction [Hexachlorocyclohexane results in increased expression of IL1A protein]CTDPMID:15025948
Il1aRat(S)-colchicine multiple interactionsISOIL1A (Homo sapiens)6480464Colchicine inhibits the reaction [IL1A protein results in increased expression of VCAM1 protein]CTDPMID:11154858
Il1aRat(S)-duloxetine hydrochloride multiple interactionsEXP 6480464Duloxetine Hydrochloride inhibits the reaction [Indomethacin results in increased expression of IL1A protein]CTDPMID:38701902
Il1aRat(S)-nicotine multiple interactionsISOIL1A (Homo sapiens)6480464Nicotine results in increased expression of and results in increased secretion of IL1A proteinCTDPMID:18082304
Il1aRat1,1'-azobis(N,N-dimethylformamide) multiple interactionsISOIL1A (Homo sapiens)6480464Diamide inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA] and Diamide inhibits the reaction [IL1A protein results in increased expression of SOD2 protein]CTDPMID:7476933
Il1aRat1,3-benzothiazole-2-thiol increases expressionISOIl1a (Mus musculus)6480464captax results in increased expression of IL1A proteinCTDPMID:23178550
Il1aRat1,3-benzothiazole-2-thiol increases expressionISOIL1A (Homo sapiens)6480464captax results in increased expression of IL1A mRNACTDPMID:33715048
Il1aRat1,3-dinitrobenzene increases expressionEXP 64804643-dinitrobenzene results in increased expression of IL1A mRNACTDPMID:22841810
Il1aRat1,4-dithiothreitol multiple interactionsISOIL1A (Homo sapiens)6480464[Dithiothreitol co-treated with IL1A protein] results in increased expression of SOD2 protein and Dithiothreitol promotes the reaction [IL1A protein results in increased expression of SOD2 mRNA]CTDPMID:7476933
Il1aRat1,4-phenylenediamine increases expressionISOIl1a (Mus musculus)64804644-phenylenediamine results in increased expression of IL1A proteinCTDPMID:23178550
Il1aRat1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acid increases expressionISOIL1A (Homo sapiens)6480464ibuprofen acyl glucuronide results in increased expression of IL1A mRNACTDPMID:26528891
Il1aRat1-chloro-2,4-dinitrobenzene increases activityISOIl1a (Mus musculus)6480464Dinitrochlorobenzene results in increased activity of IL1A proteinCTDPMID:15840424
Il1aRat1-chloro-2,4-dinitrobenzene affects expressionISOIl1a (Mus musculus)6480464Dinitrochlorobenzene affects the expression of IL1A mRNACTDPMID:28219650

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Biological Process
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Original Reference(s)
Il1aRatcellular response to heat involved_inISSUniProtKB:P015831600115GO_REF:0000024UniProtGO_REF:0000024
Il1aRatcellular response to heat involved_inISOIL1A (Homo sapiens)1624291 PMID:12746488RGDPMID:12746488
Il1aRatcellular response to lipopolysaccharide involved_inIBAPANTHER:PTN002560644 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Il1aRatconnective tissue replacement involved in inflammatory response wound healing acts_upstream_of_or_withinISOIl1a (Mus musculus)1624291 PMID:15784728RGDPMID:15784728
Il1aRatcytokine-mediated signaling pathway involved_inISOIL1A (Homo sapiens)1624291 PMID:2989698RGDPMID:2989698
Il1aRatcytokine-mediated signaling pathway involved_inIBAMGI:107936 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Il1aRatectopic germ cell programmed cell death acts_upstream_of_or_withinISOIl1a (Mus musculus)1624291MGI:96543 PMID:11536012RGDPMID:11536012
Il1aRatextrinsic apoptotic signaling pathway in absence of ligand acts_upstream_of_or_withinISOIl1a (Mus musculus)1624291MGI:2157371 PMID:11536012RGDPMID:11536012
Il1aRatfever generation involved_inIEAUniRule:UR0000006561600115GO_REF:0000104UniProtGO_REF:0000104
Il1aRatfever generation involved_inIEAUniProtKB-KW:KW-06661600115GO_REF:0000043UniProtGO_REF:0000043
Il1aRatheart development  IEP 7794762 RGD 
Il1aRatimmune response involved_inIEAInterPro:IPR000975 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Il1aRatimmune response involved_inIBAMGI:107936 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Il1aRatinflammatory response involved_inIEAUniProtKB-KW:KW-03951600115GO_REF:0000043UniProtGO_REF:0000043
Il1aRatinflammatory response involved_inIBAMGI:107936 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Il1aRatinflammatory response involved_inIEAInterPro:IPR000975 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Il1aRatintracellular sodium ion homeostasis acts_upstream_of_or_withinISOIl1a (Mus musculus)1624291 PMID:19766171RGDPMID:19766171
Il1aRatkeratinization  IDA 4142790 RGD 
Il1aRatnegative regulation of cell population proliferation involved_inISOIL1A (Homo sapiens)1624291 PMID:3493774RGDPMID:3493774
Il1aRatnegative regulation of establishment of Sertoli cell barrier  IDA 10046056 RGD 
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Cellular Component
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Original Reference(s)
Il1aRatcell surface  IDA 2311093 RGD 
Il1aRatcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Il1aRatcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Il1aRatcytosol located_inIEAUniRule:UR0000006561600115GO_REF:0000104UniProtGO_REF:0000104
Il1aRatcytosol located_inISOIL1A (Homo sapiens)1624291 PMID:12746488RGDGO_REF:0000052 and PMID:12746488
Il1aRatcytosol located_inISSUniProtKB:P015831600115GO_REF:0000024UniProtGO_REF:0000024
Il1aRatextracellular region located_inIEAUniProtKB-SubCell:SL-02431600115GO_REF:0000044UniProtGO_REF:0000044
Il1aRatextracellular region located_inIEAUniProtKB-KW:KW-09641600115GO_REF:0000043UniProtGO_REF:0000043
Il1aRatextracellular region located_inIEAInterPro:IPR0032951600115GO_REF:0000002InterProGO_REF:0000002
Il1aRatextracellular space  IDA 729411 RGD 
Il1aRatextracellular space located_inISOIl1a (Mus musculus)1624291 PMID:21148126RGDPMID:21148126
Il1aRatextracellular space is_active_inIBAMGI:107936 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Il1aRatextracellular space located_inIEAInterPro:IPR000975 and InterPro:IPR0208771600115GO_REF:0000002InterProGO_REF:0000002
Il1aRatextracellular space located_inISOIL1A (Homo sapiens)1624291 PMID:12746488 and PMID:3493774RGDPMID:12746488 and PMID:3493774
Il1aRatextracellular space located_inIEAUniProtKB-KW:KW-02021600115GO_REF:0000043UniProtGO_REF:0000043
Il1aRatextracellular space located_inISSUniProtKB:P015831600115GO_REF:0000024UniProtGO_REF:0000024
Il1aRatextracellular space  IDA 8693643 RGD 
Il1aRatnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
Il1aRatnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
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Molecular Function
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Original Reference(s)
Il1aRatcopper ion binding enablesISSUniProtKB:P015831600115GO_REF:0000024UniProtGO_REF:0000024
Il1aRatcopper ion binding enablesISOIL1A (Homo sapiens)1624291 PMID:12746488RGDPMID:12746488
Il1aRatcytokine activity enablesIEAUniRule:UR0000006561600115GO_REF:0000104UniProtGO_REF:0000104
Il1aRatcytokine activity enablesIEAInterPro:IPR0009751600115GO_REF:0000002InterProGO_REF:0000002
Il1aRatcytokine activity enablesIEAUniProtKB-KW:KW-02021600115GO_REF:0000043UniProtGO_REF:0000043
Il1aRatcytokine activity enablesIBAMGI:107936 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Il1aRatcytokine activity enablesISOIl1a (Mus musculus)1624291 PMID:23395675RGDPMID:23395675
Il1aRatcytokine activity enablesISOIL1A (Homo sapiens)1624291 PMID:2989698RGDPMID:2989698
Il1aRatinterleukin-1 receptor binding enablesIEAUniRule:UR0000006561600115GO_REF:0000104UniProtGO_REF:0000104
Il1aRatinterleukin-1 receptor binding enablesIEAInterPro:IPR003295 and InterPro:IPR0035021600115GO_REF:0000002InterProGO_REF:0000002
Il1aRatprotein binding enablesISOIL1A (Homo sapiens)1624291UniProtKB:O00165 more ...RGDPMID:11554782 more ...
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RGD Manual Annotations


  
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Original Reference(s)
Il1aRatinterleukin-1 signaling pathway   ISOIL1A (Homo sapiens)5490209 RGD 

Imported Annotations - KEGG (archival)

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Original Reference(s)
Il1aRatapoptotic cell death pathway  IEA 6907045 KEGGrno:04210
Il1aRatcytokine mediated signaling pathway  IEA 6907045 KEGGrno:04060
Il1aRatgraft-versus-host disease pathway  IEA 6907045 KEGGrno:05332
Il1aRatinfluenza A pathway  IEA 6907045 KEGGrno:05164
Il1aRatLeishmaniasis pathway  IEA 6907045 KEGGrno:05140
Il1aRatmeasles pathway  IEA 6907045 KEGGrno:05162
Il1aRatmitogen activated protein kinase signaling pathway   IEA 6907045 KEGGrno:04010
Il1aRatprion disease pathway  IEA 6907045 KEGGrno:05020
Il1aRatrheumatoid arthritis pathway  IEA 6907045 KEGGrno:05323
Il1aRattuberculosis pathway  IEA 6907045 KEGGrno:05152
Il1aRattype 1 diabetes mellitus pathway  IEA 6907045 KEGGrno:04940
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Imported Annotations - PID (archival)

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Original Reference(s)
Il1aRatinterleukin-1 signaling pathway   ISOIL1A (Homo sapiens)6484113 PIDPID:200089

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#
Reference Title
Reference Citation
1. Association of interleukin-1A, interleukin-1B and interleukin-1 receptor antagonist gene polymorphisms with multiple myeloma. Abazis-Stamboulieh D, etal., Leuk Lymphoma. 2007 Nov;48(11):2196-203.
2. Effect of methyl substitution of benzene on the percutaneous absorption and skin irritation in hairless rats. Ahaghotu E, etal., Toxicol Lett. 2005 Dec 15;159(3):261-71. Epub 2005 Aug 8.
3. Exogenous nitric oxide donor and related compounds protect against lung inflammatory response after hemorrhagic shock and resuscitation. Anaya-Prado R, etal., J Trauma. 2004 Nov;57(5):980-8.
4. Differential actions of IL-1 alpha and IL-1 beta in glial cells share common IL-1 signalling pathways. Andre R, etal., Neuroreport 2005 Feb 8;16(2):153-7.
5. Characterization of the innate immune response to chronic aspiration in a novel rodent model. Appel JZ 3rd, etal., Respir Res. 2007 Nov 27;8:87.
6. The role of cell-associated interleukin-1 in bleomycin-induced pulmonary fibrosis. Asada K, etal., Tokushima J Exp Med. 1996 Dec;43(3-4):79-86.
7. Assessment of skin irritation and molecular responses in rat skin exposed to nonane, dodecane and tetradecane. Babu RJ, etal., Toxicol Lett. 2004 Nov 2;153(2):255-66.
8. Insulin-like growth factor-I, interleukin-1 alpha and beta in pancreatic cancer: role in tumor invasiveness and associated diabetes. Basso D, etal., Int J Clin Lab Res. 1995;25(1):40-3.
9. Nucleotide variation, haplotype structure, and association with end-stage renal disease of the human interleukin-1 gene cluster. Bensen JT, etal., Genomics. 2003 Aug;82(2):194-217.
10. Association of an IL-1A 3'UTR polymorphism with end-stage renal disease and IL-1 alpha expression. Bensen JT, etal., Kidney Int. 2003 Apr;63(4):1211-9.
11. Amelioration of ozone-induced lung injury by anti-tumor necrosis factor-alpha. Bhalla DK, etal., Toxicol Sci. 2002 Oct;69(2):400-8.
12. Increased tumor necrosis factor alpha (TNF-alpha) and interleukin 1 alpha (IL1-alpha) levels in the lesional skin of patients with nonsegmental vitiligo. Birol A, etal., Int J Dermatol. 2006 Aug;45(8):992-3.
13. Cord blood cytokine profile detection in neonates with T1D parents -- monitoring of cellular auto-reactivity using protein microarray. Bohmova K, etal., Scand J Immunol. 2007 Nov;66(5):563-71.
14. Analysis of IL1 gene polymorphisms and transcript levels in periodontal and chronic kidney disease. Braosi AP, etal., Cytokine. 2012 Oct;60(1):76-82. Epub 2012 Jul 13.
15. Enhanced antitumor efficacy in mice by combination treatment with interleukin-1 alpha and interferon-alpha. Brunda MJ, etal., J Immunother Emphasis Tumor Immunol. 1994 May;15(4):233-41.
16. Evaluation of five interleukin genes for association with end-stage renal disease in white Europeans. Buckham TA, etal., Am J Nephrol. 2010;32(2):103-8. Epub 2010 Jun 16.
17. Partial volume rat lung irradiation: temporal fluctuations of in-field and out-of-field DNA damage and inflammatory cytokines following irradiation. Calveley VL, etal., Int J Radiat Biol. 2005 Dec;81(12):887-99.
18. Evaluation of bone turnover and osteoclastic cytokines in early rheumatoid arthritis treated with alendronate. Cantatore FP, etal., J Rheumatol. 1999 Nov;26(11):2318-23.
19. Chondrocyte cytokine and growth factor expression in murine osteoarthritis. Chambers MG, etal., Osteoarthritis Cartilage. 1997 Sep;5(5):301-8.
20. [The changes of IL-1 and NO levels in the testes of rats with experimental varicocele] Chen LP, etal., Zhonghua Nan Ke Xue 2002;8(2):125-6.
1 to 20 of 144 rows
PMID:1739124   PMID:2989698   PMID:3493774   PMID:9564845   PMID:10432220   PMID:11536012   PMID:12534936   PMID:12598651   PMID:12746488   PMID:12785009   PMID:12878449   PMID:14643175  
PMID:15025948   PMID:15032628   PMID:15063785   PMID:15154090   PMID:15467353   PMID:15784728   PMID:15990800   PMID:16083355   PMID:16825798   PMID:16905534   PMID:17117141   PMID:19341730  
PMID:19567205   PMID:19666510   PMID:20529813   PMID:21148126   PMID:21191089   PMID:21595923   PMID:22634325   PMID:23123184   PMID:23395675   PMID:23817958   PMID:24253784   PMID:24338227  
PMID:24338258   PMID:24644058   PMID:26002466   PMID:26899371   PMID:32920036   PMID:33106949   PMID:33107399   PMID:34047944  



Il1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83136,979,804 - 136,990,236 (-)NCBIGRCr8
mRatBN7.23116,526,601 - 116,537,055 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3116,526,604 - 116,536,822 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3120,424,348 - 120,434,552 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03129,019,955 - 129,030,165 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03126,680,432 - 126,690,642 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03121,824,712 - 121,836,122 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3121,825,412 - 121,836,086 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03128,180,475 - 128,190,980 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43116,913,612 - 116,924,114 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13116,819,184 - 116,829,687 (-)NCBI
Celera3115,352,857 - 115,362,929 (-)NCBICelera
Cytogenetic Map3q36NCBI
IL1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382112,773,925 - 112,784,493 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2112,773,925 - 112,784,493 (-)EnsemblGRCh38hg38GRCh38
GRCh372113,531,502 - 113,542,070 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362113,247,963 - 113,259,442 (-)NCBINCBI36Build 36hg18NCBI36
Build 342113,247,723 - 113,259,202NCBI
Celera2106,917,026 - 106,928,133 (-)NCBICelera
Cytogenetic Map2q14.1NCBI
HuRef2105,986,068 - 105,997,547 (-)NCBIHuRef
CHM1_12113,535,646 - 113,546,806 (-)NCBICHM1_1
T2T-CHM13v2.02113,200,569 - 113,210,953 (-)NCBIT2T-CHM13v2.0
Il1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392129,141,530 - 129,151,892 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2129,141,530 - 129,151,892 (-)EnsemblGRCm39 Ensembl
GRCm382129,299,609 - 129,310,186 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2129,299,610 - 129,309,972 (-)EnsemblGRCm38mm10GRCm38
MGSCv372129,125,346 - 129,135,708 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362128,991,051 - 129,001,413 (-)NCBIMGSCv36mm8
Celera2130,527,298 - 130,537,642 (-)NCBICelera
Cytogenetic Map2F1NCBI
cM Map262.9NCBI
Il1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554701,527,674 - 1,538,466 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554701,527,710 - 1,538,418 (+)NCBIChiLan1.0ChiLan1.0
IL1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21215,339,536 - 15,350,287 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A15,343,032 - 15,352,074 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A89,273,482 - 89,284,421 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A113,784,854 - 113,795,801 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A113,784,854 - 113,795,801 (-)Ensemblpanpan1.1panPan2
IL1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11736,969,581 - 36,979,445 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1736,970,573 - 36,979,435 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1736,739,697 - 36,748,565 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01737,745,380 - 37,755,259 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1737,746,372 - 37,755,235 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11736,881,972 - 36,890,833 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01736,938,236 - 36,947,096 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01737,152,126 - 37,160,990 (-)NCBIUU_Cfam_GSD_1.0
Il1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629282,315,498 - 82,324,623 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367831,210,809 - 1,218,315 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367831,210,715 - 1,218,315 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl343,718,368 - 43,731,121 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1343,718,320 - 43,731,668 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2345,452,989 - 45,466,307 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap3q12-q13NCBI
IL1A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11415,789,710 - 15,801,938 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1415,789,013 - 15,796,611 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660803,883,451 - 3,894,101 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il1a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474912,795,946 - 12,805,154 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474912,795,967 - 12,805,658 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Il1a
89 total Variants

Predicted Target Of
Summary Value
Count of predictions:778
Count of miRNA genes:262
Interacting mature miRNAs:326
Transcripts:ENSRNOT00000006113, ENSRNOT00000006126
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 33 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)384091273129091273Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat

1 to 10 of 33 rows
D3Kyo4   No map positions available.
RH129736  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23116,526,606 - 116,526,773 (+)MAPPERmRatBN7.2
Rnor_6.03121,824,715 - 121,824,881NCBIRnor6.0
Rnor_5.03128,190,811 - 128,190,977UniSTSRnor5.0
RGSC_v3.43116,913,615 - 116,913,781UniSTSRGSC3.4
Celera3115,352,860 - 115,353,026UniSTS
RH 3.4 Map3996.9UniSTS
Cytogenetic Map3q36UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 6 40 81 87 87 57 25 57 6 159 81 61 6 46 30



Ensembl Acc Id: ENSRNOT00000006113   ⟹   ENSRNOP00000006113
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3116,526,604 - 116,536,822 (-)Ensembl
Rnor_6.0 Ensembl3121,825,412 - 121,836,086 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000006126   ⟹   ENSRNOP00000006126
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3116,526,604 - 116,536,822 (-)Ensembl
Rnor_6.0 Ensembl3121,825,832 - 121,835,360 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000080818   ⟹   ENSRNOP00000071252
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3116,526,604 - 116,534,436 (-)Ensembl
Rnor_6.0 Ensembl3121,825,835 - 121,835,360 (-)Ensembl
RefSeq Acc Id: NM_017019   ⟹   NP_058715
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83136,979,805 - 136,990,017 (-)NCBI
mRatBN7.23116,526,604 - 116,536,822 (-)NCBI
Rnor_6.03121,824,712 - 121,836,122 (-)NCBI
Rnor_5.03128,180,475 - 128,190,980 (+)NCBI
RGSC_v3.43116,913,612 - 116,924,114 (-)RGD
Celera3115,352,857 - 115,362,929 (-)RGD
Sequence:
RefSeq Acc Id: XM_039104244   ⟹   XP_038960172
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83136,979,804 - 136,989,931 (-)NCBI
mRatBN7.23116,526,601 - 116,536,708 (-)NCBI
RefSeq Acc Id: XM_039104245   ⟹   XP_038960173
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83136,979,804 - 136,990,236 (-)NCBI
mRatBN7.23116,526,601 - 116,537,055 (-)NCBI
RefSeq Acc Id: NP_058715   ⟸   NM_017019
- UniProtKB: Q546R9 (UniProtKB/Swiss-Prot),   P16598 (UniProtKB/Swiss-Prot),   F1LQB1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000006126   ⟸   ENSRNOT00000006126
Ensembl Acc Id: ENSRNOP00000006113   ⟸   ENSRNOT00000006113
Ensembl Acc Id: ENSRNOP00000071252   ⟸   ENSRNOT00000080818
RefSeq Acc Id: XP_038960173   ⟸   XM_039104245
- Peptide Label: isoform X2
- UniProtKB: F1MAF9 (UniProtKB/TrEMBL),   Q9ESW2 (UniProtKB/TrEMBL)
Interleukin-1 propeptide

Name Modeler Protein Id AA Range Protein Structure
AF-P16598-F1-model_v2 AlphaFold P16598 1-270 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13692424
Promoter ID:EPDNEW_R2947
Type:single initiation site
Name:Il1a_1
Description:interleukin 1 alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03121,836,122 - 121,836,182EPDNEW


1 to 34 of 34 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-47911 BioCyc
Ensembl Genes ENSRNOG00000004575 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000006113 ENTREZGENE
  ENSRNOT00000006113.9 UniProtKB/Swiss-Prot
  ENSRNOT00000006126 ENTREZGENE
Gene3D-CATH 2.80.10.50 UniProtKB/Swiss-Prot
InterPro IL-1_alpha UniProtKB/Swiss-Prot
  IL-1_CS UniProtKB/Swiss-Prot
  IL-1_fam UniProtKB/Swiss-Prot
  IL-1_propep UniProtKB/Swiss-Prot
  IL1/FGF UniProtKB/Swiss-Prot
KEGG Report rno:24493 UniProtKB/Swiss-Prot
NCBI Gene 24493 ENTREZGENE
PANTHER PTHR10078 UniProtKB/Swiss-Prot
  PTHR10078:SF33 UniProtKB/Swiss-Prot
Pfam IL1 UniProtKB/Swiss-Prot
  IL1_propep UniProtKB/Swiss-Prot
PhenoGen Il1a PhenoGen
PRINTS INTERLEUKIN1 UniProtKB/Swiss-Prot
  INTRLEUKIN1A UniProtKB/Swiss-Prot
  INTRLEUKN1AB UniProtKB/Swiss-Prot
PROSITE INTERLEUKIN_1 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000004575 RatGTEx
SMART IL1 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50353 UniProtKB/Swiss-Prot
UniProt A0A0G2K003_RAT UniProtKB/TrEMBL
  A6HQ59_RAT UniProtKB/TrEMBL
  A6HQ60_RAT UniProtKB/TrEMBL
  F1LQB1 ENTREZGENE, UniProtKB/TrEMBL
  F1MAF9 ENTREZGENE
  IL1A_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q546R9 ENTREZGENE
  Q9ESW2 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q546R9 UniProtKB/Swiss-Prot
1 to 34 of 34 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Il1a  Interleukin 1 alpha      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_expression expressed in tesis 729411
gene_protein may be posttranslationally modified in the testis to create alternate isoforms 729411