Il1a (interleukin 1 alpha) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Il1a (interleukin 1 alpha) Rattus norvegicus
Analyze
Symbol: Il1a
Name: interleukin 1 alpha
RGD ID: 2890
Description: Predicted to have copper ion binding activity; cytokine activity; and interleukin-1 receptor binding activity. Involved in several processes, including negative regulation of establishment of Sertoli cell barrier; positive regulation of cytokine production; and positive regulation of intracellular signal transduction. Localizes to several cellular components, including cell surface; cytosol; and extracellular space. Used to study interstitial lung disease. Biomarker of several diseases, including endometritis; lung disease (multiple); urinary tract infection; uveitis; and varicocele. Human ortholog(s) of this gene implicated in several diseases, including Fabry disease; Schnitzler syndrome; autoimmune disease (multiple); hematologic cancer (multiple); and lung disease (multiple). Orthologous to human IL1A (interleukin 1 alpha); PARTICIPATES IN interleukin-1 signaling pathway; apoptotic cell death pathway; cytokine mediated signaling pathway; INTERACTS WITH (+)-alpha-tocopherol; (R)-lipoic acid; (R)-mevalonic acid.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: IL-1 alpha; IL-1F1; interleukin-1 alpha
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23116,526,601 - 116,537,055 (-)NCBI
Rnor_6.0 Ensembl3121,825,412 - 121,836,086 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.03121,824,712 - 121,836,122 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03128,180,475 - 128,190,980 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43116,913,612 - 116,924,114 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13116,819,184 - 116,829,687 (-)NCBI
Celera3115,352,857 - 115,362,929 (-)NCBICelera
Cytogenetic Map3q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
acute myeloid leukemia  (ISO)
allergic bronchopulmonary aspergillosis  (ISO)
allergic contact dermatitis  (ISO)
Alzheimer's disease  (ISO)
amnestic disorder  (ISO)
Anorexia  (IEP)
anthracosis  (ISO)
Arsenic Poisoning  (ISO)
aspiration pneumonia  (IEP)
asthma  (ISO)
autoimmune thrombocytopenic purpura  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
beta thalassemia  (ISO)
Brain Injuries  (IEP,ISO)
brain ischemia  (ISO)
Burns  (ISO)
Burns, Chemical  (ISO)
cardiomyopathy  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholestasis  (IEP)
cholesteatoma  (ISO)
cholesteatoma of middle ear  (ISO)
chorioamnionitis  (ISO)
chronic progressive external ophthalmoplegia  (ISO)
common cold  (ISO)
corneal edema  (ISO)
Craniocerebral Trauma  (ISO)
Creutzfeldt-Jakob disease  (ISO)
cystic fibrosis  (ISO)
dermatomyositis  (ISO)
diabetic retinopathy  (ISO)
diarrhea  (ISO)
Disease Progression  (ISO)
Drug-Induced Immune Thrombocytopenia  (ISO)
Drug-induced Neutropenia  (ISO)
end stage renal disease  (ISO)
endometritis  (IEP)
Endotoxemia  (IEP,ISO)
Enterocolitis  (IEP)
Experimental Arthritis  (IDA,IEP)
Experimental Diabetes Mellitus  (IEP)
Experimental Leukemia  (ISO)
Experimental Melanoma  (ISO)
extrinsic allergic alveolitis  (ISO)
Fabry disease  (ISO)
Femoral Fractures  (IEP)
Fetal Growth Retardation  (ISO)
Fever  (ISO)
glomerulonephritis  (ISO)
Graft vs Host Disease  (ISO)
Graves Ophthalmopathy  (ISO)
head and neck squamous cell carcinoma  (ISO)
Heat Stroke  (IEP,ISO)
hemolytic-uremic syndrome  (ISO)
Hemorrhage  (IEP)
Hemorrhagic Shock  (IEP)
HIV Wasting Syndrome  (ISO)
Human Influenza  (ISO)
Hyperalgesia  (ISO)
hyperglycemia  (ISO)
Hypotension  (ISO)
IgA glomerulonephritis  (ISO)
Inflammation  (ISO)
interstitial lung disease  (IMP,ISO)
Invasive Pulmonary Aspergillosis  (ISO)
iridocyclitis  (ISO)
juvenile rheumatoid arthritis  (ISO)
Kearns-Sayre syndrome  (ISO)
keratoconus  (ISO)
Knee Osteoarthritis  (IEP,ISO)
Leber hereditary optic neuropathy  (ISO)
Liver Reperfusion Injury  (IDA,IEP)
lung disease  (ISO)
lung non-small cell carcinoma  (ISO)
malignant mesothelioma  (ISO)
MELAS syndrome  (ISO)
MERRF Syndrome  (ISO)
mesenchymal chondrosarcoma  (ISO)
Middle East respiratory syndrome  (ISO)
mitochondrial myopathy  (ISO)
multiple myeloma  (ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (IEP,ISO)
Nasal Polyps  (ISO)
non-alcoholic fatty liver disease  (ISO)
Oral Lichen Planus  (ISO)
osteoarthritis  (ISO)
osteoporosis  (ISO)
otitis media  (IEP)
pancreatic cancer  (ISO)
Perennial Allergic Rhinitis  (ISO)
periodontitis  (ISO)
pneumonia  (IEP)
Poisoning  (ISO)
polymyositis  (ISO)
pulmonary fibrosis  (IEP,ISO)
pulmonary tuberculosis  (ISO)
Radiation Injuries  (IEP)
Radiation Pneumonitis  (ISO)
Reperfusion Injury  (ISO)
respiratory allergy  (ISO)
Retina Reperfusion Injury  (IEP)
rheumatoid arthritis  (ISO)
Schnitzler syndrome  (ISO)
Sclerosis  (ISO)
severe acute respiratory syndrome  (ISO)
skin disease  (ISO)
Skin Neoplasms  (ISO)
tick infestation  (ISO)
type 1 diabetes mellitus  (ISO)
urinary tract infection  (IEP,ISO)
uveitis  (IEP)
varicocele  (IEP)
Venous Thrombosis  (IEP)
vitiligo  (ISO)
Wounds and Injuries  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-tocopherol  (EXP)
(+)-epicatechin-3-O-gallate  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-lipoic acid  (EXP)
(R)-mevalonic acid  (EXP,ISO)
(S)-colchicine  (ISO)
(S)-nicotine  (ISO)
1,1'-azobis(N,N-dimethylformamide)  (ISO)
1,3-benzothiazole-2-thiol  (ISO)
1,3-dinitrobenzene  (EXP)
1,4-dithiothreitol  (ISO)
1,4-phenylenediamine  (ISO)
1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acid  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP,ISO)
1-nitropyrene  (ISO)
1-O-palmitoyl-2-O-(5-oxovaleryl)-sn-glycero-3-phosphocholine  (ISO)
1-phenyl-1-cyclopentanecarboxylic acid 2-[2-(diethylamino)ethoxy]ethyl ester  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2'-bipyridine  (ISO)
2,2,2-trichloroethanol  (ISO)
2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methoxy-17beta-estradiol  (EXP)
2-tert-butylhydroquinone  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (EXP,ISO)
22-Hydroxycholesterol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3-methylcholanthrene  (ISO)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-tert-butylphenol  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (EXP)
actinomycin D  (EXP)
acyclovir  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP)
albendazole  (ISO)
albuterol  (ISO)
aldehydo-D-glucosamine  (EXP)
all-trans-retinoic acid  (EXP,ISO)
alpha-hexylcinnamaldehyde  (ISO)
aluminium oxide  (ISO)
amikacin  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
amodiaquine  (ISO)
amphibole asbestos  (ISO)
aniline  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
anthracene-1,8,9-triol  (ISO)
arachidonic acid  (ISO)
aripiprazole  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
asbestos  (ISO)
ATP  (ISO)
azathioprine  (ISO)
BAPTA  (ISO)
benzalkonium chloride  (ISO)
benzatropine  (ISO)
benzbromarone  (ISO)
benzene  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzoates  (ISO)
benzocaine  (ISO)
benzoic acid  (ISO)
Benzoyl peroxide  (ISO)
benzyl alcohol  (ISO)
benzylpenicillin  (ISO)
beta-D-glucosamine  (EXP)
beta-naphthoflavone  (EXP,ISO)
biperiden  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
bromfenac  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
butylated hydroxyanisole  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium selenide  (ISO)
cadmium sulfate  (ISO)
Calcimycin  (ISO)
calcitriol  (ISO)
capsaicin  (EXP)
carazolol  (ISO)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
carrageenan  (ISO)
ceric oxide  (EXP)
cetylpyridinium  (ISO)
chlorobenzene  (ISO)
chlorogenic acid  (ISO)
chloropicrin  (ISO)
chloroquine  (ISO)
chlorpromazine  (ISO)
choline  (ISO)
ciprofloxacin  (ISO)
cisplatin  (ISO)
citral  (ISO)
clarithromycin  (EXP,ISO)
clavulanic acid  (ISO)
clobetasol  (ISO)
clofibrate  (ISO)
clomipramine  (ISO)
clonidine  (EXP)
clonidine (amino form)  (EXP)
clonidine (imino form)  (EXP)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
cortisol  (ISO)
crocidolite asbestos  (EXP,ISO)
CU-O LINKAGE  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP)
daidzein  (ISO)
delta-tocotrienol  (ISO)
demeclocycline  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP,ISO)
dichloromethane  (ISO)
diclofenac  (ISO)
diethyl maleate  (ISO)
diethylamine  (ISO)
diethylstilbestrol  (ISO)
dimethyl sulfoxide  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (ISO)
disulfiram  (ISO)
dodecane  (ISO)
doxorubicin  (ISO)
enalapril  (ISO)
endosulfan  (EXP)
entacapone  (ISO)
entinostat  (ISO)
erlotinib hydrochloride  (ISO)
erythromycin A  (ISO)
esmolol  (ISO)
estriol  (ISO)
estrone 3-sulfate  (ISO)
ethambutol  (ISO)
ethanol  (ISO)
ethidium  (ISO)
ethionamide  (EXP)
ethylene glycol dimethacrylate  (ISO)
etodolac  (ISO)
eugenol  (ISO)
farnesol  (ISO)
ferroheme b  (ISO)
ferulic acid  (ISO)
Fexofenadine hydrochloride  (ISO)
flucloxacillin  (ISO)
fludrocortisone  (ISO)
flufenamic acid  (ISO)
fluocinolone acetonide  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
furan  (ISO)
gadodiamide hydrate  (EXP)
gadolinium trichloride  (EXP)
gamma-hexachlorocyclohexane  (EXP)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (EXP)
geranial  (ISO)
geraniol  (ISO)
Goe 6976  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
griseofulvin  (ISO)
heme b  (ISO)
hesperetin  (ISO)
hexadecane  (ISO)
hexadecanoic acid  (ISO)
Hexadimethrine bromide  (EXP)
hexane  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
ibuprofen  (ISO)
imidurea  (ISO)
imiquimod  (ISO)
indometacin  (EXP,ISO)
ionomycin  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
iron(III) citrate  (ISO)
isoeugenol  (ISO)
isoniazide  (ISO)
isoprenaline  (EXP,ISO)
isotretinoin  (EXP)
ivermectin  (ISO)
ketoconazole  (ISO)
kojic acid  (EXP)
L-1,4-dithiothreitol  (ISO)
lead nitrate  (ISO)
lenalidomide  (ISO)
leupeptin  (ISO)
levofloxacin  (ISO)
limonene  (ISO)
lipoic acid  (EXP)
lipopolysaccharide  (EXP,ISO)
losartan  (EXP,ISO)
LY294002  (ISO)
m-xylene  (EXP)
manganese(II) chloride  (EXP)
mangiferin  (ISO)
mebendazole  (ISO)
melatonin  (ISO)
menadione  (EXP,ISO)
mercaptoethanol  (ISO)
mercury dichloride  (ISO)
mesalamine  (ISO)
metam  (ISO)
metaproterenol  (ISO)
methadone  (EXP)
methamphetamine  (EXP)
methapyrilene  (EXP)
methotrexate  (ISO)
methoxyacetic acid  (EXP)
methyl methacrylate  (ISO)
methyl salicylate  (ISO)
methylisothiazolinone  (ISO)
metoprolol  (ISO)
mexiletine  (ISO)
Mezerein  (ISO)
mifepristone  (ISO)
Mofezolac (TN)  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
monocrotaline  (EXP)
morphine  (ISO)
muramyl dipeptide  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (ISO)
N,N-diethyl-m-toluamide  (EXP,ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethylmaleimide  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
naloxone  (ISO)
naproxen  (EXP)
nebivolol  (ISO)
nefazodone  (EXP,ISO)
neocuproine  (ISO)
neoechinulin A  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
nimesulide  (ISO)
nitric oxide  (EXP,ISO)
nitrososulfamethoxazole  (ISO)
nonane  (EXP)
nonanoic acid  (ISO)
Nonidet P-40  (ISO)
Nonylphenol  (ISO)
nortriptyline  (ISO)
notoginsenoside R1  (ISO)
NS-398  (ISO)
ochratoxin A  (ISO)
octenidine  (ISO)
oleic acid  (ISO)
orciprenaline  (ISO)
Osajin  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
paliperidone palmitate  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
paricalcitol  (ISO)
parthenolide  (ISO)
pemetrexed  (ISO)
penbutolol  (ISO)
pentane-2,3-dione  (EXP)
peptidoglycan  (ISO)
perfluorododecanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phenethyl caffeate  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP)
phenol  (ISO)
phloretin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
phthalic anhydride  (ISO)
pimecrolimus  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
polymyxin B2  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
potassium hydroxide  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
primaquine  (ISO)
primidone  (ISO)
probenecid  (ISO)
procyclidine  (ISO)
promethazine  (ISO)
propan-2-ol  (ISO)
prostaglandin E2  (EXP,ISO)
prostaglandin F2alpha  (ISO)
prostaglandin I2  (ISO)
puerarin  (ISO)
Pyridostigmine bromide  (EXP,ISO)
quercetin  (ISO)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
quinacrine  (ISO)
quinine  (ISO)
rac-lactic acid  (ISO)
ranitidine  (EXP)
resorcinol  (ISO)
resveratrol  (ISO)
Riluzole  (ISO)
rofecoxib  (ISO)
Roridin A  (ISO)
rotenone  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
salicylic acid  (ISO)
SB 203580  (ISO)
SCH 23390  (EXP)
scopolamine  (ISO)
serpentine asbestos  (EXP,ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP)
sodium dodecyl sulfate  (ISO)
sodium perchlorate  (EXP)
streptozocin  (ISO)
sulindac  (EXP)
sumatriptan  (EXP)
T-2 toxin  (EXP,ISO)
telithromycin  (EXP)
testosterone  (EXP,ISO)
testosterone enanthate  (EXP)
tetrachloromethane  (EXP,ISO)
tetradecane  (ISO)
tetraphene  (ISO)
tetrathiomolybdate(2-)  (ISO)
thioacetamide  (EXP)
thiostrepton  (ISO)
tienilic acid  (ISO)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP)
toremifene  (ISO)
trans-isoeugenol  (ISO)
trazodone  (ISO)
tremolite asbestos  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
tridecane  (ISO)
Trihexyphenidyl  (ISO)
trimethyltin  (ISO)
triptonide  (ISO)
Triton X-100  (ISO)
troglitazone  (ISO)
trovafloxacin  (EXP,ISO)
urethane  (ISO)
usnic acid  (ISO)
vadimezan  (EXP)
valproic acid  (ISO)
vanadium atom  (EXP)
vanadium(0)  (EXP)
vanadyl sulfate  (ISO)
verapamil  (ISO)
vinclozolin  (EXP)
vitamin E  (EXP)
vorinostat  (ISO)
wortmannin  (ISO)
Y-27632  (EXP)
Z-Val-Phe-H  (ISO)
zidovudine  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc sulfate  (ISO)
zinc(0)  (EXP,ISO)
zomepirac  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute inflammatory response  (IEP)
cellular response to heat  (IEA,ISO,ISS)
cellular response to lipopolysaccharide  (IBA)
cellular sodium ion homeostasis  (IEA,ISO)
connective tissue replacement involved in inflammatory response wound healing  (IEA,ISO)
cytokine-mediated signaling pathway  (IBA,IEA,ISO)
ectopic germ cell programmed cell death  (IEA,ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (IEA,ISO)
fever generation  (IEA)
heart development  (IEP)
immune response  (IEA)
inflammatory response  (IBA,ISO)
interleukin-1-mediated signaling pathway  (ISO)
keratinization  (IDA)
negative regulation of cell population proliferation  (IEA,ISO)
negative regulation of establishment of Sertoli cell barrier  (IDA)
positive regulation of angiogenesis  (IEA,ISO)
positive regulation of cell division  (IEA)
positive regulation of cytokine production  (ISO)
positive regulation of ERK1 and ERK2 cascade  (IDA)
positive regulation of gene expression  (IBA,ISO)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (IDA)
positive regulation of immature T cell proliferation in thymus  (IBA)
positive regulation of interleukin-2 production  (IEA,IMP,ISO)
positive regulation of interleukin-6 production  (IMP,ISO)
positive regulation of JNK cascade  (IDA)
positive regulation of mitotic nuclear division  (IEA,ISO)
positive regulation of monocyte chemotactic protein-1 production  (ISO)
positive regulation of neutrophil extravasation  (ISO)
positive regulation of neutrophil migration  (IMP)
positive regulation of prostaglandin secretion  (IDA)
positive regulation of protein secretion  (IEA,ISO)
positive regulation of steroid biosynthetic process  (IDA)
positive regulation of stress-activated MAPK cascade  (IDA)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of tumor necrosis factor production  (IMP)
positive regulation of vascular endothelial growth factor production  (IEA,ISO)
regulation of actin cytoskeleton organization  (IDA)
regulation of nitric-oxide synthase activity  (IBA)
regulation of sensory perception of pain  (IDA)
response to copper ion  (IEA,ISO,ISS)
response to gamma radiation  (IEP)
response to heat  (IEP)
response to hypoxia  (IEP)
response to L-ascorbic acid  (IEP)
response to lipopolysaccharide  (IEP)
response to organic cyclic compound  (IEP)
response to organic substance  (IEP)
response to organonitrogen compound  (IEP)
response to ozone  (IEP)
signal transduction  (IEA)
spermatogenesis  (IEP)
wound healing  (IEP)

Cellular Component
cell surface  (IDA)
cytoplasm  (ISO)
cytosol  (IDA,IEA,ISO,ISS)
extracellular space  (IBA,IDA,IEA,ISO,ISS)
plasma membrane  (IDA)

Molecular Function

References

References - curated
1. Abazis-Stamboulieh D, etal., Leuk Lymphoma. 2007 Nov;48(11):2196-203.
2. Ahaghotu E, etal., Toxicol Lett. 2005 Dec 15;159(3):261-71. Epub 2005 Aug 8.
3. Anaya-Prado R, etal., J Trauma. 2004 Nov;57(5):980-8.
4. Andre R, etal., Neuroreport 2005 Feb 8;16(2):153-7.
5. Appel JZ 3rd, etal., Respir Res. 2007 Nov 27;8:87.
6. Asada K, etal., Tokushima J Exp Med. 1996 Dec;43(3-4):79-86.
7. Babu RJ, etal., Toxicol Lett. 2004 Nov 2;153(2):255-66.
8. Basso D, etal., Int J Clin Lab Res. 1995;25(1):40-3.
9. Bensen JT, etal., Genomics. 2003 Aug;82(2):194-217.
10. Bensen JT, etal., Kidney Int. 2003 Apr;63(4):1211-9.
11. Bhalla DK, etal., Toxicol Sci. 2002 Oct;69(2):400-8.
12. Birol A, etal., Int J Dermatol. 2006 Aug;45(8):992-3.
13. Bohmova K, etal., Scand J Immunol. 2007 Nov;66(5):563-71.
14. Braosi AP, etal., Cytokine. 2012 Oct;60(1):76-82. Epub 2012 Jul 13.
15. Brunda MJ, etal., J Immunother Emphasis Tumor Immunol. 1994 May;15(4):233-41.
16. Buckham TA, etal., Am J Nephrol. 2010;32(2):103-8. Epub 2010 Jun 16.
17. Calveley VL, etal., Int J Radiat Biol. 2005 Dec;81(12):887-99.
18. Cantatore FP, etal., J Rheumatol. 1999 Nov;26(11):2318-23.
19. Chambers MG, etal., Osteoarthritis Cartilage. 1997 Sep;5(5):301-8.
20. Chen LP, etal., Zhonghua Nan Ke Xue 2002;8(2):125-6.
21. Chen Y, etal., Semin Radiat Oncol. 2002 Jan;12(1 Suppl 1):26-33.
22. Chu HW, etal., Lab Anim Sci. 1996 Feb;46(1):42-7.
23. Coban S, etal., J Surg Res. 2008 Nov 24.
24. Dias CN, etal., Cytokine. 2014 Apr;66(2):164-5. doi: 10.1016/j.cyto.2014.01.006. Epub 2014 Feb 16.
25. Enjuanes A, etal., Cancer Res. 2008 Dec 15;68(24):10178-86. doi: 10.1158/0008-5472.CAN-08-2221.
26. Erbek SS, etal., Arch Otolaryngol Head Neck Surg. 2007 Jul;133(7):705-9.
27. Esser RE, etal., Int J Tissue React. 1989;11(6):291-300.
28. Fong KY, etal., Clin Exp Rheumatol. 1994 Jan-Feb;12(1):55-8.
29. Futami H, etal., J Immunol. 1990 Dec 15;145(12):4121-30.
30. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
31. GOA data from the GO Consortium
32. Gorgi Y, etal., Tunis Med. 2010 Nov;88(11):789-93.
33. Greally P, etal., Arch Dis Child. 1993 Jun;68(6):785-7.
34. Griffin WS, etal., Neurosci Lett. 1994 Aug 1;176(2):133-6.
35. Groves RW, etal., Proc Natl Acad Sci U S A. 1995 Dec 5;92(25):11874-8.
36. Gustafsson K, etal., Biochem Biophys Res Commun 2002 Sep 27;297(3):492-7.
37. Hangai M, etal., Invest Ophthalmol Vis Sci. 1995 Mar;36(3):571-8.
38. Hashida R, etal., Eur J Biochem. 1996 Mar 1;236(2):517-22.
39. Haugen TB, etal., Mol Cell Endocrinol. 1994 Nov;105(2):R19-23.
40. Hawley TS, etal., Growth Factors. 1991;5(4):327-38.
41. Heinig J, etal., Zentralbl Gynakol. 2000;122(8):413-8.
42. Hernandez-Pando R, etal., Immunology. 1997 Apr;90(4):607-17.
43. Heufelder AE and Bahn RS, Eur J Clin Invest. 1993 Jan;23(1):10-7.
44. Hildebrandt MA, etal., PLoS One. 2010 Aug 25;5(8):e12402.
45. Hojo H, etal., Immunol Lett. 1994 Dec;43(3):215-20.
46. Hong JH, etal., Int J Radiat Biol. 2003 Mar;79(3):159-67.
47. Hu Y, et al., Cell Biochem Funct. 2009 Jul;27(5):284-8. doi: 10.1002/cbf.1570.
48. Jacob CO, etal., Proc Natl Acad Sci U S A. 1990 Feb;87(3):968-72.
49. Ji LJ, etal., J Cell Biochem. 2019 Sep;120(9):15268-15279. doi: 10.1002/jcb.28794. Epub 2019 Jun 6.
50. Jiang Y and Steinle JJ, Can J Physiol Pharmacol. 2010 May;88(5):553-61.
51. Johnson CS, etal., Cancer Res. 1990 Sep 1;50(17 Suppl):5682S-5686S.
52. Johnston CJ, etal., Toxicol Appl Pharmacol. 1996 Sep;140(1):154-63.
53. Joki-Erkkila VP, etal., Ann Allergy Asthma Immunol. 2003 Sep;91(3):275-9.
54. Kamikubo Y, etal., Immunopharmacology. 1995 Apr;29(3):261-71.
55. Karjalainen J, etal., Allergy. 2003 May;58(5):393-6.
56. Kawaguchi Y, etal., Arthritis Rheum. 2003 Jan;48(1):186-92.
57. KEGG
58. Kim SH, etal., Mol Vis. 2008;14:2109-16. Epub 2008 Nov 21.
59. Kline KA, etal., Infect Immun. 2011 Sep;79(9):3588-95. Epub 2011 Jun 20.
60. Kloeters O, etal., Wound Repair Regen. 2008 Jul-Aug;16(4):568-75.
61. Konstantinos AP and Sheridan JF, Respir Physiol. 2001 Oct;128(1):71-7.
62. Kordek R, etal., Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9754-8.
63. Kumar S, etal., Am J Pathol. 2003 Dec;163(6):2531-41.
64. Lai ME, etal., Acta Haematol. 2011;126(2):87-94. doi: 10.1159/000327252. Epub 2011 May 11.
65. Langberg CW, etal., Radiother Oncol. 1994 Jul;32(1):29-36.
66. Lee JW, etal., Korean J Intern Med. 2011 Jun;26(2):187-94. Epub 2011 Jun 1.
67. Lin XJ, etal., Shock. 2009 Nov;32(5):524-9.
68. Liu J, etal., Zhonghua Er Bi Yan Hou Ke Za Zhi. 2002 Feb;37(1):30-3.
69. Liu YL, etal., Acta Pharmacol Sin. 2009 Feb;30(2):219-27. doi: 10.1038/aps.2008.20. Epub 2009 Jan 26.
70. Lotem J and Sachs L, Blood. 1988 Nov;72(5):1595-601.
71. Lowell CA and Berton G, Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7580-4.
72. Lu KT, etal., Neurosci Lett. 2005 Sep 23;386(1):40-5.
73. Mahdaviani SA, etal., J Clin Immunol. 2009 Jan;29(1):57-62. Epub 2008 Sep 2.
74. Maniwa K, etal., Respirology. 2000 Dec;5(4):315-20.
75. Manzer R, etal., Am J Respir Cell Mol Biol. 2008 Mar;38(3):318-23. Epub 2007 Sep 27.
76. Mbow ML, etal., Immunology. 1994 Aug;82(4):596-602.
77. McCall RD, etal., Gastroenterology. 1994 Apr;106(4):960-72.
78. Mester M, etal., Surgery. 1994 May;115(5):588-96.
79. Mika J, etal., Pain. 2008 Sep 15;138(3):587-97. Epub 2008 Apr 18.
80. Molina PE, etal., Neuroimmunomodulation. 1997 Jan-Feb;4(1):28-36.
81. Murphy GM Jr, etal., Neurology. 2001 Jun 12;56(11):1595-7.
82. Nakae S, etal., Int Immunol. 2003 Apr;15(4):483-90.
83. Nakagawa M, etal., Dev Dyn. 1992 Oct;195(2):87-99.
84. NCBI rat LocusLink and RefSeq merged data July 26, 2002
85. Nicoll JA, etal., Ann Neurol 2000 Mar;47(3):365-8.
86. Nishida T, etal., J Biochem (Tokyo) 1989 Mar;105(3):351-7.
87. Nogae C, etal., J Mol Cell Cardiol. 1995 Oct;27(10):2091-9.
88. Noori-Daloii MR, etal., Mol Biol Rep. 2013 Aug;40(8):4861-7. doi: 10.1007/s11033-013-2585-4. Epub 2013 May 6.
89. O'Shaughnessy RF, etal., Hum Mol Genet. 2010 Jul 1;19(13):2594-605. Epub 2010 Apr 12.
90. Oliver SJ, etal., J Rheumatol. 2007 Sep;34(9):1802-9. Epub 2007 Aug 1.
91. Opara EI, etal., Nutrition. 1995 Sep-Oct;11(5 Suppl):678-9.
92. Pehlivan M, etal., Platelets. 2011;22(8):588-95. doi: 10.3109/09537104.2011.577255. Epub 2011 May 19.
93. Pipeline to import KEGG annotations from KEGG into RGD
94. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
95. Pirnik Z, etal., Cell Mol Neurobiol. 2009 Sep;29(6-7):951-60. Epub 2009 Mar 13.
96. Qiu J, etal., J Neurosci Res. 2004 Jul 1;77(1):108-18.
97. Rabinovitch A, etal., Endocrinology. 1996 May;137(5):2093-9.
98. Renlund N, etal., J Mol Endocrinol. 2006 Apr;36(2):327-36.
99. Renz JF and Kalf GF, Blood. 1991 Aug 15;78(4):938-44.
100. Reverter JL, etal., Invest Ophthalmol Vis Sci. 2009 Mar;50(3):1378-82. Epub 2008 Oct 31.
101. Reyes L, etal., BMC Infect Dis. 2009 Jan 26;9:9.
102. RGD automated data pipeline
103. RGD automated import pipeline for gene-chemical interactions
104. Rhodus NL, etal., Oral Dis. 2006 Mar;12(2):112-6.
105. Robertson FM, etal., Carcinogenesis. 1996 Aug;17(8):1719-28.
106. Rosa JS, etal., Pediatr Diabetes. 2008 Feb;9(1):9-16.
107. Rosenbaum JT, etal., Invest Ophthalmol Vis Sci. 1995 Sep;36(10):2151-5.
108. Safyan R, etal., Eur Cytokine Netw. 2006 Dec;17(4):271-5.
109. Sahin Z, etal., Fertil Steril. 2006 Apr;85 Suppl 1:1265-75.
110. Sainz J, etal., J Clin Immunol. 2008 Sep;28(5):473-85. Epub 2008 May 17.
111. Sarkar O, etal., Biol Reprod. 2008 Mar;78(3):445-54. Epub 2007 Dec 5.
112. Saurat JH, etal., J Allergy Clin Immunol. 1991 Aug;88(2):244-56.
113. Schilling V, etal., Am J Otol. 1992 Jul;13(4):350-5.
114. Schuyler M, etal., J Lab Clin Med. 2000 Jul;136(1):29-38.
115. Sears BW, etal., J Inflamm Res. 2010 Aug 1;2010(3):105-114.
116. Serretti A, etal., J Alzheimers Dis. 2009;16(1):181-7. doi: 10.3233/JAD-2009-0946.
117. Setoguchi C, etal., Mod Rheumatol. 2010 Aug;20(4):381-8. Epub 2010 Apr 9.
118. Sheng JG, etal., Neuropathol Appl Neurobiol. 1998 Aug;24(4):278-83.
119. Shi Q, etal., Cancer. 2015 Apr 1;121(7):1138-46. doi: 10.1002/cncr.29154. Epub 2014 Dec 2.
120. Shiwa M, etal., Am J Otolaryngol. 1995 Sep-Oct;16(5):319-24.
121. Sims JE and Smith DE, Nat Rev Immunol. 2010 Feb;10(2):89-102. Epub 2010 Jan 18.
122. Sinniah R, etal., Int J Exp Pathol. 1999 Apr;80(2):87-95.
123. Smith MD, etal., J Rheumatol. 1997 Feb;24(2):365-71.
124. Sredni B, etal., J Clin Oncol. 1995 Sep;13(9):2342-53.
125. Sugawara Y, etal., Hepatogastroenterology. 1998 Sep-Oct;45(23):1781-6.
126. Tomofuji T, etal., Free Radic Biol Med. 2009 Jan 15;46(2):163-8. Epub 2008 Oct 21.
127. Tong HH, etal., Int J Pediatr Otorhinolaryngol. 2008 Aug;72(8):1183-91. Epub 2008 Jun 3.
128. Towle CA, etal., Osteoarthritis Cartilage. 1997 Sep;5(5):293-300.
129. Turquier V, etal., Ann N Y Acad Sci 2002 Oct;971:45-8.
130. Vadhan-Raj S, etal., J Clin Oncol. 1994 Apr;12(4):707-14.
131. Van Dyke AL, etal., Cancer Epidemiol Biomarkers Prev. 2009 Jun;18(6):1829-40.
132. Vasakova M, etal., Scand J Immunol. 2007 Mar;65(3):265-70.
133. Walch L and Morris PL, Endocrinology 2002 Sep;143(9):3276-83.
134. Warren JS Biochem Biophys Res Commun. 1991 Mar 15;175(2):604-10.
135. Westerholm-Ormio M, etal., Diabetes. 2003 Sep;52(9):2287-95.
136. Westphal E, etal., J Endotoxin Res. 2007;13(1):25-34.
137. Winnall WR, etal., Mol Cell Endocrinol. 2009 Aug 13;307(1-2):169-75. Epub 2009 Feb 28.
138. Xu D, etal., Am J Reprod Immunol. 2015 Mar;73(3):214-20. doi: 10.1111/aji.12330. Epub 2014 Oct 20.
139. Yoon HJ, etal., J Immunol. 1999 Jun 15;162(12):7461-9.
140. Yoshida M, etal., Invest Ophthalmol Vis Sci. 1994 Mar;35(3):1107-13.
141. Zhang CQ, etal., Chin J Traumatol. 2007 Aug;10(4):206-12.
142. Zhao D and Yang BX, Zhonghua Wai Ke Za Zhi. 2009 Mar 1;47(5):373-6.
143. Zhou J, etal., Microvasc Res. 2012 May;83(3):276-80. doi: 10.1016/j.mvr.2012.03.003. Epub 2012 Mar 9.
Additional References at PubMed
PMID:1739124   PMID:2989698   PMID:3493774   PMID:9564845   PMID:10432220   PMID:11536012   PMID:12534936   PMID:12598651   PMID:12746488   PMID:12785009   PMID:12878449   PMID:14643175  
PMID:15025948   PMID:15032628   PMID:15063785   PMID:15154090   PMID:15467353   PMID:15784728   PMID:15990800   PMID:16083355   PMID:16825798   PMID:16905534   PMID:17117141   PMID:19341730  
PMID:19567205   PMID:19666510   PMID:20529813   PMID:21148126   PMID:21191089   PMID:21595923   PMID:22634325   PMID:23123184   PMID:23395675   PMID:23817958   PMID:24253784   PMID:24338227  
PMID:24338258   PMID:24644058   PMID:26002466   PMID:26899371  


Genomics

Comparative Map Data
Il1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23116,526,601 - 116,537,055 (-)NCBI
Rnor_6.0 Ensembl3121,825,412 - 121,836,086 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.03121,824,712 - 121,836,122 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03128,180,475 - 128,190,980 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43116,913,612 - 116,924,114 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13116,819,184 - 116,829,687 (-)NCBI
Celera3115,352,857 - 115,362,929 (-)NCBICelera
Cytogenetic Map3q36NCBI
IL1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2112,773,915 - 112,784,590 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl2112,773,925 - 112,784,493 (-)EnsemblGRCh38hg38GRCh38
GRCh382112,773,925 - 112,784,493 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372113,531,502 - 113,542,070 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362113,247,963 - 113,259,442 (-)NCBINCBI36hg18NCBI36
Build 342113,247,723 - 113,259,202NCBI
Celera2106,917,026 - 106,928,133 (-)NCBI
Cytogenetic Map2q14.1NCBI
HuRef2105,986,068 - 105,997,547 (-)NCBIHuRef
CHM1_12113,535,646 - 113,546,810 (-)NCBICHM1_1
Il1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392129,141,530 - 129,151,892 (-)NCBIGRCm39mm39
GRCm39 Ensembl2129,141,530 - 129,151,892 (-)Ensembl
GRCm382129,299,609 - 129,310,186 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2129,299,610 - 129,309,972 (-)EnsemblGRCm38mm10GRCm38
MGSCv372129,125,346 - 129,135,708 (-)NCBIGRCm37mm9NCBIm37
MGSCv362128,991,051 - 129,001,413 (-)NCBImm8
Celera2130,527,298 - 130,537,642 (-)NCBICelera
Cytogenetic Map2F1NCBI
cM Map262.9NCBI
Il1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554701,527,674 - 1,538,466 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554701,527,710 - 1,538,418 (+)NCBIChiLan1.0ChiLan1.0
IL1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A113,784,854 - 113,795,801 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A113,784,854 - 113,795,801 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A89,273,482 - 89,284,421 (+)NCBIMhudiblu_PPA_v0panPan3
IL1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11736,969,581 - 36,979,445 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1736,970,573 - 36,979,435 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1736,739,697 - 36,748,565 (-)NCBI
ROS_Cfam_1.01737,745,380 - 37,755,259 (-)NCBI
UMICH_Zoey_3.11736,881,972 - 36,890,833 (-)NCBI
UNSW_CanFamBas_1.01736,938,236 - 36,947,096 (-)NCBI
UU_Cfam_GSD_1.01737,152,126 - 37,160,990 (-)NCBI
Il1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629282,315,498 - 82,324,623 (-)NCBI
SpeTri2.0NW_0049367831,210,715 - 1,218,315 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl343,718,368 - 43,731,119 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1343,718,320 - 43,731,668 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2345,452,989 - 45,466,307 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap3q12-q13NCBI
IL1A
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11415,789,710 - 15,801,938 (-)NCBI
ChlSab1.1 Ensembl1415,789,013 - 15,796,611 (-)Ensembl
Il1a
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474912,795,967 - 12,805,658 (-)NCBI

Position Markers
D3Kyo4   No map positions available.
RH129736  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23116,526,606 - 116,526,773 (+)MAPPER
Rnor_6.03121,824,715 - 121,824,881NCBIRnor6.0
Rnor_5.03128,190,811 - 128,190,977UniSTSRnor5.0
RGSC_v3.43116,913,615 - 116,913,781UniSTSRGSC3.4
Celera3115,352,860 - 115,353,026UniSTS
RH 3.4 Map3996.9UniSTS
Cytogenetic Map3q36UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)310639528127023997Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)310639528127023997Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)330114912123700444Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)330846101172879276Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)339248391140271184Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)343295930163640485Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)343295930163640485Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)345406058127023997Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)345406058177699992Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)348561928155263151Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)351821836124513579Rat
1581568Rf53Renal function QTL 53total urine protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)358204463170534769Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)361241033165369047Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)362922868127023997Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)372672290127023997Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)372973445127023997Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)378700444123700444Rat
1581546Pur13Proteinuria QTL 132.930.0335total urine protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)381136227154416635Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)388910015133910015Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)394788365139788365Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)397009185142009185Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)399465522168732722Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)3101058963146058963Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)3102152812155263151Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)3102466149147466149Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)3103141814176418101Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)3103141814176418101Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3103141814176418101Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3103141944170934860Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3114376250159376250Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3117303473141971336Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3119471263164471263Rat
1358204Insglur1Insulin/glucose ratio QTL 13.8blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)3120917788141971336Rat
1358204Insglur1Insulin/glucose ratio QTL 13.8blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)3120917788141971336Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:778
Count of miRNA genes:262
Interacting mature miRNAs:326
Transcripts:ENSRNOT00000006113, ENSRNOT00000006126
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 6 6 6 8
Low 3 11 46 31 18 31 13 10 3
Below cutoff 23 3 2 1 2 6 6 33 5 20 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000006113   ⟹   ENSRNOP00000006113
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl3121,825,412 - 121,836,086 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000006126   ⟹   ENSRNOP00000006126
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl3121,825,832 - 121,835,360 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000080818   ⟹   ENSRNOP00000071252
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl3121,825,835 - 121,835,360 (-)Ensembl
RefSeq Acc Id: NM_017019   ⟹   NP_058715
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23116,526,604 - 116,536,822 (-)NCBI
Rnor_6.03121,824,712 - 121,836,122 (-)NCBI
Rnor_5.03128,180,475 - 128,190,980 (+)NCBI
RGSC_v3.43116,913,612 - 116,924,114 (-)RGD
Celera3115,352,857 - 115,362,929 (-)RGD
Sequence:
RefSeq Acc Id: XM_039104244   ⟹   XP_038960172
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23116,526,601 - 116,536,708 (-)NCBI
RefSeq Acc Id: XM_039104245   ⟹   XP_038960173
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23116,526,601 - 116,537,055 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_058715   ⟸   NM_017019
- UniProtKB: P16598 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000006126   ⟸   ENSRNOT00000006126
RefSeq Acc Id: ENSRNOP00000006113   ⟸   ENSRNOT00000006113
RefSeq Acc Id: ENSRNOP00000071252   ⟸   ENSRNOT00000080818
RefSeq Acc Id: XP_038960173   ⟸   XM_039104245
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038960172   ⟸   XM_039104244
- Peptide Label: isoform X1
Protein Domains
IL1_propep

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692424
Promoter ID:EPDNEW_R2947
Type:single initiation site
Name:Il1a_1
Description:interleukin 1 alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03121,836,122 - 121,836,182EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2890 AgrOrtholog
Ensembl Genes ENSRNOG00000004575 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000006113 UniProtKB/TrEMBL
  ENSRNOP00000006126 UniProtKB/TrEMBL
  ENSRNOP00000071252 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006113 UniProtKB/TrEMBL
  ENSRNOT00000006126 UniProtKB/TrEMBL
  ENSRNOT00000080818 ENTREZGENE, UniProtKB/TrEMBL
InterPro IL-1_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-1_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-1_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-1_propep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL1/FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24493 UniProtKB/Swiss-Prot
NCBI Gene 24493 ENTREZGENE
PANTHER PTHR10078 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10078:SF33 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IL1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL1_propep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Il1a PhenoGen
PRINTS INTERLEUKIN1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INTRLEUKIN1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE INTERLEUKIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50353 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K003_RAT UniProtKB/TrEMBL
  F1LQB1_RAT UniProtKB/TrEMBL
  F1MAF9_RAT UniProtKB/TrEMBL
  IL1A_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q546R9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Il1a  Interleukin 1 alpha      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in tesis 729411
gene_protein may be posttranslationally modified in the testis to create alternate isoforms 729411