Il1a (interleukin 1 alpha) - Rat Genome Database

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Gene: Il1a (interleukin 1 alpha) Rattus norvegicus
Analyze
Symbol: Il1a
Name: interleukin 1 alpha
RGD ID: 2890
Description: Predicted to enable copper ion binding activity and cytokine activity. Involved in several processes, including keratinization; negative regulation of establishment of Sertoli cell barrier; and positive regulation of intracellular signal transduction. Located in cell surface and extracellular space. Used to study interstitial lung disease. Biomarker of several diseases, including endometritis; lung disease (multiple); urinary tract infection; uveitis; and varicocele. Human ortholog(s) of this gene implicated in several diseases, including Fabry disease; Schnitzler syndrome; autoimmune disease (multiple); hematologic cancer (multiple); and lung disease (multiple). Orthologous to human IL1A (interleukin 1 alpha); PARTICIPATES IN interleukin-1 signaling pathway; apoptotic cell death pathway; cytokine mediated signaling pathway; INTERACTS WITH (+)-taxifolin; (R)-lipoic acid; (R,R,R)-alpha-tocopherol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: IL-1 alpha; IL-1F1; interleukin-1 alpha
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83136,979,804 - 136,990,236 (-)NCBIGRCr8
mRatBN7.23116,526,601 - 116,537,055 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3116,526,604 - 116,536,822 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3120,424,348 - 120,434,552 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03129,019,955 - 129,030,165 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03126,680,432 - 126,690,642 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03121,824,712 - 121,836,122 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3121,825,412 - 121,836,086 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03128,180,475 - 128,190,980 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43116,913,612 - 116,924,114 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13116,819,184 - 116,829,687 (-)NCBI
Celera3115,352,857 - 115,362,929 (-)NCBICelera
Cytogenetic Map3q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
acute myeloid leukemia  (ISO)
allergic bronchopulmonary aspergillosis  (ISO)
allergic contact dermatitis  (ISO)
Alzheimer's disease  (ISO)
amnestic disorder  (ISO)
Anorexia  (IEP)
anthracosis  (ISO)
Arsenic Poisoning  (ISO)
aspiration pneumonia  (IEP)
asthma  (ISO)
autoimmune thrombocytopenic purpura  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
beta thalassemia  (ISO)
Brain Injuries  (IEP,ISO)
brain ischemia  (ISO)
Burns  (ISO)
cardiomyopathy  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chemical Burns  (ISO)
cholestasis  (IEP)
cholesteatoma  (ISO)
cholesteatoma of middle ear  (ISO)
chorioamnionitis  (ISO)
chronic progressive external ophthalmoplegia  (ISO)
common cold  (ISO)
corneal edema  (ISO)
Craniocerebral Trauma  (ISO)
Creutzfeldt-Jakob disease  (ISO)
cystic fibrosis  (ISO)
dermatomyositis  (ISO)
diabetic retinopathy  (ISO)
diarrhea  (ISO)
Disease Progression  (ISO)
Drug-Induced Immune Thrombocytopenia  (ISO)
Drug-induced Neutropenia  (ISO)
end stage renal disease  (ISO)
endometritis  (IEP)
Endotoxemia  (IEP,ISO)
Enterocolitis  (IEP)
Experimental Arthritis  (IDA,IEP)
Experimental Diabetes Mellitus  (IEP)
Experimental Leukemia  (ISO)
Experimental Melanoma  (ISO)
extrinsic allergic alveolitis  (ISO)
Fabry disease  (ISO)
Femoral Fractures  (IEP)
Fetal Growth Retardation  (ISO)
Fever  (ISO)
glomerulonephritis  (ISO)
graft-versus-host disease  (ISO)
Graves ophthalmopathy  (ISO)
head and neck squamous cell carcinoma  (ISO)
Heat Stroke  (IEP,ISO)
hemolytic-uremic syndrome  (ISO)
Hemorrhage  (IEP)
Hemorrhagic Shock  (IEP)
HIV Wasting Syndrome  (ISO)
Human Influenza  (ISO)
Hyperalgesia  (ISO)
hyperglycemia  (ISO)
Hypotension  (ISO)
IgA glomerulonephritis  (ISO)
Inflammation  (ISO)
interstitial lung disease  (IMP,ISO)
Invasive Pulmonary Aspergillosis  (ISO)
iridocyclitis  (ISO)
juvenile rheumatoid arthritis  (ISO)
Kearns-Sayre syndrome  (ISO)
keratoconus  (ISO)
Knee Osteoarthritis  (IEP,ISO)
Leber hereditary optic neuropathy  (ISO)
Liver Reperfusion Injury  (IDA,IEP)
lung disease  (ISO)
lung non-small cell carcinoma  (ISO)
malignant mesothelioma  (ISO)
MELAS syndrome  (ISO)
MERRF Syndrome  (ISO)
mesenchymal chondrosarcoma  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Middle East respiratory syndrome  (ISO)
mitochondrial myopathy  (ISO)
multiple myeloma  (ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (IEP,ISO)
Nasal Polyps  (ISO)
Oral Lichen Planus  (ISO)
osteoarthritis  (ISO)
osteoporosis  (ISO)
otitis media  (IEP)
pancreatic cancer  (ISO)
Perennial Allergic Rhinitis  (ISO)
periodontitis  (ISO)
pneumonia  (IEP)
Poisoning  (ISO)
polymyositis  (ISO)
pulmonary fibrosis  (IEP,ISO)
pulmonary tuberculosis  (ISO)
Radiation Injuries  (IEP)
Radiation Pneumonitis  (ISO)
Reperfusion Injury  (ISO)
respiratory allergy  (ISO)
Retina Reperfusion Injury  (IEP)
rheumatoid arthritis  (ISO)
Schnitzler syndrome  (ISO)
Sclerosis  (ISO)
severe acute respiratory syndrome  (ISO)
skin disease  (ISO)
Skin Neoplasms  (ISO)
tick infestation  (ISO)
type 1 diabetes mellitus  (ISO)
urinary tract infection  (IEP,ISO)
uveitis  (IEP)
varicocele  (IEP)
Venous Thrombosis  (IEP)
vitiligo  (ISO)
Wounds and Injuries  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-epicatechin-3-O-gallate  (ISO)
(+)-taxifolin  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(E)-cinnamyl alcohol  (ISO)
(R)-lipoic acid  (EXP)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-colchicine  (ISO)
(S)-duloxetine hydrochloride  (EXP)
(S)-nicotine  (ISO)
1,1'-azobis(N,N-dimethylformamide)  (ISO)
1,3-benzothiazole-2-thiol  (ISO)
1,3-dinitrobenzene  (EXP)
1,4-dithiothreitol  (ISO)
1,4-phenylenediamine  (ISO)
1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acid  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP,ISO)
1-nitropyrene  (ISO)
1-O-palmitoyl-2-O-(5-oxovaleryl)-sn-glycero-3-phosphocholine  (ISO)
1-phenyl-1-cyclopentanecarboxylic acid 2-[2-(diethylamino)ethoxy]ethyl ester  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,2'-bipyridine  (ISO)
2,2,2-trichloroethanol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-bis(4-hydroxyphenyl)propionitrile  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-hydroxyethyl methacrylate  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methoxy-17beta-estradiol  (EXP)
2-palmitoylglycerol  (ISO)
2-tert-butylhydroquinone  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (EXP,ISO)
22-Hydroxycholesterol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3-acetyldeoxynivalenol  (ISO)
3-methylcholanthrene  (ISO)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitrobenzyl bromide  (ISO)
4-octylphenol  (ISO)
4-phenylbutyric acid  (ISO)
4-tert-butylphenol  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
8-Br-cAMP  (ISO)
AB-Fubinaca  (EXP)
acetylsalicylic acid  (ISO)
acrylamide  (EXP)
actinomycin D  (EXP)
acyclovir  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP)
albendazole  (ISO)
albuterol  (ISO)
aldehydo-D-glucosamine  (EXP)
all-trans-retinoic acid  (EXP,ISO)
alogliptin  (EXP)
alpha-hexylcinnamaldehyde  (ISO)
aluminium oxide  (ISO)
amikacin  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
amodiaquine  (ISO)
amphibole asbestos  (ISO)
aniline  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
anthracene-1,8,9-triol  (ISO)
apigenin  (ISO)
arachidonic acid  (ISO)
aripiprazole  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
asbestos  (ISO)
ATP  (ISO)
azathioprine  (ISO)
Azoxymethane  (ISO)
BAPTA  (ISO)
benzalkonium chloride  (ISO)
benzatropine  (ISO)
benzbromarone  (ISO)
benzene  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzoates  (ISO)
benzocaine  (ISO)
benzoic acid  (ISO)
Benzoyl peroxide  (ISO)
benzyl alcohol  (ISO)
benzylpenicillin  (ISO)
beta-D-glucosamine  (EXP)
beta-naphthoflavone  (EXP,ISO)
biperiden  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
bromfenac  (ISO)
bromoacetate  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
butylated hydroxyanisole  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium selenide  (ISO)
cadmium sulfate  (ISO)
Calcimycin  (ISO)
calcitriol  (ISO)
Calphostin C  (ISO)
cannabidiol  (ISO)
capsaicin  (EXP)
carazolol  (ISO)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
carrageenan  (ISO)
carteolol  (ISO)
ceric oxide  (EXP)
cetylpyridinium  (ISO)
CGP 52608  (ISO)
chlorobenzene  (ISO)
chlorogenic acid  (ISO)
chlorophyllin  (ISO)
chloropicrin  (ISO)
chloroquine  (ISO)
chlorothalonil  (ISO)
chlorpromazine  (ISO)
choline  (ISO)
cinnamyl alcohol  (ISO)
ciprofloxacin  (ISO)
cisplatin  (ISO)
citral  (ISO)
clarithromycin  (EXP,ISO)
clavulanic acid  (ISO)
clobetasol  (ISO)
clofibrate  (ISO)
clomipramine  (ISO)
clonidine  (EXP)
clonidine (amino form)  (EXP)
clonidine (imino form)  (EXP)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
cordycepin  (ISO)
corn oil  (EXP)
cortisol  (ISO)
crocidolite asbestos  (EXP,ISO)
CU-O LINKAGE  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP)
cytochalasin D  (ISO)
daidzein  (ISO)
delta-tocotrienol  (ISO)
demeclocycline  (ISO)
deoxynivalenol  (EXP,ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP,ISO)
dichloromethane  (ISO)
diclofenac  (ISO)
dicyclanil  (ISO)
Didecyldimethylammonium  (ISO)
diethyl maleate  (ISO)
diethylamine  (ISO)
diethylstilbestrol  (ISO)
dimethyl sulfoxide  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (EXP,ISO)
disulfiram  (ISO)
dodecane  (ISO)
doxorubicin  (ISO)
edaravone  (ISO)
enalapril  (ISO)
endosulfan  (EXP)
enilconazole  (ISO)
entacapone  (ISO)
entinostat  (ISO)
erlotinib hydrochloride  (ISO)
erythromycin A  (ISO)
esmolol  (ISO)
estriol  (ISO)
estrone 3-sulfate  (ISO)
ethambutol  (ISO)
ethanol  (EXP,ISO)
ethidium  (ISO)
ethionamide  (EXP)
ethylene glycol dimethacrylate  (ISO)
etodolac  (ISO)
eugenol  (ISO)
farnesol  (ISO)
fentanyl  (EXP)
ferroheme b  (ISO)
ferulic acid  (ISO)
Fexofenadine hydrochloride  (ISO)
flucloxacillin  (ISO)
fludrocortisone  (ISO)
flufenamic acid  (ISO)
fluocinolone acetonide  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
furan  (EXP,ISO)
gadodiamide hydrate  (EXP)
gadolinium trichloride  (EXP)
gamma-hexachlorocyclohexane  (EXP)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (EXP)
geranial  (ISO)
geraniol  (ISO)
glyoxal  (ISO)
Goe 6976  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
griseofulvin  (ISO)
heme b  (ISO)
hesperetin  (ISO)
hexadecane  (ISO)
hexadecanoic acid  (ISO)
Hexadimethrine bromide  (EXP)
hexane  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
ibuprofen  (ISO)
imidurea  (ISO)
imiquimod  (ISO)
indometacin  (EXP,ISO)
ionomycin  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
iron(III) citrate  (ISO)
isoeugenol  (ISO)
isoniazide  (ISO)
isoprenaline  (EXP,ISO)
isotretinoin  (EXP)
ivermectin  (ISO)
ketoconazole  (ISO)
kojic acid  (EXP)
L-1,4-dithiothreitol  (ISO)
L-arginine  (EXP)
lead diacetate  (ISO)
lead nitrate  (ISO)
lenalidomide  (ISO)
leupeptin  (ISO)
levofloxacin  (ISO)
Licochalcone B  (ISO)
limonene  (ISO)
lipoic acid  (EXP)
lipopolysaccharide  (EXP,ISO)
losartan  (EXP,ISO)
LY294002  (ISO)
m-xylene  (EXP)
malathion  (ISO)
manganese(II) chloride  (EXP)
mangiferin  (ISO)
mebendazole  (ISO)
melatonin  (ISO)
menadione  (EXP,ISO)
mephedrone  (EXP)
mercaptoethanol  (ISO)
mercury dichloride  (ISO)
mesalamine  (ISO)
metam  (ISO)
metaproterenol  (ISO)
methadone  (EXP)
methamphetamine  (EXP,ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
methoxyacetic acid  (EXP)
methyl caffeate  (ISO)
methyl methacrylate  (ISO)
methyl salicylate  (ISO)
methylisothiazolinone  (ISO)
metoprolol  (ISO)
mevalonic acid  (EXP,ISO)
mexiletine  (ISO)
Mezerein  (ISO)
microcystin-LR  (ISO)
mifepristone  (ISO)
mitomycin C  (ISO)
MJN110  (ISO)
Mofezolac (TN)  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
monocrotaline  (EXP)
morphine  (ISO)
muramyl dipeptide  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (ISO)
N,N-diethyl-m-toluamide  (EXP,ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethylmaleimide  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
naloxone  (ISO)
naproxen  (EXP)
nebivolol  (ISO)
nefazodone  (EXP,ISO)
neocuproine  (ISO)
neoechinulin A  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
nimesulide  (ISO)
nitric oxide  (EXP,ISO)
nitrofen  (EXP)
nitroprusside  (EXP)
nitrososulfamethoxazole  (ISO)
nonane  (EXP)
nonanoic acid  (ISO)
Nonidet P-40  (ISO)
Nonylphenol  (ISO)
nortriptyline  (ISO)
notoginsenoside R1  (ISO)
NS-398  (ISO)
ochratoxin A  (ISO)
octenidine  (ISO)
oleic acid  (ISO)
orciprenaline  (ISO)
oroxylin A  (ISO)
Osajin  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
paliperidone palmitate  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
paricalcitol  (ISO)
parthenolide  (ISO)
pemetrexed  (ISO)
penbutolol  (ISO)
pentane-2,3-dione  (EXP)
peptidoglycan  (ISO)
perfluorododecanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP,ISO)
phenethyl caffeate  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP)
phenol  (ISO)
phloretin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
phthalic anhydride  (ISO)
pimecrolimus  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
poly(I:C)  (ISO)
polycyclic arene  (ISO)
polymyxin B2  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
potassium hydroxide  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
primaquine  (ISO)
primidone  (ISO)
probenecid  (ISO)
procyclidine  (ISO)
promethazine  (ISO)
propamocarb  (ISO)
propan-2-ol  (ISO)
prostaglandin E2  (EXP,ISO)
prostaglandin F2alpha  (ISO)
prostaglandin I2  (ISO)
pterostilbene  (ISO)
puerarin  (ISO)
Pyridostigmine bromide  (EXP,ISO)
quartz  (ISO)
quercetin  (ISO)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
quinacrine  (ISO)
quinine  (ISO)
rac-lactic acid  (ISO)
ranitidine  (EXP)
resorcinol  (ISO)
resveratrol  (ISO)
Riluzole  (ISO)
rofecoxib  (ISO)
Roridin A  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
salicylic acid  (ISO)
SB 203580  (ISO)
SB-202190  (ISO)
SCH 23390  (EXP)
scopolamine  (ISO)
serpentine asbestos  (EXP,ISO)
silibinin  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (EXP)
sodium perchlorate  (EXP)
streptozocin  (ISO)
sulindac  (EXP)
sumatriptan  (EXP)
T-2 toxin  (EXP,ISO)
telithromycin  (EXP)
terameprocol  (ISO)
testosterone  (EXP,ISO)
testosterone enanthate  (EXP)
tetrachloromethane  (EXP,ISO)
tetracyclines  (ISO)
tetradecane  (ISO)
Tetramethylthiourea  (EXP)
tetraphene  (ISO)
tetrathiomolybdate(2-)  (ISO)
thioacetamide  (EXP,ISO)
thiostrepton  (ISO)
thiram  (ISO)
tienilic acid  (ISO)
titanium dioxide  (ISO)
TMC-120A  (ISO)
Tolmetin glucuronide  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP)
toremifene  (ISO)
trans-isoeugenol  (ISO)
trazodone  (ISO)
tremolite asbestos  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
tridecane  (ISO)
Trihexyphenidyl  (ISO)
trimethyltin  (ISO)
triptonide  (ISO)
Triton X-100  (ISO)
troglitazone  (ISO)
trovafloxacin  (EXP,ISO)
urethane  (ISO)
usnic acid  (ISO)
vadimezan  (EXP)
valproic acid  (ISO)
vanadium atom  (EXP)
vanadium(0)  (EXP)
vanadyl sulfate  (ISO)
verapamil  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
wortmannin  (ISO)
Y-27632  (EXP)
Z-Val-Phe-H  (ISO)
zidovudine  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc oxide  (EXP)
zinc sulfate  (ISO)
zinc(0)  (EXP,ISO)
zomepirac  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to heat  (IEA,ISO,ISS)
cellular response to lipopolysaccharide  (IBA)
connective tissue replacement involved in inflammatory response wound healing  (IEA,ISO)
cytokine-mediated signaling pathway  (IBA,IEA,ISO)
ectopic germ cell programmed cell death  (IEA,ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (IEA,ISO)
fever generation  (IEA)
heart development  (IEP)
immune response  (IBA,IEA)
inflammatory response  (IBA)
intracellular sodium ion homeostasis  (IEA,ISO)
keratinization  (IDA)
negative regulation of cell population proliferation  (IEA,ISO)
negative regulation of establishment of Sertoli cell barrier  (IDA)
positive regulation of angiogenesis  (IEA,ISO)
positive regulation of canonical NF-kappaB signal transduction  (IBA,IDA)
positive regulation of cell division  (IEA)
positive regulation of cytokine production  (IEA,ISO)
positive regulation of ERK1 and ERK2 cascade  (IDA)
positive regulation of gene expression  (ISO)
positive regulation of immature T cell proliferation in thymus  (IBA)
positive regulation of interleukin-2 production  (IEA,IMP,ISO)
positive regulation of interleukin-6 production  (IMP)
positive regulation of JNK cascade  (IDA)
positive regulation of mitotic nuclear division  (IEA,ISO)
positive regulation of neutrophil migration  (IMP)
positive regulation of prostaglandin secretion  (IDA)
positive regulation of protein secretion  (IEA,ISO)
positive regulation of steroid biosynthetic process  (IDA)
positive regulation of stress-activated MAPK cascade  (IDA)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of tumor necrosis factor production  (IMP)
positive regulation of vascular endothelial growth factor production  (IEA,ISO)
regulation of actin cytoskeleton organization  (IDA)
regulation of ERK1 and ERK2 cascade  (IBA)
response to benzene  (IEP)
response to copper ion  (IEA,ISO,ISS)
response to gamma radiation  (IEP)
response to hypoxia  (IEP)
response to L-ascorbic acid  (IEP)
response to lipopolysaccharide  (IEP)
response to ozone  (IEP)
response to vanadate(3-)  (IEP)
signal transduction  (IEA)
spermatogenesis  (IEP)

Cellular Component
cell surface  (IDA)
cytosol  (IEA,ISO,ISS)
extracellular space  (IBA,IDA,IEA,ISO,ISS)
nucleus  (IEA)

Molecular Function

References

References - curated
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Additional References at PubMed
PMID:1739124   PMID:2989698   PMID:3493774   PMID:9564845   PMID:10432220   PMID:11536012   PMID:12534936   PMID:12598651   PMID:12746488   PMID:12785009   PMID:12878449   PMID:14643175  
PMID:15025948   PMID:15032628   PMID:15063785   PMID:15154090   PMID:15467353   PMID:15784728   PMID:15990800   PMID:16083355   PMID:16825798   PMID:16905534   PMID:17117141   PMID:19341730  
PMID:19567205   PMID:19666510   PMID:20529813   PMID:21148126   PMID:21191089   PMID:21595923   PMID:22634325   PMID:23123184   PMID:23395675   PMID:23817958   PMID:24253784   PMID:24338227  
PMID:24338258   PMID:24644058   PMID:26002466   PMID:26899371   PMID:32920036   PMID:33106949   PMID:33107399   PMID:34047944  


Genomics

Comparative Map Data
Il1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83136,979,804 - 136,990,236 (-)NCBIGRCr8
mRatBN7.23116,526,601 - 116,537,055 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3116,526,604 - 116,536,822 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3120,424,348 - 120,434,552 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03129,019,955 - 129,030,165 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03126,680,432 - 126,690,642 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03121,824,712 - 121,836,122 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3121,825,412 - 121,836,086 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03128,180,475 - 128,190,980 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43116,913,612 - 116,924,114 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13116,819,184 - 116,829,687 (-)NCBI
Celera3115,352,857 - 115,362,929 (-)NCBICelera
Cytogenetic Map3q36NCBI
IL1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382112,773,925 - 112,784,493 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2112,773,925 - 112,784,493 (-)EnsemblGRCh38hg38GRCh38
GRCh372113,531,502 - 113,542,070 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362113,247,963 - 113,259,442 (-)NCBINCBI36Build 36hg18NCBI36
Build 342113,247,723 - 113,259,202NCBI
Celera2106,917,026 - 106,928,133 (-)NCBICelera
Cytogenetic Map2q14.1NCBI
HuRef2105,986,068 - 105,997,547 (-)NCBIHuRef
CHM1_12113,535,646 - 113,546,806 (-)NCBICHM1_1
T2T-CHM13v2.02113,200,569 - 113,210,953 (-)NCBIT2T-CHM13v2.0
Il1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392129,141,530 - 129,151,892 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2129,141,530 - 129,151,892 (-)EnsemblGRCm39 Ensembl
GRCm382129,299,609 - 129,310,186 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2129,299,610 - 129,309,972 (-)EnsemblGRCm38mm10GRCm38
MGSCv372129,125,346 - 129,135,708 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362128,991,051 - 129,001,413 (-)NCBIMGSCv36mm8
Celera2130,527,298 - 130,537,642 (-)NCBICelera
Cytogenetic Map2F1NCBI
cM Map262.9NCBI
Il1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554701,527,674 - 1,538,466 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554701,527,710 - 1,538,418 (+)NCBIChiLan1.0ChiLan1.0
IL1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21215,339,536 - 15,350,287 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A15,343,032 - 15,352,074 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A89,273,482 - 89,284,421 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A113,784,854 - 113,795,801 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A113,784,854 - 113,795,801 (-)Ensemblpanpan1.1panPan2
IL1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11736,969,581 - 36,979,445 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1736,970,573 - 36,979,435 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1736,739,697 - 36,748,565 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01737,745,380 - 37,755,259 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1737,746,372 - 37,755,235 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11736,881,972 - 36,890,833 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01736,938,236 - 36,947,096 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01737,152,126 - 37,160,990 (-)NCBIUU_Cfam_GSD_1.0
Il1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629282,315,498 - 82,324,623 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367831,210,809 - 1,218,315 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367831,210,715 - 1,218,315 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl343,718,368 - 43,731,121 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1343,718,320 - 43,731,668 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2345,452,989 - 45,466,307 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap3q12-q13NCBI
IL1A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11415,789,710 - 15,801,938 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1415,789,013 - 15,796,611 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660803,883,451 - 3,894,101 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il1a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474912,795,946 - 12,805,154 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474912,795,967 - 12,805,658 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

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Variants in Il1a
89 total Variants