IL1A (interleukin 1 alpha) - Rat Genome Database

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Gene: IL1A (interleukin 1 alpha) Homo sapiens
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Symbol: IL1A
Name: interleukin 1 alpha
RGD ID: 735707
HGNC Page HGNC
Description: Exhibits copper ion binding activity and cytokine activity. Involved in several processes, including positive regulation of interleukin-2 production; positive regulation of mitotic nuclear division; and response to copper ion. Localizes to cytosol and extracellular space. Implicated in several diseases, including Fabry disease; Schnitzler syndrome; autoimmune disease (multiple); hematologic cancer (multiple); and lung disease (multiple). Biomarker of several diseases, including autoimmune disease (multiple); cholesteatoma (multiple); common cold; cystic fibrosis; and osteoarthritis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: hematopoietin-1; IL-1 alpha; IL-1A; IL1; IL1-ALPHA; IL1F1; interleukin 1, alpha; interleukin-1 alpha; preinterleukin 1 alpha; pro-interleukin-1-alpha
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in cytokine storm inflammatory response.
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2112,773,925 - 112,784,493 (-)EnsemblGRCh38hg38GRCh38
GRCh382112,773,925 - 112,784,493 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372113,531,502 - 113,542,070 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362113,247,963 - 113,259,442 (-)NCBINCBI36hg18NCBI36
Build 342113,247,723 - 113,259,202NCBI
Celera2106,917,026 - 106,928,133 (-)NCBI
Cytogenetic Map2q14.1NCBI
HuRef2105,986,068 - 105,997,547 (-)NCBIHuRef
CHM1_12113,535,646 - 113,546,810 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
acute myeloid leukemia  (IDA)
allergic bronchopulmonary aspergillosis  (ISO)
allergic contact dermatitis  (EXP)
Alzheimer's disease  (IAGP,IEP)
amnestic disorder  (EXP)
Anorexia  (ISO)
anthracosis  (EXP)
Arsenic Poisoning  (EXP)
aspiration pneumonia  (ISO)
asthma  (IAGP)
autoimmune thrombocytopenic purpura  (IAGP)
B-Cell Chronic Lymphocytic Leukemia  (IAGP)
beta thalassemia  (IEP)
Brain Injuries  (EXP,ISO)
brain ischemia  (EXP)
Burns  (EXP)
Burns, Chemical  (EXP)
cardiomyopathy  (EXP)
Chemical and Drug Induced Liver Injury  (EXP)
cholestasis  (ISO)
cholesteatoma  (IEP)
cholesteatoma of middle ear  (IEP)
chorioamnionitis  (EXP)
chronic progressive external ophthalmoplegia  (EXP)
common cold  (IEP)
corneal edema  (IEP)
Craniocerebral Trauma  (IEP)
Creutzfeldt-Jakob disease  (ISO)
cystic fibrosis  (IEP)
dermatomyositis  (EXP)
diabetic retinopathy  (IEP)
diarrhea  (EXP)
Disease Progression  (EXP)
Drug-Induced Immune Thrombocytopenia  (IDA,IEP)
Drug-induced Neutropenia  (IEP)
end stage renal disease  (IAGP)
endometritis  (ISO)
Endotoxemia  (ISO)
Enterocolitis  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Leukemia  (ISO)
Experimental Melanoma  (ISO)
extrinsic allergic alveolitis  (ISO)
Fabry disease  (IAGP)
Femoral Fractures  (ISO)
Fetal Growth Retardation  (IEP)
Fever  (EXP)
glomerulonephritis  (ISO)
Graft vs Host Disease  (IAGP)
Graves Ophthalmopathy  (IEP)
head and neck squamous cell carcinoma  (EXP)
Heat Stroke  (EXP,ISO)
hemolytic-uremic syndrome  (EXP)
Hemorrhage  (ISO)
Hemorrhagic Shock  (ISO)
HIV Wasting Syndrome  (EXP)
Human Influenza  (ISO)
Hyperalgesia  (EXP)
hyperglycemia  (IEP)
Hypotension  (EXP)
IgA glomerulonephritis  (IAGP)
Inflammation  (EXP,IDA,ISO)
interstitial lung disease  (IAGP,ISO)
Invasive Pulmonary Aspergillosis  (IAGP)
iridocyclitis  (IAGP)
juvenile rheumatoid arthritis  (IAGP)
Kearns-Sayre syndrome  (EXP)
keratoconus  (IAGP)
Knee Osteoarthritis  (IEP,ISO)
Leber hereditary optic neuropathy  (EXP)
Liver Reperfusion Injury  (ISO)
lung disease  (IEP,ISO)
lung non-small cell carcinoma  (IAGP)
malignant mesothelioma  (EXP)
MELAS syndrome  (EXP)
MERRF Syndrome  (EXP)
mesenchymal chondrosarcoma  (EXP)
Middle East respiratory syndrome  (ISO)
mitochondrial myopathy  (EXP)
multiple myeloma  (IAGP,ISO)
Myocardial Ischemia  (EXP)
Myocardial Reperfusion Injury  (IDA,ISO)
Nasal Polyps  (IAGP)
non-alcoholic fatty liver disease  (EXP)
Oral Lichen Planus  (IEP)
osteoarthritis  (IEP)
osteoporosis  (IDA)
otitis media  (ISO)
pancreatic cancer  (IEP)
Perennial Allergic Rhinitis  (IAGP)
periodontitis  (IEP)
pneumonia  (ISO)
Poisoning  (IDA,ISO)
polymyositis  (EXP)
pulmonary fibrosis  (IAGP,ISO)
pulmonary tuberculosis  (ISO)
Radiation Injuries  (ISO)
Radiation Pneumonitis  (IAGP)
Reperfusion Injury  (EXP)
respiratory allergy  (ISO)
Retina Reperfusion Injury  (ISO)
rheumatoid arthritis  (IDA,IEP)
Schnitzler syndrome  (IDA)
Sclerosis  (IAGP)
severe acute respiratory syndrome  (ISO)
skin disease  (EXP,ISO)
Skin Neoplasms  (EXP)
tick infestation  (ISO)
type 1 diabetes mellitus  (IEP,IMP,ISO)
urinary tract infection  (ISO)
uveitis  (ISO)
varicocele  (ISO)
Venous Thrombosis  (ISO)
vitiligo  (EXP,IEP)
Wounds and Injuries  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-tocopherol  (ISO)
(+)-epicatechin-3-O-gallate  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(E)-cinnamyl alcohol  (EXP)
(R)-lipoic acid  (ISO)
(R)-mevalonic acid  (EXP,ISO)
(S)-colchicine  (EXP)
(S)-nicotine  (EXP)
1,1'-azobis(N,N-dimethylformamide)  (EXP)
1,3-benzothiazole-2-thiol  (EXP,ISO)
1,3-dinitrobenzene  (ISO)
1,4-dithiothreitol  (EXP)
1,4-phenylenediamine  (ISO)
1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acid  (EXP)
1-chloro-2,4-dinitrobenzene  (EXP,ISO)
1-fluoro-2,4-dinitrobenzene  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-nitropyrene  (EXP)
1-O-palmitoyl-2-O-(5-oxovaleryl)-sn-glycero-3-phosphocholine  (EXP)
1-phenyl-1-cyclopentanecarboxylic acid 2-[2-(diethylamino)ethoxy]ethyl ester  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2'-bipyridine  (EXP)
2,2,2-trichloroethanol  (EXP)
2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-hydroxypropanoic acid  (EXP,ISO)
2-methoxy-17beta-estradiol  (ISO)
2-tert-butylhydroquinone  (EXP)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (EXP,ISO)
22-Hydroxycholesterol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
3-methylcholanthrene  (EXP)
3-phenylprop-2-enal  (EXP,ISO)
3H-1,2-dithiole-3-thione  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP,ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitrobenzyl bromide  (EXP)
4-tert-butylphenol  (EXP)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
8-Br-cAMP  (EXP)
acetylsalicylic acid  (EXP)
acrylamide  (ISO)
actinomycin D  (ISO)
acyclovir  (EXP)
afimoxifene  (EXP)
aflatoxin B1  (ISO)
albendazole  (EXP)
albuterol  (EXP)
aldehydo-D-glucosamine  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-hexylcinnamaldehyde  (ISO)
aluminium oxide  (EXP)
amikacin  (EXP)
amiodarone  (EXP)
ammonium chloride  (ISO)
amodiaquine  (EXP)
amphibole asbestos  (EXP)
aniline  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
anthracene-1,8,9-triol  (ISO)
arachidonic acid  (ISO)
aripiprazole  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (EXP)
arsenous acid  (EXP,ISO)
asbestos  (EXP)
ATP  (ISO)
azathioprine  (EXP)
BAPTA  (ISO)
benzalkonium chloride  (EXP,ISO)
benzatropine  (EXP)
benzbromarone  (EXP)
benzene  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
benzoates  (ISO)
benzocaine  (ISO)
benzoic acid  (EXP)
Benzoyl peroxide  (EXP,ISO)
benzyl alcohol  (EXP)
benzylpenicillin  (ISO)
beta-D-glucosamine  (ISO)
beta-naphthoflavone  (EXP,ISO)
biperiden  (EXP)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP,ISO)
bromfenac  (EXP)
butan-1-ol  (EXP)
butanal  (EXP)
butylated hydroxyanisole  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium selenide  (EXP)
cadmium sulfate  (EXP)
Calcimycin  (ISO)
calcitriol  (ISO)
capsaicin  (ISO)
carazolol  (EXP)
carbon nanotube  (EXP,ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (EXP)
carrageenan  (ISO)
ceric oxide  (ISO)
cetylpyridinium  (EXP)
chlorobenzene  (ISO)
chlorogenic acid  (EXP)
chloropicrin  (EXP)
chloroquine  (EXP,ISO)
chlorpromazine  (EXP)
choline  (ISO)
cinnamyl alcohol  (EXP)
ciprofloxacin  (EXP)
cisplatin  (ISO)
citral  (ISO)
clarithromycin  (EXP,ISO)
clavulanic acid  (EXP)
clobetasol  (ISO)
clofibrate  (ISO)
clomipramine  (EXP)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (EXP)
cortisol  (EXP)
crocidolite asbestos  (EXP,ISO)
CU-O LINKAGE  (EXP)
curcumin  (ISO)
cycloheximide  (EXP)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (ISO)
daidzein  (ISO)
delta-tocotrienol  (ISO)
demeclocycline  (EXP)
deoxynivalenol  (ISO)
desferrioxamine B  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP,ISO)
dichloromethane  (EXP)
diclofenac  (EXP)
diethyl maleate  (EXP)
diethylamine  (ISO)
diethylstilbestrol  (ISO)
dimethyl sulfoxide  (EXP)
dimethylarsinous acid  (EXP)
dioxygen  (EXP)
disulfiram  (EXP)
dodecane  (EXP)
doxorubicin  (EXP)
enalapril  (EXP)
endosulfan  (ISO)
entacapone  (EXP)
entinostat  (EXP)
erlotinib hydrochloride  (EXP)
erythromycin A  (ISO)
esmolol  (EXP)
estriol  (EXP)
estrone 3-sulfate  (EXP)
ethambutol  (EXP)
ethanol  (EXP,ISO)
ethidium  (ISO)
ethionamide  (ISO)
ethylene glycol dimethacrylate  (ISO)
etodolac  (EXP)
eugenol  (EXP)
farnesol  (EXP)
ferroheme b  (ISO)
ferulic acid  (ISO)
Fexofenadine hydrochloride  (EXP,ISO)
flucloxacillin  (EXP)
fludrocortisone  (EXP)
flufenamic acid  (EXP)
fluocinolone acetonide  (ISO)
folic acid  (EXP)
formaldehyde  (EXP)
fulvestrant  (EXP)
fumonisin B1  (ISO)
furan  (ISO)
gadodiamide hydrate  (ISO)
gadolinium trichloride  (ISO)
gamma-hexachlorocyclohexane  (ISO)
gemcitabine  (EXP)
genistein  (EXP,ISO)
gentamycin  (ISO)
geranial  (ISO)
geraniol  (EXP)
glyoxal  (EXP)
Goe 6976  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
griseofulvin  (EXP)
heme b  (ISO)
hesperetin  (EXP)
hexadecane  (EXP)
hexadecanoic acid  (EXP)
Hexadimethrine bromide  (ISO)
hexane  (EXP)
hydrogen peroxide  (EXP)
hydroquinone  (EXP,ISO)
ibuprofen  (EXP)
imidurea  (ISO)
imiquimod  (ISO)
indometacin  (EXP,ISO)
ionomycin  (EXP)
iron atom  (ISO)
iron(0)  (ISO)
iron(III) citrate  (EXP)
isoeugenol  (ISO)
isoniazide  (EXP)
isoprenaline  (EXP,ISO)
isotretinoin  (ISO)
ivermectin  (EXP)
ketoconazole  (EXP)
kojic acid  (ISO)
L-1,4-dithiothreitol  (EXP)
lead nitrate  (ISO)
lenalidomide  (ISO)
leupeptin  (EXP)
levofloxacin  (EXP)
limonene  (EXP)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
losartan  (EXP,ISO)
LY294002  (EXP)
m-xylene  (ISO)
manganese(II) chloride  (ISO)
mangiferin  (ISO)
mebendazole  (EXP)
melatonin  (ISO)
menadione  (EXP,ISO)
mercaptoethanol  (EXP)
mercury dichloride  (ISO)
mesalamine  (EXP)
metam  (ISO)
metaproterenol  (EXP)
methadone  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methotrexate  (EXP,ISO)
methoxyacetic acid  (ISO)
methyl methacrylate  (ISO)
methyl salicylate  (ISO)
methylisothiazolinone  (EXP)
metoprolol  (EXP)
mexiletine  (EXP)
Mezerein  (ISO)
mifepristone  (EXP)
Mofezolac (TN)  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (ISO)
morphine  (ISO)
muramyl dipeptide  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-acetyl-L-cysteine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-ethylmaleimide  (EXP)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
naloxone  (ISO)
naproxen  (ISO)
nebivolol  (EXP)
nefazodone  (EXP,ISO)
neocuproine  (ISO)
neoechinulin A  (ISO)
nickel atom  (EXP)
nickel dichloride  (EXP,ISO)
nickel sulfate  (EXP)
nicotine  (EXP)
nimesulide  (EXP)
nitric oxide  (EXP,ISO)
nitrososulfamethoxazole  (EXP)
nonane  (ISO)
nonanoic acid  (ISO)
Nonidet P-40  (EXP)
Nonylphenol  (EXP)
nortriptyline  (EXP)
notoginsenoside R1  (ISO)
NS-398  (EXP)
ochratoxin A  (EXP)
octenidine  (EXP)
oleic acid  (EXP)
orciprenaline  (EXP)
Osajin  (EXP)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
paliperidone palmitate  (EXP)
paracetamol  (ISO)
paraquat  (EXP,ISO)
paricalcitol  (ISO)
parthenolide  (EXP)
pemetrexed  (EXP)
penbutolol  (EXP)
pentane-2,3-dione  (ISO)
peptidoglycan  (EXP)
perfluorododecanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
permethrin  (ISO)
phenethyl caffeate  (EXP)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
phenol  (EXP)
phloretin  (EXP)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
phthalic anhydride  (ISO)
pimecrolimus  (ISO)
pioglitazone  (EXP)
pirinixic acid  (ISO)
polymyxin B2  (EXP)
potassium chromate  (EXP)
potassium dichromate  (EXP)
potassium hydroxide  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
primaquine  (EXP)
primidone  (EXP)
probenecid  (ISO)
procyclidine  (EXP)
promethazine  (EXP)
propan-2-ol  (ISO)
prostaglandin E2  (EXP,ISO)
prostaglandin F2alpha  (EXP)
prostaglandin I2  (EXP)
puerarin  (EXP)
Pyridostigmine bromide  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
quinacrine  (ISO)
quinine  (EXP)
rac-lactic acid  (EXP,ISO)
ranitidine  (ISO)
resorcinol  (EXP)
resveratrol  (EXP,ISO)
Riluzole  (EXP)
rofecoxib  (EXP)
Roridin A  (ISO)
rotenone  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
salicylic acid  (ISO)
SB 203580  (EXP)
SCH 23390  (ISO)
scopolamine  (ISO)
serpentine asbestos  (EXP,ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
simvastatin  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (EXP)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (EXP)
sodium perchlorate  (ISO)
streptozocin  (ISO)
sulindac  (ISO)
sumatriptan  (ISO)
T-2 toxin  (ISO)
telithromycin  (ISO)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
tetradecane  (EXP)
tetraphene  (EXP)
tetrathiomolybdate(2-)  (ISO)
thioacetamide  (ISO)
thiostrepton  (EXP)
thiram  (EXP)
tienilic acid  (EXP)
titanium dioxide  (EXP)
Tolmetin glucuronide  (EXP)
toluene 2,4-diisocyanate  (EXP,ISO)
topotecan  (ISO)
toremifene  (ISO)
trans-isoeugenol  (ISO)
trazodone  (EXP)
tremolite asbestos  (ISO)
tributylstannane  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP)
triclosan  (ISO)
tridecane  (EXP)
Trihexyphenidyl  (EXP)
trimethyltin  (ISO)
triptonide  (ISO)
Triton X-100  (EXP)
troglitazone  (EXP)
trovafloxacin  (EXP,ISO)
urethane  (EXP)
usnic acid  (EXP)
vadimezan  (ISO)
valproic acid  (EXP,ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vanadyl sulfate  (EXP)
verapamil  (EXP)
vinclozolin  (ISO)
vitamin E  (ISO)
vorinostat  (EXP)
wortmannin  (EXP)
Y-27632  (ISO)
Z-Val-Phe-H  (EXP)
zidovudine  (EXP)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc sulfate  (EXP)
zinc(0)  (EXP,ISO)
zomepirac  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute inflammatory response  (ISO)
apoptotic process  (TAS)
cellular response to heat  (IDA)
cellular response to lipopolysaccharide  (IBA)
cellular sodium ion homeostasis  (IEA,ISO)
connective tissue replacement involved in inflammatory response wound healing  (IEA,ISO)
cytokine-mediated signaling pathway  (IBA,IMP,TAS)
ectopic germ cell programmed cell death  (IEA,ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (IEA,ISO)
fever generation  (IEA)
heart development  (ISO)
immune response  (IEA)
inflammatory response  (IBA,ISO)
interleukin-1-mediated signaling pathway  (ISO,TAS)
keratinization  (ISO)
negative regulation of cell population proliferation  (IDA)
negative regulation of establishment of Sertoli cell barrier  (ISO)
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  (TAS)
positive regulation of angiogenesis  (ISS)
positive regulation of cell division  (IEA)
positive regulation of cytokine production  (IDA)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of gene expression  (IBA,IDA)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (ISO)
positive regulation of immature T cell proliferation in thymus  (IBA)
positive regulation of interleukin-2 production  (IMP,ISO,ISS)
positive regulation of interleukin-6 production  (ISO,ISS)
positive regulation of JNK cascade  (ISO)
positive regulation of mitotic nuclear division  (IMP)
positive regulation of monocyte chemotactic protein-1 production  (ISO)
positive regulation of neutrophil extravasation  (ISO)
positive regulation of neutrophil migration  (ISO)
positive regulation of prostaglandin secretion  (ISO)
positive regulation of protein secretion  (IMP)
positive regulation of steroid biosynthetic process  (ISO)
positive regulation of stress-activated MAPK cascade  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of tumor necrosis factor production  (ISS)
positive regulation of vascular endothelial growth factor production  (ISS)
regulation of actin cytoskeleton organization  (ISO)
regulation of nitric-oxide synthase activity  (IBA)
regulation of sensory perception of pain  (ISO)
response to copper ion  (IDA)
response to gamma radiation  (ISO)
response to heat  (ISO)
response to hypoxia  (ISO)
response to L-ascorbic acid  (ISO)
response to lipopolysaccharide  (ISO)
response to organic cyclic compound  (ISO)
response to organic substance  (ISO)
response to organonitrogen compound  (ISO)
response to ozone  (ISO)
spermatogenesis  (ISO)
wound healing  (ISO)

Cellular Component
cell surface  (ISO)
cytoplasm  (ISO)
cytosol  (IDA,ISO)
extracellular region  (TAS)
extracellular space  (IBA,IDA,IMP,ISO)
plasma membrane  (ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

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PMID:19546559   PMID:19559392   PMID:19563289   PMID:19573080   PMID:19594368   PMID:19625176   PMID:19648252   PMID:19658300   PMID:19661089   PMID:19671938   PMID:19680808   PMID:19683555  
PMID:19684156   PMID:19692168   PMID:19701653   PMID:19702713   PMID:19708438   PMID:19729601   PMID:19733643   PMID:19738620   PMID:19742166   PMID:19764937   PMID:19773279   PMID:19773451  
PMID:19775068   PMID:19786079   PMID:19789190   PMID:19792847   PMID:19805069   PMID:19811432   PMID:19820020   PMID:19844779   PMID:19860911   PMID:19884766   PMID:19889475   PMID:19892918  
PMID:19913121   PMID:19917630   PMID:19926874   PMID:19934104   PMID:19948975   PMID:20005085   PMID:20011938   PMID:20027454   PMID:20056178   PMID:20059417   PMID:20059631   PMID:20065999  
PMID:20070880   PMID:20080142   PMID:20113359   PMID:20113413   PMID:20116409   PMID:20127018   PMID:20131253   PMID:20140262   PMID:20141484   PMID:20157068   PMID:20169140   PMID:20173430  
PMID:20178882   PMID:20182449   PMID:20192980   PMID:20196868   PMID:20200332   PMID:20207250   PMID:20213229   PMID:20217044   PMID:20220089   PMID:20227257   PMID:20237496   PMID:20299682  
PMID:20335539   PMID:20347268   PMID:20353565   PMID:20371868   PMID:20400062   PMID:20413850   PMID:20418110   PMID:20427258   PMID:20445556   PMID:20452482   PMID:20453000   PMID:20459687  
PMID:20472930   PMID:20490394   PMID:20490891   PMID:20495422   PMID:20503287   PMID:20534741   PMID:20536507   PMID:20536609   PMID:20561568   PMID:20565898   PMID:20568250   PMID:20574532  
PMID:20594066   PMID:20595916   PMID:20602615   PMID:20603037   PMID:20603050   PMID:20619343   PMID:20628086   PMID:20630038   PMID:20673868   PMID:20677014   PMID:20725607   PMID:20800603  
PMID:20844546   PMID:20847078   PMID:20848459   PMID:20889944   PMID:20934174   PMID:20940514   PMID:20942594   PMID:20959405   PMID:20961668   PMID:21035110   PMID:21037510   PMID:21048327  
PMID:21054222   PMID:21070631   PMID:21086908   PMID:21107309   PMID:21133705   PMID:21154765   PMID:21196890   PMID:21205020   PMID:21235388   PMID:21270123   PMID:21279638   PMID:21311438  
PMID:21336718   PMID:21385326   PMID:21394384   PMID:21449691   PMID:21509504   PMID:21518761   PMID:21620624   PMID:21621860   PMID:21682548   PMID:21712624   PMID:21768915   PMID:21795706  
PMID:21816944   PMID:21847358   PMID:21871094   PMID:21873635   PMID:21968104   PMID:22083707   PMID:22092925   PMID:22124068   PMID:22143786   PMID:22151432   PMID:22153345   PMID:22177239  
PMID:22197408   PMID:22211888   PMID:22216303   PMID:22234841   PMID:22282663   PMID:22285242   PMID:22312160   PMID:22344672   PMID:22348697   PMID:22364598   PMID:22417897   PMID:22513697  
PMID:22582837   PMID:22633328   PMID:22675954   PMID:22678894   PMID:22732089   PMID:22805136   PMID:22868802   PMID:22879895   PMID:22894561   PMID:22949675   PMID:23018032   PMID:23038715  
PMID:23052182   PMID:23076369   PMID:23078215   PMID:23100272   PMID:23159404   PMID:23203659   PMID:23216199   PMID:23241110   PMID:23271701   PMID:23284306   PMID:23289806   PMID:23322030  
PMID:23349093   PMID:23383108   PMID:23395675   PMID:23454256   PMID:23509928   PMID:23527710   PMID:23542780   PMID:23554905   PMID:23583823   PMID:23592003   PMID:23594042   PMID:23635948  
PMID:23639700   PMID:23722873   PMID:23723976   PMID:23747396   PMID:23749763   PMID:23817958   PMID:23846687   PMID:23900673   PMID:23927441   PMID:24024155   PMID:24043886   PMID:24055697  
PMID:24060296   PMID:24062309   PMID:24063019   PMID:24063999   PMID:24096733   PMID:24103372   PMID:24146121   PMID:24162774   PMID:24265545   PMID:24272484   PMID:24273934   PMID:24275344  
PMID:24300227   PMID:24313836   PMID:24352037   PMID:24452718   PMID:24453029   PMID:24477584   PMID:24515998   PMID:24530664   PMID:24612355   PMID:24613844   PMID:24615437   PMID:24670917  
PMID:24787052   PMID:24839866   PMID:24843315   PMID:24862933   PMID:24866792   PMID:24918527   PMID:24924428   PMID:24952309   PMID:25025954   PMID:25036364   PMID:25058342   PMID:25098424  
PMID:25158036   PMID:25195148   PMID:25197060   PMID:25205122   PMID:25207923   PMID:25223242   PMID:25241761   PMID:25263616   PMID:25322977   PMID:25323745   PMID:25336714   PMID:25416956  
PMID:25425967   PMID:25432444   PMID:25446437   PMID:25545357   PMID:25548252   PMID:25554695   PMID:25609807   PMID:25617388   PMID:25693732   PMID:25730877   PMID:25732517   PMID:25826984  
PMID:25888634   PMID:25902400   PMID:25910212   PMID:25917615   PMID:25955681   PMID:25980612   PMID:26040073   PMID:26097611   PMID:26116899   PMID:26147250   PMID:26193214   PMID:26200829  
PMID:26224856   PMID:26232334   PMID:26239639   PMID:26254854   PMID:26263533   PMID:26305372   PMID:26324711   PMID:26345777   PMID:26380303   PMID:26381575   PMID:26439902   PMID:26460957  
PMID:26506473   PMID:26629874   PMID:26728383   PMID:26808616   PMID:26879815   PMID:26889982   PMID:26909953   PMID:26909967   PMID:26934083   PMID:27031441   PMID:27078871   PMID:27098064  
PMID:27121322   PMID:27136893   PMID:27221874   PMID:27246313   PMID:27253397   PMID:27260388   PMID:27314954   PMID:27418555   PMID:27434011   PMID:27451139   PMID:27493109   PMID:27525354  
PMID:27527810   PMID:27655512   PMID:27706611   PMID:27717726   PMID:27883292   PMID:27918732   PMID:28019133   PMID:28067797   PMID:28078769   PMID:28081267   PMID:28129679   PMID:28151075  
PMID:28152513   PMID:28412968   PMID:28423679   PMID:28483765   PMID:28627263   PMID:28629997   PMID:28656529   PMID:28659656   PMID:28725984   PMID:29023981   PMID:29096839   PMID:29145255  
PMID:29179746   PMID:29228441   PMID:29310992   PMID:29382706   PMID:29419674   PMID:29456054   PMID:29498183   PMID:29577711   PMID:29641282   PMID:29771405   PMID:29802240   PMID:29808330  
PMID:29855451   PMID:29879187   PMID:29884765   PMID:29968322   PMID:29976772   PMID:30018088   PMID:30070872   PMID:30142580   PMID:30243010   PMID:30305325   PMID:30366016   PMID:30465622  
PMID:30554608   PMID:30583087   PMID:30664211   PMID:30670674   PMID:30760333   PMID:30799135   PMID:30819119   PMID:30898979   PMID:30916891   PMID:30940725   PMID:30969811   PMID:31127430  
PMID:31172560   PMID:31248297   PMID:31359795   PMID:31376337   PMID:31499272   PMID:31666193   PMID:31692000   PMID:31759990   PMID:31901915   PMID:31912349   PMID:31953354   PMID:31981288  
PMID:32081612   PMID:32159969   PMID:32174642   PMID:32447774   PMID:32457454   PMID:32503645   PMID:32610117   PMID:32657162   PMID:32682440   PMID:32733443   PMID:32825489  


Genomics

Comparative Map Data
IL1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2112,773,925 - 112,784,493 (-)EnsemblGRCh38hg38GRCh38
GRCh382112,773,925 - 112,784,493 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372113,531,502 - 113,542,070 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362113,247,963 - 113,259,442 (-)NCBINCBI36hg18NCBI36
Build 342113,247,723 - 113,259,202NCBI
Celera2106,917,026 - 106,928,133 (-)NCBI
Cytogenetic Map2q14.1NCBI
HuRef2105,986,068 - 105,997,547 (-)NCBIHuRef
CHM1_12113,535,646 - 113,546,810 (-)NCBICHM1_1
Il1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392129,141,530 - 129,151,892 (-)NCBIGRCm39mm39
GRCm39 Ensembl2129,141,530 - 129,151,892 (-)Ensembl
GRCm382129,299,609 - 129,310,186 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2129,299,610 - 129,309,972 (-)EnsemblGRCm38mm10GRCm38
MGSCv372129,125,346 - 129,135,708 (-)NCBIGRCm37mm9NCBIm37
MGSCv362128,991,051 - 129,001,413 (-)NCBImm8
Celera2130,527,298 - 130,537,642 (-)NCBICelera
Cytogenetic Map2F1NCBI
cM Map262.9NCBI
Il1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23116,526,601 - 116,537,055 (-)NCBI
Rnor_6.0 Ensembl3121,825,412 - 121,836,086 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.03121,824,712 - 121,836,122 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03128,180,475 - 128,190,980 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43116,913,612 - 116,924,114 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13116,819,184 - 116,829,687 (-)NCBI
Celera3115,352,857 - 115,362,929 (-)NCBICelera
Cytogenetic Map3q36NCBI
Il1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554701,527,674 - 1,538,466 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554701,527,710 - 1,538,418 (+)NCBIChiLan1.0ChiLan1.0
IL1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A113,784,854 - 113,795,801 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A113,784,854 - 113,795,801 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A89,273,482 - 89,284,421 (+)NCBIMhudiblu_PPA_v0panPan3
IL1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11736,969,581 - 36,979,445 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1736,970,573 - 36,979,435 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1736,739,697 - 36,748,565 (-)NCBI
ROS_Cfam_1.01737,745,380 - 37,755,259 (-)NCBI
UMICH_Zoey_3.11736,881,972 - 36,890,833 (-)NCBI
UNSW_CanFamBas_1.01736,938,236 - 36,947,096 (-)NCBI
UU_Cfam_GSD_1.01737,152,126 - 37,160,990 (-)NCBI
Il1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629282,315,498 - 82,324,623 (-)NCBI
SpeTri2.0NW_0049367831,210,715 - 1,218,315 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl343,718,368 - 43,731,119 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1343,718,320 - 43,731,668 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2345,452,989 - 45,466,307 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap3q12-q13NCBI
IL1A
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11415,789,710 - 15,801,938 (-)NCBI
ChlSab1.1 Ensembl1415,789,013 - 15,796,611 (-)Ensembl
Vero_WHO_p1.0NW_0236660803,883,451 - 3,894,101 (+)NCBI
Il1a
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474912,795,967 - 12,805,658 (-)NCBI

Position Markers
D2S2565  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372113,532,330 - 113,532,629UniSTSGRCh37
Build 362113,248,801 - 113,249,100RGDNCBI36
Celera2106,917,864 - 106,918,163RGD
Cytogenetic Map2q14UniSTS
HuRef2105,986,906 - 105,987,205UniSTS
TNG Radiation Hybrid Map264479.0UniSTS
Stanford-G3 RH Map24708.0UniSTS
GeneMap99-G3 RH Map25621.0UniSTS
G43002  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372113,538,413 - 113,538,663UniSTSGRCh37
Build 362113,254,884 - 113,255,134RGDNCBI36
Celera2106,923,575 - 106,923,825RGD
Cytogenetic Map2q14UniSTS
HuRef2105,992,989 - 105,993,239UniSTS
SHGC-86275  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372113,542,280 - 113,542,583UniSTSGRCh37
Build 362113,258,751 - 113,259,054RGDNCBI36
Celera2106,927,442 - 106,927,745RGD
Cytogenetic Map2q14UniSTS
HuRef2105,996,856 - 105,997,159UniSTS
TNG Radiation Hybrid Map264486.0UniSTS
GDB:177384  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372113,538,273 - 113,538,364UniSTSGRCh37
Build 362113,254,744 - 113,254,835RGDNCBI36
Celera2106,923,438 - 106,923,526RGD
Cytogenetic Map2q14UniSTS
HuRef2105,992,849 - 105,992,940UniSTS
GDB:178390  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372113,538,281 - 113,538,669UniSTSGRCh37
Build 362113,254,752 - 113,255,140RGDNCBI36
Celera2106,923,446 - 106,923,831RGD
Cytogenetic Map2q14UniSTS
HuRef2105,992,857 - 105,993,245UniSTS
GDB:181250  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372113,542,506 - 113,542,901UniSTSGRCh37
Build 362113,258,977 - 113,259,372RGDNCBI36
Celera2106,927,668 - 106,928,063RGD
Cytogenetic Map2q14UniSTS
HuRef2105,997,082 - 105,997,477UniSTS
GDB:196942  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372113,533,791 - 113,534,780UniSTSGRCh37
Celera2106,919,326 - 106,919,945RGD
Cytogenetic Map2q14UniSTS
HuRef2105,988,367 - 105,989,356UniSTS
GDB:210902  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372113,542,940 - 113,543,038UniSTSGRCh37
Build 362113,259,411 - 113,259,509RGDNCBI36
Celera2106,928,102 - 106,928,200RGD
Cytogenetic Map2q14UniSTS
HuRef2105,997,516 - 105,997,614UniSTS
GDB:211100  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372113,537,041 - 113,537,253UniSTSGRCh37
Build 362113,253,512 - 113,253,724RGDNCBI36
Celera2106,922,206 - 106,922,418RGD
Cytogenetic Map2q14UniSTS
HuRef2105,991,617 - 105,991,829UniSTS
GDB:190869  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372113,535,736 - 113,535,868UniSTSGRCh37
Build 362113,252,207 - 113,252,339RGDNCBI36
Celera2106,920,901 - 106,921,033RGD
Cytogenetic Map2q14UniSTS
HuRef2105,990,312 - 105,990,444UniSTS
IL1A_v436  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372113,531,634 - 113,532,453UniSTSGRCh37
Build 362113,248,105 - 113,248,924RGDNCBI36
Celera2106,917,168 - 106,917,987RGD
HuRef2105,986,210 - 105,987,029UniSTS
SHGC-6140  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372113,535,570 - 113,535,906UniSTSGRCh37
Build 362113,252,041 - 113,252,377RGDNCBI36
Celera2106,920,735 - 106,921,071RGD
Cytogenetic Map2q14UniSTS
HuRef2105,990,146 - 105,990,482UniSTS
Stanford-G3 RH Map24758.0UniSTS
GeneMap99-G3 RH Map25671.0UniSTS
IL1A  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372113,532,653 - 113,532,840UniSTSGRCh37
Build 362113,249,124 - 113,249,311RGDNCBI36
Celera2106,918,187 - 106,918,374RGD
HuRef2105,987,229 - 105,987,416UniSTS
RH18071  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2q14UniSTS
GeneMap99-GB4 RH Map2409.69UniSTS
NCBI RH Map2842.6UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:344
Count of miRNA genes:288
Interacting mature miRNAs:312
Transcripts:ENST00000263339
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High 1 1 1
Medium 23 1 9 12 226 3 22 6 9 27 393 97 17 5 4
Low 201 48 167 55 402 28 1180 64 686 61 283 628 34 1 162 484 4
Below cutoff 1590 1203 1098 328 808 221 1420 913 2621 219 439 700 110 518 1034 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_008850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_000575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001371554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA856674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC079753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC112235 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF536338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK314850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC013142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC035169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BN000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT007014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA307202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR457414 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M15329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X02531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X02851 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X03833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X56086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000263339   ⟹   ENSP00000263339
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2112,773,925 - 112,784,493 (-)Ensembl
RefSeq Acc Id: NM_000575   ⟹   NP_000566
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382112,773,925 - 112,784,493 (-)NCBI
GRCh372113,531,492 - 113,542,971 (-)ENTREZGENE
Build 362113,247,963 - 113,259,442 (-)NCBI Archive
HuRef2105,986,068 - 105,997,547 (-)ENTREZGENE
CHM1_12113,535,646 - 113,546,810 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001371554   ⟹   NP_001358483
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382112,773,925 - 112,784,400 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_000566   ⟸   NM_000575
- Peptide Label: precursor
- UniProtKB: P01583 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001358483   ⟸   NM_001371554
- Peptide Label: precursor
RefSeq Acc Id: ENSP00000263339   ⟸   ENST00000263339

Promoters
RGD ID:6861370
Promoter ID:EPDNEW_H3850
Type:initiation region
Name:IL1A_1
Description:interleukin 1 alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382112,784,493 - 112,784,553EPDNEW
RGD ID:6797182
Promoter ID:HG_KWN:34563
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562,   Lymphoblastoid
Transcripts:ENST00000409071
Position:
Human AssemblyChrPosition (strand)Source
Build 362113,257,751 - 113,258,482 (-)MPROMDB
RGD ID:6797631
Promoter ID:HG_KWN:34564
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3,   K562,   Lymphoblastoid
Transcripts:NM_000575
Position:
Human AssemblyChrPosition (strand)Source
Build 362113,258,291 - 113,258,791 (-)MPROMDB
RGD ID:6850110
Promoter ID:EP14063
Type:single initiation site
Name:HS_IL1A
Description:Interleukin-1 alpha, IL1A gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Primer extension
Regulation:macrophages; (induced by or strongly expressed in) LPS, (induced by or strongly expressed in) PHA, (repressed by or weakly expressed in) glucc
Position:
Human AssemblyChrPosition (strand)Source
Build 362113,258,541 - 113,258,601EPD

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh37/hg19 2q12.2-14.1(chr2:106423310-115054828)x1 copy number loss See cases [RCV000240053] Chr2:106423310..115054828 [GRCh37]
Chr2:2q12.2-14.1
pathogenic
GRCh37/hg19 2q12.3-14.3(chr2:109798247-125658380)x1 copy number loss See cases [RCV000240485] Chr2:109798247..125658380 [GRCh37]
Chr2:2q12.3-14.3
pathogenic
GRCh37/hg19 2q12.3-14.1(chr2:109556627-117570152)x1 copy number loss See cases [RCV000240490] Chr2:109556627..117570152 [GRCh37]
Chr2:2q12.3-14.1
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384) copy number gain See cases [RCV000512056] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384)x3 copy number gain See cases [RCV000511212] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2q12.1-24.3(chr2:104172062-168223828)x1 copy number loss PARP Inhibitor response [RCV000626436] Chr2:104172062..168223828 [GRCh37]
Chr2:2q12.1-24.3
drug response
GRCh37/hg19 2p25.3-q37.3(chr2:14238-243048760)x3 copy number gain not provided [RCV000752802] Chr2:14238..243048760 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
Single allele inversion not provided [RCV000714264] Chr2:40608411..146900718 [GRCh37]
Chr2:2p22.1-q22.3
likely pathogenic
GRCh37/hg19 2q11.1-13(chr2:96353030-114045463)x3 copy number gain not provided [RCV000682168] Chr2:96353030..114045463 [GRCh37]
Chr2:2q11.1-13
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:15672-243101834)x3 copy number gain not provided [RCV000752804] Chr2:15672..243101834 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
NM_000575.5(IL1A):c.373A>G (p.Asn125Asp) single nucleotide variant not provided [RCV000961974] Chr2:112779613 [GRCh38]
Chr2:113537190 [GRCh37]
Chr2:2q14.1
likely benign
NM_000575.5(IL1A):c.459G>A (p.Thr153=) single nucleotide variant not provided [RCV000916427] Chr2:112779527 [GRCh38]
Chr2:113537104 [GRCh37]
Chr2:2q14.1
likely benign
NM_000575.5(IL1A):c.412G>A (p.Asp138Asn) single nucleotide variant not provided [RCV000974923] Chr2:112779574 [GRCh38]
Chr2:113537151 [GRCh37]
Chr2:2q14.1
benign
NM_000575.5(IL1A):c.276C>T (p.Ile92=) single nucleotide variant not provided [RCV000955961] Chr2:112781647 [GRCh38]
Chr2:113539224 [GRCh37]
Chr2:2q14.1
benign

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:5991 AgrOrtholog
COSMIC IL1A COSMIC
Ensembl Genes ENSG00000115008 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000263339 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000263339 ENTREZGENE, UniProtKB/Swiss-Prot
GTEx ENSG00000115008 GTEx
HGNC ID HGNC:5991 ENTREZGENE
Human Proteome Map IL1A Human Proteome Map
InterPro IL-1_alpha UniProtKB/Swiss-Prot
  IL-1_CS UniProtKB/Swiss-Prot
  IL-1_fam UniProtKB/Swiss-Prot
  IL-1_propep UniProtKB/Swiss-Prot
  IL1/FGF UniProtKB/Swiss-Prot
KEGG Report hsa:3552 UniProtKB/Swiss-Prot
NCBI Gene 3552 ENTREZGENE
OMIM 147760 OMIM
PANTHER PTHR10078 UniProtKB/Swiss-Prot
  PTHR10078:SF33 UniProtKB/Swiss-Prot
Pfam IL1 UniProtKB/Swiss-Prot
  IL1_propep UniProtKB/Swiss-Prot
PharmGKB PA29807 PharmGKB
PRINTS INTERLEUKIN1 UniProtKB/Swiss-Prot
  INTRLEUKIN1A UniProtKB/Swiss-Prot
PROSITE INTERLEUKIN_1 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50353 UniProtKB/Swiss-Prot
UniProt IL1A_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q53QF9 UniProtKB/Swiss-Prot
  Q7RU02 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-24 IL1A  interleukin 1 alpha    interleukin 1, alpha  Symbol and/or name change 5135510 APPROVED
2011-08-16 IL1A  interleukin 1, alpha  IL1A  interleukin 1, alpha  Symbol and/or name change 5135510 APPROVED