RGD Reference Report - Microglial interleukin-1 alpha expression in human head injury: correlations with neuronal and neuritic beta-amyloid precursor protein expression. - Rat Genome Database

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Microglial interleukin-1 alpha expression in human head injury: correlations with neuronal and neuritic beta-amyloid precursor protein expression.

Authors: Griffin, WS  Sheng, JG  Gentleman, SM  Graham, DI  Mrak, RE  Roberts, GW 
Citation: Griffin WS, etal., Neurosci Lett. 1994 Aug 1;176(2):133-6.
RGD ID: 10045949
Pubmed: PMID:7830934   (View Abstract at PubMed)
PMCID: PMC3833643   (View Article at PubMed Central)

Activated microglia containing IL-1 alpha-immunoreactive (IL-1 alpha +) product were increased 3-fold in number in the acute phase following head injury, a risk factor for later development of Alzheimer's disease, and this increase was correlated with a 7-fold increase in the number of neurons with elevated beta-amyloid precursor protein (beta-APP) levels (R = 0.78; P < 0.05). Furthermore, clusters of beta-APP+ dystrophic neurites present in these patients were invariably associated with activated IL-1 alpha + microglia. These findings suggest that early overexpression of IL-1 alpha and beta-APP is a priming event for later neuropathological changes evident at end stages of Alzheimer's disease.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IL1AHumanCraniocerebral Trauma  IEP protein:increased expression:microglial cellRGD 
Il1aRatCraniocerebral Trauma  ISOIL1A (Homo sapiens)protein:increased expression:microglial cellRGD 
Il1aMouseCraniocerebral Trauma  ISOIL1A (Homo sapiens)protein:increased expression:microglial cellRGD 

Objects Annotated

Genes (Rattus norvegicus)
Il1a  (interleukin 1 alpha)

Genes (Mus musculus)
Il1a  (interleukin 1 alpha)

Genes (Homo sapiens)
IL1A  (interleukin 1 alpha)


Additional Information