Il1a (interleukin 1 alpha) - Rat Genome Database

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Gene: Il1a (interleukin 1 alpha) Mus musculus
Symbol: Il1a
Name: interleukin 1 alpha
RGD ID: 10789
Description: Exhibits cytokine activity and interleukin-1 receptor binding activity. Involved in several processes, including cell surface receptor signaling pathway; connective tissue replacement involved in inflammatory response wound healing; and positive regulation of cytokine production. Localizes to cytoplasm and extracellular space. Is expressed in dorsal aorta; early conceptus; hemolymphoid system; liver; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including Fabry disease; Schnitzler syndrome; autoimmune disease (multiple); hematologic cancer (multiple); and lung disease (multiple). Orthologous to human IL1A (interleukin 1 alpha); PARTICIPATES IN interleukin-1 signaling pathway; apoptotic cell death pathway; graft-versus-host disease pathway; INTERACTS WITH (+)-epicatechin-3-O-gallate; (-)-epigallocatechin 3-gallate; 1,3-benzothiazole-2-thiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Il; IL-1 alpha; Il-1a; interleukin-1 alpha
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm392129,141,530 - 129,151,892 (-)NCBIGRCm39mm39
GRCm39 Ensembl2129,141,530 - 129,151,892 (-)Ensembl
GRCm382129,299,609 - 129,310,186 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2129,299,610 - 129,309,972 (-)EnsemblGRCm38mm10GRCm38
MGSCv372129,125,346 - 129,135,708 (-)NCBIGRCm37mm9NCBIm37
MGSCv362128,991,051 - 129,001,413 (-)NCBImm8
Celera2130,527,298 - 130,537,642 (-)NCBICelera
Cytogenetic Map2F1NCBI
cM Map262.9NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (IMP)
acute myeloid leukemia  (ISO)
allergic bronchopulmonary aspergillosis  (IEP)
allergic contact dermatitis  (ISO)
Alzheimer's disease  (ISO)
amnestic disorder  (ISO)
Anorexia  (ISO)
anthracosis  (ISO)
Arsenic Poisoning  (ISO)
aspiration pneumonia  (ISO)
asthma  (ISO)
autoimmune thrombocytopenic purpura  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
beta thalassemia  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
Burns  (ISO)
Burns, Chemical  (ISO)
cardiomyopathy  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholestasis  (ISO)
cholesteatoma  (ISO)
cholesteatoma of middle ear  (ISO)
chorioamnionitis  (ISO)
chronic progressive external ophthalmoplegia  (ISO)
common cold  (ISO)
corneal edema  (ISO)
Craniocerebral Trauma  (ISO)
Creutzfeldt-Jakob disease  (IEP)
cystic fibrosis  (ISO)
dermatomyositis  (ISO)
diabetic retinopathy  (ISO)
diarrhea  (ISO)
Disease Progression  (ISO)
Drug-Induced Immune Thrombocytopenia  (ISO)
Drug-induced Neutropenia  (ISO)
end stage renal disease  (ISO)
endometritis  (ISO)
Endotoxemia  (IEP,ISO)
Enterocolitis  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Leukemia  (IDA)
Experimental Melanoma  (IDA)
extrinsic allergic alveolitis  (IEP)
Fabry disease  (ISO)
Femoral Fractures  (ISO)
Fetal Growth Retardation  (ISO)
Fever  (ISO)
glomerulonephritis  (IEP)
Graft vs Host Disease  (ISO)
Graves Ophthalmopathy  (ISO)
head and neck squamous cell carcinoma  (ISO)
Heat Stroke  (ISO)
hemolytic-uremic syndrome  (ISO)
Hemorrhage  (ISO)
Hemorrhagic Shock  (ISO)
HIV Wasting Syndrome  (ISO)
Human Influenza  (IEP)
Hyperalgesia  (ISO)
hyperglycemia  (ISO)
Hypotension  (ISO)
IgA glomerulonephritis  (ISO)
Inflammation  (IEP,ISO)
interstitial lung disease  (ISO)
Invasive Pulmonary Aspergillosis  (ISO)
iridocyclitis  (ISO)
juvenile rheumatoid arthritis  (ISO)
Kearns-Sayre syndrome  (ISO)
keratoconus  (ISO)
Knee Osteoarthritis  (IEP,ISO)
Leber hereditary optic neuropathy  (ISO)
Liver Reperfusion Injury  (ISO)
lung disease  (IEP,ISO)
lung non-small cell carcinoma  (ISO)
malignant mesothelioma  (ISO)
MELAS syndrome  (ISO)
MERRF Syndrome  (ISO)
mesenchymal chondrosarcoma  (ISO)
Middle East respiratory syndrome  (HEP)
mitochondrial myopathy  (ISO)
multiple myeloma  (IMP,ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
Nasal Polyps  (ISO)
non-alcoholic fatty liver disease  (ISO)
Oral Lichen Planus  (ISO)
osteoarthritis  (ISO)
osteoporosis  (ISO)
otitis media  (ISO)
pancreatic cancer  (ISO)
Perennial Allergic Rhinitis  (ISO)
periodontitis  (ISO)
pneumonia  (ISO)
Poisoning  (IDA,ISO)
polymyositis  (ISO)
pulmonary fibrosis  (ISO)
pulmonary tuberculosis  (IEP)
Radiation Injuries  (ISO)
Radiation Pneumonitis  (ISO)
Reperfusion Injury  (ISO)
respiratory allergy  (IMP)
Retina Reperfusion Injury  (ISO)
rheumatoid arthritis  (ISO)
Schnitzler syndrome  (ISO)
Sclerosis  (ISO)
severe acute respiratory syndrome  (HEP)
skin disease  (IMP,ISO)
Skin Neoplasms  (ISO)
tick infestation  (IEP)
type 1 diabetes mellitus  (IEP,ISO)
urinary tract infection  (IEP,ISO)
uveitis  (ISO)
varicocele  (ISO)
Venous Thrombosis  (ISO)
vitiligo  (ISO)
Wounds and Injuries  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-tocopherol  (ISO)
(+)-epicatechin-3-O-gallate  (EXP)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(E)-cinnamyl alcohol  (ISO)
(R)-lipoic acid  (ISO)
(R)-mevalonic acid  (ISO)
(S)-colchicine  (ISO)
(S)-nicotine  (ISO)
1,1'-azobis(N,N-dimethylformamide)  (ISO)
1,3-benzothiazole-2-thiol  (EXP,ISO)
1,3-dinitrobenzene  (ISO)
1,4-dithiothreitol  (ISO)
1,4-phenylenediamine  (EXP)
1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acid  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP,ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP,ISO)
1-nitropyrene  (ISO)
1-O-palmitoyl-2-O-(5-oxovaleryl)-sn-glycero-3-phosphocholine  (ISO)
1-phenyl-1-cyclopentanecarboxylic acid 2-[2-(diethylamino)ethoxy]ethyl ester  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2'-bipyridine  (ISO)
2,2,2-trichloroethanol  (ISO)
2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-hydroxypropanoic acid  (EXP,ISO)
2-methoxy-17beta-estradiol  (ISO)
2-tert-butylhydroquinone  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
22-Hydroxycholesterol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3-methylcholanthrene  (ISO)
3-phenylprop-2-enal  (EXP,ISO)
3H-1,2-dithiole-3-thione  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP,ISO)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (EXP)
4-nitrobenzyl bromide  (ISO)
4-tert-butylphenol  (ISO)
5-fluorouracil  (EXP)
6-propyl-2-thiouracil  (ISO)
8-Br-cAMP  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
acyclovir  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
albendazole  (ISO)
albuterol  (ISO)
aldehydo-D-glucosamine  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-hexylcinnamaldehyde  (EXP)
aluminium oxide  (ISO)
amikacin  (ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
amodiaquine  (ISO)
amphibole asbestos  (ISO)
aniline  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
anthracene-1,8,9-triol  (EXP)
arachidonic acid  (EXP)
aripiprazole  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
azathioprine  (ISO)
benzalkonium chloride  (EXP,ISO)
benzatropine  (ISO)
benzbromarone  (ISO)
benzene  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzoates  (EXP)
benzocaine  (EXP)
benzoic acid  (ISO)
Benzoyl peroxide  (EXP,ISO)
benzyl alcohol  (ISO)
benzylpenicillin  (EXP)
beta-D-glucosamine  (ISO)
beta-naphthoflavone  (ISO)
biperiden  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP,ISO)
bromfenac  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
butylated hydroxyanisole  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium selenide  (ISO)
cadmium sulfate  (ISO)
Calcimycin  (EXP)
calcitriol  (EXP)
capsaicin  (ISO)
carazolol  (ISO)
carbon nanotube  (EXP,ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
carrageenan  (EXP)
ceric oxide  (ISO)
cetylpyridinium  (ISO)
chlorobenzene  (EXP)
chlorogenic acid  (ISO)
chloropicrin  (ISO)
chloroquine  (EXP,ISO)
chlorpromazine  (ISO)
choline  (EXP)
cinnamyl alcohol  (ISO)
ciprofloxacin  (ISO)
cisplatin  (EXP)
citral  (EXP)
clarithromycin  (ISO)
clavulanic acid  (ISO)
clobetasol  (EXP)
clofibrate  (EXP)
clomipramine  (ISO)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
cobalt dichloride  (EXP)
cocaine  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
cortisol  (ISO)
crocidolite asbestos  (EXP,ISO)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (ISO)
daidzein  (EXP)
delta-tocotrienol  (EXP)
demeclocycline  (ISO)
deoxynivalenol  (EXP,ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
dichloromethane  (ISO)
diclofenac  (ISO)
diethyl maleate  (ISO)
diethylamine  (EXP)
diethylstilbestrol  (EXP)
dimethyl sulfoxide  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (ISO)
disulfiram  (ISO)
dodecane  (ISO)
doxorubicin  (ISO)
enalapril  (ISO)
endosulfan  (ISO)
entacapone  (ISO)
entinostat  (ISO)
erlotinib hydrochloride  (ISO)
erythromycin A  (EXP)
esmolol  (ISO)
estriol  (ISO)
estrone 3-sulfate  (ISO)
ethambutol  (ISO)
ethanol  (EXP,ISO)
ethidium  (EXP)
ethionamide  (ISO)
ethylene glycol dimethacrylate  (EXP)
etodolac  (ISO)
eugenol  (ISO)
farnesol  (ISO)
ferroheme b  (EXP)
ferulic acid  (EXP)
Fexofenadine hydrochloride  (EXP,ISO)
flucloxacillin  (ISO)
fludrocortisone  (ISO)
flufenamic acid  (ISO)
fluocinolone acetonide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
fumonisin B1  (EXP)
furan  (EXP)
gadodiamide hydrate  (ISO)
gadolinium trichloride  (ISO)
gamma-hexachlorocyclohexane  (ISO)
gemcitabine  (ISO)
genistein  (EXP,ISO)
gentamycin  (ISO)
geranial  (EXP)
geraniol  (ISO)
glyoxal  (ISO)
Goe 6976  (ISO)
gold atom  (EXP)
gold(0)  (EXP)
griseofulvin  (ISO)
heme b  (EXP)
hesperetin  (ISO)
hexadecane  (ISO)
hexadecanoic acid  (ISO)
Hexadimethrine bromide  (ISO)
hexane  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (EXP,ISO)
ibuprofen  (ISO)
imidurea  (EXP)
imiquimod  (EXP)
indometacin  (EXP,ISO)
ionomycin  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
iron(III) citrate  (ISO)
isoeugenol  (EXP)
isoniazide  (ISO)
isoprenaline  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
ketoconazole  (ISO)
kojic acid  (ISO)
L-1,4-dithiothreitol  (ISO)
lead nitrate  (EXP)
lenalidomide  (EXP)
leupeptin  (ISO)
levofloxacin  (ISO)
limonene  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
losartan  (ISO)
LY294002  (ISO)
m-xylene  (ISO)
manganese(II) chloride  (ISO)
mangiferin  (EXP)
mebendazole  (ISO)
melatonin  (EXP)
menadione  (ISO)
mercaptoethanol  (ISO)
mercury dichloride  (EXP)
mesalamine  (ISO)
metam  (EXP)
metaproterenol  (ISO)
methadone  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methotrexate  (EXP,ISO)
methoxyacetic acid  (ISO)
methyl methacrylate  (EXP)
methyl salicylate  (EXP)
methylisothiazolinone  (ISO)
metoprolol  (ISO)
mexiletine  (ISO)
Mezerein  (EXP)
mifepristone  (ISO)
Mofezolac (TN)  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (ISO)
morphine  (EXP)
muramyl dipeptide  (EXP)
N(gamma)-nitro-L-arginine methyl ester  (EXP)
N,N-diethyl-m-toluamide  (EXP,ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-ethylmaleimide  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
naloxone  (EXP)
naproxen  (ISO)
nebivolol  (ISO)
nefazodone  (ISO)
neocuproine  (EXP)
neoechinulin A  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
nimesulide  (ISO)
nitric oxide  (ISO)
nitrososulfamethoxazole  (ISO)
nonane  (ISO)
nonanoic acid  (EXP)
Nonidet P-40  (ISO)
Nonylphenol  (ISO)
nortriptyline  (ISO)
notoginsenoside R1  (EXP)
NS-398  (ISO)
ochratoxin A  (ISO)
octenidine  (ISO)
oleic acid  (ISO)
orciprenaline  (ISO)
Osajin  (ISO)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
paliperidone palmitate  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
paricalcitol  (EXP)
parthenolide  (ISO)
pemetrexed  (ISO)
penbutolol  (ISO)
pentane-2,3-dione  (ISO)
peptidoglycan  (ISO)
perfluorododecanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phenethyl caffeate  (ISO)
phenethyl isothiocyanate  (EXP)
phenobarbital  (ISO)
phenol  (ISO)
phloretin  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosphorus atom  (EXP)
phosphorus(.)  (EXP)
phthalic anhydride  (EXP)
pimecrolimus  (EXP)
pioglitazone  (ISO)
pirinixic acid  (EXP)
polymyxin B2  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
potassium hydroxide  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
primaquine  (ISO)
primidone  (ISO)
probenecid  (EXP)
procyclidine  (ISO)
promethazine  (ISO)
propan-2-ol  (EXP)
prostaglandin E2  (EXP,ISO)
prostaglandin F2alpha  (ISO)
prostaglandin I2  (ISO)
puerarin  (ISO)
Pyridostigmine bromide  (EXP,ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
quinacrine  (EXP)
quinine  (ISO)
rac-lactic acid  (EXP,ISO)
ranitidine  (ISO)
resorcinol  (ISO)
resveratrol  (EXP,ISO)
Riluzole  (ISO)
rofecoxib  (ISO)
Roridin A  (EXP)
rotenone  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
salicylic acid  (EXP)
SB 203580  (ISO)
SCH 23390  (ISO)
scopolamine  (EXP)
serpentine asbestos  (EXP,ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (ISO)
sodium perchlorate  (ISO)
streptozocin  (EXP)
sulindac  (ISO)
sumatriptan  (ISO)
T-2 toxin  (EXP,ISO)
telithromycin  (ISO)
testosterone  (EXP,ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
tetradecane  (ISO)
tetraphene  (ISO)
tetrathiomolybdate(2-)  (EXP)
thioacetamide  (ISO)
thiostrepton  (ISO)
thiram  (ISO)
tienilic acid  (ISO)
titanium dioxide  (ISO)
Tolmetin glucuronide  (ISO)
toluene 2,4-diisocyanate  (EXP,ISO)
topotecan  (ISO)
toremifene  (EXP)
trans-isoeugenol  (EXP)
trazodone  (ISO)
tremolite asbestos  (EXP)
tributylstannane  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (EXP)
tridecane  (ISO)
Trihexyphenidyl  (ISO)
trimethyltin  (EXP)
triptonide  (EXP)
Triton X-100  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
usnic acid  (ISO)
vadimezan  (ISO)
valproic acid  (EXP,ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vanadyl sulfate  (ISO)
verapamil  (ISO)
vinclozolin  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
wortmannin  (ISO)
Y-27632  (ISO)
Z-Val-Phe-H  (ISO)
zidovudine  (ISO)
zinc atom  (ISO)
zinc dichloride  (EXP)
zinc sulfate  (ISO)
zinc(0)  (ISO)
zomepirac  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute inflammatory response  (ISO)
cellular response to heat  (ISO)
cellular response to lipopolysaccharide  (IBA)
cellular sodium ion homeostasis  (IDA)
connective tissue replacement involved in inflammatory response wound healing  (IMP)
cytokine-mediated signaling pathway  (IBA,ISO)
ectopic germ cell programmed cell death  (IGI)
extrinsic apoptotic signaling pathway in absence of ligand  (IMP)
fever generation  (IEA)
heart development  (ISO)
immune response  (IEA)
inflammatory response  (IBA,IDA)
interleukin-1-mediated signaling pathway  (IDA)
keratinization  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of establishment of Sertoli cell barrier  (ISO)
positive regulation of angiogenesis  (IMP)
positive regulation of cell division  (IEA)
positive regulation of cytokine production  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of gene expression  (IBA,ISO)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (ISO)
positive regulation of immature T cell proliferation in thymus  (IBA)
positive regulation of interleukin-2 production  (IDA,ISO)
positive regulation of interleukin-6 production  (IDA,ISO)
positive regulation of JNK cascade  (ISO)
positive regulation of mitotic nuclear division  (ISO)
positive regulation of monocyte chemotactic protein-1 production  (IDA)
positive regulation of neutrophil extravasation  (IDA)
positive regulation of neutrophil migration  (ISO)
positive regulation of prostaglandin secretion  (ISO)
positive regulation of protein secretion  (ISO)
positive regulation of steroid biosynthetic process  (ISO)
positive regulation of stress-activated MAPK cascade  (ISO)
positive regulation of transcription by RNA polymerase II  (IGI)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of vascular endothelial growth factor production  (IMP)
regulation of actin cytoskeleton organization  (ISO)
regulation of nitric-oxide synthase activity  (IBA)
regulation of sensory perception of pain  (ISO)
response to copper ion  (ISO)
response to gamma radiation  (ISO)
response to heat  (ISO)
response to hypoxia  (ISO)
response to L-ascorbic acid  (ISO)
response to lipopolysaccharide  (ISO)
response to organic cyclic compound  (ISO)
response to organic substance  (ISO)
response to organonitrogen compound  (ISO)
response to ozone  (ISO)
spermatogenesis  (ISO)
wound healing  (ISO)

Cellular Component

Molecular Function


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Additional References at PubMed
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PMID:33087404   PMID:33361152  


Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm392129,141,530 - 129,151,892 (-)NCBIGRCm39mm39
GRCm39 Ensembl2129,141,530 - 129,151,892 (-)Ensembl
GRCm382129,299,609 - 129,310,186 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2129,299,610 - 129,309,972 (-)EnsemblGRCm38mm10GRCm38
MGSCv372129,125,346 - 129,135,708 (-)NCBIGRCm37mm9NCBIm37
MGSCv362128,991,051 - 129,001,413 (-)NCBImm8
Celera2130,527,298 - 130,537,642 (-)NCBICelera
Cytogenetic Map2F1NCBI
cM Map262.9NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl2112,773,925 - 112,784,493 (-)EnsemblGRCh38hg38GRCh38
GRCh382112,773,925 - 112,784,493 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372113,531,502 - 113,542,070 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362113,247,963 - 113,259,442 (-)NCBINCBI36hg18NCBI36
Build 342113,247,723 - 113,259,202NCBI
Celera2106,917,026 - 106,928,133 (-)NCBI
Cytogenetic Map2q14.1NCBI
HuRef2105,986,068 - 105,997,547 (-)NCBIHuRef
CHM1_12113,535,646 - 113,546,806 (-)NCBICHM1_1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.23116,526,601 - 116,537,055 (-)NCBI
Rnor_6.0 Ensembl3121,825,412 - 121,836,086 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.03121,824,712 - 121,836,122 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03128,180,475 - 128,190,980 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43116,913,612 - 116,924,114 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13116,819,184 - 116,829,687 (-)NCBI
Celera3115,352,857 - 115,362,929 (-)NCBICelera
Cytogenetic Map3q36NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554701,527,674 - 1,538,466 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554701,527,710 - 1,538,418 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.12A113,784,854 - 113,795,801 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A113,784,854 - 113,795,801 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A89,273,482 - 89,284,421 (+)NCBIMhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11736,969,581 - 36,979,445 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1736,970,573 - 36,979,435 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1736,739,697 - 36,748,565 (-)NCBI
ROS_Cfam_1.01737,745,380 - 37,755,259 (-)NCBI
UMICH_Zoey_3.11736,881,972 - 36,890,833 (-)NCBI
UNSW_CanFamBas_1.01736,938,236 - 36,947,096 (-)NCBI
UU_Cfam_GSD_1.01737,152,126 - 37,160,990 (-)NCBI
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440629282,315,498 - 82,324,623 (-)NCBI
SpeTri2.0NW_0049367831,210,715 - 1,218,315 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl343,718,368 - 43,731,119 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1343,718,320 - 43,731,668 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2345,452,989 - 45,466,307 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap3q12-q13NCBI
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11415,789,710 - 15,801,938 (-)NCBI
ChlSab1.1 Ensembl1415,789,013 - 15,796,611 (-)Ensembl
Vero_WHO_p1.0NW_0236660803,883,451 - 3,894,101 (+)NCBI
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_00462474912,795,967 - 12,805,658 (-)NCBI

Position Markers
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv372129,126,065 - 129,126,199UniSTSGRCm37
Celera2130,527,388 - 130,527,559UniSTS
Cytogenetic Map2FUniSTS
cM Map273.0UniSTS
Whitehead_YAC2 UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382129,300,159 - 129,300,314UniSTSGRCm38
MGSCv372129,125,895 - 129,126,050UniSTSGRCm37
Celera2130,527,847 - 130,528,002UniSTS
Cytogenetic Map2FUniSTS
cM Map273.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2FUniSTS
cM Map273.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2FUniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2FUniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382129,300,329 - 129,300,463UniSTSGRCm38
MGSCv372129,126,065 - 129,126,199UniSTSGRCm37
Celera2130,528,017 - 130,528,151UniSTS
Cytogenetic Map2FUniSTS

QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224334620148858457Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229417935148533014Mouse
1301344Lith1_mlithogenic gene 1 (mouse)Not determined245457623145470727Mouse
13824983Vclq1_mcurvilinear velocity QTL 1 (mouse)262000000137000000Mouse
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265439402162677006Mouse
11528549Sluc31_msusceptibility to lung cancer 31 (mouse)274693773129371085Mouse
4141155Plast2b_mplasma plant sterol 2b (mouse)Not determined284182854148680255Mouse
10412082Hylaq1_mHyperlocomotor activity related QTL 1 (mouse)Not determined284182854148825550Mouse
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285893925181254801Mouse
27226761Feml18_mfemur length 18, 16 week (mouse)294400000154400000Mouse
11049568Lmr28c_mleishmaniasis resistance 28c (mouse)297292889131293051Mouse
11049569Lmr28d_mleishmaniasis resistance 28d (mouse)297292889131293051Mouse
12904935Edlmmq2_mextensor digitorum longus muscle mass QTL 2 (mouse)297379883131379883Mouse
12904954Gmmq2_mgastrocnemius muscle mass QTL 2 (mouse)297379883131379883Mouse
4141802Ignpq1_mIgA nephropathy QTL 1 (mouse)Not determined2100993579134993788Mouse
1301330Tbbmd2_mtotal body bone mineral density 2 (mouse)Not determined2101112449135112609Mouse
1302203Gvhd3_mgraft-versus host disease 3 (mouse)Not determined2101112449135112609Mouse
1302071Fembrs1_mfemur breaking strength 1 (mouse)Not determined2101112449135112609Mouse
27226788Feml13_mfemur length 13, 10 week (mouse)2102800000160100000Mouse
11041906Lmr28a_mleishmaniasis resistance 28a (mouse)2103265371129371085Mouse
11038702Ltpr2_mLeishmania tropica response 2 (mouse)2103265371167370436Mouse
1301825Pbrgcsf1_mperipheral blood stem cell response to granulocyte colony stimulating factor 1 (mouse)Not determined2106391660140391809Mouse
10043875Bw25_mbody weight QTL 25 (mouse)Not determined2107413756141413756Mouse
1301087Bbaa15_mB.burgdorferi-associated arthritis 15 (mouse)Not determined2110647738144647887Mouse
10045885Cplaq15_mcircadian period of locomotor activity 15 (mouse)Not determined2111085773154512747Mouse
1300793Pcfm2_mperiosteal circumference and femur length 2 (mouse)Not determined2111331784145331901Mouse
1301755Hrq1_mheart rate quantitative locus 1 (mouse)Not determined2111331784145331901Mouse
1301905Lgth2_mbody length 2 (mouse)Not determined2111331784145331901Mouse
1558990Skmw9_mskeletal muscle weight 9 (mouse)Not determined2111331784145331901Mouse
1301201Chab1_mcholesterol absorption 1 (mouse)Not determined2111709108145709243Mouse
1302033Nsv1_mNeuroadapted Sindbis viral RNA level 1 (mouse)Not determined2111781466145781606Mouse
11038699Ltpr2b_mLeishmania tropica response 2b (mouse)2112370826146371085Mouse
11038700Ltpr2a_mLeishmania tropica response 2a (mouse)2112370826146371085Mouse
11039520Ltpr2h_mLeishmania tropica response 2h (mouse)2112370826146371085Mouse
1301029T2dm3_mtype 2 diabetes mellitus 3 (mouse)Not determined2114457594132872237Mouse
11038696Ltpr2f_mLeishmania tropica response 2f (mouse)2115370937149371074Mouse
11039521Ltpr2g_mLeishmania tropica response 2g (mouse)2115370937149371074Mouse
1301295Prdt1_mprion disease incubation time 1 (mouse)Not determined2116235703150235821Mouse
1558881Ses7_msalmonella enteritidis susceptibility 7 (mouse)Not determined2116464410150464554Mouse
1301618Bglu1_mblood glucose level 1 (mouse)Not determined2118112449174483070Mouse
12910795Pwbwq5_mpost-weaning body weight QTL 5 (mouse)2118758772160769245Mouse
12910799Pwgrq2_mpre-weaning growth rate QTL 2 (mouse)2118758772160769245Mouse
12910812Pwgrq1_mpre-weaning growth rate QTL 1 (mouse)2118758772160769245Mouse
12910814Pwbwq1_mpre-weaning body weight QTL 1 (mouse)2118758772160769245Mouse
1300712El2_mepilepsy 2 (mouse)Not determined2122376665142690215Mouse
1301294Hrtfm5_mheart failure modifier 5 (mouse)Not determined2123041095157041211Mouse
1301066Otx2m2_morthodenticle homolog 2 (Drosophila) modifier 2 (mouse)Not determined2123390053148858457Mouse
1301822Pgia2_mproteoglycan induced arthritis 2 (mouse)Not determined2124095391158095504Mouse
27226749Femd10_mfemur midshaft diameter 10, 16 week (mouse)2124600000168400000Mouse
13506763Tbvq1_mtrabecular bone volume QTL 1 (mouse)2126200000135600000Mouse
1301031Bdln3_mbody length 3 (mouse)Not determined2127822099161822198Mouse
1302143Bwq5_mbody weight (mouse)Not determined2127822099161822198Mouse
1558989Gnf4_mgrowth and fatness 4 (mouse)Not determined2128331784132872237Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:410
Count of miRNA genes:310
Interacting mature miRNAs:352
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.



Reference Sequences
RefSeq Acc Id: ENSMUST00000028882   ⟹   ENSMUSP00000028882
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl2129,299,610 - 129,309,972 (-)Ensembl
RefSeq Acc Id: NM_010554   ⟹   NP_034684
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm392129,141,530 - 129,151,892 (-)NCBI
GRCm382129,299,610 - 129,309,972 (-)NCBI
MGSCv372129,125,346 - 129,135,708 (-)RGD
Celera2130,527,298 - 130,537,642 (-)RGD
Reference Sequences
RefSeq Acc Id: NP_034684   ⟸   NM_010554
- UniProtKB: P01582 (UniProtKB/Swiss-Prot),   Q3U0Y6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000028882   ⟸   ENSMUST00000028882
Protein Domains

RGD ID:6831613
Promoter ID:MM_KWN:31691
SO ACC ID:SO:0000170
Tissues & Cell Lines:Liver
Mouse AssemblyChrPosition (strand)Source
MGSCv362129,135,576 - 129,136,076 (-)MPROMDB
RGD ID:6878710
Promoter ID:EPDNEW_M2806
Type:initiation region
Description:Mus musculus interleukin 1 alpha , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm382129,309,972 - 129,310,032EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96542 AgrOrtholog
Ensembl Genes ENSMUSG00000027399 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000028882 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000028882 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro IL-1_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-1_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-1_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-1_propep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL1/FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:16175 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PANTHER PTHR10078 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10078:SF33 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IL1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL1_propep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Il1a PhenoGen
  INTRLEUKIN1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50353 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Q62161_MOUSE UniProtKB/TrEMBL