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Gene: Il1a (interleukin 1 alpha) Mus musculus
Symbol: Il1a
Name: interleukin 1 alpha
Description: Exhibits cytokine activity and interleukin-1 receptor binding activity. Involved in several processes, including cell surface receptor signaling pathway; connective tissue replacement involved in inflammatory response wound healing; and positive regulation of cytokine production. Localizes to the cytoplasm and extracellular space. Human ortholog(s) of this gene implicated in several diseases, including Fabry disease; Schnitzler syndrome; hematologic cancer (multiple); lung disease (multiple); and rheumatoid arthritis (multiple). Is expressed in dorsal aorta; early conceptus; hemolymphoid system; liver; and reproductive system. Orthologous to human IL1A (interleukin 1 alpha); PARTICIPATES IN interleukin-1 signaling pathway; apoptotic cell death pathway; graft-versus-host disease pathway; INTERACTS WITH (+)-epicatechin-3-O-gallate; (-)-epigallocatechin 3-gallate; 1,3-benzothiazole-2-thiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: IL-1 alpha; Il-1a; interleukin-1 alpha
Homo sapiens (human) : IL1A (interleukin 1 alpha)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Il1a (interleukin 1 alpha)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Il1a (interleukin 1 alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : IL1A (interleukin 1 alpha)
Canis lupus familiaris (dog) : IL1A (interleukin 1 alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Il1a (interleukin 1 alpha)
Sus scrofa (pig) : IL1A (interleukin 1 alpha)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm382129,299,609 - 129,310,186 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv372129,125,346 - 129,135,708 (-)NCBIGRCm37mm9NCBIm37
MGSCv362128,991,051 - 129,001,413 (-)NCBImm8
Celera2130,527,298 - 130,537,642 (-)NCBICelera
Cytogenetic Map2 F1NCBI
cM Map262.9NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Il1a
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10789
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.