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Gene: Il1a (interleukin 1 alpha) Mus musculus
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Symbol: Il1a
Name: interleukin 1 alpha
Description: Exhibits cytokine activity and interleukin-1 receptor binding activity. Involved in several processes, including cell surface receptor signaling pathway; connective tissue replacement involved in inflammatory response wound healing; and positive regulation of cytokine production. Localizes to the cytoplasm and extracellular space. Human ortholog(s) of this gene implicated in several diseases, including Fabry disease; Schnitzler syndrome; hematologic cancer (multiple); lung disease (multiple); and rheumatoid arthritis (multiple). Is expressed in dorsal aorta; early conceptus; hemolymphoid system; liver; and reproductive system. Orthologous to human IL1A (interleukin 1 alpha); PARTICIPATES IN interleukin-1 signaling pathway; apoptotic cell death pathway; graft-versus-host disease pathway; INTERACTS WITH (+)-epicatechin-3-O-gallate; (-)-epigallocatechin 3-gallate; 1,3-benzothiazole-2-thiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: IL-1 alpha; Il-1a; interleukin-1 alpha
Orthologs:
Homo sapiens (human) : IL1A (interleukin 1 alpha)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Il1a (interleukin 1 alpha)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Il1a (interleukin 1 alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : IL1A (interleukin 1 alpha)
Canis lupus familiaris (dog) : IL1A (interleukin 1 alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Il1a (interleukin 1 alpha)
Sus scrofa (pig) : IL1A (interleukin 1 alpha)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm382129,299,609 - 129,310,186 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv372129,125,346 - 129,135,708 (-)NCBIGRCm37mm9NCBIm37
MGSCv362128,991,051 - 129,001,413 (-)NCBImm8
Celera2130,527,298 - 130,537,642 (-)NCBICelera
Cytogenetic Map2 F1NCBI
cM Map262.9NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Il1a
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10789
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.