IL1A (interleukin 1 alpha) - Rat Genome Database

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Gene: IL1A (interleukin 1 alpha) Canis lupus familiaris
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Symbol: IL1A
Name: interleukin 1 alpha
RGD ID: 12334798
Description: ENCODES a protein that exhibits copper ion binding (ortholog); INVOLVED IN acute inflammatory response (ortholog); cellular response to heat (ortholog); cellular sodium ion homeostasis (ortholog); PARTICIPATES IN interleukin-1 signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); acute myeloid leukemia (ortholog); allergic bronchopulmonary aspergillosis (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: IL-1 alpha; interleukin-1 alpha
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11736,969,581 - 36,979,445 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1736,970,573 - 36,979,435 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1736,739,697 - 36,748,565 (-)NCBI
ROS_Cfam_1.01737,745,380 - 37,755,259 (-)NCBI
UMICH_Zoey_3.11736,881,972 - 36,890,833 (-)NCBI
UNSW_CanFamBas_1.01736,938,236 - 36,947,096 (-)NCBI
UU_Cfam_GSD_1.01737,152,126 - 37,160,990 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
acute myeloid leukemia  (ISO)
allergic bronchopulmonary aspergillosis  (ISO)
allergic contact dermatitis  (ISO)
Alzheimer's disease  (ISO)
amnestic disorder  (ISO)
Anorexia  (ISO)
anthracosis  (ISO)
Arsenic Poisoning  (ISO)
aspiration pneumonia  (ISO)
asthma  (ISO)
autoimmune thrombocytopenic purpura  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
beta thalassemia  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
Burns  (ISO)
Burns, Chemical  (ISO)
cardiomyopathy  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholestasis  (ISO)
cholesteatoma  (ISO)
cholesteatoma of middle ear  (ISO)
chorioamnionitis  (ISO)
chronic progressive external ophthalmoplegia  (ISO)
common cold  (ISO)
corneal edema  (ISO)
Craniocerebral Trauma  (ISO)
Creutzfeldt-Jakob disease  (ISO)
cystic fibrosis  (ISO)
dermatomyositis  (ISO)
diabetic retinopathy  (ISO)
diarrhea  (ISO)
Disease Progression  (ISO)
Drug-Induced Immune Thrombocytopenia  (ISO)
Drug-induced Neutropenia  (ISO)
end stage renal disease  (ISO)
endometritis  (ISO)
Endotoxemia  (ISO)
Enterocolitis  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Leukemia  (ISO)
Experimental Melanoma  (ISO)
extrinsic allergic alveolitis  (ISO)
Fabry disease  (ISO)
Femoral Fractures  (ISO)
Fetal Growth Retardation  (ISO)
Fever  (ISO)
glomerulonephritis  (ISO)
Graft vs Host Disease  (ISO)
Graves Ophthalmopathy  (ISO)
head and neck squamous cell carcinoma  (ISO)
Heat Stroke  (ISO)
hemolytic-uremic syndrome  (ISO)
Hemorrhage  (ISO)
Hemorrhagic Shock  (ISO)
HIV Wasting Syndrome  (ISO)
Human Influenza  (ISO)
Hyperalgesia  (ISO)
hyperglycemia  (ISO)
Hypotension  (ISO)
IgA glomerulonephritis  (ISO)
Inflammation  (ISO)
interstitial lung disease  (ISO)
Invasive Pulmonary Aspergillosis  (ISO)
iridocyclitis  (ISO)
juvenile rheumatoid arthritis  (ISO)
Kearns-Sayre syndrome  (ISO)
keratoconus  (ISO)
Knee Osteoarthritis  (ISO)
Leber hereditary optic neuropathy  (ISO)
Liver Reperfusion Injury  (ISO)
lung disease  (ISO)
lung non-small cell carcinoma  (ISO)
malignant mesothelioma  (ISO)
MELAS syndrome  (ISO)
MERRF Syndrome  (ISO)
mesenchymal chondrosarcoma  (ISO)
Middle East respiratory syndrome  (ISO)
mitochondrial myopathy  (ISO)
multiple myeloma  (ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
Nasal Polyps  (ISO)
non-alcoholic fatty liver disease  (ISO)
Oral Lichen Planus  (ISO)
osteoarthritis  (ISO)
osteoporosis  (ISO)
otitis media  (ISO)
pancreatic cancer  (ISO)
Perennial Allergic Rhinitis  (ISO)
periodontitis  (ISO)
pneumonia  (ISO)
Poisoning  (ISO)
polymyositis  (ISO)
pulmonary fibrosis  (ISO)
pulmonary tuberculosis  (ISO)
Radiation Injuries  (ISO)
Radiation Pneumonitis  (ISO)
Reperfusion Injury  (ISO)
respiratory allergy  (ISO)
Retina Reperfusion Injury  (ISO)
rheumatoid arthritis  (ISO)
Schnitzler syndrome  (ISO)
Sclerosis  (ISO)
severe acute respiratory syndrome  (ISO)
skin disease  (ISO)
Skin Neoplasms  (ISO)
tick infestation  (ISO)
type 1 diabetes mellitus  (ISO)
urinary tract infection  (ISO)
uveitis  (ISO)
varicocele  (ISO)
Venous Thrombosis  (ISO)
vitiligo  (ISO)
Wounds and Injuries  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute inflammatory response  (ISO)
cellular response to heat  (IEA,ISS)
cellular response to lipopolysaccharide  (IBA)
cellular sodium ion homeostasis  (IEA,ISO)
connective tissue replacement involved in inflammatory response wound healing  (IEA,ISO)
cytokine-mediated signaling pathway  (IBA)
ectopic germ cell programmed cell death  (IEA,ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (IEA,ISO)
fever generation  (IEA)
heart development  (ISO)
immune response  (IEA)
inflammatory response  (IBA,ISO)
interleukin-1-mediated signaling pathway  (ISO)
keratinization  (ISO)
negative regulation of cell population proliferation  (IEA)
negative regulation of establishment of Sertoli cell barrier  (ISO)
positive regulation of angiogenesis  (IEA)
positive regulation of cell division  (IEA)
positive regulation of cytokine production  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of gene expression  (IBA)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (ISO)
positive regulation of immature T cell proliferation in thymus  (IBA)
positive regulation of interleukin-2 production  (IEA,ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of JNK cascade  (ISO)
positive regulation of mitotic nuclear division  (IEA)
positive regulation of monocyte chemotactic protein-1 production  (ISO)
positive regulation of neutrophil extravasation  (ISO)
positive regulation of neutrophil migration  (ISO)
positive regulation of prostaglandin secretion  (ISO)
positive regulation of protein secretion  (IEA)
positive regulation of steroid biosynthetic process  (ISO)
positive regulation of stress-activated MAPK cascade  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of vascular endothelial growth factor production  (IEA)
regulation of actin cytoskeleton organization  (ISO)
regulation of nitric-oxide synthase activity  (IBA)
regulation of sensory perception of pain  (ISO)
response to copper ion  (IEA,ISS)
response to gamma radiation  (ISO)
response to heat  (ISO)
response to hypoxia  (ISO)
response to L-ascorbic acid  (ISO)
response to lipopolysaccharide  (ISO)
response to organic cyclic compound  (ISO)
response to organic substance  (ISO)
response to organonitrogen compound  (ISO)
response to ozone  (ISO)
signal transduction  (IEA)
spermatogenesis  (ISO)
wound healing  (ISO)

Cellular Component
cell surface  (ISO)
cytoplasm  (ISO)
cytosol  (IEA,ISO,ISS)
extracellular space  (IBA,IEA,ISO,ISS)
plasma membrane  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:10452947   PMID:17573384  


Genomics

Comparative Map Data
IL1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11736,969,581 - 36,979,445 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1736,970,573 - 36,979,435 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1736,739,697 - 36,748,565 (-)NCBI
ROS_Cfam_1.01737,745,380 - 37,755,259 (-)NCBI
UMICH_Zoey_3.11736,881,972 - 36,890,833 (-)NCBI
UNSW_CanFamBas_1.01736,938,236 - 36,947,096 (-)NCBI
UU_Cfam_GSD_1.01737,152,126 - 37,160,990 (-)NCBI
IL1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2112,773,925 - 112,784,493 (-)EnsemblGRCh38hg38GRCh38
GRCh382112,773,925 - 112,784,493 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372113,531,502 - 113,542,070 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362113,247,963 - 113,259,442 (-)NCBINCBI36hg18NCBI36
Build 342113,247,723 - 113,259,202NCBI
Celera2106,917,026 - 106,928,133 (-)NCBI
Cytogenetic Map2q14.1NCBI
HuRef2105,986,068 - 105,997,547 (-)NCBIHuRef
CHM1_12113,535,646 - 113,546,810 (-)NCBICHM1_1
Il1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392129,141,530 - 129,151,892 (-)NCBIGRCm39mm39
GRCm39 Ensembl2129,141,530 - 129,151,892 (-)Ensembl
GRCm382129,299,609 - 129,310,186 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2129,299,610 - 129,309,972 (-)EnsemblGRCm38mm10GRCm38
MGSCv372129,125,346 - 129,135,708 (-)NCBIGRCm37mm9NCBIm37
MGSCv362128,991,051 - 129,001,413 (-)NCBImm8
Celera2130,527,298 - 130,537,642 (-)NCBICelera
Cytogenetic Map2F1NCBI
cM Map262.9NCBI
Il1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23116,526,601 - 116,537,055 (-)NCBI
Rnor_6.0 Ensembl3121,825,412 - 121,836,086 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.03121,824,712 - 121,836,122 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03128,180,475 - 128,190,980 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43116,913,612 - 116,924,114 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13116,819,184 - 116,829,687 (-)NCBI
Celera3115,352,857 - 115,362,929 (-)NCBICelera
Cytogenetic Map3q36NCBI
Il1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554701,527,674 - 1,538,466 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554701,527,710 - 1,538,418 (+)NCBIChiLan1.0ChiLan1.0
IL1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A113,784,854 - 113,795,801 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A113,784,854 - 113,795,801 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A89,273,482 - 89,284,421 (+)NCBIMhudiblu_PPA_v0panPan3
Il1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629282,315,498 - 82,324,623 (-)NCBI
SpeTri2.0NW_0049367831,210,715 - 1,218,315 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl343,718,368 - 43,731,119 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1343,718,320 - 43,731,668 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2345,452,989 - 45,466,307 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap3q12-q13NCBI
IL1A
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11415,789,710 - 15,801,938 (-)NCBI
ChlSab1.1 Ensembl1415,789,013 - 15,796,611 (-)Ensembl
Vero_WHO_p1.0NW_0236660803,883,451 - 3,894,101 (+)NCBI
Il1a
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474912,795,967 - 12,805,658 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 3 6 1
Low 5 1 21 5 3 5 7 3 9 5
Below cutoff 4 1 1 1 6 5 5 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000011604   ⟹   ENSCAFP00000010753
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1736,970,573 - 36,979,435 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000042801   ⟹   ENSCAFP00000042694
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1736,970,573 - 36,979,435 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000045928   ⟹   ENSCAFP00000038305
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1736,970,573 - 36,978,736 (-)Ensembl
RefSeq Acc Id: NM_001003157   ⟹   NP_001003157
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11736,970,573 - 36,979,435 (-)NCBI
Dog10K_Boxer_Tasha1736,739,697 - 36,748,565 (-)NCBI
ROS_Cfam_1.01737,746,372 - 37,755,234 (-)NCBI
UMICH_Zoey_3.11736,881,972 - 36,890,833 (-)NCBI
UNSW_CanFamBas_1.01736,938,236 - 36,947,096 (-)NCBI
UU_Cfam_GSD_1.01737,152,126 - 37,160,990 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005630066   ⟹   XP_005630123
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11736,969,581 - 36,979,445 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038690436   ⟹   XP_038546364
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01737,745,380 - 37,755,259 (-)NCBI
Reference Sequences
RefSeq Acc Id: XP_005630123   ⟸   XM_005630066
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001003157   ⟸   NM_001003157
- UniProtKB: O46612 (UniProtKB/Swiss-Prot),   A0A140T8E9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000010753   ⟸   ENSCAFT00000011604
RefSeq Acc Id: ENSCAFP00000038305   ⟸   ENSCAFT00000045928
RefSeq Acc Id: ENSCAFP00000042694   ⟸   ENSCAFT00000042801
RefSeq Acc Id: XP_038546364   ⟸   XM_038690436
- Peptide Label: isoform X1
Protein Domains
IL1_propep

Promoters
RGD ID:13686256
Promoter ID:EPDNEW_C4326
Type:single initiation site
Name:IL1A_1
Description:interleukin 1 alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11736,979,406 - 36,979,466EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000007245 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000010753 ENTREZGENE, UniProtKB/TrEMBL
  ENSCAFP00000038305 UniProtKB/TrEMBL
  ENSCAFP00000042694 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000011604 ENTREZGENE, UniProtKB/TrEMBL
  ENSCAFT00000042801 UniProtKB/TrEMBL
  ENSCAFT00000045928 UniProtKB/TrEMBL
InterPro IL-1_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-1_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-1_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-1_propep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL1/FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report cfa:403782 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene IL1A ENTREZGENE
PANTHER PTHR10078 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10078:SF33 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IL1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL1_propep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS INTERLEUKIN1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INTRLEUKIN1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE INTERLEUKIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50353 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A023SDF3_CANLF UniProtKB/TrEMBL
  A0A023SFA8_CANLF UniProtKB/TrEMBL
  A0A140T8E1_CANLF UniProtKB/TrEMBL
  A0A140T8E9 ENTREZGENE, UniProtKB/TrEMBL
  A0T125_CANLF UniProtKB/TrEMBL
  IL1A_CANLF UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q006K7 UniProtKB/Swiss-Prot
VGNC ID VGNC:41956 ENTREZGENE