IL1A (interleukin 1 alpha) - Rat Genome Database
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Gene: IL1A (interleukin 1 alpha) Sus scrofa
Analyze
Symbol: IL1A
Name: interleukin 1 alpha
RGD ID: 14209343
Description: ENCODES a protein that exhibits copper ion binding (ortholog); INVOLVED IN acute inflammatory response (ortholog); cellular response to heat (ortholog); heart development (ortholog); PARTICIPATES IN interleukin-1 signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); acute myeloid leukemia (ortholog); allergic bronchopulmonary aspergillosis (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); cytosol (ortholog); INTERACTS WITH deoxynivalenol; dichlorine; fumonisin B1
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: IL-1 alpha; IL-1alpha; interleukin-1 alpha
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl343,718,368 - 43,731,119 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1343,718,320 - 43,731,668 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2345,452,989 - 45,466,307 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap3q12-q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
acute myeloid leukemia  (ISO)
allergic bronchopulmonary aspergillosis  (ISO)
allergic contact dermatitis  (ISO)
Alzheimer's disease  (ISO)
amnestic disorder  (ISO)
Anorexia  (ISO)
anthracosis  (ISO)
Arsenic Poisoning  (ISO)
aspiration pneumonia  (ISO)
asthma  (ISO)
autoimmune thrombocytopenic purpura  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
beta thalassemia  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
Burns  (ISO)
Burns, Chemical  (ISO)
cardiomyopathy  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholestasis  (ISO)
cholesteatoma  (ISO)
cholesteatoma of middle ear  (ISO)
chorioamnionitis  (ISO)
chronic progressive external ophthalmoplegia  (ISO)
common cold  (ISO)
corneal edema  (ISO)
Craniocerebral Trauma  (ISO)
Creutzfeldt-Jakob disease  (ISO)
cystic fibrosis  (ISO)
dermatomyositis  (ISO)
diabetic retinopathy  (ISO)
diarrhea  (ISO)
Disease Progression  (ISO)
Drug-Induced Immune Thrombocytopenia  (ISO)
Drug-induced Neutropenia  (ISO)
end stage renal disease  (ISO)
endometritis  (ISO)
Endotoxemia  (ISO)
Enterocolitis  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Leukemia  (ISO)
Experimental Melanoma  (ISO)
extrinsic allergic alveolitis  (ISO)
Fabry disease  (ISO)
Femoral Fractures  (ISO)
Fetal Growth Retardation  (ISO)
Fever  (ISO)
glomerulonephritis  (ISO)
Graft vs Host Disease  (ISO)
Graves Ophthalmopathy  (ISO)
head and neck squamous cell carcinoma  (ISO)
Heat Stroke  (ISO)
hemolytic-uremic syndrome  (ISO)
Hemorrhage  (ISO)
Hemorrhagic Shock  (ISO)
HIV Wasting Syndrome  (ISO)
Human Influenza  (ISO)
Hyperalgesia  (ISO)
hyperglycemia  (ISO)
Hypotension  (ISO)
IgA glomerulonephritis  (ISO)
Inflammation  (ISO)
interstitial lung disease  (ISO)
Invasive Pulmonary Aspergillosis  (ISO)
iridocyclitis  (ISO)
juvenile rheumatoid arthritis  (ISO)
Kearns-Sayre syndrome  (ISO)
keratoconus  (ISO)
Knee Osteoarthritis  (ISO)
Leber hereditary optic neuropathy  (ISO)
Liver Reperfusion Injury  (ISO)
lung disease  (ISO)
lung non-small cell carcinoma  (ISO)
MELAS syndrome  (ISO)
MERRF Syndrome  (ISO)
mesenchymal chondrosarcoma  (ISO)
Middle East respiratory syndrome  (ISO)
mitochondrial myopathy  (ISO)
multiple myeloma  (ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
Nasal Polyps  (ISO)
non-alcoholic fatty liver disease  (ISO)
Oral Lichen Planus  (ISO)
osteoarthritis  (ISO)
osteoporosis  (ISO)
otitis media  (ISO)
pancreatic cancer  (ISO)
Perennial Allergic Rhinitis  (ISO)
periodontitis  (ISO)
pneumonia  (ISO)
Poisoning  (ISO)
polymyositis  (ISO)
pulmonary fibrosis  (ISO)
pulmonary tuberculosis  (ISO)
Radiation Injuries  (ISO)
Radiation Pneumonitis  (ISO)
Reperfusion Injury  (ISO)
respiratory allergy  (ISO)
Retina Reperfusion Injury  (ISO)
rheumatoid arthritis  (ISO)
Schnitzler syndrome  (ISO)
Sclerosis  (ISO)
severe acute respiratory syndrome  (ISO)
skin disease  (ISO)
Skin Neoplasms  (ISO)
tick infestation  (ISO)
type 1 diabetes mellitus  (ISO)
urinary tract infection  (ISO)
uveitis  (ISO)
varicocele  (ISO)
Venous Thrombosis  (ISO)
vitiligo  (ISO)
Wounds and Injuries  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute inflammatory response  (ISO)
cellular response to heat  (ISS)
cellular response to lipopolysaccharide  (IBA)
cellular sodium ion homeostasis  (IEA)
connective tissue replacement involved in inflammatory response wound healing  (IEA)
cytokine-mediated signaling pathway  (IBA)
ectopic germ cell programmed cell death  (IEA)
extrinsic apoptotic signaling pathway in absence of ligand  (IEA)
fever generation  (IEA)
heart development  (ISO)
immune response  (IEA)
inflammatory response  (IBA)
interleukin-1-mediated signaling pathway  (ISO)
keratinization  (ISO)
negative regulation of cell population proliferation  (IEA)
negative regulation of establishment of Sertoli cell barrier  (ISO)
positive regulation of angiogenesis  (IEA)
positive regulation of cell division  (IEA)
positive regulation of cytokine production  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of gene expression  (IBA)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (ISO)
positive regulation of immature T cell proliferation in thymus  (IBA)
positive regulation of interleukin-2 production  (IEA)
positive regulation of interleukin-6 production  (ISO)
positive regulation of JNK cascade  (ISO)
positive regulation of mitotic nuclear division  (IEA)
positive regulation of monocyte chemotactic protein-1 production  (ISO)
positive regulation of neutrophil extravasation  (ISO)
positive regulation of neutrophil migration  (ISO)
positive regulation of prostaglandin secretion  (ISO)
positive regulation of protein secretion  (IEA)
positive regulation of steroid biosynthetic process  (ISO)
positive regulation of stress-activated MAPK cascade  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of vascular endothelial growth factor production  (IEA)
regulation of actin cytoskeleton organization  (ISO)
regulation of nitric-oxide synthase activity  (IBA)
regulation of sensory perception of pain  (ISO)
response to copper ion  (ISS)
response to gamma radiation  (ISO)
response to heat  (ISO)
response to hypoxia  (ISO)
response to L-ascorbic acid  (ISO)
response to lipopolysaccharide  (ISO)
response to organic cyclic compound  (ISO)
response to organic substance  (ISO)
response to organonitrogen compound  (ISO)
response to ozone  (ISO)
signal transduction  (IEA)
spermatogenesis  (ISO)
wound healing  (ISO)

Cellular Component
cell surface  (ISO)
cytoplasm  (ISO)
cytosol  (IEA,ISS)
extracellular space  (IBA,IEA,ISS)
plasma membrane  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:2377484   PMID:7894160   PMID:8075502   PMID:18292602  


Genomics

Comparative Map Data
IL1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl343,718,368 - 43,731,119 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1343,718,320 - 43,731,668 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2345,452,989 - 45,466,307 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap3q12-q13NCBI
IL1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2112,773,925 - 112,784,493 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl2112,773,915 - 112,784,590 (-)EnsemblGRCh38hg38GRCh38
GRCh382112,773,925 - 112,784,493 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372113,531,492 - 113,542,971 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362113,247,963 - 113,259,442 (-)NCBINCBI36hg18NCBI36
Build 342113,247,723 - 113,259,202NCBI
Celera2106,917,026 - 106,928,133 (-)NCBI
Cytogenetic Map2q14.1NCBI
HuRef2105,986,068 - 105,997,547 (-)NCBIHuRef
CHM1_12113,535,646 - 113,546,810 (-)NCBICHM1_1
Il1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392129,141,530 - 129,151,892 (-)NCBIGRCm39mm39
GRCm382129,299,609 - 129,310,186 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2129,299,610 - 129,309,972 (-)EnsemblGRCm38mm10GRCm38
MGSCv372129,125,346 - 129,135,708 (-)NCBIGRCm37mm9NCBIm37
MGSCv362128,991,051 - 129,001,413 (-)NCBImm8
Celera2130,527,298 - 130,537,642 (-)NCBICelera
Cytogenetic Map2F1NCBI
cM Map262.9NCBI
Il1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.03121,824,712 - 121,836,122 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3121,825,412 - 121,836,086 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03128,180,475 - 128,190,980 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43116,913,612 - 116,924,114 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13116,819,184 - 116,829,687 (-)NCBI
Celera3115,352,857 - 115,362,929 (-)NCBICelera
Cytogenetic Map3q36NCBI
Il1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554701,527,674 - 1,538,466 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554701,527,710 - 1,538,418 (+)NCBIChiLan1.0ChiLan1.0
IL1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A113,784,854 - 113,795,801 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A113,784,854 - 113,795,801 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A89,273,482 - 89,284,421 (+)NCBIMhudiblu_PPA_v0panPan3
IL1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1736,970,573 - 36,979,435 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11736,969,581 - 36,979,445 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Il1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049367831,210,715 - 1,218,315 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL1A
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11415,789,710 - 15,801,938 (-)NCBI
ChlSab1.1 Ensembl1415,789,013 - 15,796,611 (-)Ensembl
Il1a
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474912,795,967 - 12,805,658 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 3 1 1 3
Low 7 2 4 10 1 1
Below cutoff 2 3 2 10 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000008863   ⟹   ENSSSCP00000008638
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl343,718,368 - 43,731,119 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000082619   ⟹   ENSSSCP00000067323
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl343,718,368 - 43,731,119 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000089751   ⟹   ENSSSCP00000065513
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl343,721,905 - 43,731,119 (+)Ensembl
RefSeq Acc Id: NM_214029   ⟹   NP_999194
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1343,719,109 - 43,731,121 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005655198   ⟹   XP_005655255
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1343,718,320 - 43,731,668 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013987856   ⟹   XP_013843310
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1343,718,465 - 43,731,668 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013987857   ⟹   XP_013843311
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1343,718,416 - 43,731,668 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021085846   ⟹   XP_020941505
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1343,718,416 - 43,731,668 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_005655255   ⟸   XM_005655198
- Peptide Label: isoform X1
- UniProtKB: P18430 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_020941505   ⟸   XM_021085846
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_013843311   ⟸   XM_013987857
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_013843310   ⟸   XM_013987856
- Peptide Label: isoform X1
- UniProtKB: P18430 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_999194   ⟸   NM_214029
- Peptide Label: precursor
- UniProtKB: P18430 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSSSCP00000065513   ⟸   ENSSSCT00000089751
RefSeq Acc Id: ENSSSCP00000067323   ⟸   ENSSSCT00000082619
RefSeq Acc Id: ENSSSCP00000008638   ⟸   ENSSSCT00000008863
Protein Domains
IL1_propep


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000008090 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00005020761 UniProtKB/Swiss-Prot
  ENSSSCG00015054935 UniProtKB/Swiss-Prot
  ENSSSCG00025004335 UniProtKB/Swiss-Prot
  ENSSSCG00030061899 UniProtKB/Swiss-Prot
  ENSSSCG00035037108 UniProtKB/Swiss-Prot
  ENSSSCG00040056346 UniProtKB/Swiss-Prot
  ENSSSCG00045020752 UniProtKB/Swiss-Prot
  ENSSSCG00050076581 UniProtKB/Swiss-Prot
  ENSSSCG00060059637 UniProtKB/Swiss-Prot
  ENSSSCG00065063958 UniProtKB/Swiss-Prot
  ENSSSCG00070020828 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000008638 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSSSCP00000065513 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000067323 UniProtKB/TrEMBL
  ENSSSCP00005020029 UniProtKB/Swiss-Prot
  ENSSSCP00015029482 UniProtKB/Swiss-Prot
  ENSSSCP00025002306 UniProtKB/Swiss-Prot
  ENSSSCP00030039935 UniProtKB/Swiss-Prot
  ENSSSCP00035019686 UniProtKB/Swiss-Prot
  ENSSSCP00040032842 UniProtKB/Swiss-Prot
  ENSSSCP00045024574 UniProtKB/Swiss-Prot
  ENSSSCP00050046274 UniProtKB/Swiss-Prot
  ENSSSCP00060035221 UniProtKB/Swiss-Prot
  ENSSSCP00065038405 UniProtKB/Swiss-Prot
  ENSSSCP00070034846 UniProtKB/TrEMBL
  ENSSSCP00070034968 UniProtKB/TrEMBL
  ENSSSCP00070035061 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000008863 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSSSCT00000082619 UniProtKB/TrEMBL
  ENSSSCT00000089751 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00005032853 UniProtKB/Swiss-Prot
  ENSSSCT00015073404 UniProtKB/Swiss-Prot
  ENSSSCT00025005795 UniProtKB/Swiss-Prot
  ENSSSCT00030086587 UniProtKB/Swiss-Prot
  ENSSSCT00035049201 UniProtKB/Swiss-Prot
  ENSSSCT00040076415 UniProtKB/Swiss-Prot
  ENSSSCT00045035395 UniProtKB/Swiss-Prot
  ENSSSCT00050105243 UniProtKB/Swiss-Prot
  ENSSSCT00060081338 UniProtKB/Swiss-Prot
  ENSSSCT00065087782 UniProtKB/Swiss-Prot
  ENSSSCT00070041503 UniProtKB/TrEMBL
  ENSSSCT00070041641 UniProtKB/TrEMBL
  ENSSSCT00070041755 UniProtKB/TrEMBL
InterPro IL-1_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-1_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-1_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-1_propep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL1/FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:397094 UniProtKB/Swiss-Prot
NCBI Gene IL1A ENTREZGENE
PANTHER PTHR10078 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10078:SF33 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IL1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL1_propep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS INTERLEUKIN1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INTRLEUKIN1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE INTERLEUKIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50353 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Ssc.113 ENTREZGENE
UniProt A0A4X1UX98_PIG UniProtKB/TrEMBL
  A0A4X1V1C4_PIG UniProtKB/TrEMBL
  A0A5G2QZE8_PIG UniProtKB/TrEMBL
  A0A5G2R4M2_PIG UniProtKB/TrEMBL
  IL1A_PIG UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:89091 ENTREZGENE