RGD Reference Report - IL1 gene cluster polymorphisms and its haplotypes may predict the risk to develop invasive pulmonary aspergillosis and modulate C-reactive protein level. - Rat Genome Database

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IL1 gene cluster polymorphisms and its haplotypes may predict the risk to develop invasive pulmonary aspergillosis and modulate C-reactive protein level.

Authors: Sainz, J  Perez, E  Gomez-Lopera, S  Jurado, M 
Citation: Sainz J, etal., J Clin Immunol. 2008 Sep;28(5):473-85. Epub 2008 May 17.
RGD ID: 4142867
Pubmed: PMID:18484169   (View Abstract at PubMed)
DOI: DOI:10.1007/s10875-008-9197-0   (Journal Full-text)

OBJECTIVE: The aim of this study was to determine whether interleukin-1 alpha (IL1alpha), interleukin-1 beta (IL1beta), and IL1 receptor antagonist (IL1Ra) polymorphisms are implicated in invasive pulmonary aspergillosis (IPA) pathogenesis. MATERIALS AND METHODS: Subjects comprised 110 hematological patients and 148 healthy controls. Genotypic and allelic frequencies were similar between hematological patients and controls. IPA was diagnosed in 59 of the 110 patients according to consensus criteria published by the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group (EORTC/IFICG). RESULTS AND DISCUSSIONS: Individual locus analysis showed that IL1alpha and IL1Ra polymorphisms were not associated with the presence of IPA (p = 0.560 and p = 0.680, respectively). However, a trend towards a higher presence of IL1beta( - ) (511TT) genotype (or IL1beta(-511T) allele) in the IPA group than in the non-IPA patient group (p = 0.092 and p = 0.095, respectively) was found. Haplotype analysis revealed that VNTR2/-889C/-511T haplotype was strongly associated with susceptibility to develop IPA infection (p = 0.020). Haplotype analysis also showed an association between VNTR2/-889C/-511C haplotype and resistance to IPA infection (p = 0.028). Furthermore, patients with IL1Ra VNTR2/2 and IL1beta(-511)T/T genotypes had a higher positive serum galactomannan percentage versus patients with other genotypes. Finally, C-reactive protein (CRP) production was significantly associated with IL1 gene cluster polymorphisms, although CRP values were similar between IPA and non-IPA groups. CONCLUSION: These findings indicate a critical role of IL1 gene cluster polymorphisms in the susceptibility to IPA infection and CRP production.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IL1AHumanInvasive Pulmonary Aspergillosis  IAGP DNA:polymorphism and haplotype:promoter:-889C>T (human)RGD 
IL1BHumanInvasive Pulmonary Aspergillosis  IAGP DNA:polymorphism and haplotype: :-511C>T (human)RGD 
Il1aRatInvasive Pulmonary Aspergillosis  ISOIL1A (Homo sapiens)DNA:polymorphism and haplotype:promoter:-889C>T (human)RGD 
Il1aMouseInvasive Pulmonary Aspergillosis  ISOIL1A (Homo sapiens)DNA:polymorphism and haplotype:promoter:-889C>T (human)RGD 
Il1bRatInvasive Pulmonary Aspergillosis  ISOIL1B (Homo sapiens)DNA:polymorphism and haplotype: :-511C>T (human)RGD 
Il1bMouseInvasive Pulmonary Aspergillosis  ISOIL1B (Homo sapiens)DNA:polymorphism and haplotype: :-511C>T (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il1a  (interleukin 1 alpha)
Il1b  (interleukin 1 beta)

Genes (Mus musculus)
Il1a  (interleukin 1 alpha)
Il1b  (interleukin 1 beta)

Genes (Homo sapiens)
IL1A  (interleukin 1 alpha)
IL1B  (interleukin 1 beta)


Additional Information