RGD Reference Report - Possible role of interleukin 1 alpha and interleukin 1 beta in the pathogenesis of cholesteatoma of the middle ear. - Rat Genome Database

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Possible role of interleukin 1 alpha and interleukin 1 beta in the pathogenesis of cholesteatoma of the middle ear.

Authors: Schilling, V  Negri, B  Bujia, J  Schulz, P  Kastenbauer, E 
Citation: Schilling V, etal., Am J Otol. 1992 Jul;13(4):350-5.
RGD ID: 7401205
Pubmed: PMID:1384343   (View Abstract at PubMed)

Cholesteatoma of the middle ear is characterized by the presence of hyperproliferative keratinizing squamous epithelium in the middle ear cavity and destruction of adjacent bone. Interleukin 1 (IL-1) is an autocrine growth factor for normal keratinocytes and is capable of inducing bone degradation. The distribution of two molecular species of IL-1, IL-1 alpha and IL-1 beta, was investigated immunohistochemically in the hyperproliferative epithelium of cholesteatoma, in normal epidermis of the auditory canal and of the retroauricular region, and in nonkeratinizing tonsillar epithelium. In all squamous epithelia examined, IL-1 alpha and IL-1 beta were present in comparable amounts. The IL-1 content of cholesteatoma epithelium was clearly increased in relation to normal skin keratinocytes. All cellular layers of cholesteatoma epithelium stained strongly and uniformly for Il-1 alpha and IL-1 beta, whereas the keratin layer was negative for IL-1. No particularly strong reaction with basal cells was detected. In the connective tissue under the squamous epithelium of cholesteatoma, intensely positive cells were scattered between negative stromal cells. Our results suggest that IL-1 could be liberated from disintegrating keratinocytes and cells of the monocyte-macrophage lineage, stimulate the proliferation of the cholesteatoma epithelium in an autocrine manner, and contribute to the enhancement of bone destruction in the presence of cholesteatoma.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
cholesteatoma  IEP 7401205; 7401205 RGD 
cholesteatoma  ISOIL1A (Homo sapiens)7401205; 7401205 RGD 
cholesteatoma  ISOIL1B (Homo sapiens)7401205; 7401205 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il1a  (interleukin 1 alpha)
Il1b  (interleukin 1 beta)

Genes (Mus musculus)
Il1a  (interleukin 1 alpha)
Il1b  (interleukin 1 beta)

Genes (Homo sapiens)
IL1A  (interleukin 1 alpha)
IL1B  (interleukin 1 beta)


Additional Information