Il1a (interleukin 1 alpha) - Rat Genome Database

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Pathways
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Gene: Il1a (interleukin 1 alpha) Heterocephalus glaber
Analyze
Symbol: Il1a
Name: interleukin 1 alpha
RGD ID: 18912575
Description: ENCODES a protein that exhibits copper ion binding (ortholog); INVOLVED IN cellular response to heat (ortholog); connective tissue replacement involved in inflammatory response wound healing (ortholog); ectopic germ cell programmed cell death (ortholog); PARTICIPATES IN interleukin-1 signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); acute myeloid leukemia (ortholog); allergic bronchopulmonary aspergillosis (ortholog); FOUND IN cell surface (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Interleukin-1 alpha; interleukin-1 alpha proprotein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474912,795,946 - 12,805,154 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474912,795,967 - 12,805,658 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
acute myeloid leukemia  (ISO)
allergic bronchopulmonary aspergillosis  (ISO)
allergic contact dermatitis  (ISO)
Alzheimer's disease  (ISO)
amnestic disorder  (ISO)
Anorexia  (ISO)
anthracosis  (ISO)
Arsenic Poisoning  (ISO)
aspiration pneumonia  (ISO)
asthma  (ISO)
autoimmune thrombocytopenic purpura  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
beta thalassemia  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
Burns  (ISO)
cardiomyopathy  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chemical Burns  (ISO)
cholestasis  (ISO)
cholesteatoma  (ISO)
cholesteatoma of middle ear  (ISO)
chorioamnionitis  (ISO)
chronic progressive external ophthalmoplegia  (ISO)
common cold  (ISO)
corneal edema  (ISO)
Craniocerebral Trauma  (ISO)
Creutzfeldt-Jakob disease  (ISO)
cystic fibrosis  (ISO)
dermatomyositis  (ISO)
diabetic retinopathy  (ISO)
diarrhea  (ISO)
Disease Progression  (ISO)
Drug-Induced Immune Thrombocytopenia  (ISO)
Drug-induced Neutropenia  (ISO)
end stage renal disease  (ISO)
endometritis  (ISO)
Endotoxemia  (ISO)
Enterocolitis  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Leukemia  (ISO)
Experimental Melanoma  (ISO)
extrinsic allergic alveolitis  (ISO)
Fabry disease  (ISO)
Femoral Fractures  (ISO)
Fetal Growth Retardation  (ISO)
Fever  (ISO)
genetic disease  (ISO)
glomerulonephritis  (ISO)
graft-versus-host disease  (ISO)
Graves ophthalmopathy  (ISO)
head and neck squamous cell carcinoma  (ISO)
Heat Stroke  (ISO)
hemolytic-uremic syndrome  (ISO)
Hemorrhage  (ISO)
Hemorrhagic Shock  (ISO)
HIV Wasting Syndrome  (ISO)
Human Influenza  (ISO)
Hyperalgesia  (ISO)
hyperglycemia  (ISO)
Hypotension  (ISO)
IgA glomerulonephritis  (ISO)
Inflammation  (ISO)
interstitial lung disease  (ISO)
Invasive Pulmonary Aspergillosis  (ISO)
iridocyclitis  (ISO)
juvenile rheumatoid arthritis  (ISO)
Kearns-Sayre syndrome  (ISO)
keratoconus  (ISO)
Knee Osteoarthritis  (ISO)
Leber hereditary optic neuropathy  (ISO)
Liver Reperfusion Injury  (ISO)
lung disease  (ISO)
lung non-small cell carcinoma  (ISO)
malignant mesothelioma  (ISO)
MELAS syndrome  (ISO)
MERRF Syndrome  (ISO)
mesenchymal chondrosarcoma  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Middle East respiratory syndrome  (ISO)
mitochondrial myopathy  (ISO)
multiple myeloma  (ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
Nasal Polyps  (ISO)
Oral Lichen Planus  (ISO)
osteoarthritis  (ISO)
osteoporosis  (ISO)
otitis media  (ISO)
pancreatic cancer  (ISO)
Perennial Allergic Rhinitis  (ISO)
periodontitis  (ISO)
pneumonia  (ISO)
Poisoning  (ISO)
polymyositis  (ISO)
pulmonary fibrosis  (ISO)
pulmonary tuberculosis  (ISO)
Radiation Injuries  (ISO)
Radiation Pneumonitis  (ISO)
Reperfusion Injury  (ISO)
respiratory allergy  (ISO)
Retina Reperfusion Injury  (ISO)
rheumatoid arthritis  (ISO)
Schnitzler syndrome  (ISO)
Sclerosis  (ISO)
severe acute respiratory syndrome  (ISO)
skin disease  (ISO)
Skin Neoplasms  (ISO)
tick infestation  (ISO)
type 1 diabetes mellitus  (ISO)
urinary tract infection  (ISO)
uveitis  (ISO)
varicocele  (ISO)
Venous Thrombosis  (ISO)
vitiligo  (ISO)
Wounds and Injuries  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to heat  (ISO)
cellular response to lipopolysaccharide  (IEA)
connective tissue replacement involved in inflammatory response wound healing  (ISO)
cytokine-mediated signaling pathway  (IEA)
ectopic germ cell programmed cell death  (ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
fever generation  (IEA)
heart development  (ISO)
immune response  (IEA)
inflammatory response  (IEA)
intracellular sodium ion homeostasis  (ISO)
keratinization  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of establishment of Sertoli cell barrier  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of canonical NF-kappaB signal transduction  (ISO)
positive regulation of cell division  (IEA)
positive regulation of cytokine production  (IEA)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of gene expression  (IEA)
positive regulation of immature T cell proliferation in thymus  (IEA)
positive regulation of interleukin-2 production  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of JNK cascade  (ISO)
positive regulation of mitotic nuclear division  (ISO)
positive regulation of neutrophil migration  (ISO)
positive regulation of prostaglandin secretion  (ISO)
positive regulation of protein secretion  (ISO)
positive regulation of steroid biosynthetic process  (ISO)
positive regulation of stress-activated MAPK cascade  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of vascular endothelial growth factor production  (ISO)
regulation of actin cytoskeleton organization  (ISO)
response to copper ion  (ISO)
response to gamma radiation  (ISO)
response to hypoxia  (ISO)
response to L-ascorbic acid  (ISO)
response to lipopolysaccharide  (ISO)
response to organic cyclic compound  (ISO)
response to organic substance  (ISO)
response to organonitrogen compound  (ISO)
response to ozone  (ISO)
spermatogenesis  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Il1a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474912,795,946 - 12,805,154 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474912,795,967 - 12,805,658 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
IL1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382112,773,925 - 112,784,493 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2112,773,925 - 112,784,493 (-)EnsemblGRCh38hg38GRCh38
GRCh372113,531,502 - 113,542,070 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362113,247,963 - 113,259,442 (-)NCBINCBI36Build 36hg18NCBI36
Build 342113,247,723 - 113,259,202NCBI
Celera2106,917,026 - 106,928,133 (-)NCBICelera
Cytogenetic Map2q14.1NCBI
HuRef2105,986,068 - 105,997,547 (-)NCBIHuRef
CHM1_12113,535,646 - 113,546,806 (-)NCBICHM1_1
T2T-CHM13v2.02113,200,569 - 113,210,953 (-)NCBIT2T-CHM13v2.0
Il1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392129,141,530 - 129,151,892 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2129,141,530 - 129,151,892 (-)EnsemblGRCm39 Ensembl
GRCm382129,299,609 - 129,310,186 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2129,299,610 - 129,309,972 (-)EnsemblGRCm38mm10GRCm38
MGSCv372129,125,346 - 129,135,708 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362128,991,051 - 129,001,413 (-)NCBIMGSCv36mm8
Celera2130,527,298 - 130,537,642 (-)NCBICelera
Cytogenetic Map2F1NCBI
cM Map262.9NCBI
Il1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83136,979,804 - 136,990,236 (-)NCBIGRCr8
mRatBN7.23116,526,601 - 116,537,055 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3116,526,604 - 116,536,822 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3120,424,348 - 120,434,552 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03129,019,955 - 129,030,165 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03126,680,432 - 126,690,642 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03121,824,712 - 121,836,122 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3121,825,412 - 121,836,086 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03128,180,475 - 128,190,980 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43116,913,612 - 116,924,114 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13116,819,184 - 116,829,687 (-)NCBI
Celera3115,352,857 - 115,362,929 (-)NCBICelera
Cytogenetic Map3q36NCBI
Il1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554701,527,674 - 1,538,466 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554701,527,710 - 1,538,418 (+)NCBIChiLan1.0ChiLan1.0
IL1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21215,339,536 - 15,350,287 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A15,343,032 - 15,352,074 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A89,273,482 - 89,284,421 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A113,784,854 - 113,795,801 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A113,784,854 - 113,795,801 (-)Ensemblpanpan1.1panPan2
IL1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11736,969,581 - 36,979,445 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1736,970,573 - 36,979,435 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1736,739,697 - 36,748,565 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01737,745,380 - 37,755,259 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1737,746,372 - 37,755,235 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11736,881,972 - 36,890,833 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01736,938,236 - 36,947,096 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01737,152,126 - 37,160,990 (-)NCBIUU_Cfam_GSD_1.0
Il1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629282,315,498 - 82,324,623 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367831,210,809 - 1,218,315 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367831,210,715 - 1,218,315 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl343,718,368 - 43,731,119 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1343,718,320 - 43,731,668 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2345,452,989 - 45,466,307 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap3q12-q13NCBI
IL1A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11415,789,710 - 15,801,938 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1415,789,013 - 15,796,611 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660803,883,451 - 3,894,101 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000007479   ⟹   ENSHGLP00000007394
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462474912,795,946 - 12,805,154 (-)Ensembl
RefSeq Acc Id: ENSHGLT00000007480   ⟹   ENSHGLP00000007395
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462474912,795,946 - 12,805,154 (-)Ensembl
RefSeq Acc Id: XM_004844529   ⟹   XP_004844586
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474912,795,967 - 12,805,658 (-)NCBI
RefSeq Acc Id: XM_021258166   ⟹   XP_021113825
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474912,795,967 - 12,805,622 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004844586 (Get FASTA)   NCBI Sequence Viewer  
  XP_021113825 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB02616 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000007394
GenBank Protein JAO02166 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_004844586   ⟸   XM_004844529
- Peptide Label: isoform X2
- UniProtKB: A0A0N8EUI7 (UniProtKB/TrEMBL),   G5B005 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021113825   ⟸   XM_021258166
- Peptide Label: isoform X1
- UniProtKB: G5B005 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000007395   ⟸   ENSHGLT00000007480
RefSeq Acc Id: ENSHGLP00000007394   ⟸   ENSHGLT00000007479


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000005385 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000007479 ENTREZGENE
Gene3D-CATH 2.80.10.50 UniProtKB/TrEMBL
InterPro IL-1_alpha UniProtKB/TrEMBL
  IL-1_fam UniProtKB/TrEMBL
  IL-1_propep UniProtKB/TrEMBL
  IL1/FGF UniProtKB/TrEMBL
KEGG Report hgl:101703933 UniProtKB/TrEMBL
NCBI Gene Il1a ENTREZGENE
PANTHER PTHR10078 UniProtKB/TrEMBL
  PTHR10078:SF33 UniProtKB/TrEMBL
Pfam IL1 UniProtKB/TrEMBL
  IL1_propep UniProtKB/TrEMBL
PRINTS INTERLEUKIN1 UniProtKB/TrEMBL
  INTRLEUKIN1A UniProtKB/TrEMBL
  INTRLEUKN1AB UniProtKB/TrEMBL
SMART IL1 UniProtKB/TrEMBL
Superfamily-SCOP SSF50353 UniProtKB/TrEMBL
UniProt A0A0N8EUI7 ENTREZGENE, UniProtKB/TrEMBL
  G5B005 ENTREZGENE, UniProtKB/TrEMBL