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Gene: Plcd1 (phospholipase C, delta 1) Rattus norvegicus
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Symbol: Plcd1
Name: phospholipase C, delta 1
Description: Exhibits anion binding activity; calcium ion binding activity; and phosphatidylinositol phospholipase C activity. Involved in several processes, including positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; positive regulation of inositol trisphosphate biosynthetic process; and positive regulation of norepinephrine secretion. Localizes to the cytoplasm; membrane raft; and nucleus. Used to study congestive heart failure and hypertension. Biomarker of hypertension. Human ortholog(s) of this gene implicated in nonsyndromic congenital nail disorder 3. Orthologous to human PLCD1 (phospholipase C delta 1); PARTICIPATES IN G protein mediated signaling pathway; calcium/calcium-mediated signaling pathway; inositol phosphate metabolic pathway; INTERACTS WITH (R)-noradrenaline; (RS)-amphetamine; 3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-1; phosphoinositide phospholipase C; phosphoinositide phospholipase C-delta-1; phospholipase C delta 1 long form; phospholipase C-delta-1; Phospholipase C-delta1; phospholipase C-III; PLC-delta-1; PLC-III; Plc1
Orthologs:
Homo sapiens (human) : PLCD1 (phospholipase C delta 1)  HGNC  Alliance
Mus musculus (house mouse) : Plcd1 (phospholipase C, delta 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Plcd1 (phospholipase C delta 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PLCD1 (phospholipase C delta 1)
Canis lupus familiaris (dog) : PLCD1 (phospholipase C delta 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Plcd1 (phospholipase C delta 1)
Sus scrofa (pig) : PLCD1 (phospholipase C delta 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08127,753,514 - 127,782,070 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.08126,970,643 - 126,991,422 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48124,023,090 - 124,052,193 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18124,042,827 - 124,071,930 (-)NCBI
Celera8117,968,204 - 117,991,136 (-)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Candidate Gene Status
Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Plcd1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3346
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-06-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.