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Gene: Plcd1 (phospholipase C, delta 1) Rattus norvegicus
Symbol: Plcd1
Name: phospholipase C, delta 1
RGD ID: 3346
Description: Exhibits anion binding activity; calcium ion binding activity; and phosphatidylinositol phospholipase C activity. Involved in several processes, including positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; positive regulation of inositol trisphosphate biosynthetic process; and positive regulation of norepinephrine secretion. Localizes to several cellular components, including cytosol; membrane raft; and mitochondrial membrane. Used to study congestive heart failure and hypertension. Biomarker of hypertension. Human ortholog(s) of this gene implicated in nonsyndromic congenital nail disorder 3. Orthologous to human PLCD1 (phospholipase C delta 1); PARTICIPATES IN G protein mediated signaling pathway; calcium/calcium-mediated signaling pathway; inositol phosphate metabolic pathway; INTERACTS WITH (R)-noradrenaline; 3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione; acetamide.
Type: protein-coding
Also known as: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-1; phosphoinositide phospholipase C; phosphoinositide phospholipase C-delta-1; phospholipase C delta 1 long form; phospholipase C-delta-1; Phospholipase C-delta1; phospholipase C-III; PLC-delta-1; PLC-III; Plc1
Homo sapiens (human) : PLCD1 (phospholipase C delta 1)  HGNC  Alliance
Mus musculus (house mouse) : Plcd1 (phospholipase C, delta 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Plcd1 (phospholipase C delta 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PLCD1 (phospholipase C delta 1)
Canis lupus familiaris (dog) : PLCD1 (phospholipase C delta 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Plcd1 (phospholipase C delta 1)
Sus scrofa (pig) : PLCD1 (phospholipase C delta 1)
Chlorocebus sabaeus (African green monkey) : PLCD1 (phospholipase C delta 1)
Heterocephalus glaber (naked mole-rat) : Plcd1 (phospholipase C delta 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.08127,753,514 - 127,782,070 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8127,753,539 - 127,782,070 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08126,970,643 - 126,991,422 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48124,023,090 - 124,052,193 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18124,042,827 - 124,071,930 (-)NCBI
Celera8117,968,204 - 117,991,136 (-)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Plcd1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3346
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.