Gene: Tgm2 (transglutaminase 2) Rattus norvegicus
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Symbol: Tgm2
Name: transglutaminase 2
Description: ENCODES a protein that exhibits GTP binding; protein domain specific binding; protein-glutamine gamma-glutamyltransferase activity (ortholog); INVOLVED IN blood vessel remodeling; isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine; phospholipase C-activating G protein-coupled receptor signaling pathway; PARTICIPATES IN eicosanoid signaling pathway; Huntington's disease pathway; ASSOCIATED WITH Left Ventricular Hypertrophy; Brain Neoplasms (ortholog); Breast Neoplasms (ortholog); FOUND IN cytoplasm; mitochondrion; plasma membrane; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine
AGR Description: Exhibits GTP binding activity and protein domain specific binding activity; involved in several processes, including blood vessel remodeling, isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine, and positive regulation of I-kappaB kinase/NF-kappaB signaling; localizes to the mitochondrion and plasma membrane; orthologous to human TGM2 (transglutaminase 2).
Merged Description: Exhibits GTP binding activity and protein domain specific binding activity; involved in several processes, including blood vessel remodeling, isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine, and positive regulation of I-kappaB kinase/NF-kappaB signaling; localizes to the mitochondrion and plasma membrane; orthologous to human TGM2 (transglutaminase 2); PARTICIPATES IN eicosanoid signaling pathway; Huntington's disease pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: glutamine gamma-glutamyltransferase 2; protein-glutamine gamma-glutamyltransferase 2; TgaseII; tissue-type transglutaminase; transglutaminase 2, C polypeptide
Orthologs:
Homo sapiens (human) : TGM2 (transglutaminase 2)  HGNC  Alliance
Mus musculus (house mouse) : Tgm2 (transglutaminase 2, C polypeptide)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tgm2 (transglutaminase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : TGM2 (transglutaminase 2)
Canis lupus familiaris (dog) : TGM2 (transglutaminase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tgm2 (transglutaminase 2)
Sus scrofa (pig) : TGM2 (transglutaminase 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.03154,597,165 - 154,627,257 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03160,977,905 - 161,007,261 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43148,832,866 - 148,862,385 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13148,738,777 - 148,768,294 (-)NCBI
Celera3145,473,663 - 145,503,117 (-)NCBICelera
Cytogenetic Map3q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
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Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Tgm2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621081
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.