Plcd1 (phospholipase C, delta 1) - Rat Genome Database
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Gene: Plcd1 (phospholipase C, delta 1) Mus musculus
Analyze
Symbol: Plcd1
Name: phospholipase C, delta 1
RGD ID: 1553559
MGI Page MGI
Description: Exhibits phospholipase C activity and phospholipid binding activity. Involved in angiogenesis; labyrinthine layer blood vessel development; and regulation of cell population proliferation. Localizes to cytosol. Is expressed in several structures, including alimentary system; appendicular skeleton; cranium; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in nonsyndromic congenital nail disorder 3. Orthologous to human PLCD1 (phospholipase C delta 1); PARTICIPATES IN G protein mediated signaling pathway; inositol phosphate metabolic pathway; phosphatidylinositol 3-kinase signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 4-hydroxyphenyl retinamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-1; AW212592; C79986; phosphoinositide phospholipase C-delta-1; phospholipase C delta 1 Lf; phospholipase C delta-1; phospholipase C-delta-1; PLC-delta 1; PLC-delta-1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399118,900,595 - 118,922,570 (-)NCBIGRCm39mm39
GRCm389119,071,527 - 119,093,502 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9119,071,527 - 119,093,502 (-)EnsemblGRCm38mm10GRCm38
MGSCv379118,980,645 - 119,002,614 (-)NCBIGRCm37mm9NCBIm37
MGSCv369118,920,225 - 118,942,194 (-)NCBImm8
Celera9119,539,423 - 119,561,381 (-)NCBICelera
Cytogenetic Map9F3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IDA,ISO)
cytosol  (IDA,ISO)
membrane  (ISO)
membrane raft  (ISO)
mitochondrial membrane  (ISO)
nucleus  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:2033248   PMID:7664667   PMID:8672127   PMID:9287114   PMID:10349636   PMID:10425196   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11222494   PMID:12477932  
PMID:14550290   PMID:14610273   PMID:14681479   PMID:15037625   PMID:15489334   PMID:15702972   PMID:15782199   PMID:15809301   PMID:15899900   PMID:16141072   PMID:16141073   PMID:16159958  
PMID:16314520   PMID:17397799   PMID:17938256   PMID:18177742   PMID:18588506   PMID:18799693   PMID:19002527   PMID:20138965   PMID:21266583   PMID:21267068   PMID:21617180   PMID:21677750  
PMID:21795401   PMID:21873635   PMID:22723964   PMID:22805570   PMID:23055941   PMID:23892088   PMID:23969236   PMID:24810051   PMID:24952961   PMID:25197077   PMID:25242442   PMID:26410627  
PMID:26643908   PMID:27371838   PMID:27434733   PMID:28430185   PMID:29030553   PMID:29793503   PMID:30791982   PMID:32325033  


Genomics

Comparative Map Data
Plcd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399118,900,595 - 118,922,570 (-)NCBIGRCm39mm39
GRCm389119,071,527 - 119,093,502 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9119,071,527 - 119,093,502 (-)EnsemblGRCm38mm10GRCm38
MGSCv379118,980,645 - 119,002,614 (-)NCBIGRCm37mm9NCBIm37
MGSCv369118,920,225 - 118,942,194 (-)NCBImm8
Celera9119,539,423 - 119,561,381 (-)NCBICelera
Cytogenetic Map9F3NCBI
PLCD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl338,007,496 - 38,029,642 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl338,007,496 - 38,029,762 (-)EnsemblGRCh38hg38GRCh38
GRCh38338,007,496 - 38,029,642 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37338,048,987 - 38,071,154 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36338,023,991 - 38,059,068 (-)NCBINCBI36hg18NCBI36
Build 34338,024,010 - 38,046,119NCBI
Celera337,983,370 - 38,005,535 (-)NCBI
Cytogenetic Map3p22.2NCBI
HuRef337,991,684 - 38,013,851 (-)NCBIHuRef
CHM1_1338,000,639 - 38,022,806 (-)NCBICHM1_1
Plcd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08127,753,514 - 127,782,070 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8127,753,539 - 127,782,070 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08126,970,643 - 126,991,422 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48124,023,090 - 124,052,193 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18124,042,827 - 124,071,930 (-)NCBI
Celera8117,968,204 - 117,991,136 (-)NCBICelera
Cytogenetic Map8q32NCBI
Plcd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554214,856,366 - 4,880,309 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554214,856,366 - 4,880,309 (-)NCBIChiLan1.0ChiLan1.0
PLCD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1338,189,496 - 38,211,784 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl338,189,496 - 38,206,886 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0337,906,359 - 37,928,564 (-)NCBIMhudiblu_PPA_v0panPan3
PLCD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl237,781,787 - 7,805,336 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1237,782,495 - 7,804,969 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Plcd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493647327,364,404 - 27,387,337 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLCD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1322,851,584 - 22,865,175 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11322,851,581 - 22,872,950 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21324,826,459 - 24,847,853 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PLCD1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1151,372,874 - 1,395,475 (+)NCBI
ChlSab1.1 Ensembl151,373,234 - 1,395,711 (+)Ensembl
Plcd1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477320,108,383 - 20,130,630 (+)NCBI

Position Markers
RH126779  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389119,071,662 - 119,071,871UniSTSGRCm38
MGSCv379118,980,780 - 118,980,989UniSTSGRCm37
Celera9119,539,558 - 119,539,767UniSTS
Cytogenetic Map9F4UniSTS
Cytogenetic Map9F3UniSTS
Whitehead/MRC_RH91174.04UniSTS
AW212592  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389119,071,585 - 119,071,698UniSTSGRCm38
MGSCv379118,980,703 - 118,980,816UniSTSGRCm37
Celera9119,539,481 - 119,539,594UniSTS
Cytogenetic Map9F3UniSTS
Cytogenetic Map9F4UniSTS
Whitehead/MRC_RH91174.04UniSTS
Plcd1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9F3UniSTS
cM Map9 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63332429120362868Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63332429120362868Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963332429120362868Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986230401120230530Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986239845120289624Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986748483120748483Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987800000121800000Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989284925123284925Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989412277123412396Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989563342123563342Mouse
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993762590124595110Mouse
1301484Bwq6_mbody weight (mouse)Not determined993762590124595110Mouse
14746992Manh67_mmandible shape 67 (mouse)994036768124595110Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996917590124595110Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9101060861124595110Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9102000187124595110Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9102000187124595110Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103289445124595110Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103289445124595110Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103289445124595110Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:170
Count of miRNA genes:153
Interacting mature miRNAs:166
Transcripts:ENSMUST00000010804
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000010804   ⟹   ENSMUSP00000010804
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9119,071,527 - 119,093,502 (-)Ensembl
RefSeq Acc Id: ENSMUST00000213464   ⟹   ENSMUSP00000149676
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9119,071,527 - 119,093,502 (-)Ensembl
RefSeq Acc Id: ENSMUST00000214470   ⟹   ENSMUSP00000149813
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9119,071,527 - 119,088,261 (-)Ensembl
RefSeq Acc Id: ENSMUST00000214491
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9119,072,579 - 119,074,303 (-)Ensembl
RefSeq Acc Id: NM_001293648   ⟹   NP_001280577
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399118,900,595 - 118,917,329 (-)NCBI
GRCm389119,071,527 - 119,088,261 (-)NCBI
Celera9119,539,423 - 119,561,387 (-)NCBI
Sequence:
RefSeq Acc Id: NM_019676   ⟹   NP_062650
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399118,900,595 - 118,922,570 (-)NCBI
GRCm389119,071,527 - 119,093,502 (-)NCBI
MGSCv379118,980,645 - 119,002,614 (-)RGD
Celera9119,539,423 - 119,561,387 (-)NCBI
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_121571
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399118,900,595 - 118,922,570 (-)NCBI
GRCm389119,071,527 - 119,093,502 (-)NCBI
Celera9119,539,423 - 119,561,387 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006511984   ⟹   XP_006512047
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399118,900,595 - 118,914,224 (-)NCBI
GRCm389119,071,527 - 119,085,174 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_062650   ⟸   NM_019676
- Peptide Label: isoform 2
- UniProtKB: Q8R3B1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006512047   ⟸   XM_006511984
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001280577   ⟸   NM_001293648
- Peptide Label: isoform 1
- UniProtKB: Q8R3B1 (UniProtKB/Swiss-Prot),   G5DDB7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000149676   ⟸   ENSMUST00000213464
RefSeq Acc Id: ENSMUSP00000010804   ⟸   ENSMUST00000010804
RefSeq Acc Id: ENSMUSP00000149813   ⟸   ENSMUST00000214470
Protein Domains
C2   EF-hand   PH   PI-PLC X-box   PI-PLC Y-box

Promoters
RGD ID:6848449
Promoter ID:MM_ACW:52396
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell,   Kidney,   Lung,   MEF_B4,   MEF_B6
Transcripts:PLCD1.DSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369118,997,374 - 118,997,874 (-)MPROMDB
RGD ID:6844957
Promoter ID:MM_KWN:59112
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   Brain,   Kidney,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000010804
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369119,002,414 - 119,002,914 (-)MPROMDB
RGD ID:8671174
Promoter ID:EPDNEW_M13618
Type:multiple initiation site
Name:Plcd1_1
Description:Mus musculus phospholipase C, delta 1 , transcript variant 3,non-coding RNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389119,093,492 - 119,093,552EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97614 AgrOrtholog
Ensembl Genes ENSMUSG00000010660 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000010804 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000149676 UniProtKB/TrEMBL
  ENSMUSP00000149813 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000010804 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000213464 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000214470 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.20.20.190 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro C2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI-PLC_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLC-delta1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLC-like_Pdiesterase_TIM-brl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLC_EF-hand-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLipase_C_PInositol-sp_X_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLipase_C_Pinositol-sp_Y UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18799 UniProtKB/Swiss-Prot
MGD MGI:97614 ENTREZGENE
NCBI Gene 18799 ENTREZGENE
PANTHER PTHR10336 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10336:SF80 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam EF-hand_like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00168 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI-PLC-X UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI-PLC-Y UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Plcd1 PhenoGen
PRINTS PHPHLIPASEC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE EF_HAND_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PIPLC_X_DOMAIN UniProtKB/Swiss-Prot
  PIPLC_Y_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50004 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PLCXc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLCYc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00239 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF51695 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.23963 ENTREZGENE
UniProt G5DDB7 ENTREZGENE, UniProtKB/TrEMBL
  PLCD1_MOUSE UniProtKB/Swiss-Prot
  Q05DG3_MOUSE UniProtKB/TrEMBL
  Q8R3B1 ENTREZGENE
UniProt Secondary Q9Z1B4 UniProtKB/Swiss-Prot