Gene: Plcd1 (phospholipase C, delta 1) Mus musculus
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Symbol:
Plcd1
Name:
phospholipase C, delta 1
Description:
Exhibits phospholipase C activity and phospholipid binding activity. Involved in angiogenesis; labyrinthine layer blood vessel development; and regulation of cell population proliferation. Localizes to the cytosol. Human ortholog(s) of this gene implicated in nonsyndromic congenital nail disorder 3. Is expressed in several structures, including alimentary system; appendicular skeleton; craniocervical region; genitourinary system; and limb. Orthologous to human PLCD1 (phospholipase C delta 1); PARTICIPATES IN inositol phosphate metabolic pathway; phosphatidylinositol 3-kinase signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4-hydroxyphenyl retinamide; benzo[a]pyrene.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-1; AW212592; C79986; phosphoinositide phospholipase C-delta-1; phospholipase C delta 1 Lf; phospholipase C delta-1; phospholipase C-delta-1; PLC-delta 1; PLC-delta-1
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
PLCD1 (phospholipase C delta 1) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Rattus norvegicus (Norway rat):
Plcd1 (phospholipase C, delta 1) HGNC
EggNOG, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Plcd1 (phospholipase C delta 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
PLCD1 (phospholipase C delta 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
PLCD1 (phospholipase C delta 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Plcd1 (phospholipase C delta 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
PLCD1 (phospholipase C delta 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
PLCD4 (phospholipase C delta 4) HGNC
OrthoMCL
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Plcd1 (phospholipase C, delta 1)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Homo sapiens (human):
PLCD1 (phospholipase C delta 1)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Danio rerio (zebrafish):
plcd1a (phospholipase C, delta 1a)
Alliance
DIOPT (Ensembl Compara, Hieranoid, OMA, OrthoFinder, PANTHER, PhylomeDB, ZFIN)
Danio rerio (zebrafish):
plcd1b (phospholipase C, delta 1b)
Alliance
DIOPT (Ensembl Compara, Hieranoid, OMA, OrthoFinder, PANTHER, PhylomeDB, TreeFam, ZFIN)
Saccharomyces cerevisiae (baker's yeast):
PLC1
Alliance
DIOPT (Hieranoid, InParanoid, OMA, Roundup)
Caenorhabditis elegans (roundworm):
plc-4
Alliance
DIOPT (Ensembl Compara, InParanoid, OMA, OrthoFinder, Roundup, TreeFam)
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38 9 119,071,527 - 119,093,502 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 9 118,980,645 - 119,002,614 (-) NCBI GRCm37 mm9 NCBIm37 MGSCv36 9 118,920,225 - 118,942,194 (-) NCBI mm8 Celera 9 119,539,423 - 119,561,387 (-) NCBI Celera Cytogenetic Map 9 F3 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
Brugada syndrome ISO RGD:733331 8554872 ClinVar Annotator: match by term: Brugada syndrome ClinVar PMID:28492532 Brugada syndrome ISO RGD:733331 8554872 ClinVar Annotator: match by term: Brugada syndrome ClinVar PMID:20129283 more ... Leukonychia Totalis ISO RGD:733331 8554872 ClinVar Annotator: match by OMIM:151600 ClinVar PMID:21665001
Imported Annotations - CTD
osteoarthritis ISO RGD:733331 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:18784066 Imported Annotations - OMIM
nonsyndromic congenital nail disorder 3 ISO RGD:733331 7240710 OMIM
(R)-noradrenaline increases activity ISO RGD:3346 6480464 Norepinephrine results in increased activity of PLCD1 protein CTD PMID:16714034 (R)-noradrenaline multiple interactions ISO RGD:3346 6480464 1-(6-((3-methoxyestra-1 more ... CTD PMID:16714034 , PMID:19225867 (R)-noradrenaline increases expression ISO RGD:3346 6480464 Norepinephrine results in increased expression of PLCD1 mRNA, Norepinephrine results in increased expression of PLCD1 protein CTD PMID:16714034 , PMID:19225867 (RS)-amphetamine increases expression ISO RGD:3346 6480464 Amphetamine results in increased expression of PLCD1 mRNA CTD PMID:30779732 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 Tetrachlorodibenzodioxin affects the reaction [AHR protein binds to PLCD1 promoter] CTD PMID:19654925 3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione multiple interactions ISO RGD:3346 6480464 bisindolylmaleimide I inhibits the reaction [Norepinephrine results in increased expression of PLCD1 mRNA], bisindolylmaleimide I inhibits the reaction [Norepinephrine results in increased expression of PLCD1 protein] CTD PMID:16714034 4-hydroxyphenyl retinamide decreases expression EXP 6480464 Fenretinide results in decreased expression of PLCD1 mRNA CTD PMID:28973697 acrylonitrile multiple interactions ISO RGD:3346 6480464 Acrylonitrile results in increased expression of and affects the localization of PLCD1 protein CTD PMID:12850505 aluminium atom increases expression ISO RGD:3346 6480464 Aluminum results in increased expression of PLCD1 protein CTD PMID:10814511 aluminium(0) increases expression ISO RGD:3346 6480464 Aluminum results in increased expression of PLCD1 protein CTD PMID:10814511 aluminium(3+) increases expression ISO RGD:3346 6480464 Aluminum results in increased expression of PLCD1 protein CTD PMID:10814511 anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions ISO RGD:3346 6480464 pyrazolanthrone inhibits the reaction [Norepinephrine results in increased expression of PLCD1 mRNA] CTD PMID:19225867 arsane affects methylation ISO RGD:733331 6480464 Arsenic affects the methylation of PLCD1 gene CTD PMID:25304211 arsenic atom affects methylation ISO RGD:733331 6480464 Arsenic affects the methylation of PLCD1 gene CTD PMID:25304211 arsenic(3+) affects methylation ISO RGD:733331 6480464 Arsenic affects the methylation of PLCD1 gene CTD PMID:25304211 asbestos decreases expression ISO RGD:733331 6480464 Asbestos results in decreased expression of PLCD1 mRNA CTD PMID:22398240 atrazine increases expression ISO RGD:733331 6480464 Atrazine results in increased expression of PLCD1 mRNA CTD PMID:22378314 benzo[a]pyrene multiple interactions EXP 6480464 Benzo(a)pyrene promotes the reaction [AHR protein binds to PLCD1 promoter] CTD PMID:19654925 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of PLCD1 mRNA CTD PMID:22228805 benzo[b]fluoranthene increases expression EXP 6480464 benzo(b)fluoranthene results in increased expression of PLCD1 mRNA CTD PMID:26377693 beta-naphthoflavone multiple interactions ISO RGD:3346 6480464 [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PLCD1 mRNA CTD PMID:18164116 bisphenol A increases expression ISO RGD:733331 6480464 bisphenol A results in increased expression of PLCD1 mRNA CTD PMID:29275510 Brodifacoum increases expression ISO RGD:3346 6480464 bromfenacoum results in increased expression of PLCD1 protein CTD PMID:28903499 cerium trichloride increases expression EXP 6480464 cerous chloride results in increased expression of PLCD1 mRNA CTD PMID:23573234 choline multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of PLCD1 more ... CTD PMID:20938992 chrysene increases expression EXP 6480464 chrysene results in increased expression of PLCD1 mRNA CTD PMID:26377693 cisplatin multiple interactions ISO RGD:733331 6480464 [Cisplatin co-treated with jinfukang] results in increased expression of PLCD1 mRNA CTD PMID:27392435 dibutyl phthalate increases expression EXP 6480464 Dibutyl Phthalate results in increased expression of PLCD1 mRNA CTD PMID:21266533 dioxygen affects localization ISO RGD:3346 6480464 Oxygen affects the localization of PLCD1 protein CTD PMID:12850505 doxorubicin affects response to substance EXP 6480464 PLCD1 protein affects the susceptibility to Doxorubicin CTD PMID:16618758 doxorubicin decreases expression ISO RGD:733331 6480464 Doxorubicin results in decreased expression of PLCD1 mRNA CTD PMID:29803840 doxorubicin multiple interactions EXP 6480464 TNFRSF1A protein affects the reaction [Doxorubicin affects the expression of PLCD1 mRNA] more ... CTD PMID:16618758 ethanol increases expression ISO RGD:3346 6480464 Ethanol results in increased expression of PLCD1 mRNA CTD PMID:20655511 flavonoids decreases expression ISO RGD:3346 6480464 Flavonoids results in decreased expression of PLCD1 mRNA CTD PMID:18035473 folic acid multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of PLCD1 more ... CTD PMID:20938992 furan increases expression ISO RGD:3346 6480464 furan results in increased expression of PLCD1 mRNA CTD PMID:27387713 furan decreases methylation ISO RGD:3346 6480464 furan results in decreased methylation of PLCD1 gene CTD PMID:27387713 genistein increases expression ISO RGD:3346 6480464 Genistein results in increased expression of PLCD1 mRNA CTD PMID:21782745 L-methionine multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of PLCD1 more ... CTD PMID:20938992 methamphetamine decreases methylation EXP 6480464 Methamphetamine results in decreased methylation of PLCD1 promoter CTD PMID:26307267 methamphetamine increases expression EXP 6480464 Methamphetamine results in increased expression of PLCD1 mRNA CTD PMID:26307267 morphine multiple interactions ISO RGD:3346 6480464 Morphine deficiency inhibits the reaction [Morphine results in increased expression of PLCD1 protein] CTD PMID:23056601 morphine increases expression ISO RGD:3346 6480464 Morphine results in increased expression of PLCD1 protein CTD PMID:23056601 N-nitrosodiethylamine multiple interactions ISO RGD:3346 6480464 [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PLCD1 mRNA CTD PMID:18164116 ozone decreases expression ISO RGD:3346 6480464 Ozone results in decreased expression of PLCD1 mRNA CTD PMID:16330353 paracetamol affects expression EXP 6480464 Acetaminophen affects the expression of PLCD1 mRNA CTD PMID:17562736 phenylephrine increases expression ISO RGD:3346 6480464 Phenylephrine results in increased expression of PLCD1 mRNA CTD PMID:16714034 potassium chromate decreases expression ISO RGD:733331 6480464 potassium chromate(VI) results in decreased expression of PLCD1 mRNA CTD PMID:22714537 prazosin multiple interactions ISO RGD:3346 6480464 Prazosin inhibits the reaction [Norepinephrine results in increased expression of and results in increased activity of PLCD1 protein] more ... CTD PMID:16714034 , PMID:19225867 prostaglandin F2alpha increases expression ISO RGD:3346 6480464 Dinoprost results in increased expression of PLCD1 mRNA CTD PMID:11517196 resveratrol increases expression ISO RGD:733331 6480464 resveratrol results in increased expression of PLCD1 protein CTD PMID:18089832 silicon dioxide decreases expression ISO RGD:733331 6480464 Silicon Dioxide analog results in decreased expression of PLCD1 mRNA CTD PMID:25895662 Soman increases expression ISO RGD:3346 6480464 Soman results in increased expression of PLCD1 mRNA CTD PMID:19281266 tert-butyl hydroperoxide increases expression EXP 6480464 tert-Butylhydroperoxide results in increased expression of PLCD1 mRNA CTD PMID:15003993 tetrachloromethane affects expression EXP 6480464 Carbon Tetrachloride affects the expression of PLCD1 mRNA CTD PMID:17484886 U-73122 multiple interactions ISO RGD:3346 6480464 1-(6-((3-methoxyestra-1 more ... CTD PMID:16714034 U-73122 decreases activity EXP 6480464 1-(6-((3-methoxyestra-1 more ... CTD PMID:16618758 valproic acid increases methylation ISO RGD:733331 6480464 Valproic Acid results in increased methylation of PLCD1 gene CTD PMID:29154799 valproic acid increases expression ISO RGD:733331 6480464 Valproic Acid results in increased expression of PLCD1 mRNA CTD PMID:19101580 valproic acid increases expression EXP 6480464 Valproic Acid results in increased expression of PLCD1 mRNA CTD PMID:19136453 valproic acid affects expression ISO RGD:733331 6480464 Valproic Acid affects the expression of PLCD1 mRNA CTD PMID:25979313
Biological Process angiogenesis IGI MGI:MGI:107451 2290270 (MGI:MGI:3610693, PMID:16314520) MGI MGI:MGI:3610693 , PMID:16314520 G protein-coupled receptor signaling pathway ISO RGD:3346 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 inositol trisphosphate biosynthetic process IBA MGI:MGI:97616 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 inositol trisphosphate biosynthetic process IBA MGI:MGI:97616 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 intracellular signal transduction IEA InterPro:IPR001192 , InterPro:IPR001711 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 labyrinthine layer blood vessel development IGI MGI:MGI:107451 2290270 (MGI:MGI:3610693, PMID:16314520) MGI MGI:MGI:3610693 , PMID:16314520 lipid catabolic process IEA UniProtKB-KW:KW-0442 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 lipid metabolic process IEA UniProtKB-KW:KW-0443 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 lipid metabolic process IEA InterPro:IPR001711 , InterPro:IPR017946 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 phosphatidylinositol-mediated signaling IBA PANTHER:PTN000036885 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway ISO RGD:3346 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 positive regulation of inositol trisphosphate biosynthetic process ISO RGD:3346 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 positive regulation of norepinephrine secretion ISO RGD:3346 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 regulation of cell population proliferation IGI MGI:MGI:107451 2290270 (MGI:MGI:3610693, PMID:16314520) MGI MGI:MGI:3610693 , PMID:16314520 regulation of cytosolic calcium ion concentration ISO RGD:3346 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 regulation of phospholipase C activity ISO RGD:3346 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 release of sequestered calcium ion into cytosol IBA MGI:MGI:97616 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 response to calcium ion ISO RGD:3346 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 response to peptide hormone ISO RGD:3346 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 signal transduction IEA InterPro:IPR001711 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 signal transduction IEA UniProtKB-KW:KW-0807 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 Cellular Component cytoplasm ISO UniProtKB:P51178 2290270 (MGI:MGI:3696645, PMID:15702972) MGI MGI:MGI:3696645 , PMID:15702972 cytoplasm IDA 2290270 (MGI:MGI:5520128, PMID:23892088) MGI MGI:MGI:5520128 , PMID:23892088 cytosol IDA 2290270 (MGI:MGI:3590438, PMID:15899900) MGI MGI:MGI:3590438 , PMID:15899900 cytosol ISO RGD:3346 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 membrane ISO RGD:3346 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 membrane raft ISO RGD:3346 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 mitochondrial membrane ISO RGD:3346 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 nucleus ISO RGD:3346 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 Molecular Function calcium ion binding ISO RGD:3346 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 calcium-dependent phospholipid binding ISO RGD:3346 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 GTPase activating protein binding ISO UniProtKB:P51178 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 hydrolase activity IEA UniProtKB-KW:KW-0378 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 inositol 1,4,5 trisphosphate binding ISO RGD:3346 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 metal ion binding IEA UniProtKB-KW:KW-0479 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 phosphatidic acid binding IDA 2290270 (MGI:MGI:5520128, PMID:23892088) MGI MGI:MGI:5520128 , PMID:23892088 phosphatidylinositol phosphate binding IDA 2290270 (MGI:MGI:5520128, PMID:23892088) MGI MGI:MGI:5520128 , PMID:23892088 phosphatidylinositol phospholipase C activity ISO RGD:3346 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 phosphatidylinositol phospholipase C activity IBA MGI:MGI:97613 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 phosphatidylinositol phospholipase C activity IBA PANTHER:PTN002569901 , RGD:3346 2290270 (PMID:21873635) GO_Central PMID:21873635 phosphatidylinositol-4,5-bisphosphate binding ISO UniProtKB:P51178 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 phosphatidylinositol-4,5-bisphosphate binding IBA PANTHER:PTN002569901 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 phosphatidylinositol-4,5-bisphosphate binding ISO RGD:3346 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 phosphatidylserine binding NOT IDA 2290270 (MGI:MGI:5520128, PMID:23892088) MGI MGI:MGI:5520128 , PMID:23892088 phosphatidylserine binding IDA 2290270 (MGI:MGI:5520128, PMID:23892088) MGI MGI:MGI:5520128 , PMID:23892088 phospholipase C activity IDA 2290270 (MGI:MGI:5520128, PMID:23892088) MGI MGI:MGI:5520128 , PMID:23892088 phospholipid binding ISO RGD:3346 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 phosphoric diester hydrolase activity IEA InterPro:IPR017946 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 protein binding IPI UniProtKB:E9Q9D5 2290270 (MGI:MGI:5468889, PMID:23055941) MGI MGI:MGI:5468889 , PMID:23055941
Gene-Chemical Interaction Annotations
