RGD Reference Report - Novel regulation of PLCzeta activity via its XY-linker. - Rat Genome Database

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Novel regulation of PLCzeta activity via its XY-linker.

Authors: Nomikos, M  Elgmati, K  Theodoridou, M  Georgilis, A  Gonzalez-Garcia, JR  Nounesis, G  Swann, K  Lai, FA 
Citation: Nomikos M, etal., Biochem J. 2011 Sep 15;438(3):427-32. doi: 10.1042/BJ20110953.
RGD ID: 7349319
Pubmed: PMID:21767260   (View Abstract at PubMed)
PMCID: PMC3195331   (View Article at PubMed Central)
DOI: DOI:10.1042/BJ20110953   (Journal Full-text)

The XY-linker region of somatic cell PLC (phospholipase)-beta, -gamma, -delta and -epsilon isoforms confers potent catalytic inhibition, suggesting a common auto-regulatory role. Surprisingly, the sperm PLCzeta XY-linker does not mediate auto-inhibition. Unlike for somatic PLCs, the absence of the PLCzeta XY-linker significantly diminishes both in vitro PIP2 (phosphatidylinositol 4,5-bisphosphate) hydrolysis and in vivo Ca2+-oscillation-inducing activity, revealing evidence for a novel PLCzeta enzymatic mechanism.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
regulation of cytosolic calcium ion concentration  IMP 7349319 RGD 
regulation of phospholipase C activity  IMP 7349319 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Plcd1  (phospholipase C, delta 1)


Additional Information