Axin1 (axin 1) - Rat Genome Database

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Gene: Axin1 (axin 1) Rattus norvegicus
Symbol: Axin1
Name: axin 1
RGD ID: 620859
Description: ENCODES a protein that exhibits armadillo repeat domain binding; beta-catenin binding; identical protein binding; INVOLVED IN negative regulation of canonical Wnt signaling pathway; positive regulation of protein kinase activity; positive regulation of ubiquitin-dependent protein catabolic process; PARTICIPATES IN altered Wnt signaling, canonical pathway; colorectal cancer pathway; N-cadherin signaling pathway; ASSOCIATED WITH Caudal Duplication Anomaly (ortholog); Colorectal Neoplasms (ortholog); hepatocellular carcinoma (ortholog); FOUND IN beta-catenin destruction complex; cytoplasmic vesicle; Golgi apparatus; INTERACTS WITH 2,4-dinitrotoluene; ammonium chloride; bisphenol A
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Axin; axin-1; axis inhibition protein 1; GSK-3beta interacting protein rAxin; rAxin
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21015,163,684 - 15,215,615 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1015,163,684 - 15,215,615 (+)Ensembl
Rnor_5.01015,324,330 - 15,376,252 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41015,409,373 - 15,462,726 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11015,410,421 - 15,463,774 (+)NCBI
Celera1014,831,660 - 14,883,421 (+)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase activity  (ISO)
adult walking behavior  (ISO)
apoptotic process  (IEA)
axial mesoderm development  (ISO)
axial mesoderm formation  (ISO)
canonical Wnt signaling pathway  (ISO)
cellular protein-containing complex assembly  (ISO)
cytoplasmic microtubule organization  (ISO)
dorsal/ventral axis specification  (ISO)
dorsal/ventral pattern formation  (ISO)
embryonic skeletal joint morphogenesis  (ISO)
erythrocyte homeostasis  (ISO)
genetic imprinting  (ISO)
head development  (ISO)
hemoglobin metabolic process  (ISO)
in utero embryonic development  (ISO)
negative regulation of canonical Wnt signaling pathway  (IDA,ISO)
negative regulation of fat cell differentiation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of protein metabolic process  (ISO)
negative regulation of transcription elongation from RNA polymerase II promoter  (ISO)
negative regulation of Wnt signaling pathway  (ISO,TAS)
nervous system process  (ISO)
nucleocytoplasmic transport  (ISO)
positive regulation of JNK cascade  (ISO,ISS)
positive regulation of JUN kinase activity  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of peptidyl-threonine phosphorylation  (ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (ISO)
positive regulation of protein catabolic process  (ISO)
positive regulation of protein kinase activity  (IDA,ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of protein ubiquitination  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
positive regulation of transforming growth factor beta receptor signaling pathway  (ISO)
positive regulation of ubiquitin-dependent protein catabolic process  (IDA,ISO)
positive regulation of ubiquitin-protein transferase activity  (ISO)
post-anal tail morphogenesis  (ISO)
protein catabolic process  (ISO)
protein polyubiquitination  (ISO)
regulation of canonical Wnt signaling pathway  (ISO)
regulation of protein phosphorylation  (ISO)
sensory perception of sound  (ISO)
Wnt signaling pathway  (ISO)


References - curated
1. Chen HJ, etal., Genes Dev. 2006 Jul 15;20(14):1933-45. Epub 2006 Jun 30.
2. GOA data from the GO Consortium
3. Hino S, etal., Mol Cell Biol 2001 Jan;21(1):330-42.
4. Hirabayashi S, etal., J Neurochem 2004 Jul;90(2):332-9.
5. Ikeda S, etal., EMBO J 1998 Mar 2;17(5):1371-84.
6. Kadoya T, etal., J Biol Chem 2000 Nov 24;275(47):37030-7.
7. Kim SI, etal., Biochem Biophys Res Commun 2004 Apr 30;317(2):478-83.
8. Kishida M, etal., J Biol Chem. 2001 Aug 31;276(35):33147-55. Epub 2001 Jun 25.
9. Kishida S, etal., Mol Cell Biol. 1999 Jun;19(6):4414-22.
10. Kitagawa M, etal., EMBO J. 1999 May 4;18(9):2401-10.
11. Klaus A and Birchmeier W, Nat Rev Cancer. 2008 May;8(5):387-98.
12. MGD data from the GO Consortium
13. NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. OMIM Disease Annotation Pipeline
15. Pipeline to import KEGG annotations from KEGG into RGD
16. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
17. RGD automated data pipeline
18. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. RGD automated import pipeline for gene-chemical interactions
20. Satoh S, etal., Nat Genet 2000 Mar;24(3):245-50.
21. Schwarz-Romond T, etal., Nat Struct Mol Biol. 2007 Jun;14(6):484-92. Epub 2007 May 27.
22. Tanneberger K, etal., EMBO J. 2011 Apr 20;30(8):1433-43. doi: 10.1038/emboj.2011.28. Epub 2011 Feb 8.
23. Yamamoto H, etal., Dev Cell. 2006 Aug;11(2):213-23.
Additional References at PubMed
PMID:9230313   PMID:9601641   PMID:9920888   PMID:10318824   PMID:10330403   PMID:10581160   PMID:10644691   PMID:10937998   PMID:11955436   PMID:12072559   PMID:12138115   PMID:12601169  
PMID:12717450   PMID:12817302   PMID:12878610   PMID:14734535   PMID:14981260   PMID:15526030   PMID:15579909   PMID:16169070   PMID:16188939   PMID:16601693   PMID:17554179   PMID:17569865  
PMID:17681137   PMID:18076571   PMID:18316368   PMID:18593713   PMID:18606656   PMID:18632848   PMID:19038973   PMID:19075000   PMID:19204372   PMID:19513548   PMID:19759537   PMID:21003499  
PMID:21245303   PMID:21344612   PMID:21383061   PMID:21478859   PMID:22899650   PMID:23588680   PMID:27697743   PMID:33582657  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21015,163,684 - 15,215,615 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1015,163,684 - 15,215,615 (+)Ensembl
Rnor_5.01015,324,330 - 15,376,252 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41015,409,373 - 15,462,726 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11015,410,421 - 15,463,774 (+)NCBI
Celera1014,831,660 - 14,883,421 (+)NCBICelera
Cytogenetic Map10q12NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl16287,440 - 352,723 (-)EnsemblGRCh38hg38GRCh38
GRCh3816287,440 - 355,226 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3716337,440 - 402,723 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3616277,441 - 342,465 (-)NCBINCBI36hg18NCBI36
Build 3416277,440 - 342,465NCBI
Celera16537,339 - 602,420 (-)NCBI
Cytogenetic Map16p13.3NCBI
HuRef16255,743 - 344,360 (-)NCBIHuRef
CHM1_116337,402 - 402,637 (-)NCBICHM1_1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391726,350,208 - 26,414,785 (+)NCBIGRCm39mm39
GRCm39 Ensembl1726,357,662 - 26,414,785 (+)Ensembl
GRCm381726,131,217 - 26,195,811 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1726,138,688 - 26,195,811 (+)EnsemblGRCm38mm10GRCm38
MGSCv371726,275,631 - 26,332,756 (+)NCBIGRCm37mm9NCBIm37
MGSCv361725,866,334 - 25,923,411 (+)NCBImm8
Celera1726,676,271 - 26,729,569 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1713.07NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495544216,843,152 - 16,898,430 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544216,845,728 - 16,898,301 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.116278,239 - 337,891 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl16278,239 - 337,891 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1640,155,797 - 40,218,330 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl640,158,244 - 40,218,343 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha641,419,076 - 41,481,969 (+)NCBI
ROS_Cfam_1.0640,497,801 - 40,560,709 (+)NCBI
UMICH_Zoey_3.1640,186,114 - 40,248,973 (+)NCBI
UNSW_CanFamBas_1.0640,146,325 - 40,210,047 (+)NCBI
UU_Cfam_GSD_1.0640,625,599 - 40,688,493 (+)NCBI
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024409344112,502,114 - 112,535,977 (+)NCBI
SpeTri2.0NW_004936501599,963 - 633,837 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl341,337,071 - 41,393,997 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1341,344,908 - 41,393,999 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2341,033,961 - 41,085,857 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.15233,520 - 295,134 (-)NCBI
ChlSab1.1 Ensembl5234,060 - 290,575 (-)Ensembl
Vero_WHO_p1.0NW_02366606830,878,427 - 30,943,289 (+)NCBI
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_0046249131,139,165 - 1,195,477 (-)NCBI

Position Markers
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01015,328,132 - 15,328,789UniSTSRnor5.0
RGSC_v3.41015,413,175 - 15,413,832UniSTSRGSC3.4
Celera1014,835,340 - 14,835,997UniSTS
Cytogenetic Map10q12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2879,432,715 - 79,432,861 (+)MAPPERmRatBN7.2
Rnor_6.0885,929,741 - 85,929,886NCBIRnor6.0
Rnor_5.0885,479,029 - 85,479,174UniSTSRnor5.0
Rnor_5.01015,338,242 - 15,338,627UniSTSRnor5.0
RGSC_v3.4883,554,738 - 83,554,883UniSTSRGSC3.4
RGSC_v3.41015,423,288 - 15,423,673UniSTSRGSC3.4
Celera879,178,666 - 79,178,811UniSTS
Celera1014,845,408 - 14,845,792UniSTS
RH 3.4 Map8924.2UniSTS
Cytogenetic Map10q12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01015,324,875 - 15,325,092UniSTSRnor5.0
RGSC_v3.41015,409,918 - 15,410,135UniSTSRGSC3.4
Celera1014,832,083 - 14,832,300UniSTS
Cytogenetic Map10q12UniSTS

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10124158324Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
1576304Schws7Schwannoma susceptibility QTL 70.0115nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)10476552719816042Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402717245662Rat
737820Alc9Alcohol consumption QTL 92.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402719233348Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10615418215990232Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:226
Count of miRNA genes:123
Interacting mature miRNAs:147
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.



Reference Sequences
RefSeq Acc Id: ENSRNOT00000112116   ⟹   ENSRNOP00000094080
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1015,163,684 - 15,215,615 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000115321   ⟹   ENSRNOP00000083350
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1015,163,684 - 15,215,615 (+)Ensembl
RefSeq Acc Id: NM_024405   ⟹   NP_077381
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.21015,163,684 - 15,215,615 (+)NCBI
Rnor_5.01015,324,330 - 15,376,252 (+)NCBI
RGSC_v3.41015,409,373 - 15,462,726 (+)RGD
Celera1014,831,660 - 14,883,421 (+)RGD
Protein Sequences
Protein RefSeqs NP_077381 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC40066 (Get FASTA)   NCBI Sequence Viewer  
  EDM03995 (Get FASTA)   NCBI Sequence Viewer  
  EDM03996 (Get FASTA)   NCBI Sequence Viewer  
  EDM03997 (Get FASTA)   NCBI Sequence Viewer  
  O70239 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_077381   ⟸   NM_024405
- UniProtKB: O70239 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000083350   ⟸   ENSRNOT00000115321
RefSeq Acc Id: ENSRNOP00000094080   ⟸   ENSRNOT00000112116
Protein Domains


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSRNOG00000062714 Ensembl
Gene3D-CATH UniProtKB/Swiss-Prot UniProtKB/Swiss-Prot
InterPro Axin-like UniProtKB/Swiss-Prot
  AXIN1 UniProtKB/Swiss-Prot
  Axin_b-cat-bd UniProtKB/Swiss-Prot
  Axin_TNKS-bd UniProtKB/Swiss-Prot
  DIX UniProtKB/Swiss-Prot
  DIX_dom_sf UniProtKB/Swiss-Prot
  RGS UniProtKB/Swiss-Prot
  RGS_sf UniProtKB/Swiss-Prot
  RGS_subdom1/3 UniProtKB/Swiss-Prot
  Ubiquitin-like_domsf UniProtKB/Swiss-Prot
KEGG Report rno:79257 UniProtKB/Swiss-Prot
PANTHER PTHR46102 UniProtKB/Swiss-Prot
  PTHR46102:SF3 UniProtKB/Swiss-Prot
Pfam AXIN1_TNKS_BD UniProtKB/Swiss-Prot
  Axin_b-cat_bind UniProtKB/Swiss-Prot
  DIX UniProtKB/Swiss-Prot
  RGS UniProtKB/Swiss-Prot
PhenoGen Axin1 PhenoGen
PROSITE DIX UniProtKB/Swiss-Prot
  RGS UniProtKB/Swiss-Prot
SMART DAX UniProtKB/Swiss-Prot
  RGS UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48097 UniProtKB/Swiss-Prot
  SSF54236 UniProtKB/Swiss-Prot
UniProt AXIN1_RAT UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-12-14 Axin1  axin 1  Axin  GSK-3beta interacting protein rAxin  Symbol and Name updated 1299863 APPROVED
2002-08-07 Axin  GSK-3beta interacting protein rAxin      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains Regulators of G protein Signaling (RGS) and dishevelled (Dsh) homologous domains in its N- and C-terminals, respectively 632259
gene_homology amino acid level shows 94% identity to mouse Axin 632259
gene_physical_interaction forms a complex with synaptic scaffolding molecule S-SCAM and beta-catenin 1304344
gene_protein 832 amino acids 632259