AXIN1 (axin 1) - Rat Genome Database
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Gene: AXIN1 (axin 1) Pan paniscus
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Symbol: AXIN1
Name: axin 1
RGD ID: 11776712
Description: ENCODES a protein that exhibits armadillo repeat domain binding (ortholog); beta-catenin binding (ortholog); enzyme binding (ortholog); INVOLVED IN activation of protein kinase activity (ortholog); adult walking behavior (ortholog); axial mesoderm development (ortholog); PARTICIPATES IN altered Wnt signaling, canonical pathway; colorectal cancer pathway; N-cadherin signaling pathway; ASSOCIATED WITH Caudal Duplication Anomaly (ortholog); hepatocellular carcinoma (ortholog); FOUND IN beta-catenin destruction complex (ortholog); cell cortex (ortholog); cell periphery (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: axin-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.116278,239 - 337,891 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl16278,239 - 337,891 (-)Ensemblpanpan1.1panPan2


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase activity  (ISO)
adult walking behavior  (ISO)
axial mesoderm development  (ISO)
axial mesoderm formation  (ISO)
canonical Wnt signaling pathway  (ISO)
cellular protein-containing complex assembly  (ISO)
cytoplasmic microtubule organization  (ISO)
dorsal/ventral axis specification  (ISO)
dorsal/ventral pattern formation  (ISO)
embryonic skeletal joint morphogenesis  (ISO)
erythrocyte homeostasis  (ISO)
genetic imprinting  (ISO)
head development  (ISO)
hemoglobin metabolic process  (ISO)
in utero embryonic development  (ISO)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of fat cell differentiation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of protein metabolic process  (ISO)
negative regulation of transcription elongation from RNA polymerase II promoter  (ISO)
negative regulation of Wnt signaling pathway  (ISO)
nervous system process  (ISO)
nucleocytoplasmic transport  (ISO)
positive regulation of JNK cascade  (ISO)
positive regulation of JUN kinase activity  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of peptidyl-threonine phosphorylation  (ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (ISO)
positive regulation of protein catabolic process  (ISO)
positive regulation of protein kinase activity  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of protein ubiquitination  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
positive regulation of transforming growth factor beta receptor signaling pathway  (ISO)
positive regulation of ubiquitin-dependent protein catabolic process  (ISO)
positive regulation of ubiquitin-protein transferase activity  (ISO)
post-anal tail morphogenesis  (ISO)
protein catabolic process  (ISO)
protein polyubiquitination  (ISO)
regulation of canonical Wnt signaling pathway  (ISO)
regulation of protein phosphorylation  (ISO)
sensory perception of sound  (ISO)
Wnt signaling pathway  (ISO)

References

Genomics

Comparative Map Data
AXIN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.116278,239 - 337,891 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl16278,239 - 337,891 (-)Ensemblpanpan1.1panPan2
AXIN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl16287,440 - 352,723 (-)EnsemblGRCh38hg38GRCh38
GRCh3816287,440 - 355,226 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3716337,440 - 402,723 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3616277,441 - 342,465 (-)NCBINCBI36hg18NCBI36
Build 3416277,440 - 342,465NCBI
Celera16537,339 - 602,420 (-)NCBI
Cytogenetic Map16p13.3NCBI
HuRef16255,743 - 344,360 (-)NCBIHuRef
CHM1_116337,402 - 402,637 (-)NCBICHM1_1
Axin1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391726,350,208 - 26,414,785 (+)NCBIGRCm39mm39
GRCm39 Ensembl1726,357,662 - 26,414,785 (+)Ensembl
GRCm381726,131,217 - 26,195,811 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1726,138,688 - 26,195,811 (+)EnsemblGRCm38mm10GRCm38
MGSCv371726,275,631 - 26,332,756 (+)NCBIGRCm37mm9NCBIm37
MGSCv361725,866,334 - 25,923,411 (+)NCBImm8
Celera1726,676,271 - 26,729,569 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1713.07NCBI
Axin1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21015,163,684 - 15,215,615 (+)NCBI
Rnor_5.01015,324,330 - 15,376,252 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41015,409,373 - 15,462,726 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11015,410,421 - 15,463,774 (+)NCBI
Celera1014,831,660 - 14,883,421 (+)NCBICelera
Cytogenetic Map10q12NCBI
Axin1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544216,843,152 - 16,898,430 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544216,845,728 - 16,898,301 (+)NCBIChiLan1.0ChiLan1.0
AXIN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl640,158,244 - 40,218,343 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1640,155,797 - 40,218,330 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Axin1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936501599,963 - 633,837 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AXIN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl341,337,071 - 41,393,997 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1341,344,908 - 41,393,999 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2341,033,961 - 41,085,857 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AXIN1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.15233,520 - 295,134 (-)NCBI
ChlSab1.1 Ensembl5234,060 - 290,575 (-)Ensembl
Axin1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249131,139,165 - 1,195,477 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000038854   ⟹   ENSPPAP00000016161
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl16278,239 - 337,891 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000038858   ⟹   ENSPPAP00000016165
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl16278,239 - 337,890 (-)Ensembl
RefSeq Acc Id: XM_003809400   ⟹   XP_003809448
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.116278,239 - 337,891 (-)NCBI
Sequence:
RefSeq Acc Id: XM_003809401   ⟹   XP_003809449
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.116278,239 - 337,890 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_034807496 (Get FASTA)   NCBI Sequence Viewer  
  XP_034807497 (Get FASTA)   NCBI Sequence Viewer  
  XP_034807498 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003809448   ⟸   XM_003809400
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_003809449   ⟸   XM_003809401
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSPPAP00000016165   ⟸   ENSPPAT00000038858
RefSeq Acc Id: ENSPPAP00000016161   ⟸   ENSPPAT00000038854
Protein Domains
DIX   RGS


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000031188 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000016161 UniProtKB/TrEMBL
  ENSPPAP00000016165 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000038854 UniProtKB/TrEMBL
  ENSPPAT00000038858 UniProtKB/TrEMBL
Gene3D-CATH 1.10.196.10 UniProtKB/TrEMBL
  3.10.20.380 UniProtKB/TrEMBL
InterPro Axin-like UniProtKB/TrEMBL
  AXIN1 UniProtKB/TrEMBL
  Axin_b-cat-bd UniProtKB/TrEMBL
  Axin_TNKS-bd UniProtKB/TrEMBL
  DIX UniProtKB/TrEMBL
  DIX_dom_sf UniProtKB/TrEMBL
  RGS UniProtKB/TrEMBL
  RGS_sf UniProtKB/TrEMBL
  RGS_subdom1/3 UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/TrEMBL
KEGG Report pps:100986279 UniProtKB/TrEMBL
NCBI Gene AXIN1 ENTREZGENE
PANTHER PTHR46102 UniProtKB/TrEMBL
  PTHR46102:SF3 UniProtKB/TrEMBL
Pfam AXIN1_TNKS_BD UniProtKB/TrEMBL
  Axin_b-cat_bind UniProtKB/TrEMBL
  DIX UniProtKB/TrEMBL
  RGS UniProtKB/TrEMBL
PRINTS RGSPROTEIN UniProtKB/TrEMBL
PROSITE DIX UniProtKB/TrEMBL
  RGS UniProtKB/TrEMBL
SMART DAX UniProtKB/TrEMBL
  RGS UniProtKB/TrEMBL
Superfamily-SCOP SSF48097 UniProtKB/TrEMBL
  SSF54236 UniProtKB/TrEMBL
UniProt A0A2R9AFS0_PANPA UniProtKB/TrEMBL
  A0A2R9AKJ4_PANPA UniProtKB/TrEMBL