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Gene: AXIN1 (axin 1) Homo sapiens
Symbol: AXIN1
Name: axin 1
Description: Exhibits several functions, including I-SMAD binding activity; beta-catenin binding activity; and ubiquitin protein ligase binding activity. Involved in cellular protein-containing complex assembly; negative regulation of canonical Wnt signaling pathway; and positive regulation of macromolecule metabolic process. Localizes to several cellular components, including the beta-catenin destruction complex; lateral plasma membrane; and perinuclear region of cytoplasm. Implicated in hepatocellular carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AXIN; axin-1; axis inhibition protein 1; axis inhibitor 1; fused, mouse, homolog of; gsk-3beta interacting protein raxin; hAxin; MGC52315; PPP1R49; protein phosphatase 1, regulatory subunit 49
Mus musculus (house mouse) : Axin1 (axin 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Axin1 (axin 1)
Chinchilla lanigera (long-tailed chinchilla) : Axin1 (axin 1)
Pan paniscus (bonobo/pygmy chimpanzee) : AXIN1 (axin 1)
Canis lupus familiaris (dog) : AXIN1 (axin 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Axin1 (axin 1)
Sus scrofa (pig) : AXIN1 (axin 1)
Chlorocebus sabaeus (green monkey) : AXIN1 (axin 1)
Heterocephalus glaber (naked mole-rat) : Axin1 (axin 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl16287,440 - 352,723 (-)Ensembl
GRCh3816287,440 - 355,226 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3716337,440 - 405,244 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3616277,441 - 342,465 (-)NCBINCBI36hg18NCBI36
Build 3416277,440 - 342,465NCBI
Celera16537,339 - 602,420 (-)NCBI
Cytogenetic Map16p13.3NCBI
HuRef16255,743 - 344,360 (-)NCBIHuRef
CHM1_116337,402 - 402,637 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on AXIN1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736564
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.