Axin1 (axin 1) - Rat Genome Database

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Gene: Axin1 (axin 1) Heterocephalus glaber
Analyze
Symbol: Axin1
Name: axin 1
RGD ID: 18913434
Description: ENCODES a protein that exhibits armadillo repeat domain binding (ortholog); beta-catenin binding (ortholog); identical protein binding (ortholog); INVOLVED IN activation of protein kinase activity (ortholog); adult walking behavior (ortholog); axial mesoderm development (ortholog); PARTICIPATES IN altered Wnt signaling, canonical pathway; colorectal cancer pathway; N-cadherin signaling pathway; ASSOCIATED WITH Caudal Duplication Anomaly (ortholog); colon cancer (ortholog); CRANIOMETADIAPHYSEAL OSTEOSCLEROSIS WITH HIP DYSPLASIA (ortholog); FOUND IN Golgi apparatus (ortholog); synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Axin-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249131,139,165 - 1,195,230 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249131,139,165 - 1,195,477 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase activity  (ISO)
adult walking behavior  (ISO)
axial mesoderm development  (IEA,ISO)
axial mesoderm formation  (IEA,ISO)
beta-catenin destruction complex assembly  (ISO)
canonical Wnt signaling pathway  (IEA,ISO)
cell development  (IEA)
cytoplasmic microtubule organization  (IEA,ISO)
dorsal/ventral axis specification  (IEA,ISO)
dorsal/ventral pattern formation  (IEA,ISO)
embryonic skeletal joint morphogenesis  (ISO)
epigenetic programming in the zygotic pronuclei  (IEA,ISO)
erythrocyte homeostasis  (ISO)
head development  (IEA,ISO)
hemoglobin metabolic process  (ISO)
in utero embryonic development  (IEA,ISO)
negative regulation of canonical Wnt signaling pathway  (IEA,ISO)
negative regulation of fat cell differentiation  (IEA,ISO)
negative regulation of gene expression  (IEA,ISO)
negative regulation of protein metabolic process  (IEA,ISO)
negative regulation of transcription elongation by RNA polymerase II  (IEA,ISO)
negative regulation of Wnt signaling pathway  (IEA,ISO)
nervous system process  (ISO)
nucleocytoplasmic transport  (IEA,ISO)
positive regulation of JNK cascade  (IEA,ISO)
positive regulation of JUN kinase activity  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of peptidyl-threonine phosphorylation  (ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (IEA,ISO)
positive regulation of protein catabolic process  (IEA)
positive regulation of protein kinase activity  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of protein ubiquitination  (IEA,ISO)
positive regulation of transforming growth factor beta receptor signaling pathway  (IEA,ISO)
positive regulation of ubiquitin-dependent protein catabolic process  (IEA,ISO)
post-anal tail morphogenesis  (IEA,ISO)
protein catabolic process  (IEA,ISO)
protein polyubiquitination  (IEA,ISO)
protein-containing complex assembly  (IEA)
regulation of canonical Wnt signaling pathway  (IEA,ISO)
regulation of protein phosphorylation  (ISO)
response to quercetin  (ISO)
sensory perception of sound  (IEA,ISO)
Wnt signaling pathway  (IEA,ISO)

References
Additional References at PubMed
PMID:21993625   PMID:30032202  


Genomics

Comparative Map Data
Axin1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249131,139,165 - 1,195,230 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249131,139,165 - 1,195,477 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
AXIN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3816287,440 - 352,723 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl16287,440 - 352,723 (-)EnsemblGRCh38hg38GRCh38
GRCh3716337,440 - 402,723 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3616277,441 - 342,465 (-)NCBINCBI36Build 36hg18NCBI36
Build 3416277,440 - 342,465NCBI
Celera16537,339 - 602,420 (-)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef16255,743 - 344,360 (-)NCBIHuRef
CHM1_116337,402 - 402,637 (-)NCBICHM1_1
T2T-CHM13v2.016282,313 - 347,596 (-)NCBIT2T-CHM13v2.0
Axin1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391726,350,294 - 26,414,784 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1726,357,662 - 26,414,785 (+)EnsemblGRCm39 Ensembl
GRCm381726,131,217 - 26,195,811 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1726,138,688 - 26,195,811 (+)EnsemblGRCm38mm10GRCm38
MGSCv371726,275,631 - 26,332,756 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361725,866,334 - 25,923,411 (+)NCBIMGSCv36mm8
Celera1726,676,271 - 26,729,569 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1713.07NCBI
Axin1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81015,667,894 - 15,720,092 (+)NCBIGRCr8
mRatBN7.21015,163,477 - 15,215,615 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1015,163,684 - 15,215,615 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1019,903,082 - 19,955,387 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01019,391,961 - 19,444,266 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01014,891,384 - 14,943,546 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_5.01015,324,330 - 15,376,252 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41015,409,373 - 15,462,726 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11015,410,421 - 15,463,774 (+)NCBI
Celera1014,831,660 - 14,883,421 (+)NCBICelera
Cytogenetic Map10q12NCBI
Axin1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544216,843,152 - 16,898,430 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544216,845,728 - 16,898,301 (+)NCBIChiLan1.0ChiLan1.0
AXIN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v218506,910 - 581,764 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1164,299,164 - 4,372,528 (-)NCBINHGRI_mPanPan1
PanPan1.116278,239 - 337,891 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl16278,239 - 337,891 (-)Ensemblpanpan1.1panPan2
AXIN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1640,155,797 - 40,218,330 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl640,158,244 - 40,218,343 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha641,419,076 - 41,481,969 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0640,497,801 - 40,560,709 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl640,500,504 - 40,560,706 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1640,186,114 - 40,248,973 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0640,146,325 - 40,210,047 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0640,625,599 - 40,688,493 (+)NCBIUU_Cfam_GSD_1.0
Axin1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344112,502,114 - 112,535,977 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936501599,919 - 633,873 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936501599,963 - 633,837 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AXIN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl341,337,071 - 41,393,997 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1341,344,908 - 41,393,999 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2341,033,961 - 41,085,857 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AXIN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.15233,520 - 295,134 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl5234,060 - 290,575 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606830,878,427 - 30,943,289 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000005132   ⟹   ENSHGLP00000005066
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046249131,139,165 - 1,195,230 (-)Ensembl
Ensembl Acc Id: ENSHGLT00000005133   ⟹   ENSHGLP00000005067
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046249131,139,165 - 1,195,151 (-)Ensembl
Ensembl Acc Id: ENSHGLT00000005134   ⟹   ENSHGLP00000005068
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046249131,151,658 - 1,191,182 (-)Ensembl
RefSeq Acc Id: XM_004873701   ⟹   XP_004873758
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046249131,139,165 - 1,195,477 (-)NCBI
RefSeq Acc Id: XM_004873702   ⟹   XP_004873759
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046249131,139,165 - 1,195,186 (-)NCBI
RefSeq Acc Id: XM_021251405   ⟹   XP_021107064
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046249131,139,165 - 1,195,275 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004873758 (Get FASTA)   NCBI Sequence Viewer  
  XP_004873759 (Get FASTA)   NCBI Sequence Viewer  
  XP_021107064 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB14135 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000005066
  ENSHGLP00000005067
  ENSHGLP00100020729
GenBank Protein JAO02537 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_004873758   ⟸   XM_004873701
- Peptide Label: isoform X1
- UniProtKB: G5BXX4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021107064   ⟸   XM_021251405
- Peptide Label: isoform X2
RefSeq Acc Id: XP_004873759   ⟸   XM_004873702
- Peptide Label: isoform X1
- UniProtKB: G5BXX4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000005067   ⟸   ENSHGLT00000005133
Ensembl Acc Id: ENSHGLP00000005066   ⟸   ENSHGLT00000005132
Ensembl Acc Id: ENSHGLP00000005068   ⟸   ENSHGLT00000005134


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000003717 Ensembl, ENTREZGENE
  ENSHGLG00100015276 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000005132 ENTREZGENE
  ENSHGLT00000005133 ENTREZGENE
  ENSHGLT00100020951 UniProtKB/TrEMBL
Gene3D-CATH 1.10.167.10 UniProtKB/TrEMBL
  1.10.196.10 UniProtKB/TrEMBL
  2.40.240.130 UniProtKB/TrEMBL
InterPro Axin-like UniProtKB/TrEMBL
  Axin_b-cat-bd UniProtKB/TrEMBL
  Axin_TNKS-bd UniProtKB/TrEMBL
  DIX UniProtKB/TrEMBL
  DIX_dom_sf UniProtKB/TrEMBL
  RGS UniProtKB/TrEMBL
  RGS_sf UniProtKB/TrEMBL
  RGS_subdom1/3 UniProtKB/TrEMBL
  RGS_subdomain_2 UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/TrEMBL
KEGG Report hgl:101700795 UniProtKB/TrEMBL
NCBI Gene Axin1 ENTREZGENE
PANTHER PTHR46102 UniProtKB/TrEMBL
  PTHR46102:SF3 UniProtKB/TrEMBL
Pfam AXIN1_TNKS_BD UniProtKB/TrEMBL
  Axin_b-cat_bind UniProtKB/TrEMBL
  DIX UniProtKB/TrEMBL
  RGS UniProtKB/TrEMBL
PRINTS RGSPROTEIN UniProtKB/TrEMBL
PROSITE DIX UniProtKB/TrEMBL
  RGS UniProtKB/TrEMBL
SMART DAX UniProtKB/TrEMBL
  RGS UniProtKB/TrEMBL
Superfamily-SCOP SSF48097 UniProtKB/TrEMBL
  SSF54236 UniProtKB/TrEMBL
UniProt G5BXX4 ENTREZGENE, UniProtKB/TrEMBL