Vwf (von Willebrand factor) - Rat Genome Database

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Gene: Vwf (von Willebrand factor) Rattus norvegicus
Analyze
Symbol: Vwf
Name: von Willebrand factor
RGD ID: 621759
Description: Predicted to enable several functions, including identical protein binding activity; integrin binding activity; and protein-folding chaperone binding activity. Involved in several processes, including cellular response to lipopolysaccharide; liver regeneration; and response to L-ascorbic acid. Located in collagen-containing extracellular matrix and extracellular space. Used to study transient cerebral ischemia. Biomarker of hypertension; mesangial proliferative glomerulonephritis; myocardial infarction; pulmonary fibrosis; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; Bernard-Soulier syndrome; end stage renal disease; essential thrombocythemia; and von Willebrand's disease (multiple). Orthologous to human VWF (von Willebrand factor); PARTICIPATES IN platelet aggregation pathway; cell-extracellular matrix signaling pathway; coagulation cascade pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: von Willebrand factor homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Vwfem2Mcwi   Vwfem3Mcwi   Vwfem1Mcwi   Vwfem4Mcwi  
Genetic Models: SS-Vwfem2Mcwi-/- SD-Vwfem1Mcwi-/- SS-Vwfem3Mcwi-/- SS-Vwfem4Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84160,042,900 - 160,177,757 (+)NCBIGRCr8
mRatBN7.24158,360,152 - 158,491,539 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4158,360,152 - 158,491,539 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4164,595,998 - 164,727,404 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04160,378,929 - 160,510,343 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04159,012,985 - 159,144,157 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04158,085,059 - 158,219,525 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4158,088,505 - 158,219,523 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04225,098,521 - 225,229,257 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44161,723,415 - 161,854,766 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14162,053,065 - 162,055,090 (+)NCBI
Celera4147,092,791 - 147,223,711 (+)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Experimental Pancreatitis  (IEP)
Aortic Injuries  (IEP)
atrial fibrillation  (ISO)
autism spectrum disorder  (ISO)
autosomal hemophilia A  (ISO)
Behcet's disease  (ISO)
Bernard-Soulier syndrome  (ISO)
bipolar disorder  (ISO)
blood coagulation disease  (ISO)
cardiovascular system disease  (ISO)
carotid artery disease  (ISO)
Chemical and Drug Induced Liver Injury  (IEP,ISO)
congestive heart failure  (ISO)
Coronary Disease  (ISO)
Cytomegalovirus Infections  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
Drug Hypersensitivity Syndrome  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (IEP)
episodic ataxia type 1  (ISO)
essential thrombocythemia  (ISO)
exanthem  (ISO)
Experimental Diabetes Mellitus  (IEP)
Experimental Liver Cirrhosis  (IEP,ISO)
factor VIII deficiency  (ISO)
familial combined hyperlipidemia  (ISO)
focal segmental glomerulosclerosis  (ISO)
Gastrointestinal Hemorrhage  (IEP)
genetic disease  (ISO)
Hemorrhage  (ISO)
hemorrhagic disease  (ISO)
Hemorrhagic Shock  (IEP)
Hyperphosphatemic Familial Tumoral Calcinosis 1  (ISO)
hypertension  (IEP,ISO)
Hypothermia  (ISO)
Insulin Resistance  (ISO)
Intestinal Reperfusion Injury  (IEP)
intracranial aneurysm  (ISO)
intracranial thrombosis  (ISO)
Kidney Reperfusion Injury  (IEP)
lymphoproliferative syndrome 2  (ISO)
mesangial proliferative glomerulonephritis  (IEP)
Metabolic Syndrome  (ISO)
myocardial infarction  (IEP)
obesity  (ISO)
osteonecrosis  (ISO)
pulmonary fibrosis  (IEP)
pulmonary hypertension  (ISO)
renal cell carcinoma  (ISO)
schizophrenia  (ISO)
severe acute respiratory syndrome  (ISO)
Spinal Cord Injuries  (IEP)
Stevens-Johnson syndrome  (ISO)
Stroke  (ISO)
systemic scleroderma  (ISO)
thrombocytopenia  (ISO)
Thrombocytopenic Purpura  (ISO)
thrombosis  (ISO)
Thrombotic Microangiopathies  (ISO)
Thrombotic Thrombocytopenic Purpura, Acquired  (ISO)
transient cerebral ischemia  (IDA)
type 1 diabetes mellitus  (IEP)
Venous Thromboembolism  (ISO)
Von Willebrand Factor, Deficiency  (ISO)
von Willebrand's disease  (ISO,ISS)
von Willebrand's disease 1  (ISO)
von Willebrand's disease 2  (ISO,ISS)
von Willebrand's disease 3  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(S)-nicotine  (ISO)
1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4,6-tribromophenol  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (ISO)
7,12-dimethyltetraphene  (EXP)
acrolein  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (ISO)
benzene  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bilirubin IXalpha  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
cantharidin  (ISO)
carbon atom  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
cholesterol  (EXP)
cisplatin  (ISO)
cocaine  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
cortisol  (ISO)
cumene  (ISO)
Cuprizon  (EXP)
curcumin  (EXP)
Curcumol  (ISO)
D-glucose  (ISO)
desmopressin  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental carbon  (ISO)
enalapril  (ISO)
ergosterol  (EXP)
ethanol  (ISO)
fenoldopam  (EXP)
fenvalerate  (EXP)
folic acid  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (EXP)
gestodene  (ISO)
glucose  (ISO)
graphite  (EXP)
indole-3-methanol  (EXP)
indometacin  (ISO)
isoprenaline  (ISO)
L-methionine  (ISO)
Lasiocarpine  (ISO)
lipopolysaccharide  (ISO)
luteolin  (EXP)
maneb  (ISO)
mercury dibromide  (ISO)
methamphetamine  (EXP)
methapyrilene  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
methylmercury chloride  (EXP,ISO)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP)
nicotine  (ISO)
Nor-9-carboxy-delta9-THC  (ISO)
ozone  (EXP,ISO)
p-menthan-3-ol  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
paricalcitol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
perindopril  (ISO)
phenethyl caffeate  (EXP)
phenylmercury acetate  (ISO)
phytoestrogen  (ISO)
picoxystrobin  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
resveratrol  (EXP)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
simvastatin  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sophoraflavanone B  (ISO)
succimer  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP,ISO)
toluene  (EXP)
tremolite asbestos  (ISO)
triadimefon  (EXP)
trichloroethene  (EXP)
triclosan  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vincaleukoblastine  (EXP)
vincristine  (EXP)
vitamin E  (ISO)
xanthohumol  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Small bowel ischaemia-reperfusion increases plasma concentrations of oxidised proteins in rats. Abu-Zidan FM, etal., Eur J Surg. 1999 Apr;165(4):383-9.
2. Baseline vWF factor predicts the development of elevated pulmonary artery pressure in systemic sclerosis. Barnes T, etal., Rheumatology (Oxford). 2012 Sep;51(9):1606-9. Epub 2012 May 16.
3. Von Willebrand factor in plasma and in liver tissue after partial hepatectomy in the rat. Baruch Y, etal., J Hepatol 2002 Oct;37(4):471-7.
4. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
5. Fibrin polymerization is crucial for thrombin generation in platelet-rich plasma in a VWF-GPIb-dependent process, defective in Bernard-Soulier syndrome. Beguin S, etal., J Thromb Haemost. 2004 Jan;2(1):170-6.
6. The vascular biology of the glycoprotein Ib-IX-V complex. Berndt MC, etal., Thromb Haemost. 2001 Jul;86(1):178-88.
7. Von Willebrand factor antigen levels in Behcet disease. Beyan E, etal., Am J Hematol. 2005 May;79(1):70-2.
8. Increased deposition of von Willebrand factor in the rat heart after local ionizing irradiation. Boerma M, etal., Strahlenther Onkol. 2004 Feb;180(2):109-16.
9. Hypoxia and altered platelet behavior influence von Willebrand factor multimeric composition in secondary pulmonary hypertension. Caramuru LH, etal., Clin Appl Thromb Hemost. 2003 Jul;9(3):251-8.
10. Rosiglitazone does not improve vascular function in subjects with chronic kidney disease. Chan DT, etal., Nephrol Dial Transplant. 2011 Nov;26(11):3543-9. doi: 10.1093/ndt/gfr049. Epub 2011 Mar 4.
11. Variable content of von Willebrand factor mutant monomer drives the phenotypic variability in a family with von Willebrand disease. Chen J, etal., Blood. 2015 Jul 9;126(2):262-9. doi: 10.1182/blood-2014-11-613935. Epub 2015 May 27.
12. Effect of abdominal obesity on prothrombotic tendency in type 2 diabetes. Behavior of clotting factors VII and VIII, fibrinogen and von Willebrand Factor. Coca M, etal., Rom J Intern Med. 2005;43(1-2):115-26.
13. Oxidation of Met1606 in von Willebrand factor is a risk factor for thrombotic and septic complications in chronic renal failure. De Filippis V, etal., Biochem J. 2012 Mar 1;442(2):423-32. doi: 10.1042/BJ20111798.
14. Dominant type 1 von Willebrand disease caused by mutated cysteine residues in the D3 domain of von Willebrand factor. Eikenboom JC, etal., Blood. 1996 Oct 1;88(7):2433-41.
15. Small intestinal production of nitric oxide is decreased following resuscitated hemorrhage. Fruchterman TM, etal., J Surg Res. 1998 Nov;80(1):102-9.
16. Circulating thrombomodulin and hematological alterations in type 2 diabetic patients with retinopathy. Fujiwara Y, etal., J Atheroscler Thromb. 1998;5(1):21-8.
17. Long Non-coding RNA MALAT1/microRNA-143/VEGFA Signal Axis Modulates Vascular Endothelial Injury-Induced Intracranial Aneurysm. Gao G, etal., Nanoscale Res Lett. 2020 Jun 29;15(1):139. doi: 10.1186/s11671-020-03357-2.
18. Effects of Radix et Rhizoma Rhodiolae Kirilowii on expressions of von Willebrand factor, hypoxia-inducible factor 1 and vascular endothelial growth factor in myocardium of rats with acute myocardial infarction. Gao XF, etal., Zhong Xi Yi Jie He Xue Bao. 2009 May;7(5):434-40. doi: 10.3736/jcim20090507.
19. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
20. Hemostatic efficacy, safety, and pharmacokinetics of a recombinant von Willebrand factor in severe von Willebrand disease. Gill JC, etal., Blood. 2015 Oct 22;126(17):2038-46. doi: 10.1182/blood-2015-02-629873. Epub 2015 Aug 3.
21. Mechanisms of severe acute respiratory syndrome coronavirus-induced acute lung injury. Gralinski LE, etal., mBio. 2013 Aug 6;4(4). pii: mBio.00271-13. doi: 10.1128/mBio.00271-13.
22. Impact of alpha-tocopherol and vitamin C on endothelial markers in rats with streptozotocin-induced diabetes. Haidara MA, etal., Med Sci Monit. 2004 Feb;10(2):BR41-6.
23. Neurovascular protection conferred by 2-BFI treatment during rat cerebral ischemia. Han Z, etal., Biochem Biophys Res Commun. 2012 Aug 3;424(3):544-8. doi: 10.1016/j.bbrc.2012.06.152. Epub 2012 Jul 6.
24. Type 2M vWD resulting from a lysine deletion within a four lysine residue repeat in the A1 loop of von Willebrand factor. Hilbert L, etal., Thromb Haemost. 2000 Aug;84(2):188-94.
25. Similar immune profile in bipolar disorder and schizophrenia: selective increase in soluble tumor necrosis factor receptor I and von Willebrand factor. Hope S, etal., Bipolar Disord. 2009 Nov;11(7):726-34. doi: 10.1111/j.1399-5618.2009.00757.x.
26. Hypothermia-induced activation of the splenic platelet pool as a risk factor for thrombotic disease in a mouse model. Horioka K, etal., J Thromb Haemost. 2019 Oct;17(10):1762-1771. doi: 10.1111/jth.14555. Epub 2019 Jul 17.
27. Molecular evolution of the nuclear von Willebrand factor gene in mammals and the phylogeny of rodents. Huchon D, etal., Mol Biol Evol 1999 May;16(5):577-89.
28. Elevated Von Willebrand factor propeptide for the diagnosis of thrombotic microangiopathy and for predicting a poor outcome. Ito-Habe N, etal., Int J Hematol. 2011 Jan;93(1):47-52. doi: 10.1007/s12185-010-0732-4. Epub 2010 Dec 9.
29. Stress-induced rise in endothelaemia, von Willebrand factor and hypothalamic-pituitary-adrenocortical axis activation is reduced by pretreatment with pentoxifylline. Jezova D, etal., J Physiol Pharmacol. 2003 Sep;54(3):329-38.
30. A randomised pilot trial of the anti-von Willebrand factor aptamer ARC1779 in patients with type 2b von Willebrand disease. Jilma B, etal., Thromb Haemost. 2010 Sep;104(3):563-70. doi: 10.1160/TH10-01-0027. Epub 2010 Jun 29.
31. Endothelial haemostatic markers in members of families with familial combined hyperlipidemia. Karásek D, etal., Thromb Res. 2009;123(3):466-75. doi: 10.1016/j.thromres.2008.02.011. Epub 2008 Apr 16.
32. Distribution of von Willebrand factor in capillary endothelial cells of rat lungs with pulmonary fibrosis. Kasper M, etal., Exp Toxicol Pathol. 1996 Jun;48(4):283-8.
33. Expression of von Willebrand factor in normal and diseased rat livers and in cultivated liver cells. Knittel T, etal., Hepatology. 1995 Feb;21(2):470-6.
34. An association of candidate gene haplotypes and bleeding severity in von Willebrand disease (VWD) type 1 pedigrees. Kunicki TJ, etal., Blood. 2004 Oct 15;104(8):2359-67. Epub 2004 Jun 29.
35. An association of candidate gene haplotypes and bleeding severity in von Willebrand disease type 2A, 2B, and 2M pedigrees. Kunicki TJ, etal., J Thromb Haemost. 2006 Jan;4(1):137-47.
36. Qualitative and quantitative modifications of von Willebrand factor in patients with essential thrombocythemia and controlled platelet count. Lancellotti S, etal., J Thromb Haemost. 2015 Jul;13(7):1226-37. doi: 10.1111/jth.12967. Epub 2015 May 22.
37. Anticoagulatory, antiinflammatory, and antioxidative effects of protocatechuic acid in diabetic mice. Lin CY, etal., J Agric Food Chem. 2009 Aug 12;57(15):6661-7. doi: 10.1021/jf9015202.
38. Total plasmatic homocysteine and von Willebrand factor in experimental diabetes mellitus. Lopes RD, etal., Arq Bras Cardiol. 2007 Apr;88(4):424-9.
39. Type 2M:Milwaukee-1 von Willebrand disease: an in-frame deletion in the Cys509-Cys695 loop of the von Willebrand factor A1 domain causes deficient binding of von Willebrand factor to platelets. Mancuso DJ, etal., Blood. 1996 Oct 1;88(7):2559-68.
40. Characterization of partial gene deletions in type III von Willebrand disease with alloantibody inhibitors. Mancuso DJ, etal., Thromb Haemost. 1994 Aug;72(2):180-5.
41. Diffuse and persistent blood-spinal cord barrier disruption after contusive spinal cord injury rapidly recovers following intravenous infusion of bone marrow mesenchymal stem cells. Matsushita T, etal., Exp Neurol. 2015 May;267:152-64. doi: 10.1016/j.expneurol.2015.03.001. Epub 2015 Mar 12.
42. Is visceral adipose tissue a determinant of von Willebrand factor in overweight and obese premenopausal women? Mertens I, etal., Metabolism. 2006 May;55(5):650-5.
43. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
44. von Willebrand factor, ADAMTS-13, and thrombotic thrombocytopenic purpura. Moake JL Semin Hematol. 2004 Jan;41(1):4-14.
45. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
46. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
47. Kynurenine pathway - a new link between endothelial dysfunction and carotid atherosclerosis in chronic kidney disease patients. Pawlak K, etal., Adv Med Sci. 2010;55(2):196-203. doi: 10.2478/v10039-010-0015-6.
48. Plasma concentration of von Willebrand factor predicts mortality in patients on chronic renal replacement therapy. Pequeriaux NC, etal., Nephrol Dial Transplant. 2012 Jun;27(6):2452-7. doi: 10.1093/ndt/gfr735. Epub 2011 Dec 20.
49. Caplacizumab for Acquired Thrombotic Thrombocytopenic Purpura. Peyvandi F, etal., N Engl J Med. 2016 Feb 11;374(6):511-22. doi: 10.1056/NEJMoa1505533.
50. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
51. Mutation and ADAMTS13-dependent modulation of disease severity in a mouse model for von Willebrand disease type 2B. Rayes J, etal., Blood. 2010 Jun 10;115(23):4870-7. doi: 10.1182/blood-2009-11-254193. Epub 2010 Mar 3.
52. Injury induces increase of von Willebrand factor in rat endothelial cells. Reidy MA, etal., Am J Pathol. 1989 Apr;134(4):857-64.
53. GOA pipeline RGD automated data pipeline
54. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
55. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
56. Comprehensive gene review and curation RGD comprehensive gene curation
57. Aortic endothelial cell von Willebrand factor content, and circulating plasminogen activator inhibitor-1 are increased, but expression of endothelial leukocyte adhesion molecules is unchanged in insulin-dependent diabetic BB rats. Ribau JC, etal., Atherosclerosis. 2000 Apr;149(2):331-42.
58. Plasma von Willebrand factor levels are an independent risk factor for adverse events including mortality and major bleeding in anticoagulated atrial fibrillation patients. Roldan V, etal., J Am Coll Cardiol. 2011 Jun 21;57(25):2496-504. doi: 10.1016/j.jacc.2010.12.033. Epub 2011 Apr 14.
59. Characterization of cytomegalovirus disease in solid organ transplant recipients by markers of inflammation in plasma. Rollag H, etal., PLoS One. 2013 Apr 8;8(4):e60767. doi: 10.1371/journal.pone.0060767. Print 2013.
60. Increased levels of endothelial haemostatic markers in patients with coronary heart disease. Schumacher A, etal., Thromb Res. 2002 Jan 1;105(1):25-31.
61. [Effect of the recombinant staphylokinase on pancreatic ischemia in severe acute pancreatitis of rats]. Sha JP, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2007 Aug;19(8):467-70.
62. The important role of von Willebrand factor in platelet-derived FVIII gene therapy for murine hemophilia A in the presence of inhibitory antibodies. Shi Q, etal., J Thromb Haemost. 2015 Jul;13(7):1301-9. doi: 10.1111/jth.13001. Epub 2015 Jun 11.
63. Changes in coagulation and fibrinolysis of post-SARS osteonecrosis in a Chinese population. Sun W, etal., Int Orthop. 2006 Jun;30(3):143-6. doi: 10.1007/s00264-005-0067-6. Epub 2006 Mar 18.
64. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences Sun YX, etal., Zhejiang Da Xue Xue Bao Yi Xue Ban. 2006 May;35(3):315-8.
65. Injury of the renal microvascular endothelium alters barrier function after ischemia. Sutton TA, etal., Am J Physiol Renal Physiol. 2003 Aug;285(2):F191-8. Epub 2003 Apr 8.
66. Platelet adherence to isolated rat hepatic sinusoidal endothelial cells after cold preservation. Upadhya GA and Strasberg SM, Transplantation. 2002 Jun 15;73(11):1764-70.
67. Sunitinib-induced changes in circulating endothelial cell-related proteins in patients with metastatic renal cell cancer. van der Veldt AA, etal., Int J Cancer. 2012 Aug 15;131(4):E484-93. doi: 10.1002/ijc.26456. Epub 2011 Nov 8.
68. Expression of the molecule detectable by anti-propolypeptide of von Willebrand factor antibody in rat mesangial cells in anti-Thy 1.1 mAb 1-22-3 induced glomerulonephritis: A marker of injured mesangial cells. Wakasugi M, etal., Nephron. 1999;82(4):338-47.
69. The differential involvement of von Willebrand factor, fibrinogen and fibronectin in acute experimental thrombosis in rat cerebral and mesenteric microvessels. Yamamoto J, etal., Jpn J Physiol. 1997 Oct;47(5):431-41.
70. Adjuvant effect of antibodies against von Willebrand Factor, fibrinogen, and fibronectin on staphylokinase-induced thrombolysis as measured using mural thrombi formed in rat mesenteric venules. Yamamoto J, etal., Thromb Res. 2000 Mar 1;97(5):327-33.
71. Biomarkers of endothelial dysfunction in patients with primary focal segmental glomerulosclerosis. Zhang Q, etal., Nephrology (Carlton). 2012 May;17(4):338-45. doi: 10.1111/j.1440-1797.2012.01575.x.
72. [Study on changes of blood coagulation factors in rats with hemorrhagic shock]. Zhang YJ, etal., Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2005 Feb;13(1):110-3.
73. Integrated Analysis of Multiple Microarray Studies to Identify Core Gene-Expression Signatures Involved in Tubulointerstitial Injury in Diabetic Nephropathy. Zhou H, etal., Biomed Res Int. 2022 May 10;2022:9554658. doi: 10.1155/2022/9554658. eCollection 2022.
Additional References at PubMed
PMID:2056120   PMID:3082891   PMID:3087627   PMID:3121636   PMID:6754744   PMID:7721887   PMID:7854452   PMID:8562500   PMID:8565074   PMID:8874190   PMID:9079671   PMID:9689113  
PMID:10764791   PMID:10887119   PMID:10930441   PMID:11071623   PMID:12775718   PMID:12871266   PMID:15824096   PMID:16409464   PMID:16551580   PMID:16735600   PMID:17380206   PMID:17895385  
PMID:18182488   PMID:18433458   PMID:18492805   PMID:19056867   PMID:21037087   PMID:21592973   PMID:21857647   PMID:23376485   PMID:23979707   PMID:24006456   PMID:27068509   PMID:27224245  


Genomics

Comparative Map Data
Vwf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84160,042,900 - 160,177,757 (+)NCBIGRCr8
mRatBN7.24158,360,152 - 158,491,539 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4158,360,152 - 158,491,539 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4164,595,998 - 164,727,404 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04160,378,929 - 160,510,343 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04159,012,985 - 159,144,157 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04158,085,059 - 158,219,525 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4158,088,505 - 158,219,523 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04225,098,521 - 225,229,257 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44161,723,415 - 161,854,766 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14162,053,065 - 162,055,090 (+)NCBI
Celera4147,092,791 - 147,223,711 (+)NCBICelera
Cytogenetic Map4q42NCBI
VWF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38125,948,877 - 6,124,670 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl125,948,877 - 6,124,770 (-)EnsemblGRCh38hg38GRCh38
GRCh37126,058,043 - 6,233,836 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36125,928,301 - 6,104,097 (-)NCBINCBI36Build 36hg18NCBI36
Build 34125,928,307 - 6,104,097NCBI
Celera127,677,686 - 7,853,476 (-)NCBICelera
Cytogenetic Map12p13.31NCBI
HuRef125,910,003 - 6,085,514 (-)NCBIHuRef
CHM1_1126,057,433 - 6,233,298 (-)NCBICHM1_1
T2T-CHM13v2.0125,956,421 - 6,132,275 (-)NCBIT2T-CHM13v2.0
Vwf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396125,529,911 - 125,663,642 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6125,523,737 - 125,663,642 (+)EnsemblGRCm39 Ensembl
GRCm386125,552,948 - 125,686,679 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6125,546,774 - 125,686,679 (+)EnsemblGRCm38mm10GRCm38
MGSCv376125,502,981 - 125,636,695 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366125,520,072 - 125,652,161 (+)NCBIMGSCv36mm8
Celera6127,212,807 - 127,346,911 (+)NCBICelera
Cytogenetic Map6F3NCBI
cM Map659.32NCBI
Vwf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554133,672,470 - 3,819,571 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554133,672,470 - 3,825,588 (-)NCBIChiLan1.0ChiLan1.0
VWF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21011,504,401 - 11,680,404 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11211,501,159 - 11,677,162 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0126,073,836 - 6,249,806 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1125,990,612 - 6,166,632 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl125,990,612 - 6,165,153 (-)Ensemblpanpan1.1panPan2
VWF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12738,834,812 - 38,972,614 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2738,833,837 - 39,320,142 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha277,641,828 - 7,779,174 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02739,191,850 - 39,329,540 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2739,193,140 - 39,329,536 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12739,062,625 - 39,200,071 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02739,104,190 - 39,241,989 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0277,119,622 - 7,257,688 (-)NCBIUU_Cfam_GSD_1.0
Vwf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945102,910,587 - 103,074,328 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367091,579,096 - 1,741,754 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367091,578,137 - 1,741,877 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VWF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl564,519,186 - 65,002,452 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1564,516,627 - 64,655,938 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2566,999,793 - 67,078,133 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap5q21NCBI
VWF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1115,994,499 - 6,176,949 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl115,994,039 - 6,162,260 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660632,072,116 - 2,236,240 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Vwf
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248602,858,088 - 2,973,052 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248602,843,268 - 2,973,888 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Vwf
1377 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:61
Count of miRNA genes:56
Interacting mature miRNAs:60
Transcripts:ENSRNOT00000026643
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4148090542168069246Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)426775591168368347Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4155561574182687754Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
1581574Eae20Experimental allergic encephalomyelitis QTL 207.8nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)4153031106158841762Rat
1300109Rf13Renal function QTL 133.91renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)4157710145182687754Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1581566Eae21Experimental allergic encephalomyelitis QTL 216.2body mass (VT:0001259)maximum body weight loss to initial body weight ratio (CMO:0001400)4157680158158841762Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132642577167139601Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4147278504167139601Rat

Markers in Region
D4Wox36  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24158,447,303 - 158,447,479 (+)MAPPERmRatBN7.2
Rnor_6.04158,175,129 - 158,175,304NCBIRnor6.0
Rnor_5.04225,185,117 - 225,185,292UniSTSRnor5.0
RGSC_v3.44161,808,751 - 161,808,926UniSTSRGSC3.4
Celera4147,179,655 - 147,179,830UniSTS
Cytogenetic Map4q42UniSTS
Vwf  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24158,447,823 - 158,448,025 (+)MAPPERmRatBN7.2
Rnor_6.04158,175,649 - 158,175,850NCBIRnor6.0
Rnor_5.04225,185,637 - 225,185,838UniSTSRnor5.0
RGSC_v3.44161,809,271 - 161,809,472UniSTSRGSC3.4
Celera4147,180,175 - 147,180,376UniSTS
Cytogenetic Map4q42UniSTS
RH132777  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24158,491,246 - 158,491,439 (+)MAPPERmRatBN7.2
Rnor_6.04158,219,233 - 158,219,425NCBIRnor6.0
Rnor_5.04225,228,965 - 225,229,157UniSTSRnor5.0
RGSC_v3.44161,854,469 - 161,854,661UniSTSRGSC3.4
Celera4147,223,419 - 147,223,611UniSTS
Cytogenetic Map4q42UniSTS


Genetic Models
This gene Vwf is modified in the following models/strains:
SS-Vwfem2Mcwi-/-     SD-Vwfem1Mcwi-/-     SS-Vwfem3Mcwi-/-     SS-Vwfem4Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000026643   ⟹   ENSRNOP00000026643
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4158,360,152 - 158,491,539 (+)Ensembl
Rnor_6.0 Ensembl4158,088,505 - 158,219,523 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000116998   ⟹   ENSRNOP00000084421
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4158,394,481 - 158,491,539 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117299   ⟹   ENSRNOP00000091836
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4158,361,767 - 158,491,539 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118023   ⟹   ENSRNOP00000079544
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4158,381,564 - 158,491,539 (+)Ensembl
RefSeq Acc Id: NM_053889   ⟹   NP_446341
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84160,046,369 - 160,177,757 (+)NCBI
mRatBN7.24158,360,152 - 158,491,539 (+)NCBI
Rnor_6.04158,088,533 - 158,219,525 (+)NCBI
Rnor_5.04225,098,521 - 225,229,257 (+)NCBI
Celera4147,092,791 - 147,223,711 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063285420   ⟹   XP_063141490
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84160,042,900 - 160,177,757 (+)NCBI
RefSeq Acc Id: NP_446341   ⟸   NM_053889
- Peptide Label: precursor
- UniProtKB: A0A8J8XVZ5 (UniProtKB/TrEMBL),   A6ILU6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000026643   ⟸   ENSRNOT00000026643
Ensembl Acc Id: ENSRNOP00000091836   ⟸   ENSRNOT00000117299
Ensembl Acc Id: ENSRNOP00000084421   ⟸   ENSRNOT00000116998
Ensembl Acc Id: ENSRNOP00000079544   ⟸   ENSRNOT00000118023
RefSeq Acc Id: XP_063141490   ⟸   XM_063285420
- Peptide Label: isoform X1
- UniProtKB: A0A8J8XVZ5 (UniProtKB/TrEMBL)
Protein Domains
CTCK   VWFA   VWFC   VWFD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62935-F1-model_v2 AlphaFold Q62935 1-430 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693414
Promoter ID:EPDNEW_R3939
Type:single initiation site
Name:Vwf_1
Description:von Willebrand factor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04158,088,533 - 158,088,593EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621759 AgrOrtholog
BioCyc Gene G2FUF-42984 BioCyc
Ensembl Genes ENSRNOG00000019689 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026643.8 UniProtKB/TrEMBL
  ENSRNOT00000116998.1 UniProtKB/TrEMBL
  ENSRNOT00000117299.1 UniProtKB/TrEMBL
  ENSRNOT00000118023.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.410 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
InterPro Cys_knot_C UniProtKB/TrEMBL
  ECM_Assembly_Org UniProtKB/Swiss-Prot
  Mucin_vWF_Thrombospondin_sf UniProtKB/TrEMBL
  Prot_Inh_CR_TIL UniProtKB/TrEMBL
  Ser_inhib-like_sf UniProtKB/TrEMBL
  Unchr_dom_Cys-rich UniProtKB/TrEMBL
  Von_Willebrand_factor UniProtKB/TrEMBL
  VWA_N2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWF_A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWF_C UniProtKB/TrEMBL
  VWF_type-D UniProtKB/TrEMBL
  vWFA_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:116669 UniProtKB/TrEMBL
NCBI Gene 116669 ENTREZGENE
PANTHER COLLAGEN ALPHA UniProtKB/Swiss-Prot
  EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED UniProtKB/TrEMBL
  MUCIN-2-LIKE-RELATED UniProtKB/TrEMBL
  PH DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot
  PTHR11339:SF361 UniProtKB/TrEMBL
Pfam PF08742 UniProtKB/TrEMBL
  TIL UniProtKB/TrEMBL
  VWA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWA_N2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWC UniProtKB/TrEMBL
  VWD UniProtKB/TrEMBL
PhenoGen Vwf PhenoGen
PIRSF VWF UniProtKB/TrEMBL
PRINTS VWFADOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CTCK_1 UniProtKB/TrEMBL
  CTCK_2 UniProtKB/TrEMBL
  VWFA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWFC_1 UniProtKB/TrEMBL
  VWFC_2 UniProtKB/TrEMBL
  VWFD UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019689 RatGTEx
SMART SM00041 UniProtKB/TrEMBL
  SM00832 UniProtKB/TrEMBL
  VWA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWC UniProtKB/TrEMBL
  VWC_out UniProtKB/TrEMBL
  VWD UniProtKB/TrEMBL
Superfamily-SCOP Cysrich_TIL UniProtKB/TrEMBL
  FnI-like domain UniProtKB/TrEMBL
  SSF53300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZNS8_RAT UniProtKB/TrEMBL
  A0A8I6A191_RAT UniProtKB/TrEMBL
  A0A8I6AF98_RAT UniProtKB/TrEMBL
  A0A8J8XVZ5 ENTREZGENE, UniProtKB/TrEMBL
  A6ILU6 ENTREZGENE, UniProtKB/TrEMBL
  F1M957_RAT UniProtKB/TrEMBL
  Q62935 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary F5XVC1 UniProtKB/TrEMBL
  Q78E31 UniProtKB/Swiss-Prot
  Q9Z0P2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-05-25 Vwf  von Willebrand factor  Vwf  von Willebrand factor homolog  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-10-22 Vwf  von Willebrand factor homolog  Vwf  Von Willebrand factor homolog  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-15 Vwf  Von Willebrand factor homolog  Vwf  von Willebrand factor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Vwf  von Willebrand factor      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Vwf  Von Willebrand factor      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression protein levels increase after partial hepatectomy 727737