Vwf (von Willebrand factor) - Rat Genome Database

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Gene: Vwf (von Willebrand factor) Rattus norvegicus
Analyze
Symbol: Vwf
Name: von Willebrand factor
RGD ID: 621759
Description: Predicted to have several functions, including chaperone binding activity; identical protein binding activity; and integrin binding activity. Involved in several processes, including liver regeneration; platelet activation; and response to L-ascorbic acid. Localizes to collagen-containing extracellular matrix; endoplasmic reticulum; and extracellular space. Used to study transient cerebral ischemia. Biomarker of hypertension; mesangial proliferative glomerulonephritis; myocardial infarction; pulmonary fibrosis; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; Bernard-Soulier syndrome; end stage renal disease; essential thrombocythemia; and von Willebrand's disease (multiple). Orthologous to human VWF (von Willebrand factor); PARTICIPATES IN platelet aggregation pathway; cell-extracellular matrix signaling pathway; coagulation cascade pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: von Willebrand factor homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Vwfem2Mcwi   Vwfem3Mcwi   Vwfem1Mcwi  
Genetic Models: SS-Vwfem2Mcwi-/- SD-Vwfem1Mcwi-/- SS-Vwfem3Mcwi-/-
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24158,360,152 - 158,491,539 (+)NCBI
Rnor_6.0 Ensembl4158,088,505 - 158,219,523 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.04158,085,059 - 158,219,525 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04225,098,521 - 225,229,257 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44161,723,415 - 161,854,766 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14162,053,065 - 162,055,090 (+)NCBI
Celera4147,092,791 - 147,223,711 (+)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Aortic Injuries  (IEP)
atrial fibrillation  (ISO)
Behcet's disease  (ISO)
Bernard-Soulier syndrome  (ISO)
bipolar disorder  (ISO)
blood coagulation disease  (ISO)
cardiovascular system disease  (ISO)
carotid artery disease  (ISO)
Chemical and Drug Induced Liver Injury  (IEP,ISO)
congestive heart failure  (ISO)
Coronary Disease  (ISO)
Cytomegalovirus Infections  (ISO)
diabetes mellitus  (ISO)
diabetic retinopathy  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (IEP)
episodic ataxia type 1  (ISO)
essential thrombocythemia  (ISO)
Experimental Diabetes Mellitus  (IEP)
Experimental Liver Cirrhosis  (IEP,ISO)
Experimental Pancreatitis, Acute  (IEP)
factor VIII deficiency  (ISO)
familial combined hyperlipidemia  (ISO)
focal segmental glomerulosclerosis  (ISO)
Gastrointestinal Hemorrhage  (IEP)
genetic disease  (ISO)
hemorrhagic disease  (ISO)
Hemorrhagic Shock  (IEP)
Hyperphosphatemic Familial Tumoral Calcinosis 1  (ISO)
hypertension  (IEP,ISO)
Insulin Resistance  (ISO)
Intestinal Reperfusion Injury  (IEP)
intracranial thrombosis  (ISO)
Kidney Reperfusion Injury  (IEP)
mesangial proliferative glomerulonephritis  (IEP)
Metabolic Syndrome  (ISO)
myocardial infarction  (IEP)
obesity  (ISO)
osteonecrosis  (ISO)
pulmonary fibrosis  (IEP)
pulmonary hypertension  (ISO)
renal cell carcinoma  (ISO)
schizophrenia  (ISO)
severe acute respiratory syndrome  (ISO)
Spinal Cord Injuries  (IEP)
Stroke  (ISO)
systemic scleroderma  (ISO)
thrombocytopenia  (ISO)
Thrombocytopenic Purpura  (ISO)
thrombosis  (ISO)
Thrombotic Microangiopathies  (ISO)
Thrombotic Thrombocytopenic Purpura, Acquired  (ISO)
transient cerebral ischemia  (IDA)
type 1 diabetes mellitus  (IEP)
Venous Thromboembolism  (ISO)
Von Willebrand Factor, Deficiency  (ISO)
von Willebrand's disease  (ISO,ISS)
von Willebrand's disease 1  (ISO)
von Willebrand's disease 2  (ISO)
von Willebrand's disease 3  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-hydroxypropanoic acid  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (ISO)
7,12-dimethyltetraphene  (EXP)
acrolein  (ISO)
aflatoxin B1  (EXP,ISO)
aflatoxin B2  (ISO)
aldehydo-D-glucose  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (ISO)
benzene  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon atom  (ISO)
carbon nanotube  (ISO)
cholesterol  (EXP)
cisplatin  (ISO)
cocaine  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
cortisol  (ISO)
cumene  (ISO)
curcumin  (EXP)
D-glucose  (ISO)
desmopressin  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental carbon  (ISO)
enalapril  (ISO)
ergosterol  (EXP)
ethanol  (ISO)
fenoldopam  (EXP)
fenvalerate  (EXP)
folic acid  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
gestodene  (ISO)
glucose  (ISO)
graphite  (EXP)
indole-3-methanol  (EXP)
indometacin  (ISO)
isoprenaline  (ISO)
L-methionine  (ISO)
Lasiocarpine  (ISO)
lipopolysaccharide  (ISO)
luteolin  (EXP)
mercury dibromide  (ISO)
methamphetamine  (EXP)
methapyrilene  (ISO)
methylmercury chloride  (EXP,ISO)
mifepristone  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP)
nicotine  (ISO)
Nor-9-carboxy-delta9-THC  (ISO)
ozone  (EXP)
p-menthan-3-ol  (EXP)
paracetamol  (ISO)
paricalcitol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
perindopril  (ISO)
phenethyl caffeate  (EXP)
phenylmercury acetate  (ISO)
phytoestrogen  (ISO)
progesterone  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
resveratrol  (EXP)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
simvastatin  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sophoraflavanone B  (ISO)
succimer  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP,ISO)
toluene  (EXP)
tremolite asbestos  (ISO)
trichloroethene  (EXP)
triptonide  (ISO)
valproic acid  (ISO)
vincaleukoblastine  (EXP)
vincristine  (EXP)
vitamin E  (ISO)
xanthohumol  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
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20. Gralinski LE, etal., mBio. 2013 Aug 6;4(4). pii: mBio.00271-13. doi: 10.1128/mBio.00271-13.
21. Haidara MA, etal., Med Sci Monit. 2004 Feb;10(2):BR41-6.
22. Han Z, etal., Biochem Biophys Res Commun. 2012 Aug 3;424(3):544-8. doi: 10.1016/j.bbrc.2012.06.152. Epub 2012 Jul 6.
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24. Hope S, etal., Bipolar Disord. 2009 Nov;11(7):726-34. doi: 10.1111/j.1399-5618.2009.00757.x.
25. Huchon D, etal., Mol Biol Evol 1999 May;16(5):577-89.
26. Ito-Habe N, etal., Int J Hematol. 2011 Jan;93(1):47-52. doi: 10.1007/s12185-010-0732-4. Epub 2010 Dec 9.
27. Jezova D, etal., J Physiol Pharmacol. 2003 Sep;54(3):329-38.
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31. Knittel T, etal., Hepatology. 1995 Feb;21(2):470-6.
32. Kunicki TJ, etal., Blood. 2004 Oct 15;104(8):2359-67. Epub 2004 Jun 29.
33. Kunicki TJ, etal., J Thromb Haemost. 2006 Jan;4(1):137-47.
34. Lancellotti S, etal., J Thromb Haemost. 2015 Jul;13(7):1226-37. doi: 10.1111/jth.12967. Epub 2015 May 22.
35. Lin CY, etal., J Agric Food Chem. 2009 Aug 12;57(15):6661-7. doi: 10.1021/jf9015202.
36. Lopes RD, etal., Arq Bras Cardiol. 2007 Apr;88(4):424-9.
37. Mancuso DJ, etal., Blood. 1996 Oct 1;88(7):2559-68.
38. Mancuso DJ, etal., Thromb Haemost. 1994 Aug;72(2):180-5.
39. Matsushita T, etal., Exp Neurol. 2015 May;267:152-64. doi: 10.1016/j.expneurol.2015.03.001. Epub 2015 Mar 12.
40. Mertens I, etal., Metabolism. 2006 May;55(5):650-5.
41. MGD data from the GO Consortium
42. Moake JL Semin Hematol. 2004 Jan;41(1):4-14.
43. NCBI rat LocusLink and RefSeq merged data July 26, 2002
44. OMIM Disease Annotation Pipeline
45. Pawlak K, etal., Adv Med Sci. 2010;55(2):196-203. doi: 10.2478/v10039-010-0015-6.
46. Pequeriaux NC, etal., Nephrol Dial Transplant. 2012 Jun;27(6):2452-7. doi: 10.1093/ndt/gfr735. Epub 2011 Dec 20.
47. Peyvandi F, etal., N Engl J Med. 2016 Feb 11;374(6):511-22. doi: 10.1056/NEJMoa1505533.
48. Pipeline to import KEGG annotations from KEGG into RGD
49. Rayes J, etal., Blood. 2010 Jun 10;115(23):4870-7. doi: 10.1182/blood-2009-11-254193. Epub 2010 Mar 3.
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51. RGD automated data pipeline
52. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
53. RGD automated import pipeline for gene-chemical interactions
54. RGD comprehensive gene curation
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Additional References at PubMed
PMID:2056120   PMID:3082891   PMID:3087627   PMID:3121636   PMID:6754744   PMID:7721887   PMID:7854452   PMID:8562500   PMID:8565074   PMID:8874190   PMID:9079671   PMID:9689113  
PMID:10764791   PMID:10887119   PMID:10930441   PMID:11071623   PMID:12775718   PMID:12871266   PMID:15824096   PMID:16409464   PMID:16551580   PMID:16735600   PMID:17380206   PMID:17895385  
PMID:18182488   PMID:18433458   PMID:18492805   PMID:19056867   PMID:21037087   PMID:21592973   PMID:21857647   PMID:23376485   PMID:23979707   PMID:24006456   PMID:27068509   PMID:27224245  


Genomics

Comparative Map Data
Vwf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24158,360,152 - 158,491,539 (+)NCBI
Rnor_6.0 Ensembl4158,088,505 - 158,219,523 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.04158,085,059 - 158,219,525 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04225,098,521 - 225,229,257 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44161,723,415 - 161,854,766 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14162,053,065 - 162,055,090 (+)NCBI
Celera4147,092,791 - 147,223,711 (+)NCBICelera
Cytogenetic Map4q42NCBI
VWF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl125,948,874 - 6,124,770 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl125,948,877 - 6,124,770 (-)EnsemblGRCh38hg38GRCh38
GRCh38125,948,877 - 6,124,670 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37126,058,043 - 6,233,836 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36125,928,301 - 6,104,097 (-)NCBINCBI36hg18NCBI36
Build 34125,928,307 - 6,104,097NCBI
Celera127,677,686 - 7,853,476 (-)NCBI
Cytogenetic Map12p13.31NCBI
HuRef125,910,003 - 6,085,514 (-)NCBIHuRef
CHM1_1126,057,433 - 6,233,303 (-)NCBICHM1_1
Vwf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396125,529,911 - 125,663,642 (+)NCBIGRCm39mm39
GRCm39 Ensembl6125,523,737 - 125,663,642 (+)Ensembl
GRCm386125,552,948 - 125,686,679 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6125,546,774 - 125,686,679 (+)EnsemblGRCm38mm10GRCm38
MGSCv376125,502,981 - 125,636,695 (+)NCBIGRCm37mm9NCBIm37
MGSCv366125,520,072 - 125,652,161 (+)NCBImm8
Celera6127,212,807 - 127,346,911 (+)NCBICelera
Cytogenetic Map6F3NCBI
cM Map659.32NCBI
Vwf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554133,672,470 - 3,819,571 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554133,672,470 - 3,825,588 (-)NCBIChiLan1.0ChiLan1.0
VWF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1125,990,612 - 6,166,632 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl125,990,612 - 6,165,153 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0126,073,836 - 6,249,806 (-)NCBIMhudiblu_PPA_v0panPan3
VWF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12738,834,812 - 38,972,614 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2738,833,837 - 39,320,142 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha277,641,828 - 7,779,174 (-)NCBI
ROS_Cfam_1.02739,191,850 - 39,329,540 (+)NCBI
UMICH_Zoey_3.12739,062,625 - 39,200,071 (+)NCBI
UNSW_CanFamBas_1.02739,104,190 - 39,241,989 (+)NCBI
UU_Cfam_GSD_1.0277,119,622 - 7,257,688 (-)NCBI
Vwf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945102,910,587 - 103,074,328 (+)NCBI
SpeTri2.0NW_0049367091,578,137 - 1,741,877 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VWF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl564,519,186 - 65,002,098 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1564,516,627 - 64,655,938 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2566,999,793 - 67,078,133 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap5q21NCBI
VWF
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1115,994,499 - 6,176,949 (-)NCBI
ChlSab1.1 Ensembl115,994,039 - 6,162,260 (-)Ensembl
Vwf
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248602,843,268 - 2,973,888 (-)NCBI

Position Markers
D4Wox36  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.04158,175,129 - 158,175,304NCBIRnor6.0
Rnor_5.04225,185,117 - 225,185,292UniSTSRnor5.0
RGSC_v3.44161,808,751 - 161,808,926UniSTSRGSC3.4
Celera4147,179,655 - 147,179,830UniSTS
Cytogenetic Map4q42UniSTS
Vwf  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.04158,175,649 - 158,175,850NCBIRnor6.0
Rnor_5.04225,185,637 - 225,185,838UniSTSRnor5.0
RGSC_v3.44161,809,271 - 161,809,472UniSTSRGSC3.4
Celera4147,180,175 - 147,180,376UniSTS
Cytogenetic Map4q42UniSTS
RH132777  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.04158,219,233 - 158,219,425NCBIRnor6.0
Rnor_5.04225,228,965 - 225,229,157UniSTSRnor5.0
RGSC_v3.44161,854,469 - 161,854,661UniSTSRGSC3.4
Celera4147,223,419 - 147,223,611UniSTS
Cytogenetic Map4q42UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4125884464168047091Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4117926139162926139Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4131834282176834282Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4136351734180689124Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4108876717169215811Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4105971071168047091Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4123111827168111827Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131532269168047091Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4146942075168998263Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4136351734174694858Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131532269168047091Rat
1581566Eae21Experimental allergic encephalomyelitis QTL 216.2body mass (VT:0001259)maximum body weight loss to initial body weight ratio (CMO:0001400)4157399119158564471Rat
1581574Eae20Experimental allergic encephalomyelitis QTL 207.8nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)4152482121158564471Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4136908430182878540Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)494893247168046938Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4145373934176509907Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123478354168478354Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)484475257178931073Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)4137171018182171018Rat
1300109Rf13Renal function QTL 133.91renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)4157423126184226339Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)47850904182171018Rat
1358364Sradr4Stress Responsive Adrenal Weight QTL 44.92adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)4128602727173602727Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)486438317168047091Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (VE) (CMO:0000132)4134917642179917642Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4131864442176864442Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4136351734174694858Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132455408168047091Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4145547014184226339Rat
6478720Alc23Alcohol consumption QTL 230.00509drinking behavior trait (VT:0001422)ethanol drink intake rate to body weight ratio (CMO:0001616)4155386197184226339Rat
6478728Anxrr36Anxiety related response QTL 360.01061locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155386197184226339Rat
6478733Anxrr37Anxiety related response QTL 370.00095locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155386197184226339Rat
6478737Anxrr38Anxiety related response QTL 380.00159locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155386197184226339Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4145547014184226339Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4145547014184226339Rat
6478757Anxrr44Anxiety related response QTL 440.01087locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155386197184226339Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4123587009168587009Rat
6478782Anxrr52Anxiety related response QTL 520.02091locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155386197184226339Rat
6478785Anxrr53Anxiety related response QTL 530.01397locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155386197184226339Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4145547014184226339Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4145547014184226339Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4124442168169442168Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4156855449184226339Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4146497452184226339Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)423850384169318094Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146086918168047091Rat


Genetic Models
This gene Vwf is modified in the following models/strains
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:61
Count of miRNA genes:56
Interacting mature miRNAs:60
Transcripts:ENSRNOT00000026643
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 35 14 6 15 6 1 44 7 13 11
Low 3 8 43 35 4 35 8 10 30 28 28 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000026643   ⟹   ENSRNOP00000026643
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl4158,088,505 - 158,219,523 (+)Ensembl
RefSeq Acc Id: NM_053889   ⟹   NP_446341
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24158,360,152 - 158,491,539 (+)NCBI
Rnor_6.04158,088,533 - 158,219,525 (+)NCBI
Rnor_5.04225,098,521 - 225,229,257 (+)NCBI
Celera4147,092,791 - 147,223,711 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008763279   ⟹   XP_008761501
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04158,085,059 - 158,219,525 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_446341   ⟸   NM_053889
- Peptide Label: precursor
- UniProtKB: F1M957 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008761501   ⟸   XM_008763279
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000026643   ⟸   ENSRNOT00000026643
Protein Domains
CTCK   VWFA   VWFC   VWFD

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693414
Promoter ID:EPDNEW_R3939
Type:single initiation site
Name:Vwf_1
Description:von Willebrand factor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04158,088,533 - 158,088,593EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
4 225154548 225154549 G A snv MHS/Gib (KNAW), WAG/Rij (KNAW), GK/Ox (KNAW), BUF/N (KNAW), BBDP/WorN (KNAW)
4 225161146 225161147 T C snv ACI/EurMcwi (MCW), COP/CrCrl (MCW & UW), GH/OmrMcwi (MCW), SBH/Ygl (MCW), FHH/EurMcwi (MCW), FHL/EurMcwi (MCW), SBN/Ygl (MCW), SR/JrHsd (MCW), SS/JrHsdMcwi (MCW), LH/MavRrrc (KNAW), LL/MavRrrc (KNAW), LN/MavRrrc (KNAW), MHS/Gib (KNAW), MR/N (KNAW), SR/JrHsd (KNAW), SS/Jr (KNAW), SS/JrHsdMcwi (KNAW), WAG/Rij (KNAW), ACI/N (KNAW), ACI/EurMcwi (KNAW), BBDP/WorN (KNAW), SBH/Ygl (KNAW), SBN/Ygl (KNAW), SHR/NCrlPrin (KNAW), SHR/NHsd (KNAW), SHR/OlaIpcv (KNAW), SHR/OlaIpcvPrin (KNAW), SHRSP/Gcrc (KNAW), F344/NRrrc (Illumina) (KNAW), WKY/Gcrc (KNAW), WKY/N (KNAW), WKY/NCrl (KNAW), WKY/NHsd (KNAW), BUF/N (KNAW), DA/BklArbNsi (KNAW), F344/NRrrc (SOLiD) (KNAW), F344/NCrl (KNAW), F344/NHsd (KNAW), FHH/EurMcwi (KNAW), FHL/EurMcwi (KNAW), GK/Ox (KNAW), LE/Stm (Illumina) (KNAW), LE/Stm (SOLiD) (KNAW), LEW/Crl (KNAW), LEW/NCrl (KNAW), M520/N (KNAW), MNS/Gib (KNAW), WN/N (KNAW), SDLEF7/Barth (UDEL), LE/OrlBarth (UDEL), Crl:SD (UDEL), BUF/MNa (KyushuU), NIG-III/Hok (KyushuU), F344/DuCrlCrlj (KyushuU), LE/Stm (KyushuU), HTX/Kyo (KyushuU), F344/NSlc (KyushuU), RCS/Kyo (KyushuU), F344/Stm (KyushuU), HWY/Slc (KyushuU), LEC/Tj (KyushuU), F344/Jcl (KyushuU), BDIX/NemOda (KyushuU), DOB/Oda (KyushuU), BDIX.Cg-Tal/NemOda (KyushuU), KFRS3B/Kyo (KyushuU), ZF (KyushuU), ZFDM (KyushuU)
4 225186667 225186668 G A snv ACI/EurMcwi (MCW), KFRS3B/Kyo (KyushuU), GH/OmrMcwi (MCW), SBH/Ygl (MCW), SBN/Ygl (MCW), MHS/Gib (KNAW), WAG/Rij (KNAW), ACI/N (KNAW), ACI/EurMcwi (KNAW), BBDP/WorN (KNAW), SBH/Ygl (KNAW), SBN/Ygl (KNAW), F344/NRrrc (Illumina) (KNAW), BUF/N (KNAW), DA/BklArbNsi (KNAW), F344/NRrrc (SOLiD) (KNAW), F344/NCrl (KNAW), F344/NHsd (KNAW), GK/Ox (KNAW), M520/N (KNAW), WN/N (KNAW), SDLEF7/Barth (UDEL), NIG-III/Hok (KyushuU), F344/DuCrlCrlj (KyushuU), F344/NSlc (KyushuU), RCS/Kyo (KyushuU), LEC/Tj (KyushuU), F344/Jcl (KyushuU), BDIX/NemOda (KyushuU), DOB/Oda (KyushuU), BDIX.Cg-Tal/NemOda (KyushuU), COP/CrCrl (MCW & UW)


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
4 158144560 158144561 G A snv CDS, Buf/N (MCW), WAG/Rij (RGD), GK/Ox (RGD), MHS/Gib (RGD), BBDP/Wor (RGD)
4 158151158 158151159 T C snv ACI/EurMcwi (MCW), COP/CrCrl (MCW & UW), GH/OmrMcwi (MCW), SBH/Ygl (MCW), FHH/EurMcwi (MCW), FHL/EurMcwi (MCW), SBN/Ygl (MCW), SR/JrHsd (MCW), SS/JrHsdMcwi (MCW), CDR, CDS, ACI/N (MCW), Buf/N (MCW), F344/NRrrc (MCW), M520/N (MCW), MR/N (MCW), WKY/N (MCW), WN/N (MCW), FHL/EurMcwi (RGD), ACI/EurMcwi (RGD), BBDP/Wor (RGD), F344/NCrl (RGD), FHH/EurMcwi (RGD), LE/Stm (RGD), LEW/Crl (RGD), LEW/NCrlBR (RGD), LH/MavRrrc (RGD), LN/MavRrrc (RGD), LL/MavRrrc (RGD), MHS/Gib (RGD), MNS/Gib (RGD), SBH/Ygl (RGD), SBN/Ygl (RGD), SHR/NHsd (RGD), SHRSP/Gcrc (RGD), SR/JrHsd (RGD), SS/Jr (RGD), SS/JrHsdMcwi (RGD), WAG/Rij (RGD), WKY/NCrl (RGD), WKY/Gcrc (RGD)
4 158176679 158176680 G A snv ACI/EurMcwi (MCW), WAG/Rij (RGD), GH/OmrMcwi (MCW), SBH/Ygl (MCW), SBN/Ygl (MCW), CDR, CDS, ACI/N (MCW), Buf/N (MCW), F344/NRrrc (MCW), M520/N (MCW), WN/N (MCW), ACI/EurMcwi (RGD), BBDP/Wor (RGD), F344/NCrl (RGD), GK/Ox (RGD), MHS/Gib (RGD), SBH/Ygl (RGD), SBN/Ygl (RGD), COP/CrCrl (MCW & UW)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621759 AgrOrtholog
Ensembl Genes ENSRNOG00000019689 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000026643 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026643 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.410 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cys_knot_C UniProtKB/TrEMBL
  Prot_Inh_CR_TIL UniProtKB/TrEMBL
  Ser_inhib-like_sf UniProtKB/TrEMBL
  Unchr_dom_Cys-rich UniProtKB/TrEMBL
  Von_Willebrand_factor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWA_N2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWF_A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWF_C UniProtKB/TrEMBL
  VWF_type-D UniProtKB/TrEMBL
  vWFA_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:116669 UniProtKB/TrEMBL
NCBI Gene 116669 ENTREZGENE
PANTHER PTHR11339:SF361 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PF08742 UniProtKB/TrEMBL
  TIL UniProtKB/TrEMBL
  VWA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWA_N2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWC UniProtKB/TrEMBL
  VWD UniProtKB/TrEMBL
PhenoGen Vwf PhenoGen
PIRSF VWF UniProtKB/TrEMBL
PROSITE CTCK_1 UniProtKB/TrEMBL
  CTCK_2 UniProtKB/TrEMBL
  VWFA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWFC_1 UniProtKB/TrEMBL
  VWFC_2 UniProtKB/TrEMBL
  VWFD UniProtKB/TrEMBL
SMART SM00041 UniProtKB/TrEMBL
  SM00832 UniProtKB/TrEMBL
  VWA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWC UniProtKB/TrEMBL
  VWC_out UniProtKB/TrEMBL
  VWD UniProtKB/TrEMBL
Superfamily-SCOP Cysrich_TIL UniProtKB/TrEMBL
  SSF53300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt F1M957 ENTREZGENE, UniProtKB/TrEMBL
  Q62935 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary F5XVC1 UniProtKB/TrEMBL
  Q78E31 UniProtKB/Swiss-Prot
  Q9Z0P2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-05-25 Vwf  von Willebrand factor  Vwf  von Willebrand factor homolog  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-10-22 Vwf  von Willebrand factor homolog  Vwf  Von Willebrand factor homolog  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-15 Vwf  Von Willebrand factor homolog  Vwf  von Willebrand factor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Vwf  von Willebrand factor      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Vwf  Von Willebrand factor      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression protein levels increase after partial hepatectomy 727737