VWF (von Willebrand factor) - Rat Genome Database

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Gene: VWF (von Willebrand factor) Canis lupus familiaris
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Symbol: VWF
Name: von Willebrand factor
RGD ID: 12180096
Description: ENCODES a protein that exhibits chaperone binding (ortholog); collagen binding (ortholog); identical protein binding (ortholog); INVOLVED IN blood coagulation (ortholog); cell adhesion (ortholog); cell-substrate adhesion (ortholog); PARTICIPATES IN platelet aggregation pathway; ASSOCIATED WITH von Willebrand's disease 2; Acute Experimental Pancreatitis (ortholog); Aortic Injuries (ortholog); FOUND IN collagen-containing extracellular matrix (ortholog); cytoplasm (ortholog); endoplasmic reticulum (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: F8VWF
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12738,834,812 - 38,972,614 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2738,833,837 - 39,320,142 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha277,641,828 - 7,779,174 (-)NCBI
ROS_Cfam_1.02739,191,850 - 39,329,540 (+)NCBI
UMICH_Zoey_3.12739,062,625 - 39,200,071 (+)NCBI
UNSW_CanFamBas_1.02739,104,190 - 39,241,989 (+)NCBI
UU_Cfam_GSD_1.0277,119,622 - 7,257,688 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Experimental Pancreatitis  (ISO)
Aortic Injuries  (ISO)
atrial fibrillation  (ISO)
Behcet's disease  (ISO)
Bernard-Soulier syndrome  (ISO)
bipolar disorder  (ISO)
blood coagulation disease  (ISO)
cardiovascular system disease  (ISO)
carotid artery disease  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
congestive heart failure  (ISO)
Coronary Disease  (ISO)
Cytomegalovirus Infections  (ISO)
diabetes mellitus  (ISO)
diabetic retinopathy  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (ISO)
episodic ataxia type 1  (ISO)
essential thrombocythemia  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
factor VIII deficiency  (ISO)
familial combined hyperlipidemia  (ISO)
focal segmental glomerulosclerosis  (ISO)
Gastrointestinal Hemorrhage  (ISO)
genetic disease  (ISO)
hemorrhagic disease  (ISO)
Hemorrhagic Shock  (ISO)
Hyperphosphatemic Familial Tumoral Calcinosis 1  (ISO)
hypertension  (ISO)
Insulin Resistance  (ISO)
Intestinal Reperfusion Injury  (ISO)
intracranial thrombosis  (ISO)
Kidney Reperfusion Injury  (ISO)
mesangial proliferative glomerulonephritis  (ISO)
Metabolic Syndrome  (ISO)
myocardial infarction  (ISO)
obesity  (ISO)
osteonecrosis  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
renal cell carcinoma  (ISO)
schizophrenia  (ISO)
severe acute respiratory syndrome  (ISO)
Spinal Cord Injuries  (ISO)
systemic scleroderma  (ISO)
thrombocytopenia  (ISO)
thrombosis  (ISO)
Thrombotic Microangiopathies  (ISO)
Thrombotic Thrombocytopenic Purpura, Acquired  (ISO)
transient cerebral ischemia  (ISO)
type 1 diabetes mellitus  (ISO)
Venous Thromboembolism  (ISO)
Von Willebrand Factor, Deficiency  (ISO)
von Willebrand's disease  (ISO)
von Willebrand's disease 1  (ISO)
von Willebrand's disease 2  (IAGP,ISO)
von Willebrand's disease 3  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:10668811   PMID:10961880   PMID:12871266   PMID:15331450   PMID:16774914   PMID:17593818   PMID:21592973   PMID:28696025  


Genomics

Comparative Map Data
VWF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12738,834,812 - 38,972,614 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2738,833,837 - 39,320,142 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha277,641,828 - 7,779,174 (-)NCBI
ROS_Cfam_1.02739,191,850 - 39,329,540 (+)NCBI
UMICH_Zoey_3.12739,062,625 - 39,200,071 (+)NCBI
UNSW_CanFamBas_1.02739,104,190 - 39,241,989 (+)NCBI
UU_Cfam_GSD_1.0277,119,622 - 7,257,688 (-)NCBI
VWF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl125,948,877 - 6,124,770 (-)EnsemblGRCh38hg38GRCh38
GRCh38125,948,877 - 6,124,670 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37126,058,043 - 6,233,836 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36125,928,301 - 6,104,097 (-)NCBINCBI36hg18NCBI36
Build 34125,928,307 - 6,104,097NCBI
Celera127,677,686 - 7,853,476 (-)NCBI
Cytogenetic Map12p13.31NCBI
HuRef125,910,003 - 6,085,514 (-)NCBIHuRef
CHM1_1126,057,433 - 6,233,298 (-)NCBICHM1_1
Vwf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396125,529,911 - 125,663,642 (+)NCBIGRCm39mm39
GRCm39 Ensembl6125,523,737 - 125,663,642 (+)Ensembl
GRCm386125,552,948 - 125,686,679 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6125,546,774 - 125,686,679 (+)EnsemblGRCm38mm10GRCm38
MGSCv376125,502,981 - 125,636,695 (+)NCBIGRCm37mm9NCBIm37
MGSCv366125,520,072 - 125,652,161 (+)NCBImm8
Celera6127,212,807 - 127,346,911 (+)NCBICelera
Cytogenetic Map6F3NCBI
cM Map659.32NCBI
Vwf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24158,360,152 - 158,491,539 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl4158,360,152 - 158,491,539 (+)Ensembl
Rnor_6.04158,085,059 - 158,219,525 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4158,088,505 - 158,219,523 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04225,098,521 - 225,229,257 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44161,723,415 - 161,854,766 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14162,053,065 - 162,055,090 (+)NCBI
Celera4147,092,791 - 147,223,711 (+)NCBICelera
Cytogenetic Map4q42NCBI
Vwf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554133,672,470 - 3,819,571 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554133,672,470 - 3,825,588 (-)NCBIChiLan1.0ChiLan1.0
VWF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1125,990,612 - 6,166,632 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl125,990,612 - 6,165,153 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0126,073,836 - 6,249,806 (-)NCBIMhudiblu_PPA_v0panPan3
Vwf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945102,910,587 - 103,074,328 (+)NCBI
SpeTri2.0NW_0049367091,578,137 - 1,741,877 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VWF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl564,519,186 - 65,002,098 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1564,516,627 - 64,655,938 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2566,999,793 - 67,078,133 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap5q21NCBI
VWF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1115,994,499 - 6,176,949 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl115,994,039 - 6,162,260 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660632,072,116 - 2,236,240 (+)NCBIVero_WHO_p1.0
Vwf
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248602,843,268 - 2,973,888 (-)NCBIHetGla_female_1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001002932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022410839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038437724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002619917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005302758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF099154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BK007981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000290 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KX661325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L16903 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L26037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L76227 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U66246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000024188   ⟹   ENSCAFP00000022453
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2738,836,959 - 38,972,610 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000024244   ⟹   ENSCAFP00000022508
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2738,976,733 - 39,320,142 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000061734   ⟹   ENSCAFP00000049941
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2738,833,837 - 38,972,610 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000071826   ⟹   ENSCAFP00000053390
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2738,833,837 - 39,000,190 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000080900   ⟹   ENSCAFP00000060771
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2738,833,837 - 38,959,658 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000083915   ⟹   ENSCAFP00000065165
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2738,833,837 - 38,972,610 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000091434   ⟹   ENSCAFP00000051145
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2738,833,837 - 38,972,610 (+)Ensembl
RefSeq Acc Id: NM_001002932   ⟹   NP_001002932
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12738,835,083 - 38,972,614 (+)NCBI
Dog10K_Boxer_Tasha277,641,828 - 7,779,174 (-)NCBI
ROS_Cfam_1.02739,191,850 - 39,329,540 (+)NCBI
UMICH_Zoey_3.12739,062,625 - 39,200,071 (+)NCBI
UNSW_CanFamBas_1.02739,104,190 - 39,241,989 (+)NCBI
UU_Cfam_GSD_1.0277,119,622 - 7,257,688 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038437724   ⟹   XP_038293652
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02739,192,049 - 39,329,540 (+)NCBI
RefSeq Acc Id: XR_005302758
RefSeq Status:
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02739,192,027 - 39,316,960 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_001002932   ⟸   NM_001002932
- Peptide Label: precursor
- UniProtKB: Q28295 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSCAFP00000022453   ⟸   ENSCAFT00000024188
RefSeq Acc Id: ENSCAFP00000022508   ⟸   ENSCAFT00000024244
RefSeq Acc Id: ENSCAFP00000065165   ⟸   ENSCAFT00000083915
RefSeq Acc Id: ENSCAFP00000051145   ⟸   ENSCAFT00000091434
RefSeq Acc Id: ENSCAFP00000060771   ⟸   ENSCAFT00000080900
RefSeq Acc Id: ENSCAFP00000049941   ⟸   ENSCAFT00000061734
RefSeq Acc Id: ENSCAFP00000053390   ⟸   ENSCAFT00000071826
RefSeq Acc Id: XP_038293652   ⟸   XM_038437724
- Peptide Label: isoform X1


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000015228 Ensembl
NCBI Gene VWF ENTREZGENE
UniProt Q28295 ENTREZGENE
VGNC ID VGNC:48329 ENTREZGENE