VWF (von Willebrand factor) - Rat Genome Database

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Gene: VWF (von Willebrand factor) Chlorocebus sabaeus
Analyze
Symbol: VWF
Name: von Willebrand factor
RGD ID: 18531238
Description: ENCODES a protein that exhibits collagen binding (inferred); identical protein binding (inferred); immunoglobulin binding (inferred); INVOLVED IN activation of blood coagulation via clotting cascade (ortholog); blood coagulation (ortholog); cell-substrate adhesion (ortholog); PARTICIPATES IN platelet aggregation pathway; ASSOCIATED WITH Acute Experimental Pancreatitis (ortholog); Aortic Injuries (ortholog); atrial fibrillation (ortholog); FOUND IN collagen-containing extracellular matrix (ortholog); external side of plasma membrane (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1115,994,499 - 6,176,949 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl115,994,039 - 6,162,260 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660632,072,116 - 2,236,240 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Experimental Pancreatitis  (ISO)
Aortic Injuries  (ISO)
atrial fibrillation  (ISO)
autism spectrum disorder  (ISO)
autosomal hemophilia A  (ISO)
Behcet's disease  (ISO)
Bernard-Soulier syndrome  (ISO)
bipolar disorder  (ISO)
blood coagulation disease  (ISO)
cardiovascular system disease  (ISO)
carotid artery disease  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
congestive heart failure  (ISO)
Coronary Disease  (ISO)
Cytomegalovirus Infections  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
Drug Hypersensitivity Syndrome  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (ISO)
episodic ataxia type 1  (ISO)
essential thrombocythemia  (ISO)
exanthem  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
factor VIII deficiency  (ISO)
familial combined hyperlipidemia  (ISO)
focal segmental glomerulosclerosis  (ISO)
Gastrointestinal Hemorrhage  (ISO)
genetic disease  (ISO)
Hemorrhage  (ISO)
hemorrhagic disease  (ISO)
Hemorrhagic Shock  (ISO)
Hyperphosphatemic Familial Tumoral Calcinosis 1  (ISO)
hypertension  (ISO)
Hypothermia  (ISO)
Insulin Resistance  (ISO)
Intestinal Reperfusion Injury  (ISO)
intracranial aneurysm  (ISO)
intracranial thrombosis  (ISO)
Kidney Reperfusion Injury  (ISO)
lymphoproliferative syndrome 2  (ISO)
mesangial proliferative glomerulonephritis  (ISO)
Metabolic Syndrome  (ISO)
myocardial infarction  (ISO)
obesity  (ISO)
osteonecrosis  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
renal cell carcinoma  (ISO)
schizophrenia  (ISO)
severe acute respiratory syndrome  (ISO)
Spinal Cord Injuries  (ISO)
Stevens-Johnson syndrome  (ISO)
systemic scleroderma  (ISO)
thrombocytopenia  (ISO)
thrombosis  (ISO)
Thrombotic Microangiopathies  (ISO)
Thrombotic Thrombocytopenic Purpura, Acquired  (ISO)
transient cerebral ischemia  (ISO)
type 1 diabetes mellitus  (ISO)
Venous Thromboembolism  (ISO)
Von Willebrand Factor, Deficiency  (ISO)
von Willebrand's disease  (ISO)
von Willebrand's disease 1  (ISO)
von Willebrand's disease 2  (ISO)
von Willebrand's disease 3  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
VWF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1115,994,499 - 6,176,949 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl115,994,039 - 6,162,260 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660632,072,116 - 2,236,240 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
VWF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38125,948,877 - 6,124,670 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl125,948,877 - 6,124,770 (-)EnsemblGRCh38hg38GRCh38
GRCh37126,058,043 - 6,233,836 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36125,928,301 - 6,104,097 (-)NCBINCBI36Build 36hg18NCBI36
Build 34125,928,307 - 6,104,097NCBI
Celera127,677,686 - 7,853,476 (-)NCBICelera
Cytogenetic Map12p13.31NCBI
HuRef125,910,003 - 6,085,514 (-)NCBIHuRef
CHM1_1126,057,433 - 6,233,298 (-)NCBICHM1_1
T2T-CHM13v2.0125,956,421 - 6,132,275 (-)NCBIT2T-CHM13v2.0
Vwf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396125,529,911 - 125,663,642 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6125,523,737 - 125,663,642 (+)EnsemblGRCm39 Ensembl
GRCm386125,552,948 - 125,686,679 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6125,546,774 - 125,686,679 (+)EnsemblGRCm38mm10GRCm38
MGSCv376125,502,981 - 125,636,695 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366125,520,072 - 125,652,161 (+)NCBIMGSCv36mm8
Celera6127,212,807 - 127,346,911 (+)NCBICelera
Cytogenetic Map6F3NCBI
cM Map659.32NCBI
Vwf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84160,042,900 - 160,177,757 (+)NCBIGRCr8
mRatBN7.24158,360,152 - 158,491,539 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4158,360,152 - 158,491,539 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4164,595,998 - 164,727,404 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04160,378,929 - 160,510,343 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04159,012,985 - 159,144,157 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04158,085,059 - 158,219,525 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4158,088,505 - 158,219,523 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04225,098,521 - 225,229,257 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44161,723,415 - 161,854,766 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14162,053,065 - 162,055,090 (+)NCBI
Celera4147,092,791 - 147,223,711 (+)NCBICelera
Cytogenetic Map4q42NCBI
Vwf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554133,672,470 - 3,819,571 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554133,672,470 - 3,825,588 (-)NCBIChiLan1.0ChiLan1.0
VWF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21011,504,401 - 11,680,404 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11211,501,159 - 11,677,162 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0126,073,836 - 6,249,806 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1125,990,612 - 6,166,632 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl125,990,612 - 6,165,153 (-)Ensemblpanpan1.1panPan2
VWF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12738,834,812 - 38,972,614 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2738,833,837 - 39,320,142 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha277,641,828 - 7,779,174 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02739,191,850 - 39,329,540 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2739,193,140 - 39,329,536 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12739,062,625 - 39,200,071 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02739,104,190 - 39,241,989 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0277,119,622 - 7,257,688 (-)NCBIUU_Cfam_GSD_1.0
Vwf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945102,910,587 - 103,074,328 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367091,579,096 - 1,741,754 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367091,578,137 - 1,741,877 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VWF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl564,519,186 - 65,002,452 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1564,516,627 - 64,655,938 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2566,999,793 - 67,078,133 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap5q21NCBI
Vwf
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248602,858,088 - 2,973,052 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248602,843,268 - 2,973,888 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000008872   ⟹   ENSCSAP00000007005
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl115,994,039 - 6,162,260 (-)Ensembl
RefSeq Acc Id: XM_037988386   ⟹   XP_037844314
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660632,072,116 - 2,236,240 (+)NCBI
Protein Sequences
Protein RefSeqs XP_037844314 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAS18294 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000007005.1
Ensembl Acc Id: ENSCSAP00000007005   ⟸   ENSCSAT00000008872
RefSeq Acc Id: XP_037844314   ⟸   XM_037988386
- UniProtKB: A0A0D9REG6 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000010786 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000008872.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.410 UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
InterPro Cys_knot_C UniProtKB/TrEMBL
  Mucin_vWF_Thrombospondin_sf UniProtKB/TrEMBL
  Ser_inhib-like_sf UniProtKB/TrEMBL
  TIL_dom UniProtKB/TrEMBL
  Unchr_dom_Cys-rich UniProtKB/TrEMBL
  Von_Willebrand_factor UniProtKB/TrEMBL
  VWA_N2 UniProtKB/TrEMBL
  VWF_A UniProtKB/TrEMBL
  VWF_dom UniProtKB/TrEMBL
  VWF_type-D UniProtKB/TrEMBL
  vWFA_dom_sf UniProtKB/TrEMBL
NCBI Gene VWF ENTREZGENE
PANTHER EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED UniProtKB/TrEMBL
  PTHR11339:SF361 UniProtKB/TrEMBL
Pfam PF08742 UniProtKB/TrEMBL
  TIL UniProtKB/TrEMBL
  VWA UniProtKB/TrEMBL
  VWA_N2 UniProtKB/TrEMBL
  VWC UniProtKB/TrEMBL
  VWD UniProtKB/TrEMBL
PIRSF VWF UniProtKB/TrEMBL
PRINTS VWFADOMAIN UniProtKB/TrEMBL
PROSITE CTCK_1 UniProtKB/TrEMBL
  CTCK_2 UniProtKB/TrEMBL
  VWFA UniProtKB/TrEMBL
  VWFC_1 UniProtKB/TrEMBL
  VWFC_2 UniProtKB/TrEMBL
  VWFD UniProtKB/TrEMBL
SMART SM00041 UniProtKB/TrEMBL
  SM00832 UniProtKB/TrEMBL
  VWA UniProtKB/TrEMBL
  VWC UniProtKB/TrEMBL
  VWC_out UniProtKB/TrEMBL
  VWD UniProtKB/TrEMBL
Superfamily-SCOP FnI-like domain UniProtKB/TrEMBL
  SSF53300 UniProtKB/TrEMBL
  SSF57567 UniProtKB/TrEMBL
UniProt A0A0D9REG6 ENTREZGENE, UniProtKB/TrEMBL
  Q6T699_CHLSB UniProtKB/TrEMBL