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Gene: Nos3 (nitric oxide synthase 3, endothelial cell) Mus musculus
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Symbol: Nos3
Name: nitric oxide synthase 3, endothelial cell
Description: Exhibits nitric-oxide synthase activity and scaffold protein binding activity. Involved in several processes, including circulatory system development; negative regulation of muscle hyperplasia; and regulation of metal ion transport. Localizes to the cytoplasm and nucleus. Used to study aortic valve disease; essential hypertension; and persistent fetal circulation syndrome. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease (multiple); artery disease (multiple); eye disease (multiple); reproductive organ cancer (multiple); and vasculitis (multiple). Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; hemolymphoid system gland; and nervous system. Orthologous to human NOS3 (nitric oxide synthase 3); PARTICIPATES IN doxorubicin pharmacokinetics pathway; eicosanoid signaling pathway; vascular endothelial growth factor signaling pathway; INTERACTS WITH (25R)-cholest-5-ene-3beta,26-diol; (R)-lipoic acid; 1,2-dichloroethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2310065A03Rik; cNOS; constitutive NOS; EC-NOS; ecNOS; endothelial nitric oxide synthase; endothelial NOS; eNOS; nitric oxide synthase, endothelial; NOS type III; Nos-3; NOSIII
Orthologs:
Homo sapiens (human) : NOS3 (nitric oxide synthase 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Nos3 (nitric oxide synthase 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nos3 (nitric oxide synthase 3)
Pan paniscus (bonobo/pygmy chimpanzee) : NOS3 (nitric oxide synthase 3)
Canis lupus familiaris (dog) : NOS3 (nitric oxide synthase 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nos3 (nitric oxide synthase 3)
Sus scrofa (pig) : NOS3 (nitric oxide synthase 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38524,364,816 - 24,384,474 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37523,870,637 - 23,890,292 (+)NCBIGRCm37mm9NCBIm37
MGSCv36523,874,884 - 23,894,536 (+)NCBImm8
Celera521,311,457 - 21,334,226 (+)NCBICelera
Cytogenetic Map5 A3NCBI
cM Map511.32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated