RGD Reference Report - Anticoagulatory, antiinflammatory, and antioxidative effects of protocatechuic acid in diabetic mice. - Rat Genome Database

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Anticoagulatory, antiinflammatory, and antioxidative effects of protocatechuic acid in diabetic mice.

Authors: Lin, CY  Huang, CS  Huang, CY  Yin, MC 
Citation: Lin CY, etal., J Agric Food Chem. 2009 Aug 12;57(15):6661-7. doi: 10.1021/jf9015202.
RGD ID: 7207029
Pubmed: PMID:19722571   (View Abstract at PubMed)
DOI: DOI:10.1021/jf9015202   (Journal Full-text)

Content of protocatechuic acid (PA) in eight locally available fresh fruits was analyzed, and the protective effects of this compound in diabetic mice were examined. PA at 1%, 2%, and 4% was supplied to diabetic mice for 8 weeks. PA treatments significantly lowered plasma glucose and increased insulin levels. PA treatments at 2% and 4% significantly lowered plasminogen activator inhibitor-1 activity and fibrinogen level; increased plasma activity of antithrombin-III and protein C; decreased triglyceride content in plasma, heart, and liver; elevated glutathione level and the retention of glutathione peroxidase and catalase activities in heart and kidney. PA treatments at 2% and 4% also significantly lowered plasma C-reactive protein and von Willebrand factor levels and reduced interleukin-6, tumor necrosis factor-alpha, and monocyte chemoattractant protein-1 levels in heart and kidney. These results support that protocatechuic acid could attenuate diabetic complications via its triglyceride-lowering, anticoagulatory, antioxidative, and antiinflammatory effects.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
diabetes mellitus treatmentISOVwf (Mus musculus)7207029; 7207029 RGD 
diabetes mellitus treatmentIDA 7207029 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Vwf  (von Willebrand factor)

Genes (Mus musculus)
Vwf  (Von Willebrand factor)

Genes (Homo sapiens)
VWF  (von Willebrand factor)


Additional Information