RGD Reference Report - Von Willebrand factor antigen levels in Behcet disease. - Rat Genome Database

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Von Willebrand factor antigen levels in Behcet disease.

Authors: Beyan, E  Sadikoglu, B  Ertugrul, E  Beyan, C 
Citation: Beyan E, etal., Am J Hematol. 2005 May;79(1):70-2.
RGD ID: 1580642
Pubmed: PMID:15849757   (View Abstract at PubMed)
DOI: DOI:10.1002/ajh.20317   (Journal Full-text)

High von Willebrand factor antigen (vWF:Ag) levels can be found due to vascular endothelial injury in Behcet disease. The aim of this study is to evaluate whether there is any relationship between vWF:Ag levels and vascular or other organ involvements and acute-phase reactants in Behcet disease. Fifteen controls and 17 Behcet's patients were included; 10 had oral ulcers, 5 had genital ulcers, 3 had skin lesions, 6 had ocular involvement, 5 had arthritis, and 6 had vascular involvement. VWF:Ag levels were higher in Behcet's patients than controls. VWF:Ag levels in Behcet's patients with oral ulcers, genital ulcers, and ocular and vascular involvement were statistically higher than in the control group. Differences between vWF:Ag levels in Behcet's patients with and without organ involvement were not statistically significant. A linear correlation between serum ferritin levels and vWF:Ag levels was observed. These results demonstrate that elevated levels of plasma vWF:Ag are related to Behcet disease exacerbation rather than vascular involvement.




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
VWFHumanBehcet's disease  IDA  RGD 
VwfRatBehcet's disease  ISOVWF (Homo sapiens) RGD 
VwfMouseBehcet's disease  ISOVWF (Homo sapiens) RGD 


Genes (Rattus norvegicus)
Vwf  (von Willebrand factor)

Genes (Mus musculus)
Vwf  (Von Willebrand factor)

Genes (Homo sapiens)
VWF  (von Willebrand factor)