Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Chrna5 (cholinergic receptor nicotinic alpha 5 subunit) Rattus norvegicus
Symbol: Chrna5
Name: cholinergic receptor nicotinic alpha 5 subunit
Description: Exhibits acetylcholine binding activity; acetylcholine-gated cation-selective channel activity; and protein heterodimerization activity. Predicted to contribute to acetylcholine receptor activity and extracellular ligand-gated ion channel activity. Predicted to be involved in several processes, including behavioral response to nicotine; chemical synaptic transmission; and nervous system process. Localizes to the acetylcholine-gated channel complex; dendrite; and neuronal cell body. Human ortholog(s) of this gene implicated in lung cancer. Orthologous to human CHRNA5 (cholinergic receptor nicotinic alpha 5 subunit); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; INTERACTS WITH 1-naphthyl isothiocyanate; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Acetylcholine receptor alpha 5; cetylcholine receptor alpha 5; cholinergic receptor, nicotinic, alpha 5; cholinergic receptor, nicotinic, alpha 5 (neuronal); cholinergic receptor, nicotinic, alpha polypeptide 5; neuronal acetylcholine receptor subunit alpha-5
Allele / Splice: Chrna5em1Mcwi   Chrna5em2Mcwi   Chrna5em18Pas   Chrna5em20(D398N)Pas  
Genetic Models: LE-Chrna5em18Pas LE-Chrna5em20(D398N)Pas LEW-Chrna5em1Mcwi LEW-Chrna5em2Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0859,561,817 - 59,590,172 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0858,143,974 - 58,172,330 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4858,538,002 - 58,566,388 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1858,557,055 - 58,585,442 (+)NCBI
Celera854,856,809 - 54,885,137 (+)NCBICelera
Cytogenetic Map8q24NCBI
RH 3.4 Map8615.2RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Chrna5
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2347
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.