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Gene: Chrna5 (cholinergic receptor nicotinic alpha 5 subunit) Rattus norvegicus
Symbol: Chrna5
Name: cholinergic receptor nicotinic alpha 5 subunit
RGD ID: 2347
Description: Exhibits acetylcholine binding activity and acetylcholine-gated cation-selective channel activity. Predicted to contribute to acetylcholine receptor activity. Predicted to be involved in several processes, including behavioral response to nicotine; cholinergic synaptic transmission; and regulation of synaptic vesicle exocytosis. Localizes to acetylcholine-gated channel complex; dendrite; and neuronal cell body. Human ortholog(s) of this gene implicated in lung cancer. Orthologous to human CHRNA5 (cholinergic receptor nicotinic alpha 5 subunit); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; INTERACTS WITH 1-naphthyl isothiocyanate; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Acetylcholine receptor alpha 5; cetylcholine receptor alpha 5; cholinergic receptor, nicotinic, alpha 5; cholinergic receptor, nicotinic, alpha 5 (neuronal); cholinergic receptor, nicotinic, alpha polypeptide 5; neuronal acetylcholine receptor subunit alpha-5
Homo sapiens (human) : CHRNA5 (cholinergic receptor nicotinic alpha 5 subunit)  HGNC  Alliance
Mus musculus (house mouse) : Chrna5 (cholinergic receptor, nicotinic, alpha polypeptide 5)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Chrna5 (cholinergic receptor nicotinic alpha 5 subunit)
Pan paniscus (bonobo/pygmy chimpanzee) : CHRNA5 (cholinergic receptor nicotinic alpha 5 subunit)
Canis lupus familiaris (dog) : CHRNA5 (cholinergic receptor nicotinic alpha 5 subunit)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Chrna5 (cholinergic receptor nicotinic alpha 5 subunit)
Sus scrofa (pig) : CHRNA5 (cholinergic receptor nicotinic alpha 5 subunit)
Chlorocebus sabaeus (African green monkey) : CHRNA5 (cholinergic receptor nicotinic alpha 5 subunit)
Heterocephalus glaber (naked mole-rat) : Chrna5 (cholinergic receptor nicotinic alpha 5 subunit)
more info ...
Allele / Splice: Chrna5em1Mcwi   Chrna5em2Mcwi   Chrna5em18Pas   Chrna5em20(D398N)Pas  
Genetic Models: LE-Chrna5em18Pas LE-Chrna5em20(D398N)Pas LEW-Chrna5em1Mcwi LEW-Chrna5em2Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0859,561,817 - 59,590,172 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl859,561,721 - 59,590,172 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0858,143,974 - 58,172,330 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4858,538,002 - 58,566,388 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1858,557,055 - 58,585,442 (+)NCBI
Celera854,856,809 - 54,885,137 (+)NCBICelera
Cytogenetic Map8q24NCBI
RH 3.4 Map8615.2RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Chrna5
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2347
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.