CHRNA5 (cholinergic receptor nicotinic alpha 5 subunit) - Rat Genome Database

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Gene: CHRNA5 (cholinergic receptor nicotinic alpha 5 subunit) Canis lupus familiaris
Analyze
Symbol: CHRNA5
Name: cholinergic receptor nicotinic alpha 5 subunit
RGD ID: 12063542
Description: ENCODES a protein that exhibits acetylcholine binding (ortholog); acetylcholine-gated monoatomic cation-selective channel activity (ortholog); protein-containing complex binding (ortholog); INVOLVED IN behavioral response to nicotine (ortholog); cellular response to nicotine (ortholog); detection of mechanical stimulus involved in sensory perception of pain (ortholog); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; ASSOCIATED WITH alcohol use disorder (ortholog); anxiety disorder (ortholog); Bloom syndrome (ortholog); FOUND IN acetylcholine-gated channel complex (ortholog); cholinergic synapse (ortholog); dendrite (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: neuronal acetylcholine receptor subunit alpha-5
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11338,343,966 - 38,355,534 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1338,346,104 - 38,355,468 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1338,303,745 - 38,339,919 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01338,817,161 - 38,853,192 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1338,819,299 - 38,851,688 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11338,508,310 - 38,544,251 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01338,617,724 - 38,654,019 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01339,092,761 - 39,127,369 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CHRNA5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11338,343,966 - 38,355,534 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1338,346,104 - 38,355,468 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1338,303,745 - 38,339,919 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01338,817,161 - 38,853,192 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1338,819,299 - 38,851,688 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11338,508,310 - 38,544,251 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01338,617,724 - 38,654,019 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01339,092,761 - 39,127,369 (-)NCBIUU_Cfam_GSD_1.0
CHRNA5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381578,565,520 - 78,595,269 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1578,565,520 - 78,595,269 (+)EnsemblGRCh38hg38GRCh38
GRCh371578,857,862 - 78,887,611 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361576,644,961 - 76,673,515 (+)NCBINCBI36Build 36hg18NCBI36
Build 341576,644,960 - 76,673,513NCBI
Celera1555,794,174 - 55,823,924 (+)NCBICelera
Cytogenetic Map15q25.1NCBI
HuRef1555,614,929 - 55,644,700 (+)NCBIHuRef
CHM1_11578,976,380 - 79,006,179 (+)NCBICHM1_1
T2T-CHM13v2.01576,428,193 - 76,457,938 (+)NCBIT2T-CHM13v2.0
Chrna5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39954,888,112 - 54,918,704 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl954,888,164 - 54,915,063 (+)EnsemblGRCm39 Ensembl
GRCm38954,980,827 - 55,011,420 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl954,980,880 - 55,007,779 (+)EnsemblGRCm38mm10GRCm38
MGSCv37954,828,687 - 54,855,586 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36954,784,760 - 54,804,712 (+)NCBIMGSCv36mm8
Celera952,224,119 - 52,251,187 (+)NCBICelera
Cytogenetic Map9BNCBI
cM Map929.84NCBI
Chrna5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8864,265,879 - 64,294,233 (+)NCBIGRCr8
mRatBN7.2855,369,794 - 55,398,526 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl855,369,794 - 55,398,146 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx860,911,231 - 60,939,461 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0859,190,233 - 59,218,459 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0857,054,472 - 57,082,703 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0859,561,817 - 59,590,172 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl859,561,721 - 59,590,172 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0858,143,974 - 58,172,330 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4858,538,002 - 58,566,388 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1858,557,055 - 58,585,442 (+)NCBI
Celera854,856,809 - 54,885,137 (+)NCBICelera
RH 3.4 Map8615.2RGD
Cytogenetic Map8q24NCBI
Chrna5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955450946,898 - 974,457 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955450945,400 - 974,129 (+)NCBIChiLan1.0ChiLan1.0
CHRNA5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21667,777,939 - 67,807,732 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11571,943,824 - 71,971,602 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01557,493,730 - 57,530,463 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11576,457,459 - 76,486,376 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1576,455,165 - 76,486,376 (+)Ensemblpanpan1.1panPan2
Chrna5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640118,602,432 - 118,644,746 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647136,452,965 - 36,492,618 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647136,451,070 - 36,492,774 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHRNA5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl747,383,792 - 47,425,841 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1747,382,860 - 47,425,871 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2752,760,970 - 52,784,694 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CHRNA5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1264,747,734 - 4,779,231 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl264,749,766 - 4,776,822 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048137,018,864 - 137,048,250 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Chrna5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248942,357,193 - 2,400,699 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CHRNA5
115 total Variants

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_022426920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038428933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038428941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038428950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038493616 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038493617 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038493618 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038555927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038619852 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038619853 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038619854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038685459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038685460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038685461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000141 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSCAFT00000002737   ⟹   ENSCAFP00000002540
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1338,346,104 - 38,355,468 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845023277   ⟹   ENSCAFP00845018261
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1338,819,299 - 38,851,688 (-)Ensembl
RefSeq Acc Id: XM_038428933   ⟹   XP_038284861
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1338,303,745 - 38,338,323 (-)NCBI
RefSeq Acc Id: XM_038428941   ⟹   XP_038284869
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1338,303,745 - 38,338,329 (-)NCBI
RefSeq Acc Id: XM_038428950   ⟹   XP_038284878
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1338,303,745 - 38,339,919 (-)NCBI
RefSeq Acc Id: XM_038493616   ⟹   XP_038349544
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11338,508,310 - 38,542,671 (-)NCBI
RefSeq Acc Id: XM_038493617   ⟹   XP_038349545
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11338,508,310 - 38,542,677 (-)NCBI
RefSeq Acc Id: XM_038493618   ⟹   XP_038349546
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11338,508,310 - 38,544,251 (-)NCBI
RefSeq Acc Id: XM_038555927   ⟹   XP_038411855
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01339,092,761 - 39,127,369 (-)NCBI
RefSeq Acc Id: XM_038619852   ⟹   XP_038475780
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01338,617,724 - 38,652,422 (-)NCBI
RefSeq Acc Id: XM_038619853   ⟹   XP_038475781
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01338,617,724 - 38,652,428 (-)NCBI
RefSeq Acc Id: XM_038619854   ⟹   XP_038475782
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01338,617,724 - 38,654,019 (-)NCBI
RefSeq Acc Id: XM_038685459   ⟹   XP_038541387
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01338,817,161 - 38,851,580 (-)NCBI
RefSeq Acc Id: XM_038685460   ⟹   XP_038541388
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01338,817,161 - 38,851,586 (-)NCBI
RefSeq Acc Id: XM_038685461   ⟹   XP_038541389
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01338,817,161 - 38,853,192 (-)NCBI
Ensembl Acc Id: ENSCAFP00000002540   ⟸   ENSCAFT00000002737
RefSeq Acc Id: XP_038349546   ⟸   XM_038493618
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038349545   ⟸   XM_038493617
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038349544   ⟸   XM_038493616
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038475782   ⟸   XM_038619854
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038475781   ⟸   XM_038619853
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038475780   ⟸   XM_038619852
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038541389   ⟸   XM_038685461
- Peptide Label: isoform X3
- UniProtKB: A0A8C0LA91 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038541388   ⟸   XM_038685460
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038541387   ⟸   XM_038685459
- Peptide Label: isoform X1
- UniProtKB: A0A8C0TI75 (UniProtKB/TrEMBL),   A0A8I3RXC0 (UniProtKB/TrEMBL),   A0A8C0ME60 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038284878   ⟸   XM_038428950
- Peptide Label: isoform X3
- UniProtKB: A0A8C0LA91 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038284869   ⟸   XM_038428941
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038284861   ⟸   XM_038428933
- Peptide Label: isoform X1
- UniProtKB: A0A8C0TI75 (UniProtKB/TrEMBL),   A0A8I3RXC0 (UniProtKB/TrEMBL),   A0A8C0ME60 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038411855   ⟸   XM_038555927
- Peptide Label: isoform X1
- UniProtKB: A0A8C0ME60 (UniProtKB/TrEMBL),   A0A8C0TI75 (UniProtKB/TrEMBL),   A0A8I3RXC0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845018261   ⟸   ENSCAFT00845023277
Protein Domains
Neurotransmitter-gated ion-channel ligand-binding   Neurotransmitter-gated ion-channel transmembrane


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000001745 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030006442 UniProtKB/TrEMBL
  ENSCAFG00040022270 UniProtKB/TrEMBL
  ENSCAFG00845013065 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000002737.6 UniProtKB/TrEMBL
  ENSCAFT00030011893.1 UniProtKB/TrEMBL
  ENSCAFT00040041406.1 UniProtKB/TrEMBL
  ENSCAFT00845023277 ENTREZGENE
  ENSCAFT00845023277.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.58.390 UniProtKB/TrEMBL
  2.70.170.10 UniProtKB/TrEMBL
InterPro Neur_chan_lig-bd UniProtKB/TrEMBL
  Neur_chan_lig-bd_sf UniProtKB/TrEMBL
  Neur_channel UniProtKB/TrEMBL
  Neuro-gated_channel_TM_sf UniProtKB/TrEMBL
  Neuro_actylchol_rec UniProtKB/TrEMBL
  Neurotrans-gated_channel_TM UniProtKB/TrEMBL
  Neurotransmitter_ion_chnl_CS UniProtKB/TrEMBL
  Nicotinic_acetylcholine_rcpt UniProtKB/TrEMBL
NCBI Gene CHRNA5 ENTREZGENE
PANTHER NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-5 UniProtKB/TrEMBL
  PTHR18945 UniProtKB/TrEMBL
Pfam Neur_chan_LBD UniProtKB/TrEMBL
  Neur_chan_memb UniProtKB/TrEMBL
PRINTS NICOTINICR UniProtKB/TrEMBL
  NRIONCHANNEL UniProtKB/TrEMBL
PROSITE NEUROTR_ION_CHANNEL UniProtKB/TrEMBL
Superfamily-SCOP SSF63712 UniProtKB/TrEMBL
  SSF90112 UniProtKB/TrEMBL
UniProt A0A8C0LA91 ENTREZGENE
  A0A8C0ME60 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0TI75 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3RXC0 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:49739 ENTREZGENE