CHRNA5 (cholinergic receptor nicotinic alpha 5 subunit) - Rat Genome Database

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Gene: CHRNA5 (cholinergic receptor nicotinic alpha 5 subunit) Chlorocebus sabaeus
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Symbol: CHRNA5
Name: cholinergic receptor nicotinic alpha 5 subunit
RGD ID: 18450230
Description: ENCODES a protein that exhibits acetylcholine binding (ortholog); acetylcholine-gated monoatomic cation-selective channel activity (ortholog); protein-containing complex binding (ortholog); INVOLVED IN behavioral response to nicotine (ortholog); cellular response to nicotine (ortholog); detection of mechanical stimulus involved in sensory perception of pain (ortholog); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; ASSOCIATED WITH alcohol use disorder (ortholog); anxiety disorder (ortholog); Bloom syndrome (ortholog); FOUND IN acetylcholine-gated channel complex (ortholog); cholinergic synapse (ortholog); dendrite (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: neuronal acetylcholine receptor subunit alpha-5
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1264,747,734 - 4,779,231 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl264,749,766 - 4,776,822 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048137,018,864 - 137,048,250 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CHRNA5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1264,747,734 - 4,779,231 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl264,749,766 - 4,776,822 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048137,018,864 - 137,048,250 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
CHRNA5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381578,565,520 - 78,595,269 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1578,565,520 - 78,595,269 (+)EnsemblGRCh38hg38GRCh38
GRCh371578,857,862 - 78,887,611 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361576,644,961 - 76,673,515 (+)NCBINCBI36Build 36hg18NCBI36
Build 341576,644,960 - 76,673,513NCBI
Celera1555,794,174 - 55,823,924 (+)NCBICelera
Cytogenetic Map15q25.1NCBI
HuRef1555,614,929 - 55,644,700 (+)NCBIHuRef
CHM1_11578,976,380 - 79,006,179 (+)NCBICHM1_1
T2T-CHM13v2.01576,428,193 - 76,457,938 (+)NCBIT2T-CHM13v2.0
Chrna5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39954,888,112 - 54,918,704 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl954,888,164 - 54,915,063 (+)EnsemblGRCm39 Ensembl
GRCm38954,980,827 - 55,011,420 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl954,980,880 - 55,007,779 (+)EnsemblGRCm38mm10GRCm38
MGSCv37954,828,687 - 54,855,586 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36954,784,760 - 54,804,712 (+)NCBIMGSCv36mm8
Celera952,224,119 - 52,251,187 (+)NCBICelera
Cytogenetic Map9BNCBI
cM Map929.84NCBI
Chrna5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8864,265,879 - 64,294,233 (+)NCBIGRCr8
mRatBN7.2855,369,794 - 55,398,526 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl855,369,794 - 55,398,146 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx860,911,231 - 60,939,461 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0859,190,233 - 59,218,459 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0857,054,472 - 57,082,703 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0859,561,817 - 59,590,172 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl859,561,721 - 59,590,172 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0858,143,974 - 58,172,330 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4858,538,002 - 58,566,388 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1858,557,055 - 58,585,442 (+)NCBI
Celera854,856,809 - 54,885,137 (+)NCBICelera
RH 3.4 Map8615.2RGD
Cytogenetic Map8q24NCBI
Chrna5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955450946,898 - 974,457 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955450945,400 - 974,129 (+)NCBIChiLan1.0ChiLan1.0
CHRNA5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21667,777,939 - 67,807,732 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11571,943,824 - 71,971,602 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01557,493,730 - 57,530,463 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11576,457,459 - 76,486,376 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1576,455,165 - 76,486,376 (+)Ensemblpanpan1.1panPan2
CHRNA5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11338,343,966 - 38,355,534 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1338,346,104 - 38,355,468 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1338,303,745 - 38,339,919 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01338,817,161 - 38,853,192 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1338,819,299 - 38,851,688 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11338,508,310 - 38,544,251 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01338,617,724 - 38,654,019 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01339,092,761 - 39,127,369 (-)NCBIUU_Cfam_GSD_1.0
Chrna5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640118,602,432 - 118,644,746 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647136,452,965 - 36,492,618 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647136,451,070 - 36,492,774 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHRNA5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl747,383,792 - 47,425,841 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1747,382,860 - 47,425,871 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2752,760,970 - 52,784,694 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Chrna5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248942,357,193 - 2,400,699 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Sequence


Ensembl Acc Id: ENSCSAT00000013064   ⟹   ENSCSAP00000011076
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl264,749,766 - 4,776,822 (-)Ensembl
RefSeq Acc Id: XM_008015703   ⟹   XP_008013894
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1264,749,316 - 4,779,231 (-)NCBI
Vero_WHO_p1.0NW_023666048137,018,864 - 137,046,661 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008015704   ⟹   XP_008013895
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1264,747,734 - 4,779,231 (-)NCBI
Vero_WHO_p1.0NW_023666048137,018,865 - 137,048,250 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008015705   ⟹   XP_008013896
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1264,749,316 - 4,779,231 (-)NCBI
Vero_WHO_p1.0NW_023666048137,018,868 - 137,047,449 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038010230   ⟹   XP_037866158
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666048137,019,257 - 137,046,661 (+)NCBI
RefSeq Acc Id: XM_038010231   ⟹   XP_037866159
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666048137,034,393 - 137,046,661 (+)NCBI
RefSeq Acc Id: XM_038010232   ⟹   XP_037866160
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666048137,019,257 - 137,046,661 (+)NCBI
RefSeq Acc Id: XM_038010233   ⟹   XP_037866161
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666048137,018,868 - 137,046,593 (+)NCBI
RefSeq Acc Id: XM_038010234   ⟹   XP_037866162
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666048137,018,868 - 137,046,593 (+)NCBI
RefSeq Acc Id: XP_008013895   ⟸   XM_008015704
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RR37 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_008013896   ⟸   XM_008015705
- Peptide Label: isoform X4
RefSeq Acc Id: XP_008013894   ⟸   XM_008015703
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RR37 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCSAP00000011076   ⟸   ENSCSAT00000013064
RefSeq Acc Id: XP_037866161   ⟸   XM_038010233
- Peptide Label: isoform X5
RefSeq Acc Id: XP_037866162   ⟸   XM_038010234
- Peptide Label: isoform X6
RefSeq Acc Id: XP_037866160   ⟸   XM_038010232
- Peptide Label: isoform X3
- UniProtKB: A0A0D9RR37 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037866158   ⟸   XM_038010230
- Peptide Label: isoform X3
- UniProtKB: A0A0D9RR37 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037866159   ⟸   XM_038010231
- Peptide Label: isoform X3
- UniProtKB: A0A0D9RR37 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000014985 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000013064.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.58.390 UniProtKB/TrEMBL
  2.70.170.10 UniProtKB/TrEMBL
InterPro Neur_chan_lig-bd UniProtKB/TrEMBL
  Neur_chan_lig-bd_sf UniProtKB/TrEMBL
  Neur_channel UniProtKB/TrEMBL
  Neuro-gated_channel_TM_sf UniProtKB/TrEMBL
  Neuro_actylchol_rec UniProtKB/TrEMBL
  Neurotrans-gated_channel_TM UniProtKB/TrEMBL
  Neurotransmitter_ion_chnl_CS UniProtKB/TrEMBL
  Nicotinic_acetylcholine_rcpt UniProtKB/TrEMBL
NCBI Gene CHRNA5 ENTREZGENE
PANTHER NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-5 UniProtKB/TrEMBL
  PTHR18945 UniProtKB/TrEMBL
Pfam Neur_chan_LBD UniProtKB/TrEMBL
  Neur_chan_memb UniProtKB/TrEMBL
PRINTS NICOTINICR UniProtKB/TrEMBL
  NRIONCHANNEL UniProtKB/TrEMBL
PROSITE NEUROTR_ION_CHANNEL UniProtKB/TrEMBL
  PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
Superfamily-SCOP SSF63712 UniProtKB/TrEMBL
  SSF90112 UniProtKB/TrEMBL
UniProt A0A0D9RR37 ENTREZGENE, UniProtKB/TrEMBL