Chrna5 (cholinergic receptor, nicotinic, alpha polypeptide 5) - Rat Genome Database

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Gene: Chrna5 (cholinergic receptor, nicotinic, alpha polypeptide 5) Mus musculus
Analyze
Symbol: Chrna5
Name: cholinergic receptor, nicotinic, alpha polypeptide 5
RGD ID: 737575
MGI Page MGI
Description: Predicted to enable acetylcholine binding activity and acetylcholine-gated monoatomic cation-selective channel activity. Predicted to contribute to acetylcholine receptor activity. Involved in presynaptic modulation of chemical synaptic transmission. Acts upstream of or within response to nicotine. Located in presynapse. Part of acetylcholine-gated channel complex. Is active in dopaminergic synapse. Is expressed in several structures, including brain; gut; lung; trigeminal nerve; and vagus ganglion. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease; cocaine abuse; esophagus squamous cell carcinoma; nicotine dependence; and respiratory system cancer (multiple). Orthologous to human CHRNA5 (cholinergic receptor nicotinic alpha 5 subunit).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ac; Acr; Acra-5; Acra5; MGC124059; MGC124168; neuronal acetylcholine receptor subunit alpha-5; nicotinic acetylcholine receptor alpha5 subunit
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39954,888,112 - 54,918,704 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl954,888,164 - 54,915,063 (+)EnsemblGRCm39 Ensembl
GRCm38954,980,827 - 55,011,420 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl954,980,880 - 55,007,779 (+)EnsemblGRCm38mm10GRCm38
MGSCv37954,828,687 - 54,855,586 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36954,784,760 - 54,804,712 (+)NCBIMGSCv36mm8
Celera952,224,119 - 52,251,187 (+)NCBICelera
Cytogenetic Map9BNCBI
cM Map929.84NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mammalian nicotinic acetylcholine receptors: from structure to function. Albuquerque EX, etal., Physiol Rev. 2009 Jan;89(1):73-120. doi: 10.1152/physrev.00015.2008.
2. Nicotinic acetylcholine receptor region on chromosome 15q25 and lung cancer risk among African Americans: a case-control study. Amos CI, etal., J Natl Cancer Inst. 2010 Aug 4;102(15):1199-205. doi: 10.1093/jnci/djq232. Epub 2010 Jun 16.
3. Nicotinic cholinergic receptors in esophagus: Early alteration during carcinogenesis and prognostic value. Chianello Nicolau M, etal., World J Gastroenterol. 2016 Aug 21;22(31):7146-56. doi: 10.3748/wjg.v22.i31.7146.
4. Multiple isoforms and differential allelic expression of CHRNA5 in lung tissue and lung adenocarcinoma. Falvella FS, etal., Carcinogenesis. 2013 Jun;34(6):1281-5. doi: 10.1093/carcin/bgt062. Epub 2013 Feb 19.
5. Transcription deregulation at the 15q25 locus in association with lung adenocarcinoma risk. Falvella FS, etal., Clin Cancer Res. 2009 Mar 1;15(5):1837-42. doi: 10.1158/1078-0432.CCR-08-2107. Epub 2009 Feb 17.
6. Alterations in nicotinic receptor alpha5 subunit gene differentially impact early and later stages of cocaine addiction: a translational study in transgenic rats and patients. Forget B, etal., Prog Neurobiol. 2021 Feb;197:101898. doi: 10.1016/j.pneurobio.2020.101898. Epub 2020 Aug 22.
7. Fine mapping of chromosome 15q25.1 lung cancer susceptibility in African-Americans. Hansen HM, etal., Hum Mol Genet. 2010 Sep 15;19(18):3652-61. doi: 10.1093/hmg/ddq268. Epub 2010 Jun 29.
8. Chr15q25 genetic variant (rs16969968) independently confers risk of lung cancer, COPD and smoking intensity in a prospective study of high-risk smokers. Hopkins RJ, etal., Thorax. 2021 Mar;76(3):272-280. doi: 10.1136/thoraxjnl-2020-214839. Epub 2021 Jan 8.
9. ASCL1 regulates the expression of the CHRNA5/A3/B4 lung cancer susceptibility locus. Improgo MR, etal., Mol Cancer Res. 2010 Feb;8(2):194-203. doi: 10.1158/1541-7786.MCR-09-0185. Epub 2010 Feb 2.
10. Role of a genetic variant on the 15q25.1 lung cancer susceptibility locus in smoking-associated nasopharyngeal carcinoma. Ji X, etal., PLoS One. 2014 Oct 20;9(10):e109036. doi: 10.1371/journal.pone.0109036. eCollection 2014.
11. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
12. MGDs mouse GO annotations MGD data from the GO Consortium
13. MGD IEA MGD IEA
14. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
15. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
16. CHRNA3 rs1051730 and CHRNA5 rs16969968 polymorphisms are associated with heavy smoking, lung cancer, and chronic obstructive pulmonary disease in a mexican population. Pérez-Morales R, etal., Ann Hum Genet. 2018 Nov;82(6):415-424. doi: 10.1111/ahg.12264. Epub 2018 Jul 11.
17. Mouse MP Annotation Import Pipeline RGD automated import pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. A Novel Tobacco Use Phenotype Suggests the 15q25 and 19q13 Loci May be Differentially Associated With Cigarettes per Day and Tobacco-Related Problems. Richmond-Rakerd LS, etal., Nicotine Tob Res. 2017 Apr 1;19(4):426-434. doi: 10.1093/ntr/ntw260.
21. The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans. Saccone NL, etal., Cancer Res. 2009 Sep 1;69(17):6848-56. doi: 10.1158/0008-5472.CAN-09-0786. Epub 2009 Aug 25.
22. CHRNA5 gene D398N polymorphism in Japanese lung adenocarcinoma. Sasaki H, etal., J Surg Res. 2010 Jul;162(1):75-8. doi: 10.1016/j.jss.2009.01.008. Epub 2009 Feb 7.
23. CHRNA5 polymorphism and susceptibility to lung cancer in a Chinese population. Shen B, etal., Braz J Med Biol Res. 2013 Jan;46(1):79-84. doi: 10.1590/1414-431x20122451. Epub 2013 Jan 11.
24. Knock down of the alpha 5 nicotinic acetylcholine receptor in spinal nerve-ligated rats alleviates mechanical allodynia. Vincler MA and Eisenach JC, Pharmacol Biochem Behav. 2005 Jan;80(1):135-43. doi: 10.1016/j.pbb.2004.10.011. Epub 2004 Nov 18.
25. Integrating expression-related SNPs into genome-wide gene- and pathway-based analyses identified novel lung cancer susceptibility genes. Wang Y, etal., Int J Cancer. 2018 Apr 15;142(8):1602-1610. doi: 10.1002/ijc.31182. Epub 2017 Dec 12.
26. Genetic variants of CHRNA5-A3 and CHRNB3-A6 predict survival of patients with advanced non-small cell lung cancer. Wang Y, etal., Oncotarget. 2016 May 3;7(18):26436-43. doi: 10.18632/oncotarget.8510.
27. Association of CHRNA5-A3-B4 variation with esophageal squamous cell carcinoma risk and smoking behaviors in a Chinese population. Wang Y, etal., PLoS One. 2013 Jul 2;8(7):e67664. doi: 10.1371/journal.pone.0067664. Print 2013.
28. Functionally significant nicotine acetylcholine receptor subunit α5 promoter haplotypes are associated with susceptibility to lung cancer in Chinese. Zheng X, etal., Cancer. 2011 Oct 15;117(20):4714-23. doi: 10.1002/cncr.26017. Epub 2011 Mar 29.
Additional References at PubMed
PMID:1505988   PMID:2004777   PMID:8563774   PMID:8748389   PMID:8838678   PMID:9096119   PMID:9495872   PMID:10349636   PMID:10765558   PMID:10805811   PMID:10922068   PMID:11042159  
PMID:11076861   PMID:11217851   PMID:12122136   PMID:12225896   PMID:12477932   PMID:12695534   PMID:14996991   PMID:15611037   PMID:15694199   PMID:15788760   PMID:15922075   PMID:15973160  
PMID:16141072   PMID:16141073   PMID:16602821   PMID:17401441   PMID:17434683   PMID:17573823   PMID:18184829   PMID:19139153   PMID:19220484   PMID:19228980   PMID:19279237   PMID:19481067  
PMID:19521566   PMID:19693710   PMID:20377613   PMID:20496163   PMID:20610759   PMID:21143907   PMID:21267068   PMID:21278726   PMID:21485013   PMID:21555077   PMID:21682884   PMID:21873635  
PMID:22030359   PMID:22072695   PMID:22380605   PMID:22396410   PMID:23213462   PMID:23613527   PMID:23869214   PMID:24144909   PMID:24296975   PMID:24647947   PMID:24750073   PMID:24827827  
PMID:24952961   PMID:25725336   PMID:25911614   PMID:25931144   PMID:26500498   PMID:27385416   PMID:28112735   PMID:28498560   PMID:29158387   PMID:29573323   PMID:29940207   PMID:29954848  
PMID:30891952   PMID:32817066   PMID:34065662   PMID:34321999   PMID:34518365   PMID:34737286   PMID:34803779   PMID:35513071   PMID:35595472   PMID:35752273   PMID:35973602   PMID:37116611  


Genomics

Comparative Map Data
Chrna5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39954,888,112 - 54,918,704 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl954,888,164 - 54,915,063 (+)EnsemblGRCm39 Ensembl
GRCm38954,980,827 - 55,011,420 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl954,980,880 - 55,007,779 (+)EnsemblGRCm38mm10GRCm38
MGSCv37954,828,687 - 54,855,586 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36954,784,760 - 54,804,712 (+)NCBIMGSCv36mm8
Celera952,224,119 - 52,251,187 (+)NCBICelera
Cytogenetic Map9BNCBI
cM Map929.84NCBI
CHRNA5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381578,565,520 - 78,595,269 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1578,565,520 - 78,595,269 (+)EnsemblGRCh38hg38GRCh38
GRCh371578,857,862 - 78,887,611 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361576,644,961 - 76,673,515 (+)NCBINCBI36Build 36hg18NCBI36
Build 341576,644,960 - 76,673,513NCBI
Celera1555,794,174 - 55,823,924 (+)NCBICelera
Cytogenetic Map15q25.1NCBI
HuRef1555,614,929 - 55,644,700 (+)NCBIHuRef
CHM1_11578,976,380 - 79,006,179 (+)NCBICHM1_1
T2T-CHM13v2.01576,428,193 - 76,457,938 (+)NCBIT2T-CHM13v2.0
Chrna5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8864,265,879 - 64,294,233 (+)NCBIGRCr8
mRatBN7.2855,369,794 - 55,398,526 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl855,369,794 - 55,398,146 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx860,911,231 - 60,939,461 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0859,190,233 - 59,218,459 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0857,054,472 - 57,082,703 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0859,561,817 - 59,590,172 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl859,561,721 - 59,590,172 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0858,143,974 - 58,172,330 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4858,538,002 - 58,566,388 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1858,557,055 - 58,585,442 (+)NCBI
Celera854,856,809 - 54,885,137 (+)NCBICelera
RH 3.4 Map8615.2RGD
Cytogenetic Map8q24NCBI
Chrna5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955450946,898 - 974,457 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955450945,400 - 974,129 (+)NCBIChiLan1.0ChiLan1.0
CHRNA5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21667,777,939 - 67,807,732 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11571,943,824 - 71,971,602 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01557,493,730 - 57,530,463 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11576,457,459 - 76,486,376 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1576,455,165 - 76,486,376 (+)Ensemblpanpan1.1panPan2
CHRNA5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11338,343,966 - 38,355,534 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1338,346,104 - 38,355,468 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1338,303,745 - 38,339,919 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01338,817,161 - 38,853,192 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1338,819,299 - 38,851,688 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11338,508,310 - 38,544,251 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01338,617,724 - 38,654,019 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01339,092,761 - 39,127,369 (-)NCBIUU_Cfam_GSD_1.0
Chrna5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640118,602,432 - 118,644,746 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647136,452,965 - 36,492,618 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647136,451,070 - 36,492,774 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHRNA5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl747,383,792 - 47,425,841 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1747,382,860 - 47,425,871 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2752,760,970 - 52,784,694 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CHRNA5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1264,747,734 - 4,779,231 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl264,749,766 - 4,776,822 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048137,018,864 - 137,048,250 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Chrna5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248942,357,193 - 2,400,699 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Chrna5
808 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:292
Count of miRNA genes:221
Interacting mature miRNAs:246
Transcripts:ENSMUST00000093844
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13208563Bmiq8_mbody mass index QTL 8 (mouse)92491129668907282Mouse
11532712Sluc39d_msusceptibility to lung cancer 39d (mouse)92558748559587581Mouse
11532696Sluc39c_msusceptibility to lung cancer 39c (mouse)92558748559587581Mouse
11532694Sluc39a_msusceptibility to lung cancer 39a (mouse)92558748559587581Mouse
11532695Sluc39b_msusceptibility to lung cancer 39b (mouse)92558748559587581Mouse
10043987Stheal13_msoft tissue heal 13 (mouse)Not determined92679642160796552Mouse
1300932Hdlq17_mHDL QTL 17 (mouse)Not determined92679642160796552Mouse
10043867Mtbcq9_mmultiple trait body composition QTL 9 (mouse)Not determined92679642160796552Mouse
10043878Adip20_madiposity 20 (mouse)Not determined92725119461251323Mouse
10043847Hdlq89_mHDL QTL 89 (mouse)Not determined92929292963293072Mouse
1301782Chol11_mcholesterol 11 (mouse)Not determined92929292963293072Mouse
1301365Ap5q_malcohol preference 5 QTL (mouse)Not determined93005316464053277Mouse
1357746Vtbt7_mvertebral trabecular bone trait 7 (mouse)Not determined93073991564740021Mouse
1302180Actd4_mactivity-distance traveled 4 (mouse)Not determined93243456366434857Mouse
4141148Cq5_mcholesterol QTL 5 (mouse)Not determined93245242166452546Mouse
1301692Hts_mhypothermia sensitivity (mouse)Not determined93251117266511421Mouse
4141323Ptnu3_mproteinuria 3 (mouse)Not determined93288970266889836Mouse
1357709Si5lq3_mserum IGFBP-5 level QTL 3 (mouse)Not determined93311102567111140Mouse
1558872Ibdq1_minflammatory bowel disease QTL 1 (mouse)Not determined93397884073439255Mouse
1301252Etohc3_methanol consumption 3 (mouse)Not determined93503447869034599Mouse
1301972Cocrb8_mcocaine related behavior 8 (mouse)Not determined93503447869034599Mouse
1558968Tbdr1_mbody temperature response to dietary restriction, QTL 1 (mouse)Not determined93503447869034599Mouse
4142042Alpq3_malcohol preference QTL 3 (mouse)Not determined93730619798701707Mouse
10043971Obq32_mobesity QTL 32 (mouse)Not determined93781952871819528Mouse
12790986Pcho9_mplasma cholesterol 9 (mouse)93809957572099575Mouse
12790992Arlsq1_maortic root lesion size QTL 1 (mouse)93809957572099575Mouse
12791002Arlsq2_maortic root lesion size QTL 2 (mouse)93809957572099575Mouse
12738449Spcq2_msperm count QTL 2 (mouse)93939988573399885Mouse
4141071Ath29_matherosclerosis 29 (mouse)Not determined94041959474607925Mouse
1301702Brm1_mbrachyury modifier 1 (mouse)Not determined94080504774805204Mouse
1301558Stheal8_msoft tissue heal 8 (mouse)Not determined94348071477480860Mouse
10045639Heal28_mwound healing/regeneration 28 (mouse)Not determined94348071477480860Mouse
1301435Trigq1_mtriglyceride QTL 1 (mouse)Not determined94442817478428262Mouse
4141572Ntta3_mneurotensin transcript abundance 3 (mouse)Not determined4659767165831177Mouse
4141754Fecq4_mfecundity QTL 4 (mouse)Not determined94754302457805204Mouse
1300563Pgia5_mproteoglycan induced arthritis 5 (mouse)Not determined94883105682831177Mouse
1300716Cd4ts4_mCD4 T cell subset 4 (mouse)Not determined94883105682831177Mouse
1301051Eae9_msusceptibility to experimental allergic encephalomyelitis 9 (mouse)Not determined94942029863239852Mouse
1301049El4_mepilepsy 4 (mouse)Not determined94942029867151448Mouse
4141224Dxmod_mdoxorubicin nephropathy modifier (mouse)Not determined49452421101406120Mouse
14746993Manh66_mmandible shape 66 (mouse)94981404883814048Mouse
1301184Bdln4_mbody length 4 (mouse)Not determined95015132084151448Mouse
1301241Renf1_mrenal failure 1 (mouse)Not determined95203447899792481Mouse
13525008Hrtiq1_mheart rate time index, QTL 1 (mouse)95242609868556008Mouse
12790990Tgl7_mtriglyceride 7 (mouse)95455996088559960Mouse

Markers in Region
Chrna5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9BUniSTS
cM Map929.84UniSTS
Chrna5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9BUniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000093844   ⟹   ENSMUSP00000091365
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl954,888,164 - 54,914,202 (+)Ensembl
GRCm38.p6 Ensembl954,980,880 - 55,006,918 (+)Ensembl
RefSeq Acc Id: ENSMUST00000213960   ⟹   ENSMUSP00000150942
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl954,888,817 - 54,914,109 (+)Ensembl
GRCm38.p6 Ensembl954,981,533 - 55,006,825 (+)Ensembl
RefSeq Acc Id: ENSMUST00000216865
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl954,888,178 - 54,905,365 (+)Ensembl
GRCm38.p6 Ensembl954,980,894 - 54,998,081 (+)Ensembl
RefSeq Acc Id: ENSMUST00000217408   ⟹   ENSMUSP00000149366
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl954,888,750 - 54,915,063 (+)Ensembl
GRCm38.p6 Ensembl954,981,466 - 55,007,779 (+)Ensembl
RefSeq Acc Id: NM_001373901   ⟹   NP_001360830
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39954,888,772 - 54,918,704 (+)NCBI
GRCm38954,981,488 - 55,011,420 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001373902   ⟹   NP_001360831
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39954,888,772 - 54,918,704 (+)NCBI
GRCm38954,981,488 - 55,011,420 (+)NCBI
Sequence:
RefSeq Acc Id: NM_176844   ⟹   NP_789814
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39954,888,164 - 54,918,704 (+)NCBI
GRCm38954,980,880 - 55,011,420 (+)NCBI
MGSCv37954,828,687 - 54,855,586 (+)RGD
Celera952,224,119 - 52,251,187 (+)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_030244017   ⟹   XP_030099877
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39954,888,112 - 54,916,515 (+)NCBI
GRCm38954,980,827 - 55,007,783 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_789814   ⟸   NM_176844
- Peptide Label: isoform 2
- UniProtKB: Q3KP94 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030099877   ⟸   XM_030244017
- Peptide Label: isoform X1
- UniProtKB: Q9QXK6 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001360830   ⟸   NM_001373901
- Peptide Label: isoform 1 precursor
- UniProtKB: Q2MKA5 (UniProtKB/Swiss-Prot),   Q6PW45 (UniProtKB/Swiss-Prot),   Q9QXK6 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001360831   ⟸   NM_001373902
- Peptide Label: isoform 3 precursor
- UniProtKB: A0A1L1SR97 (UniProtKB/TrEMBL),   Q8BIE9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSMUSP00000149366   ⟸   ENSMUST00000217408
RefSeq Acc Id: ENSMUSP00000091365   ⟸   ENSMUST00000093844
RefSeq Acc Id: ENSMUSP00000150942   ⟸   ENSMUST00000213960
Protein Domains
Neurotransmitter-gated ion-channel ligand-binding   Neurotransmitter-gated ion-channel transmembrane

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q2MKA5-F1-model_v2 AlphaFold Q2MKA5 1-467 view protein structure

Promoters
RGD ID:8669656
Promoter ID:EPDNEW_M12859
Type:initiation region
Name:Chrna5_1
Description:Mus musculus cholinergic receptor, nicotinic, alpha polypeptide5 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38954,981,532 - 54,981,592EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:87889 AgrOrtholog
Ensembl Genes ENSMUSG00000035594 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000093844 ENTREZGENE
  ENSMUST00000093844.5 UniProtKB/Swiss-Prot
  ENSMUST00000213960 ENTREZGENE
  ENSMUST00000213960.2 UniProtKB/Swiss-Prot
  ENSMUST00000217408 ENTREZGENE
  ENSMUST00000217408.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.58.390 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.70.170.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Neur_chan_lig-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_chan_lig-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neuro-gated_channel_TM_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neuro_actylchol_rec UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neurotrans-gated_channel_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neurotransmitter_ion_chnl_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nicotinic_acetylcholine_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:110835 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:87889 ENTREZGENE
NCBI Gene 110835 ENTREZGENE
PANTHER NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR18945 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Neur_chan_LBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_chan_memb UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CHRNA5 RGD
PhenoGen Chrna5 PhenoGen
PRINTS NICOTINICR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NRIONCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NEUROTR_ION_CHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF63712 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF90112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1L1SR97 ENTREZGENE, UniProtKB/TrEMBL
  ACHA5_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3KP94 ENTREZGENE, UniProtKB/TrEMBL
  Q6PW45 ENTREZGENE
  Q8BIE9 ENTREZGENE, UniProtKB/TrEMBL
  Q9QXK6 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q6PW45 UniProtKB/Swiss-Prot