Chrna5<sup>em20(D398N)Pas</sup> (cholinergic receptor, nicotinic, alpha 5 (neuronal); ZFN induced mutant 20,Pas) - Rat Genome Database

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Gene: Chrna5em20(D398N)Pas (cholinergic receptor, nicotinic, alpha 5 (neuronal); ZFN induced mutant 20,Pas) Rattus norvegicus
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Symbol: Chrna5em20(D398N)Pas
Name: cholinergic receptor, nicotinic, alpha 5 (neuronal); ZFN induced mutant 20,Pas
RGD ID: 14402422
Description: The Zinc Finger Nuclease system was used to knock-in SNP rs16969968 in exon 5 (D398N) thus created a missense mutation. The embryos were from breeding of Long Evans from Janvier Labs (RjOrl:LE) and reimplanted to foster mother Dark Agouti (Janvier).
ASSOCIATED WITH abnormal acquisiton of operant behavior for a cocaine reinforcer; high preference for an addictive substance; increased alcohol consumption
Type: allele  of Chrna5  
Previously known as: Chrna5^[em20(D398N)Pas]
Is Marker For: Strains:   LE-Chrna5em20(D398N)Pas  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Profound alteration in reward processing due to a human polymorphism in CHRNA5: a role in alcohol dependence and feeding behavior. Besson M, etal., Neuropsychopharmacology. 2019 Oct;44(11):1906-1916. doi: 10.1038/s41386-019-0462-0. Epub 2019 Jul 9.
2. A Human Polymorphism in CHRNA5 Is Linked to Relapse to Nicotine Seeking in Transgenic Rats. Forget B, etal., Curr Biol. 2018 Oct 22;28(20):3244-3253.e7. doi: 10.1016/j.cub.2018.08.044. Epub 2018 Oct 4.
3. Alterations in nicotinic receptor alpha5 subunit gene differentially impact early and later stages of cocaine addiction: a translational study in transgenic rats and patients. Forget B, etal., Prog Neurobiol. 2021 Feb;197:101898. doi: 10.1016/j.pneurobio.2020.101898. Epub 2020 Aug 22.

Genomics


Related Rat Strains
The following Strains have been annotated to Chrna5em20(D398N)Pas
LE-Chrna5em20(D398N)Pas    


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences


Additional Information