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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2347
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Chrna5
Name: cholinergic receptor nicotinic alpha 5 subunit
Acc ID: CHEBI:29623
Term: manumycin A
Definition: A polyketide with formula C31H38N2O7 initially isolated from Streptomyces parvulus as a result of a random screening program for farnesyl transferase (FTase) inhibitors. It is a natural product that exhibits anticancer and antibiotic properties.
Chemical ID: MESH:C054474
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chrna5multiple interactionsISOCHRNA5 (Homo sapiens)6480464CTDmanumycin inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; manumycin inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]; manumycin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA5 mRNA]; manumycin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA5 protein]PMID:18450646
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