Arf1 (ADP-ribosylation factor 1) - Rat Genome Database

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Gene: Arf1 (ADP-ribosylation factor 1) Rattus norvegicus
Analyze
Symbol: Arf1
Name: ADP-ribosylation factor 1
RGD ID: 621270
Description: Enables guanyl ribonucleotide binding activity; magnesium ion binding activity; and phospholipase D activator activity. Involved in several processes, including Golgi to transport vesicle transport; positive regulation of transport; and postsynapse organization. Located in late endosome. Is active in glutamatergic synapse and postsynaptic density. Colocalizes with COPI-coated vesicle; Golgi apparatus; and peroxisomal membrane. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Orthologous to human ARF1 (ADP ribosylation factor 1); PARTICIPATES IN Arf family mediated signaling pathway; phosphatidylinositol 3-kinase class I signaling pathway; vascular endothelial growth factor signaling pathway; INTERACTS WITH 2,4,6-trinitrotoluene; bexarotene; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC72830
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21043,997,983 - 44,014,461 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1043,997,986 - 44,014,434 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1048,692,668 - 48,708,202 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01048,183,026 - 48,198,560 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01043,686,624 - 43,702,158 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01045,562,700 - 45,579,214 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1045,563,547 - 45,579,029 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01045,318,170 - 45,334,673 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41045,516,609 - 45,532,091 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11045,529,387 - 45,545,841 (-)NCBI
Celera1043,262,080 - 43,277,562 (-)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,4,6-trinitrotoluene  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
5-fluorouracil  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bexarotene  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
caffeine  (ISO)
captan  (ISO)
carmustine  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cyclosporin A  (ISO)
DDT  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dichlorine  (EXP)
dorsomorphin  (ISO)
enzyme inhibitor  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
haloperidol  (EXP)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
irinotecan  (ISO)
ivermectin  (ISO)
josamycin  (ISO)
L-methionine  (ISO)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (ISO)
nefazodone  (EXP)
nicotine  (ISO)
ozone  (EXP)
p-chloromercuribenzoic acid  (ISO)
paraquat  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pyrogallol  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tetrachloromethane  (ISO)
theophylline  (ISO)
trichostatin A  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ARF-induced lysosomal lysis in vitro. Arai K, etal., J Biochem. 1998 Apr;123(4):637-43.
2. Role of ADP ribosylation factor 1 in the assembly and secretion of ApoB-100-containing lipoproteins. Asp L, etal., Arterioscler Thromb Vasc Biol. 2005 Mar;25(3):566-70. Epub 2004 Dec 23.
3. Formation of nascent secretory vesicles from the trans-Golgi network of endocrine cells is inhibited by tyrosine kinase and phosphatase inhibitors. Austin CD and Shields D, J Cell Biol. 1996 Dec;135(6 Pt 1):1471-83.
4. Membrane curvature induced by Arf1-GTP is essential for vesicle formation. Beck R, etal., Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):11731-6. doi: 10.1073/pnas.0805182105. Epub 2008 Aug 8.
5. Translocation of Arf1 to the secretory granules in rat parotid acinar cells. Dohke Y, etal., Arch Biochem Biophys. 1998 Sep 1;357(1):147-54.
6. Differential expression and targeting of endogenous Arf1 and Arf6 small GTPases in kidney epithelial cells in situ. El-Annan J, etal., Am J Physiol Cell Physiol. 2004 Apr;286(4):C768-78. Epub 2003 Dec 18.
7. A function for the AP3 coat complex in synaptic vesicle formation from endosomes. Faundez V, etal., Cell. 1998 May 1;93(3):423-32.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. The structure of rat ADP-ribosylation factor-1 (ARF-1) complexed to GDP determined from two different crystal forms. Greasley SE, etal., Nat Struct Biol. 1995 Sep;2(9):797-806.
10. Binding and functions of ADP-ribosylation factor on mammalian and yeast peroxisomes. Lay D, etal., J Biol Chem. 2005 Oct 14;280(41):34489-99. Epub 2005 Aug 12.
11. Effect of protein kinase A activity on the association of ADP-ribosylation factor 1 to golgi membranes. Martin ME, etal., J Biol Chem. 2000 Jun 23;275(25):19050-9.
12. Activation of rat brain phospholipase D by ADP-ribosylation factors 1,5, and 6: separation of ADP-ribosylation factor-dependent and oleate-dependent enzymes. Massenburg D, etal., Proc Natl Acad Sci U S A. 1994 Nov 22;91(24):11718-22.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. ADP-ribosylation factor 1 protein regulates trypsinogen activation via organellar trafficking of procathepsin B protein and autophagic maturation in acute pancreatitis. Orlichenko L, etal., J Biol Chem. 2012 Jul 13;287(29):24284-93. doi: 10.1074/jbc.M111.328815. Epub 2012 May 8.
16. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
17. Interspecies relationships among ADP-ribosylation factors (ARFs): evidence of evolutionary pressure to maintain individual identities. Price SR, etal., Mol Cell Biochem 1996 Jun 7;159(1):15-23.
18. GOA pipeline RGD automated data pipeline
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. The small GTPase Arf1 modulates Arp2/3-mediated actin polymerization via PICK1 to regulate synaptic plasticity. Rocca DL, etal., Neuron. 2013 Jul 24;79(2):293-307. doi: 10.1016/j.neuron.2013.05.003.
21. Arf-1 (ADP-ribosylation factor-1) is involved in the activation of a mammalian Na+-selective current. Straube S and Parekh AB, Biochem J 2004 Jan 15;377(Pt 2):539-44.
22. Effects of brefeldin A and accessory proteins on association of ADP-ribosylation factors 1, 3, and 5 with Golgi. Tsai SC, etal., J Biol Chem. 1993 May 25;268(15):10820-5.
23. Activation of exocytosis by cross-linking of the IgE receptor is dependent on ADP-ribosylation factor 1-regulated phospholipase D in RBL-2H3 mast cells: evidence that the mechanism of activation is via regulation of phosphatidylinositol 4,5-bisphosphate synthesis. Way G, etal., Biochem J. 2000 Feb 15;346 Pt 1:63-70.
24. Role of Arf1 in endosomal trafficking of protein-metal complexes and cadmium-metallothionein-1 toxicity in kidney proximal tubule cells. Wolff NA, etal., Toxicol Lett. 2011 Jun 24;203(3):210-8. doi: 10.1016/j.toxlet.2011.03.014. Epub 2011 Mar 21.
25. Expression of a dominant allele of human ARF1 inhibits membrane traffic in vivo. Zhang CJ, etal., J Cell Biol. 1994 Feb;124(3):289-300.
Additional References at PubMed
PMID:7890632   PMID:8947846   PMID:10022920   PMID:10623590   PMID:10747863   PMID:11092755   PMID:12477932   PMID:12668765   PMID:12679809   PMID:14728599   PMID:15489334   PMID:15616190  
PMID:16101683   PMID:17562717   PMID:17693410   PMID:18693248   PMID:19199708   PMID:20458337   PMID:21034850   PMID:21187408   PMID:21423176   PMID:22573891   PMID:22681889   PMID:23533145  
PMID:26446845   PMID:27535433   PMID:28389568  


Genomics

Comparative Map Data
Arf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21043,997,983 - 44,014,461 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1043,997,986 - 44,014,434 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1048,692,668 - 48,708,202 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01048,183,026 - 48,198,560 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01043,686,624 - 43,702,158 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01045,562,700 - 45,579,214 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1045,563,547 - 45,579,029 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01045,318,170 - 45,334,673 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41045,516,609 - 45,532,091 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11045,529,387 - 45,545,841 (-)NCBI
Celera1043,262,080 - 43,277,562 (-)NCBICelera
Cytogenetic Map10q22NCBI
ARF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381228,082,708 - 228,099,212 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1228,082,708 - 228,099,212 (+)EnsemblGRCh38hg38GRCh38
GRCh371228,270,409 - 228,286,913 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361226,336,984 - 226,353,536 (+)NCBINCBI36Build 36hg18NCBI36
Build 341224,577,163 - 224,593,645NCBI
Celera1201,460,593 - 201,477,145 (+)NCBICelera
Cytogenetic Map1q42.13NCBI
HuRef1198,785,590 - 198,802,034 (+)NCBIHuRef
CHM1_11229,542,706 - 229,559,258 (+)NCBICHM1_1
T2T-CHM13v2.01227,271,693 - 227,288,198 (+)NCBIT2T-CHM13v2.0
Arf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391159,102,237 - 59,119,042 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1159,102,238 - 59,119,096 (-)EnsemblGRCm39 Ensembl
GRCm381159,211,412 - 59,228,267 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1159,211,412 - 59,228,270 (-)EnsemblGRCm38mm10GRCm38
MGSCv371159,024,914 - 59,041,769 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361159,027,608 - 59,044,381 (-)NCBIMGSCv36mm8
Celera1163,976,432 - 63,993,249 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1137.05NCBI
Arf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955581319,942 - 335,112 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955581319,942 - 335,112 (-)NCBIChiLan1.0ChiLan1.0
ARF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1121,445,519 - 21,462,037 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01203,484,803 - 203,501,395 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11208,695,615 - 208,712,105 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1208,695,615 - 208,712,105 (+)Ensemblpanpan1.1panPan2
ARF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.114835,476 - 836,424 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl14835,476 - 836,424 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha14315,387 - 316,334 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.014554,686 - 568,903 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl14554,687 - 568,881 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.114746,548 - 747,495 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.014527,341 - 528,288 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.014513,272 - 514,220 (-)NCBIUU_Cfam_GSD_1.0
Arf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721387,776,242 - 87,778,336 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936864117,510 - 119,612 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl251,219,667 - 51,237,639 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1251,219,597 - 51,237,640 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2253,874,559 - 53,892,570 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ARF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1251,628,836 - 1,644,502 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl251,628,751 - 1,644,499 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660551,510,307 - 1,525,996 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624937857,795 - 871,089 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Arf1
51 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:137
Count of miRNA genes:108
Interacting mature miRNAs:125
Transcripts:ENSRNOT00000074900
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101790711351786432Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102887565052200160Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103449055945579777Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103539226751793994Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104194452678307017Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)104287676679813922Rat

Markers in Region
RH134612  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21043,997,921 - 43,998,116 (+)MAPPERmRatBN7.2
Rnor_6.01045,562,639 - 45,562,833NCBIRnor6.0
Rnor_5.01045,318,109 - 45,318,303UniSTSRnor5.0
RGSC_v3.41045,515,701 - 45,515,895UniSTSRGSC3.4
Celera1043,261,172 - 43,261,366UniSTS
RH 3.4 Map10503.4UniSTS
Cytogenetic Map10q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000080028   ⟹   ENSRNOP00000072575
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1043,997,986 - 44,014,434 (-)Ensembl
Rnor_6.0 Ensembl1045,563,547 - 45,579,029 (-)Ensembl
RefSeq Acc Id: NM_001414037   ⟹   NP_001400966
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21043,997,983 - 44,014,434 (-)NCBI
RefSeq Acc Id: NM_001414038   ⟹   NP_001400967
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21043,997,983 - 44,014,434 (-)NCBI
RefSeq Acc Id: NM_022518   ⟹   NP_071963
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21043,997,983 - 44,014,434 (-)NCBI
Rnor_6.01045,563,547 - 45,579,029 (-)NCBI
Rnor_5.01045,318,170 - 45,334,673 (-)NCBI
RGSC_v3.41045,516,609 - 45,532,091 (-)RGD
Celera1043,262,080 - 43,277,562 (-)RGD
Sequence:
RefSeq Acc Id: XM_008767870   ⟹   XP_008766092
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21043,997,983 - 44,014,461 (-)NCBI
Rnor_6.01045,562,700 - 45,579,173 (-)NCBI
Sequence:
RefSeq Acc Id: NP_071963   ⟸   NM_022518
- UniProtKB: P84079 (UniProtKB/Swiss-Prot),   A6HEZ7 (UniProtKB/TrEMBL),   A0A8I5ZKF2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008766092   ⟸   XM_008767870
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZKF2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000072575   ⟸   ENSRNOT00000080028
RefSeq Acc Id: NP_001400967   ⟸   NM_001414038
- UniProtKB: P84079 (UniProtKB/Swiss-Prot),   A6HEZ7 (UniProtKB/TrEMBL),   A0A8I5ZKF2 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001400966   ⟸   NM_001414037
- UniProtKB: P84079 (UniProtKB/Swiss-Prot),   A6HEZ7 (UniProtKB/TrEMBL),   A0A8I5ZKF2 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P84079-F1-model_v2 AlphaFold P84079 1-181 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621270 AgrOrtholog
BioCyc Gene G2FUF-24906 BioCyc
Ensembl Genes ENSRNOG00000004807 UniProtKB/TrEMBL
  ENSRNOG00000060229 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055029680 UniProtKB/Swiss-Prot
  ENSRNOG00060030926 UniProtKB/Swiss-Prot
  ENSRNOG00065007676 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000080028 ENTREZGENE
  ENSRNOT00000080028.2 UniProtKB/Swiss-Prot
  ENSRNOT00000113470.1 UniProtKB/TrEMBL
  ENSRNOT00055051399 UniProtKB/Swiss-Prot
  ENSRNOT00060053692 UniProtKB/Swiss-Prot
  ENSRNOT00065012012 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6889332 IMAGE-MGC_LOAD
InterPro Arf1-5-like UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTPase_ARF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTPase_ARF/SAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64310 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72830 IMAGE-MGC_LOAD
NCBI Gene 64310 ENTREZGENE
PANTHER ADP RIBOSYLATION FACTOR-RELATED UniProtKB/TrEMBL
  ADP-RIBOSYLATION FACTOR 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADP-RIBOSYLATION FACTOR 2 UniProtKB/TrEMBL
  PTHR11711 UniProtKB/Swiss-Prot
Pfam Arf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Arf1 PhenoGen
PRINTS SAR1GTPBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ARF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004807 RatGTEx
  ENSRNOG00000060229 RatGTEx
  ENSRNOG00055029680 RatGTEx
  ENSRNOG00060030926 RatGTEx
  ENSRNOG00065007676 RatGTEx
SMART ARF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP P-loop containing nucleoside triphosphate hydrolases UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A0A8I5ZKF2 ENTREZGENE, UniProtKB/TrEMBL
  A6HEZ1_RAT UniProtKB/TrEMBL
  A6HEZ2_RAT UniProtKB/TrEMBL
  A6HEZ3_RAT UniProtKB/TrEMBL
  A6HEZ5_RAT UniProtKB/TrEMBL
  A6HEZ7 ENTREZGENE, UniProtKB/TrEMBL
  A6HF00_RAT UniProtKB/TrEMBL
  ARF1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary P10947 UniProtKB/Swiss-Prot
  P32889 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Arf1  ADP-ribosylation factor 1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Arf1  ADP-ribosylation factor 1      Symbol and Name status set to provisional 70820 PROVISIONAL