Gprc5b (G protein-coupled receptor, class C, group 5, member B) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Gprc5b (G protein-coupled receptor, class C, group 5, member B) Rattus norvegicus
Analyze
Symbol: Gprc5b
Name: G protein-coupled receptor, class C, group 5, member B
RGD ID: 1309510
Description: Predicted to enable protein kinase activator activity; protein kinase inhibitor activity; and protein tyrosine kinase binding activity. Predicted to be involved in several processes, including cell volume homeostasis; positive regulation of macrophage cytokine production; and positive regulation of signal transduction. Predicted to act upstream of or within glucose homeostasis; locomotory behavior; and positive regulation of neuron projection development. Predicted to be located in cell surface. Predicted to be part of receptor complex. Predicted to be active in extracellular exosome; membrane raft; and plasma membrane. Human ortholog(s) of this gene implicated in megalencephalic leukoencephalopathy with subcortical cysts. Orthologous to human GPRC5B (G protein-coupled receptor class C group 5 member B); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: G protein-coupled receptor, family C, group 5, member B; G-protein coupled receptor family C group 5 member B; LOC293546
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81182,748,247 - 182,772,711 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1182,748,247 - 182,772,757 (-)EnsemblGRCr8
mRatBN7.21173,316,904 - 173,340,933 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1173,316,907 - 173,340,932 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1181,627,326 - 181,651,333 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01188,813,438 - 188,837,441 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01181,545,836 - 181,569,872 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01188,688,743 - 188,713,724 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1188,688,743 - 188,713,280 (-)Ensemblrn6Rnor6.0
Rnor_5.01195,631,489 - 195,656,045 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41177,205,905 - 177,230,442 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1171,079,932 - 171,104,476 (-)NCBICelera
RGSC_v3.11177,347,290 - 177,394,956 (-)NCBI
Cytogenetic Map1q35NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atazanavir sulfate  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Brodifacoum  (EXP)
Butylbenzyl phthalate  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chenodeoxycholic acid  (ISO)
clobetasol  (ISO)
cobalt dichloride  (EXP)
cyclosporin A  (ISO)
deoxycholic acid  (ISO)
dextran sulfate  (ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzofurans  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP,ISO)
ethanol  (ISO)
folic acid  (ISO)
FR900359  (ISO)
furan  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
menadione  (ISO)
morphine  (ISO)
N-nitrosodiethylamine  (ISO)
nefazodone  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
quercetin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sevoflurane  (EXP)
sinapic acid  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
Sunset Yellow FCF  (ISO)
tartrazine  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:16502470   PMID:19056867   PMID:20436672   PMID:21557262   PMID:21840300   PMID:22871113   PMID:23169819   PMID:23376485   PMID:23533145   PMID:24089469  


Genomics

Comparative Map Data
Gprc5b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81182,748,247 - 182,772,711 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1182,748,247 - 182,772,757 (-)EnsemblGRCr8
mRatBN7.21173,316,904 - 173,340,933 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1173,316,907 - 173,340,932 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1181,627,326 - 181,651,333 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01188,813,438 - 188,837,441 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01181,545,836 - 181,569,872 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01188,688,743 - 188,713,724 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1188,688,743 - 188,713,280 (-)Ensemblrn6Rnor6.0
Rnor_5.01195,631,489 - 195,656,045 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41177,205,905 - 177,230,442 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1171,079,932 - 171,104,476 (-)NCBICelera
RGSC_v3.11177,347,290 - 177,394,956 (-)NCBI
Cytogenetic Map1q35NCBI
GPRC5B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381619,856,691 - 19,885,634 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1619,856,691 - 19,886,173 (-)Ensemblhg38GRCh38
GRCh371619,868,013 - 19,896,956 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361619,777,794 - 19,803,652 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341619,777,795 - 19,803,652NCBI
Celera1619,019,238 - 19,045,130 (-)NCBICelera
Cytogenetic Map16p12.3NCBI
HuRef1618,406,875 - 18,420,767 (-)NCBIHuRef
CHM1_11619,957,576 - 19,983,445 (-)NCBICHM1_1
T2T-CHM13v2.01619,787,483 - 19,816,404 (-)NCBIT2T-CHM13v2.0
Gprc5b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397118,571,263 - 118,594,434 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7118,571,270 - 118,594,434 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm387118,972,040 - 118,995,211 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7118,972,047 - 118,995,211 (-)Ensemblmm10GRCm38
MGSCv377126,115,554 - 126,138,725 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv367118,763,196 - 118,786,304 (-)NCBIMGSCv36mm8
Celera7118,918,444 - 118,941,648 (-)NCBICelera
Cytogenetic Map7F2NCBI
cM Map763.72NCBI
Gprc5b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554423,548,478 - 3,571,341 (-)Ensembl
ChiLan1.0NW_0049554423,548,478 - 3,571,341 (-)NCBIChiLan1.0ChiLan1.0
GPRC5B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21821,123,584 - 21,150,738 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11625,645,239 - 25,671,883 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01618,425,987 - 18,454,305 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11619,959,077 - 19,985,538 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1619,959,077 - 19,985,538 (-)EnsemblpanPan2panpan1.1
GPRC5B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1625,412,968 - 25,435,895 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl625,411,595 - 25,432,824 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha626,776,412 - 26,799,194 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0625,567,735 - 25,590,548 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl625,567,749 - 25,590,546 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1625,367,935 - 25,390,739 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0625,263,337 - 25,286,128 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0625,651,743 - 25,674,546 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gprc5b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344117,367,984 - 117,387,438 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365015,461,736 - 5,485,356 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365015,465,844 - 5,485,291 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPRC5B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl325,870,403 - 25,896,106 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1325,870,369 - 25,896,113 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2326,736,185 - 26,750,881 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GPRC5B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1518,138,173 - 18,166,048 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl518,141,230 - 18,165,138 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606811,758,575 - 11,786,797 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gprc5b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247823,164,467 - 3,176,119 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247823,163,265 - 3,184,978 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Gprc5b
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1282,646,657 - 82,670,699 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Gprc5b
138 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:136
Count of miRNA genes:103
Interacting mature miRNAs:119
Transcripts:ENSRNOT00000065892
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1153679879198679879Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1177339686222339686Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1132760429191848948Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1181059071226059071Rat
61326Eae6Experimental allergic encephalomyelitis QTL 65.3body mass (VT:0001259)change in body weight (CMO:0002045)1182383862191260518Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1181059071226059071Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1153679879205813246Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1182039247227039247Rat
8694166Bw147Body weight QTL 1476.830.001body mass (VT:0001259)body weight gain (CMO:0000420)1153788989198788989Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1160573753210707719Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1181059071226059071Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1160573753210707719Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1165278545210278545Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1181059071226059071Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1161077990206077990Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1168063662213063662Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1159894717207261263Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1163992710208992710Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1182535316227535316Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1181059071226059071Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1155359438194575574Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1140833106185833106Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1116099376191260518Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1181059071226059071Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1132760429191848948Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1162753891207753891Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1180739993225739993Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
61379Bp44Blood pressure QTL 4419.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1153680016183564652Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1172718770228180370Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
2312558Glom17Glomerulus QTL 173.90.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1175967553200707874Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1178547286206690557Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753210707719Rat
1576310Schws2Schwannoma susceptibility QTL 20.029nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1153788989198788989Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1165707719210707719Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1173363824227535316Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429191190115Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
631548Bp88Blood pressure QTL 8850.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1140915717185915717Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1132760429191848948Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1160573753210707719Rat
7411599Foco11Food consumption QTL 1118.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)1153788989198788989Rat

Markers in Region
RH130029  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21173,316,734 - 173,316,916 (+)MAPPERmRatBN7.2
Rnor_6.01188,689,080 - 188,689,261NCBIRnor6.0
Rnor_5.01195,631,826 - 195,632,007UniSTSRnor5.0
RGSC_v3.41177,206,242 - 177,206,423UniSTSRGSC3.4
Celera1171,080,269 - 171,080,450UniSTS
RH 3.4 Map11379.3UniSTS
Cytogenetic Map1q35UniSTS
RH137212  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21173,317,011 - 173,317,193 (+)MAPPERmRatBN7.2
Rnor_6.01188,689,357 - 188,689,538NCBIRnor6.0
Rnor_5.01195,632,103 - 195,632,284UniSTSRnor5.0
RGSC_v3.41177,206,519 - 177,206,700UniSTSRGSC3.4
Celera1171,080,546 - 171,080,727UniSTS
RH 3.4 Map11379.59UniSTS
Cytogenetic Map1q35UniSTS
RH138704  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21173,317,811 - 173,317,983 (+)MAPPERmRatBN7.2
Rnor_6.01188,690,157 - 188,690,328NCBIRnor6.0
Rnor_5.01195,632,903 - 195,633,074UniSTSRnor5.0
RGSC_v3.41177,207,319 - 177,207,490UniSTSRGSC3.4
Celera1171,081,346 - 171,081,517UniSTS
RH 3.4 Map11379.9UniSTS
Cytogenetic Map1q35UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 68 59 6 332 168 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000065892   ⟹   ENSRNOP00000061518
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1182,748,247 - 182,761,859 (-)Ensembl
mRatBN7.2 Ensembl1173,316,907 - 173,330,455 (-)Ensembl
Rnor_6.0 Ensembl1188,688,743 - 188,713,280 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000082192   ⟹   ENSRNOP00000072971
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1182,748,247 - 182,772,276 (-)Ensembl
mRatBN7.2 Ensembl1173,316,907 - 173,340,932 (-)Ensembl
Rnor_6.0 Ensembl1188,692,104 - 188,713,270 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000159910   ⟹   ENSRNOP00000112772
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1182,748,247 - 182,772,757 (-)Ensembl
RefSeq Acc Id: NM_001398762   ⟹   NP_001385691
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81182,748,247 - 182,772,276 (-)NCBI
mRatBN7.21173,316,904 - 173,340,933 (-)NCBI
RefSeq Acc Id: XM_039107629   ⟹   XP_038963557
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81182,748,247 - 182,761,763 (-)NCBI
mRatBN7.21173,316,904 - 173,330,542 (-)NCBI
RefSeq Acc Id: XM_063286405   ⟹   XP_063142475
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81182,748,247 - 182,772,711 (-)NCBI
Ensembl Acc Id: ENSRNOP00000072971   ⟸   ENSRNOT00000082192
Ensembl Acc Id: ENSRNOP00000061518   ⟸   ENSRNOT00000065892
RefSeq Acc Id: XP_038963557   ⟸   XM_039107629
- Peptide Label: isoform X2
- UniProtKB: D4A3F5 (UniProtKB/TrEMBL),   A0A0G2K4B0 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001385691   ⟸   NM_001398762
- Peptide Label: precursor
- UniProtKB: A6I8K3 (UniProtKB/TrEMBL),   A0A0G2K4B0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063142475   ⟸   XM_063286405
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K4B0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000112772   ⟸   ENSRNOT00000159910
Protein Domains
G-protein coupled receptors family 3 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K4B0-F1-model_v2 AlphaFold A0A0G2K4B0 1-402 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690359
Promoter ID:EPDNEW_R871
Type:initiation region
Name:Gprc5b_1
Description:G protein-coupled receptor, class C, group 5, member B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01188,713,257 - 188,713,317EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309510 AgrOrtholog
BioCyc Gene G2FUF-57668 BioCyc
Ensembl Genes ENSRNOG00000016013 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000065892 ENTREZGENE
  ENSRNOT00000065892.4 UniProtKB/TrEMBL
  ENSRNOT00000082192 ENTREZGENE
  ENSRNOT00000082192.3 UniProtKB/TrEMBL
  ENSRNOT00000159910 ENTREZGENE
  ENSRNOT00000159910.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7316858 IMAGE-MGC_LOAD
InterPro GPCR_3_C UniProtKB/TrEMBL
  RA-inducible_GPCR3 UniProtKB/TrEMBL
MGC_CLONE MGC:189114 IMAGE-MGC_LOAD
NCBI Gene 293546 ENTREZGENE
PANTHER G PROTEIN COUPLED RECEPTOR, CLASS C, GROUP 5 UniProtKB/TrEMBL
  G-PROTEIN COUPLED RECEPTOR FAMILY C GROUP 5 MEMBER B UniProtKB/TrEMBL
Pfam 7tm_3 UniProtKB/TrEMBL
PhenoGen Gprc5b PhenoGen
PROSITE G_PROTEIN_RECEP_F3_4 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016013 RatGTEx
UniProt A0A0G2K4B0 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LP27_RAT UniProtKB/TrEMBL
  A6I8K3 ENTREZGENE, UniProtKB/TrEMBL
  B2RZ13_RAT UniProtKB/TrEMBL
  D4A3F5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-02-06 Gprc5b  G protein-coupled receptor, class C, group 5, member B  Gprc5b  G protein-coupled receptor, family C, group 5, member B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Gprc5b  G protein-coupled receptor, family C, group 5, member B   Gprc5b_predicted  G protein-coupled receptor, family C, group 5, member B (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Gprc5b_predicted  G protein-coupled receptor, family C, group 5, member B (predicted)      Symbol and Name status set to approved 70820 APPROVED