Nanog (Nanog homeobox) - Rat Genome Database

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Gene: Nanog (Nanog homeobox) Rattus norvegicus
Analyze
Symbol: Nanog
Name: Nanog homeobox
RGD ID: 1303178
Description: Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity; and lysine-acetylated histone binding activity. Involved in several processes, including cellular response to erythropoietin; cellular response to rapamycin; and multidimensional cell growth. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in chromatin and nucleus. Used to study colon cancer. Orthologous to several human genes including NANOG (Nanog homeobox); PARTICIPATES IN DNA modification pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: homeobox protein NANOG
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   WIC-Tg(Nanog-YFP*)1Utr  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84157,615,687 - 157,623,061 (+)NCBIGRCr8
mRatBN7.24155,943,737 - 155,951,116 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4155,943,737 - 155,951,116 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4162,211,480 - 162,218,867 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04186,563,349 - 186,570,736 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04156,639,759 - 156,647,147 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04155,531,906 - 155,539,268 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4155,531,906 - 155,539,268 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04222,552,995 - 222,560,653 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44159,190,786 - 159,198,160 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14159,438,699 - 159,441,754 (+)NCBI
Celera4144,763,722 - 144,771,060 (+)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(20S)-ginsenoside Rg3  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (ISO)
(S)-ropivacaine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-di-tert-butylphenol  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-methoxy-17beta-estradiol  (ISO)
3,5,6-trichloro-2-pyridinol  (ISO)
3,5,6-trichloropyridine-2-one  (ISO)
3-methyladenine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
5-hydroxytryptophan  (ISO)
6-bromoindirubin-3'-oxime  (ISO)
ABT-737  (ISO)
acetic acid  (ISO)
acrylamide  (EXP)
afimoxifene  (ISO)
all-trans-retinoic acid  (ISO)
Antrocin  (ISO)
apigenin  (ISO)
arsenous acid  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bromochloroacetic acid  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carboplatin  (ISO)
casticin  (ISO)
CHIR 99021  (ISO)
CHIR-98014  (ISO)
chlordecone  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
ciprofloxacin  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
cordycepin  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cypermethrin  (ISO)
decabromodiphenyl ether  (ISO)
deoxycholic acid  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dieldrin  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
entinostat  (ISO)
ethanol  (EXP,ISO)
Evodiamine  (ISO)
fluoxetine  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gemcitabine  (ISO)
GS-441524  (ISO)
GW 4064  (ISO)
heptachlor  (ISO)
hexachlorophene  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
kaempferol  (ISO)
lead diacetate  (ISO)
limonin  (ISO)
lipopolysaccharide  (EXP)
lithium chloride  (ISO)
lupeol  (ISO)
LY294002  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
nicotine  (ISO)
nocodazole  (ISO)
Nonylphenol  (ISO)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
pirinixic acid  (ISO)
proanthocyanidin  (ISO)
quercetin  (ISO)
remdesivir  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
sirolimus  (ISO)
sirtinol  (ISO)
sodium arsenite  (ISO)
sodium chlorate  (ISO)
stigmasterol  (ISO)
sunitinib  (ISO)
Tanshinone I  (EXP,ISO)
taurocholic acid  (ISO)
testosterone  (ISO)
thalidomide  (ISO)
thymoquinone  (ISO)
titanium dioxide  (ISO)
trametinib  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
urethane  (ISO)
valproic acid  (ISO)
verapamil  (ISO)
vorinostat  (ISO)
XAV939  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Direct reprogramming of rat neural precursor cells and fibroblasts into pluripotent stem cells. Chang MY, etal., PLoS One. 2010 Mar 24;5(3):e9838. doi: 10.1371/journal.pone.0009838.
2. Playing TETris with DNA modifications. Delatte B, etal., EMBO J. 2014 Jun 2;33(11):1198-211. doi: 10.15252/embj.201488290. Epub 2014 May 13.
3. Nanog attenuates lipopolysaccharide-induced inflammatory responses by blocking nuclear factor-kappaB transcriptional activity in BV-2 cells. Duan Z, etal., Neuroreport. 2013 Sep 11;24(13):718-23. doi: 10.1097/WNR.0b013e328363fd67.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. The three-dimensional collagen scaffold improves the stemness of rat bone marrow mesenchymal stem cells. Han S, etal., J Genet Genomics. 2012 Dec 20;39(12):633-41. doi: 10.1016/j.jgg.2012.08.006. Epub 2012 Nov 21.
6. Identification, cloning and expression analysis of the pluripotency promoting Nanog genes in mouse and human. Hart AH, etal., Dev Dyn 2004 May;230(1):187-98.
7. Chronic high dose intraperitoneal bisphenol A (BPA) induces substantial histological and gene expression alterations in rat penile tissue without impairing erectile function. Kovanecz I, etal., J Sex Med. 2013 Dec;10(12):2952-66. doi: 10.1111/jsm.12336. Epub 2013 Oct 17.
8. Tumourigenesis in the infarcted rat heart is eliminated through differentiation and enrichment of the transplanted embryonic stem cells. Lin Q, etal., Eur J Heart Fail. 2010 Nov;12(11):1179-85. doi: 10.1093/eurjhf/hfq144. Epub 2010 Sep 3.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. MicroRNA profiling of carcinogen-induced rat colon tumors and the influence of dietary spinach. Parasramka MA, etal., Mol Nutr Food Res. 2012 Aug;56(8):1259-69. doi: 10.1002/mnfr.201200117. Epub 2012 May 29.
11. Rapamycin induces pluripotent genes associated with avoidance of replicative senescence. Pospelova TV, etal., Cell Cycle. 2013 Dec 15;12(24):3841-51. doi: 10.4161/cc.27396. Epub 2013 Dec 2.
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Comprehensive gene review and curation RGD comprehensive gene curation
15. Stromal cells cultured from omentum express pluripotent markers, produce high amounts of VEGF, and engraft to injured sites. Singh AK, etal., Cell Tissue Res. 2008 Jan 15;.
16. Expression and role of Oct3/4, Nanog and Sox2 in regeneration of rat tracheal epithelium. Song N, etal., Cell Prolif. 2010 Feb;43(1):49-55. doi: 10.1111/j.1365-2184.2009.00653.x. Epub 2009 Oct 21.
17. Increased expression of the pluripotency markers sex-determining region Y-box 2 and Nanog homeobox in ovarian endometriosis. Song Y, etal., Reprod Biol Endocrinol. 2014 May 18;12:42. doi: 10.1186/1477-7827-12-42.
18. Regenerative therapy in experimental parkinsonism: mixed population of differentiated mouse embryonic stem cells, rather than magnetically sorted and enriched dopaminergic cells provide neuroprotection. Tripathy D, etal., CNS Neurosci Ther. 2014 Aug;20(8):717-27. doi: 10.1111/cns.12295. Epub 2014 Jun 21.
19. Effect of Recombinant Human Erythropoietin On the Stemness of Bone Marrow-derived Mesenchymal Stem Cells in vitro. Ye L, etal., Int J Stem Cells. 2010 May;3(2):175-82.
20. Nanog and beta-catenin: a new convergence point in EpSC proliferation and differentiation. Yin D, etal., Int J Mol Med. 2012 Apr;29(4):587-92. doi: 10.3892/ijmm.2011.871. Epub 2011 Dec 29.
Additional References at PubMed
PMID:12787504   PMID:12787505   PMID:15582778   PMID:15788452   PMID:16153702   PMID:16259959   PMID:16501172   PMID:16518401   PMID:16767105   PMID:16801560   PMID:16894029   PMID:17938240  
PMID:17940068   PMID:18388306   PMID:18400104   PMID:18425773   PMID:18436640   PMID:18448678   PMID:18467660   PMID:18932205   PMID:18957414   PMID:19427902   PMID:19796622   PMID:20123909  
PMID:20458727   PMID:20713518   PMID:20720539   PMID:20937355   PMID:21062744   PMID:21076177   PMID:21146513   PMID:21385842   PMID:22988117   PMID:23040477   PMID:23287475   PMID:23708658  
PMID:23824537   PMID:24036311   PMID:24268575   PMID:24515304   PMID:25304966   PMID:25335925   PMID:25397698   PMID:25633057   PMID:25825768   PMID:26707878   PMID:27723719   PMID:32471175  
PMID:34758295  


Genomics

Comparative Map Data
Nanog
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84157,615,687 - 157,623,061 (+)NCBIGRCr8
mRatBN7.24155,943,737 - 155,951,116 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4155,943,737 - 155,951,116 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4162,211,480 - 162,218,867 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04186,563,349 - 186,570,736 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04156,639,759 - 156,647,147 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04155,531,906 - 155,539,268 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4155,531,906 - 155,539,268 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04222,552,995 - 222,560,653 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44159,190,786 - 159,198,160 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14159,438,699 - 159,441,754 (+)NCBI
Celera4144,763,722 - 144,771,060 (+)NCBICelera
Cytogenetic Map4q42NCBI
NANOG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38127,789,402 - 7,799,146 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl127,787,794 - 7,799,146 (+)EnsemblGRCh38hg38GRCh38
GRCh37127,941,998 - 7,951,742 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36127,833,262 - 7,839,922 (+)NCBINCBI36Build 36hg18NCBI36
Build 34127,833,261 - 7,839,922NCBI
Celera129,520,085 - 9,526,744 (+)NCBICelera
Cytogenetic Map12p13.31NCBI
HuRef127,755,619 - 7,762,294 (+)NCBIHuRef
CHM1_1127,941,303 - 7,947,961 (+)NCBICHM1_1
T2T-CHM13v2.0127,803,995 - 7,813,735 (+)NCBIT2T-CHM13v2.0
Nanog
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396122,684,448 - 122,691,592 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6122,684,448 - 122,691,592 (+)EnsemblGRCm39 Ensembl
GRCm386122,707,489 - 122,714,633 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6122,707,489 - 122,714,633 (+)EnsemblGRCm38mm10GRCm38
MGSCv376122,657,586 - 122,663,796 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366122,673,114 - 122,680,252 (+)NCBIMGSCv36mm8
Celera6124,507,792 - 124,514,310 (+)NCBICelera
Cytogenetic Map6F1NCBI
cM Map657.8NCBI
Nanog
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554136,561,323 - 6,565,770 (+)NCBIChiLan1.0ChiLan1.0
NANOG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21013,347,790 - 13,354,739 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11213,344,549 - 13,351,498 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0127,913,037 - 7,919,715 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1128,070,877 - 8,077,556 (+)NCBIpanpan1.1PanPan1.1panPan2
NANOG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12737,262,558 - 37,266,449 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha279,348,312 - 9,354,207 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02737,614,640 - 37,620,732 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2737,614,640 - 37,620,302 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12737,494,510 - 37,500,598 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02737,530,317 - 37,536,638 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0278,831,817 - 8,837,819 (-)NCBIUU_Cfam_GSD_1.0
Nanog
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494598,997,260 - 99,003,117 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936892181,834 - 187,691 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NANOG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl562,932,382 - 62,939,082 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1562,931,642 - 62,939,086 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2565,798,046 - 65,843,373 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NANOG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1117,813,309 - 7,820,009 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666063363,373 - 369,814 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nanog
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248605,026,203 - 5,037,219 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nanog
37 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:119
Count of miRNA genes:98
Interacting mature miRNAs:101
Transcripts:ENSRNOT00000060937
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4148090542168069246Rat
61446Coreg2Compensatory renal growth QTL 23.5kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)4148423102157580971Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)426775591168368347Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4119428175157578333Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4155561574182687754Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
1581574Eae20Experimental allergic encephalomyelitis QTL 207.8nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)4153031106158841762Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132642577167139601Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4147278504167139601Rat


Related Rat Strains
The following Strains have been annotated to Nanog
WIC-Tg(Nanog-YFP*)1Utr    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 10 16 40 52 51 20 25 20 6 113 63 20 13 48 31

Sequence


Ensembl Acc Id: ENSRNOT00000060937   ⟹   ENSRNOP00000063016
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4155,943,737 - 155,951,116 (+)Ensembl
Rnor_6.0 Ensembl4155,531,906 - 155,539,268 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000077245   ⟹   ENSRNOP00000071020
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl4155,532,109 - 155,538,052 (+)Ensembl
RefSeq Acc Id: NM_001100781   ⟹   NP_001094251
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84157,615,687 - 157,623,061 (+)NCBI
mRatBN7.24155,943,737 - 155,951,116 (+)NCBI
Rnor_6.04155,531,906 - 155,539,268 (+)NCBI
Rnor_5.04222,552,995 - 222,560,653 (+)NCBI
RGSC_v3.44159,190,786 - 159,198,160 (+)RGD
Celera4144,763,722 - 144,771,060 (+)RGD
Sequence:
RefSeq Acc Id: XM_006237310   ⟹   XP_006237372
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84157,615,781 - 157,622,022 (+)NCBI
mRatBN7.24155,943,906 - 155,950,010 (+)NCBI
Rnor_6.04155,532,109 - 155,538,091 (+)NCBI
Rnor_5.04222,552,995 - 222,560,653 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001094251 (Get FASTA)   NCBI Sequence Viewer  
  XP_006237372 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAD20664 (Get FASTA)   NCBI Sequence Viewer  
  BAF91940 (Get FASTA)   NCBI Sequence Viewer  
  EDM01982 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000063016
  ENSRNOP00000063016.1
RefSeq Acc Id: NP_001094251   ⟸   NM_001100781
- UniProtKB: D3ZS29 (UniProtKB/TrEMBL),   A6ILF7 (UniProtKB/TrEMBL),   A8QWW8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006237372   ⟸   XM_006237310
- Peptide Label: isoform X1
- UniProtKB: A8QWW8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071020   ⟸   ENSRNOT00000077245
Ensembl Acc Id: ENSRNOP00000063016   ⟸   ENSRNOT00000060937
Protein Domains
Homeobox

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZS29-F1-model_v2 AlphaFold D3ZS29 1-312 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303178 AgrOrtholog
BioCyc Gene G2FUF-43146 BioCyc
Ensembl Genes ENSRNOG00000008368 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000060937 ENTREZGENE
  ENSRNOT00000060937.4 UniProtKB/TrEMBL
Gene3D-CATH Homeodomain-like UniProtKB/TrEMBL
InterPro Distal-less_Homeobox_TF UniProtKB/TrEMBL
  Homeobox UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/TrEMBL
  Homeodomain-like UniProtKB/TrEMBL
KEGG Report rno:414065 UniProtKB/TrEMBL
NCBI Gene 414065 ENTREZGENE
PANTHER HOMEOBOX PROTEIN UniProtKB/TrEMBL
  HOMEOBOX PROTEIN NANOG UniProtKB/TrEMBL
Pfam Homeobox UniProtKB/TrEMBL
PhenoGen Nanog PhenoGen
PROSITE HOMEOBOX_1 UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008368 RatGTEx
SMART HOX UniProtKB/TrEMBL
Superfamily-SCOP Homeodomain_like UniProtKB/TrEMBL
UniProt A6ILF7 ENTREZGENE, UniProtKB/TrEMBL
  A8QWW8 ENTREZGENE, UniProtKB/TrEMBL
  D3ZS29 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-11-17 Nanog  Nanog homeobox      Symbol and Name status set to approved 1299863 APPROVED
2005-07-14 Nanog  Nanog homeobox      Symbol and Name status set to provisional 70820 PROVISIONAL