F3 (coagulation factor III, tissue factor) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: F3 (coagulation factor III, tissue factor) Rattus norvegicus
Analyze
Symbol: F3
Name: coagulation factor III, tissue factor
RGD ID: 2587
Description: Exhibits protease binding activity. Is predicted to contribute to serine-type endopeptidase activity. Involved in several processes, including cellular response to low-density lipoprotein particle stimulus; positive regulation of smooth muscle cell migration; and response to estradiol. Localizes to cell surface; cytoplasm; and extracellular space. Biomarker of disseminated intravascular coagulation; hypertension; and myocardial infarction. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; COVID-19; disseminated intravascular coagulation; and von Willebrand's disease. Orthologous to human F3 (coagulation factor III, tissue factor); PARTICIPATES IN acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics pathway; INTERACTS WITH (S)-colchicine; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: coagulation factor 3; coagulation factor III; Coagulation factor III (thromboplastin tissue factor); coagulation factor III (thromboplastin, tissue factor); MGC93621; TF; tissue factor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22209,827,061 - 209,838,666 (+)NCBI
Rnor_6.0 Ensembl2225,310,624 - 225,322,272 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02225,310,686 - 225,322,281 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02243,348,430 - 243,360,439 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42218,371,050 - 218,382,645 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12218,334,111 - 218,345,706 (+)NCBI
Celera2202,257,415 - 202,269,039 (+)NCBICelera
Cytogenetic Map2q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Lung Injury  (IEP)
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
acute pancreatitis  (ISO)
acute promyelocytic leukemia  (ISO)
adult respiratory distress syndrome  (ISO)
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis  (ISO)
B-lymphoblastic leukemia/lymphoma  (ISO)
bile duct disease  (ISO)
Breast Neoplasms  (ISO)
Cardiac Allograft Vasculopathy  (IEP)
Cardiac Fibrosis  (ISO)
carotid artery thrombosis  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
COVID-19  (ISO)
diabetes mellitus  (ISO)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
disseminated intravascular coagulation  (IEP,ISO)
Embolism and Thrombosis  (ISO)
Endotoxemia  (IDA,ISO)
Experimental Diabetes Mellitus  (ISO)
familial hyperlipidemia  (ISO)
Graft vs Host Disease  (ISO)
Hemorrhage  (ISO)
hypertension  (IEP)
idiopathic pulmonary fibrosis  (ISO)
Inflammation  (IEP)
Kidney Reperfusion Injury  (IEP)
liver cirrhosis  (ISO)
Liver Injury  (ISO)
Liver Reperfusion Injury  (IMP)
Metabolic Syndrome  (ISO)
myeloid neoplasm  (ISO)
myocardial infarction  (IEP)
Myocardial Ischemia  (ISO)
Neointima  (IEP)
nephrotic syndrome  (ISO)
ovarian hyperstimulation syndrome  (ISO)
Ovary Reperfusion Injury  (IEP)
Peritoneal Fibrosis  (IEP)
pre-eclampsia  (ISO)
preterm premature rupture of the membranes  (ISO)
Sepsis  (IEP,ISO)
sickle cell anemia  (ISO)
Snake Bites  (IEP)
Spontaneous Abortions  (ISO)
Systemic Inflammatory Response Syndrome  (ISO)
Thromboembolism  (ISO)
thrombophilia  (ISO)
thrombosis  (ISO)
Thrombotic Microangiopathies  (ISO)
thrombotic thrombocytopenic purpura  (ISO)
type 2 diabetes mellitus  (ISO)
Venous Thrombosis  (ISO)
Viral Myocarditis  (ISO)
von Willebrand's disease  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(R)-mevalonic acid  (ISO)
(R)-noradrenaline  (ISO)
(S)-colchicine  (EXP)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-benzothiazole-2-thiol  (ISO)
1,4-dithiothreitol  (ISO)
1-naphthyl isothiocyanate  (ISO)
1-nitropyrene  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
abiraterone  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
AM-251  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP,ISO)
anandamide  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arachidonic acid  (ISO)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
bryostatin 1  (ISO)
bryostatin 2  (ISO)
butan-1-ol  (ISO)
cadmium dichloride  (EXP)
calciol  (ISO)
cangrelor  (ISO)
cannabidiol  (ISO)
capsazepine  (ISO)
carbon nanotube  (ISO)
carmustine  (EXP)
carvedilol  (EXP)
chloropicrin  (ISO)
chloroprene  (EXP)
chlorphenamine  (ISO)
chromium(6+)  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (EXP)
clomiphene  (ISO)
clopidogrel  (ISO)
cobalt dichloride  (ISO)
concanamycin A  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
crizotinib  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cypermethrin  (ISO)
cytochalasin D  (ISO)
daunorubicin  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
desloratadine  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenziodolium  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
dioxygen  (ISO)
diphenhydramine  (ISO)
diuron  (EXP)
dobutamine  (ISO)
donepezil hydrochloride  (ISO)
dopamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enalapril  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
etonogestrel  (EXP)
etoposide  (ISO)
everolimus  (ISO)
fenamidone  (ISO)
ferric ammonium citrate  (ISO)
ferroheme b  (ISO)
fluoranthene  (ISO)
fluvastatin  (ISO)
folic acid  (ISO)
fructose  (ISO)
furan  (EXP)
geranylgeraniol  (ISO)
glutathione  (ISO)
heme b  (ISO)
Hexadimethrine bromide  (EXP)
hinokiflavone  (ISO)
histamine  (ISO)
histamine phosphate  (ISO)
ibuprofen  (ISO)
indole-3-acetic acid  (ISO)
indometacin  (ISO)
irbesartan  (EXP)
isobutanol  (ISO)
ketoconazole  (ISO)
L-1,4-dithiothreitol  (ISO)
L-ascorbic acid  (ISO)
lenalidomide  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium chloride  (ISO)
losartan  (ISO)
LY294002  (ISO)
mancozeb  (ISO)
medroxyprogesterone acetate  (EXP,ISO)
mepyramine  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (ISO)
methamphetamine  (ISO)
Methanandamide  (ISO)
methotrexate  (EXP,ISO)
methylmercury chloride  (ISO)
mifamurtide  (ISO)
mifepristone  (EXP,ISO)
mithramycin  (ISO)
MK-2206  (ISO)
mometasone furoate  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
Monobutylphthalate  (ISO)
monocrotaline  (ISO)
N-acetyl-L-cysteine  (ISO)
N-acetylsphingosine  (ISO)
N-ethylmaleimide  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N-nitrosourea  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
naphthalene  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nicotinamide  (ISO)
nicotine  (ISO)
nimesulide  (ISO)
nitrofen  (EXP)
notoginsenoside R1  (ISO)
ochratoxin A  (EXP,ISO)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
paclitaxel  (ISO)
palbociclib  (ISO)
paracetamol  (EXP,ISO)
phenethyl isothiocyanate  (ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosgene  (ISO)
pirinixic acid  (ISO)
primaquine  (ISO)
primidone  (ISO)
probucol  (ISO)
progesterone  (EXP,ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
quercitrin  (ISO)
quinolin-8-ol  (ISO)
ranitidine  (EXP)
resveratrol  (ISO)
riddelliine  (EXP)
rivaroxaban  (EXP)
SB 203580  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sirtinol  (ISO)
splitomicin  (ISO)
staurosporine  (ISO)
streptozocin  (EXP)
succimer  (ISO)
Sudan I  (ISO)
sulfasalazine  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
Temsirolimus  (ISO)
terconazole  (ISO)
tetrachloromethane  (EXP,ISO)
tibolone  (ISO)
tin(II) chloride (anhydrous)  (ISO)
tioguanine  (EXP)
titanium dioxide  (ISO)
torin 1  (ISO)
trans-caffeic acid  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vincaleukoblastine  (EXP)
vinclozolin  (EXP)
vincristine  (EXP,ISO)
vitamin E  (ISO)
WIN 55212-2  (ISO)
wortmannin  (ISO)
XL147  (ISO)
zoledronic acid  (ISO)
zotarolimus  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
1. Andoh K, etal., Cancer. 1987 Feb 15;59(4):748-54.
2. Antoniak S, etal., J Mol Cell Cardiol. 2008 Jul;45(1):118-26. doi: 10.1016/j.yjmcc.2008.03.013. Epub 2008 Mar 29.
3. Bauer KA, etal., Thromb Res. 1989 Nov 1;56(3):425-30.
4. Bledsoe JG, etal., J Biomed Mater Res A. 2004 Sep 1;70(3):490-6.
5. Boden G, etal., J Clin Endocrinol Metab. 2007 Nov;92(11):4352-8. Epub 2007 Sep 4.
6. Bugge TH, etal., Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6258-63.
7. Castellino FJ, etal., Blood. 2011 Jan 6;117(1):283-9. doi: 10.1182/blood-2010-07-299057. Epub 2010 Sep 21.
8. Cuadrado MJ, etal., Arthritis Rheum. 1997 May;40(5):834-41.
9. Dackiw AP, etal., Arch Surg. 1996 Dec;131(12):1273-8; discussion 1278-9.
10. Diamant M, etal., Circulation. 2002 Nov 5;106(19):2442-7.
11. Egorina EM, etal., Arterioscler Thromb Vasc Biol. 2006 Oct;26(10):2401-6. Epub 2006 Aug 10.
12. Erez O, etal., J Matern Fetal Neonatal Med. 2008 Oct;21(10):732-44. doi: 10.1080/14767050802361807.
13. Erez O, etal., J Matern Fetal Neonatal Med. 2009 Aug;22(8):672-87. doi: 10.1080/14767050902853117.
14. Fujii M, etal., Thromb Res. 2000 Jul 15;99(2):111-7.
15. Gando S, etal., Crit Care Med. 1998 Dec;26(12):2005-9.
16. Gando S, etal., J Trauma. 1999 Oct;47(4):719-23.
17. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
18. Ghrib F, etal., Thromb Haemost 2002 Jun;87(6):1051-6.
19. Giesen PL, etal., Thromb Haemost. 2000 Apr;83(4):622-8.
20. GOA data from the GO Consortium
21. Han YN and Rhee IK, Arch Pharm Res. 1998 Oct;21(5):549-54.
22. Hao J, etal., J Huazhong Univ Sci Technolog Med Sci. 2009 Dec;29(6):697-700. doi: 10.1007/s11596-009-0604-4. Epub 2009 Dec 29.
23. Hara S, etal., Lab Invest. 1997 Dec;77(6):581-9.
24. Hasenstab D, etal., Circulation. 2000 Jun 6;101(22):2651-7.
25. Hendrickx ML, etal., Thromb Haemost. 2014 May 5;111(5):824-32. doi: 10.1160/TH13-08-0645. Epub 2014 Jan 9.
26. Holschermann H, etal., Am J Pathol. 1999 Jan;154(1):211-20.
27. Houston P, etal., Arterioscler Thromb Vasc Biol. 1999 Feb;19(2):281-9.
28. Isermann B, etal., Nat Med 2003 Mar;9(3):331-7.
29. Kambas K, etal., Ann Rheum Dis. 2014 Oct;73(10):1854-63. doi: 10.1136/annrheumdis-2013-203430. Epub 2013 Jul 19.
30. Kamikura Y, etal., Thromb Res. 2005;116(4):307-12. Epub 2005 Jan 28.
31. Knight V, etal., World J Gastroenterol. 2017 Aug 21;23(31):5692-5699. doi: 10.3748/wjg.v23.i31.5692.
32. Krupinski J, etal., Vasc Health Risk Manag. 2007;3(4):405-12.
33. Kung CW, etal., Thromb Res. 2011 Jun;127(6):582-8. Epub 2011 Mar 10.
34. Li D, etal., Can J Physiol Pharmacol. 2011 Mar;89(3):151-8. doi: 10.1139/Y10-115.
35. Matsuyama M, etal., Transplant Proc 2002 Aug;34(5):1475-6.
36. Maugeri N, etal., J Thromb Haemost. 2006 Dec;4(12):2593-8. Epub 2006 Sep 6.
37. May H, etal., Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2008 Feb;16(1):181-4.
38. Melis E, etal., Biochem Biophys Res Commun. 2005 Jul 29;333(2):488-95.
39. MGD data from the GO Consortium
40. Mohan JS, etal., Blood Coagul Fibrinolysis. 2005 Apr;16(3):209-14.
41. Molor-Erdene P, etal., Thromb Haemost. 2005 Jul;94(1):136-45.
42. Nakamura K, etal., Biochem Biophys Res Commun 2002 Sep 27;297(3):433-41.
43. Nakamura K, etal., Transplant Proc. 2001 Nov-Dec;33(7-8):3707-8.
44. Nakasaki T, etal., Clin Appl Thromb Hemost. 2000 Jan;6(1):14-7.
45. NCBI rat LocusLink and RefSeq merged data July 26, 2002
46. Norris LA, Best Pract Res Clin Obstet Gynaecol. 2003 Jun;17(3):369-83.
47. Ou ZB, etal., Biomed Pharmacother. 2017 Jan;85:380-388. doi: 10.1016/j.biopha.2016.11.039. Epub 2016 Dec 4.
48. Oztay F, etal., Toxicol Ind Health. 2015 Apr 16. pii: 0748233715576615.
49. Park JB, etal., PLoS One. 2011;6(11):e28327. doi: 10.1371/journal.pone.0028327. Epub 2011 Nov 29.
50. Pawlinski R, etal., Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15333-8. Epub 2002 Nov 8.
51. Penn MS, etal., Circulation. 1999 Apr 6;99(13):1753-9.
52. Pipeline to import KEGG annotations from KEGG into RGD
53. Pipeline to import SMPDB annotations from SMPDB into RGD
54. Qi H, etal., Haemostasis. 1997 Mar-Apr;27(2):57-64.
55. Ramlall V, etal., Nat Med. 2020 Aug 3. pii: 10.1038/s41591-020-1021-2. doi: 10.1038/s41591-020-1021-2.
56. Rancourt RC, etal., Am J Physiol Lung Cell Mol Physiol. 2012 Jan 1;302(1):L82-92. doi: 10.1152/ajplung.00306.2010. Epub 2011 Sep 30.
57. RGD automated data pipeline
58. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
59. RGD automated import pipeline for gene-chemical interactions
60. Rogolino A, etal., Blood Coagul Fibrinolysis. 2003 Apr;14(3):277-82.
61. Saito H, etal., Perit Dial Int. 2009 May-Jun;29(3):340-51.
62. Saito M, etal., Rinsho Ketsueki. 1996 Sep;37(9):794-8.
63. Saliola M, etal., Gut. 1998 Sep;43(3):428-32. doi: 10.1136/gut.43.3.428.
64. Schneider P, etal., Br J Haematol. 2010 Feb;148(4):582-92. doi: 10.1111/j.1365-2141.2009.07958.x. Epub 2009 Oct 28.
65. Seshan SV, etal., Blood. 2009 Aug 20;114(8):1675-83. doi: 10.1182/blood-2009-01-199117. Epub 2009 Jun 17.
66. Smith SA, etal., Crit Rev Biochem Mol Biol. 2015;50(4):326-36. doi: 10.3109/10409238.2015.1050550. Epub 2015 May 28.
67. Sommeijer DW, etal., J Thromb Haemost. 2006 Mar;4(3):574-80. Epub 2005 Dec 22.
68. Sommeijer DW, etal., Nephron Exp Nephrol. 2005;101(3):e86-94. Epub 2005 Jun 30.
69. Song KS and Kim HK, Yonsei Med J. 2004 Feb 29;45(1):38-42.
70. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
71. Sullivan BP, etal., Am J Pathol. 2010 Dec;177(6):2837-49. doi: 10.2353/ajpath.2010.100425. Epub 2010 Oct 29.
72. Taby O, etal., Thromb Haemost 1996 Nov;76(5):697-702.
73. Tanaka M and Yamanishi H, Leuk Res. 1993 Feb;17(2):103-11.
74. Taylor FB Jr Crit Care Med. 1997 Nov;25(11):1774-5.
75. Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
76. Toomey JR, etal., Proc Natl Acad Sci U S A 1997 Jun 24;94(13):6922-6.
77. Ustundag UV, etal., Reprod Biol. 2015 Sep;15(3):139-45. doi: 10.1016/j.repbio.2015.07.002. Epub 2015 Jul 26.
78. Van Thiel DH, etal., J Gastroenterol Hepatol. 2005 Jun;20(6):882-9. doi: 10.1111/j.1440-1746.2005.03761.x.
79. Vazquez E, etal., Inflamm Res. 2015 May;64(5):333-42. doi: 10.1007/s00011-015-0814-0. Epub 2015 Mar 15.
80. Wan S, etal., J Med Virol. 2020 Jul;92(7):797-806. doi: 10.1002/jmv.25783. Epub 2020 Apr 1.
81. Wang W, etal., Chin J Physiol. 2004 Jun 30;47(2):67-72.
82. Yamashita KM, etal., PLoS Negl Trop Dis. 2014 May 15;8(5):e2814. doi: 10.1371/journal.pntd.0002814. eCollection 2014 May.
83. Yu J, etal., Heart Vessels. 2011 Nov;26(6):646-53. doi: 10.1007/s00380-010-0106-0. Epub 2011 Jan 13.
84. Zacharski LR, etal., Am J Med. 1974 Jul;57(1):102-7.
85. Zhu W, etal., Chin J Integr Med. 2015 Aug 26.
86. Zumbach M, etal., Exp Clin Endocrinol Diabetes. 1997;105(4):206-12.
Additional References at PubMed
PMID:2704749   PMID:3455766   PMID:8632006   PMID:12362240   PMID:12958621   PMID:17469850   PMID:17586694   PMID:17595667   PMID:17898544   PMID:17991872   PMID:18612547   PMID:18621373  
PMID:19062044   PMID:19065458   PMID:19265029   PMID:19439347   PMID:19581412   PMID:19734584   PMID:21814178   PMID:22556343   PMID:22647506   PMID:23376485   PMID:24998411   PMID:27542118  
PMID:28738734   PMID:30449218   PMID:30840287  


Genomics

Comparative Map Data
F3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22209,827,061 - 209,838,666 (+)NCBI
Rnor_6.0 Ensembl2225,310,624 - 225,322,272 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02225,310,686 - 225,322,281 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02243,348,430 - 243,360,439 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42218,371,050 - 218,382,645 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12218,334,111 - 218,345,706 (+)NCBI
Celera2202,257,415 - 202,269,039 (+)NCBICelera
Cytogenetic Map2q41NCBI
F3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl194,529,173 - 94,541,759 (-)EnsemblGRCh38hg38GRCh38
GRCh38194,529,173 - 94,541,759 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37194,994,729 - 95,007,315 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36194,767,461 - 94,779,903 (-)NCBINCBI36hg18NCBI36
Build 34194,706,893 - 94,719,336NCBI
Celera193,249,195 - 93,261,871 (-)NCBI
Cytogenetic Map1p21.3NCBI
HuRef193,116,432 - 93,129,108 (-)NCBIHuRef
CHM1_1195,109,584 - 95,122,259 (-)NCBICHM1_1
F3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393121,517,186 - 121,528,701 (+)NCBIGRCm39mm39
GRCm39 Ensembl3121,517,186 - 121,528,697 (+)Ensembl
GRCm383121,723,537 - 121,735,052 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3121,723,537 - 121,735,048 (+)EnsemblGRCm38mm10GRCm38
MGSCv373121,426,455 - 121,437,970 (+)NCBIGRCm37mm9NCBIm37
MGSCv363121,715,560 - 121,727,066 (+)NCBImm8
Celera3128,097,400 - 128,112,071 (+)NCBICelera
Cytogenetic Map3G1NCBI
cM Map352.94NCBI
F3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955423254,189 - 264,159 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955423254,060 - 264,448 (+)NCBIChiLan1.0ChiLan1.0
F3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1195,918,359 - 95,931,050 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl195,918,502 - 95,931,050 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0197,190,381 - 97,203,076 (-)NCBIMhudiblu_PPA_v0panPan3
F3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1654,709,581 - 54,720,603 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl654,708,471 - 54,720,607 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha657,418,032 - 57,428,969 (+)NCBI
ROS_Cfam_1.0655,085,266 - 55,096,260 (+)NCBI
UMICH_Zoey_3.1654,766,195 - 54,777,118 (+)NCBI
UNSW_CanFamBas_1.0654,750,367 - 54,761,295 (+)NCBI
UU_Cfam_GSD_1.0655,203,270 - 55,214,213 (+)NCBI
F3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405058104,300,058 - 104,310,937 (-)NCBI
SpeTri2.0NW_0049365374,637,028 - 4,647,915 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
F3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4122,826,992 - 122,837,672 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14122,827,018 - 122,837,673 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24134,474,466 - 134,479,707 (+)NCBISscrofa10.2Sscrofa10.2susScr3
F3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12038,726,690 - 38,738,457 (+)NCBI
ChlSab1.1 Ensembl2038,726,798 - 38,739,408 (+)Ensembl
Vero_WHO_p1.0NW_02366603379,312,870 - 79,325,353 (-)NCBI
F3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247423,112,827 - 3,123,424 (+)NCBI

Position Markers
RH94643  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22209,838,148 - 209,838,339 (+)MAPPER
Rnor_6.02225,321,764 - 225,321,954NCBIRnor6.0
Rnor_5.02243,359,922 - 243,360,112UniSTSRnor5.0
RGSC_v3.42218,382,128 - 218,382,318UniSTSRGSC3.4
Celera2202,268,522 - 202,268,712UniSTS
Cytogenetic Map2q41UniSTS
RH135388  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22209,837,999 - 209,838,212 (+)MAPPER
Rnor_6.02225,321,615 - 225,321,827NCBIRnor6.0
Rnor_5.02243,359,773 - 243,359,985UniSTSRnor5.0
RGSC_v3.42218,381,979 - 218,382,191UniSTSRGSC3.4
Celera2202,268,373 - 202,268,585UniSTS
RH 3.4 Map21502.8UniSTS
Cytogenetic Map2q41UniSTS
RH141859  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22209,826,035 - 209,826,244 (+)MAPPER
Rnor_6.02225,309,661 - 225,309,869NCBIRnor6.0
Rnor_5.02243,347,014 - 243,347,222UniSTSRnor5.0
RGSC_v3.42218,370,025 - 218,370,233UniSTSRGSC3.4
Celera2202,256,390 - 202,256,598UniSTS
RH 3.4 Map21503.0UniSTS
Cytogenetic Map2q41UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631203Gluco14Glucose level QTL 140.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)2221880206235570970Rat
61458Bp10Blood pressure QTL 103.42arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2204003742231132207Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2184730446229730446Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2184730446229730446Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2149114878225501939Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2181990297240020001Rat
1331745Bp203Blood pressure QTL 2034.377arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2204585642235290110Rat
1298083Bp158Blood pressure QTL 1582.62arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2204003742231132207Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147122993240020001Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2147122993240020001Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2183984665228984665Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2204585642243689611Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2199380312244380312Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2116075644228737869Rat
1302789Stl26Serum triglyceride level QTL 263.10.0035blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)2218957047240977220Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2155965557254121739Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2155965557237742948Rat
1598813Memor9Memory QTL 92.7exploratory behavior trait (VT:0010471)average horizontal distance in proximity to the target during voluntary locomotion in an experimental apparatus (CMO:0002674)2214870793251212353Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2217743855262743855Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2181522444226522444Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2205583921243562243Rat
2298479Eau5Experimental allergic uveoretinitis QTL 50.0021uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)2217498545254132424Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2194378622239378622Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2116075644228737869Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2175403337239166203Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2118446646227707979Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283819608239166203Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266828236243550655Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283819608243901375Rat
2299161Iddm33Insulin dependent diabetes mellitus QTL 332.98blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2221488355254121739Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2142053350228984665Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2118446793228582621Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2177680772243901375Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2200453324236318668Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2200453324236318668Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2208594330263179188Rat
2293084Iddm26Insulin dependent diabetes mellitus QTL 262.9blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2188838511228984665Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2204585642249585642Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2204585642249585642Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2194998627239998627Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2197253963242253963Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2197253963242253963Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2197253963242253963Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2169852670243026643Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283754907237610852Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2197253963242253963Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)216679272245624402Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:125
Count of miRNA genes:73
Interacting mature miRNAs:92
Transcripts:ENSRNOT00000015836
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 7 10 5 3 4 62 35 32 11 3
Low 36 47 41 14 41 5 7 12 9 5
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000015836   ⟹   ENSRNOP00000015836
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2225,310,624 - 225,322,272 (+)Ensembl
RefSeq Acc Id: NM_013057   ⟹   NP_037189
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22209,827,061 - 209,838,666 (+)NCBI
Rnor_6.02225,310,686 - 225,322,281 (+)NCBI
Rnor_5.02243,348,430 - 243,360,439 (+)NCBI
RGSC_v3.42218,371,050 - 218,382,645 (+)RGD
Celera2202,257,415 - 202,269,039 (+)RGD
Sequence:
RefSeq Acc Id: XM_039101800   ⟹   XP_038957728
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22209,827,797 - 209,838,666 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_037189   ⟸   NM_013057
- Peptide Label: precursor
- UniProtKB: Q66HI4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000015836   ⟸   ENSRNOT00000015836
RefSeq Acc Id: XP_038957728   ⟸   XM_039101800
- Peptide Label: isoform X1
Protein Domains
Fibronectin type-III   Interfer-bind

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691719
Promoter ID:EPDNEW_R2244
Type:multiple initiation site
Name:F3_1
Description:coagulation factor III, tissue factor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02225,310,676 - 225,310,736EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2587 AgrOrtholog
Ensembl Genes ENSRNOG00000011800 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000015836 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015836 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7096602 IMAGE-MGC_LOAD
InterPro FN3_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Interferon/interleukin_rcp_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tissue_factor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tissue_Factor_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25584 UniProtKB/TrEMBL
MGC_CLONE MGC:93621 IMAGE-MGC_LOAD
NCBI Gene 25584 ENTREZGENE
PANTHER PTHR20859:SF22 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Interfer-bind UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tissue_fac UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen F3 PhenoGen
PIRSF Tissue_factor_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS TISSUEFACTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TISSUE_FACTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49265 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC235743
UniProt P42533 ENTREZGENE
  Q66HI4 ENTREZGENE, UniProtKB/TrEMBL
  TF_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-20 F3  coagulation factor III, tissue factor  F3  coagulation factor III (thromboplastin, tissue factor)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-09 F3  coagulation factor III (thromboplastin, tissue factor)  F3  coagulation factor III  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 F3  coagulation factor III      Name updated 1299863 APPROVED
2003-04-09 F3  coagulation factor 3     Coagulation factor III (thromboplastin, tissue factor)  Name updated 629478 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process mediates hepatic ischemic reperfusion injury 632791