F3 (coagulation factor III, tissue factor) - Rat Genome Database

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Gene: F3 (coagulation factor III, tissue factor) Heterocephalus glaber
Analyze
Symbol: F3
Name: coagulation factor III, tissue factor
RGD ID: 18900621
Description: ENCODES a protein that exhibits protease binding (ortholog); serine-type endopeptidase activity (ortholog); INVOLVED IN cellular response to hydrogen peroxide (ortholog); cellular response to low-density lipoprotein particle stimulus (ortholog); positive regulation of gene expression (ortholog); PARTICIPATES IN acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics pathway; ASSOCIATED WITH Acute Lung Injury (ortholog); acute lymphoblastic leukemia (ortholog); acute myeloid leukemia (ortholog); FOUND IN cell surface (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Tissue factor
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247423,112,801 - 3,124,301 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247423,112,827 - 3,123,424 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Lung Injury  (ISO)
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
acute pancreatitis  (ISO)
acute promyelocytic leukemia  (ISO)
adult respiratory distress syndrome  (ISO)
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis  (ISO)
B-lymphoblastic leukemia/lymphoma  (ISO)
bile duct disease  (ISO)
Breast Neoplasms  (ISO)
Cardiac Allograft Vasculopathy  (ISO)
Cardiac Fibrosis  (ISO)
carotid artery thrombosis  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
COVID-19  (ISO)
diabetes mellitus  (ISO)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
disseminated intravascular coagulation  (ISO)
Embolism and Thrombosis  (ISO)
Endotoxemia  (ISO)
Experimental Diabetes Mellitus  (ISO)
familial hyperlipidemia  (ISO)
graft-versus-host disease  (ISO)
Hemorrhage  (ISO)
hypertension  (ISO)
idiopathic pulmonary fibrosis  (ISO)
Inflammation  (ISO)
Kidney Reperfusion Injury  (ISO)
liver cirrhosis  (ISO)
Liver Injury  (ISO)
Liver Reperfusion Injury  (ISO)
Metabolic Syndrome  (ISO)
myeloid neoplasm  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Neointima  (ISO)
nephrotic syndrome  (ISO)
ovarian hyperstimulation syndrome  (ISO)
Ovary Reperfusion Injury  (ISO)
Peritoneal Fibrosis  (ISO)
pre-eclampsia  (ISO)
preterm premature rupture of the membranes  (ISO)
Sepsis  (ISO)
sickle cell anemia  (ISO)
Snake Bites  (ISO)
Spontaneous Abortions  (ISO)
Spontaneous Coronary Artery Dissection  (ISO)
Systemic Inflammatory Response Syndrome  (ISO)
Thromboembolism  (ISO)
thrombophilia  (ISO)
thrombosis  (ISO)
Thrombotic Microangiopathies  (ISO)
thrombotic thrombocytopenic purpura  (ISO)
type 2 diabetes mellitus  (ISO)
Venous Thrombosis  (ISO)
Viral Myocarditis  (ISO)
von Willebrand's disease  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:21993625   PMID:22301074  


Genomics

Comparative Map Data
F3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247423,112,801 - 3,124,301 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247423,112,827 - 3,123,424 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
F3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38194,529,173 - 94,541,759 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl194,529,173 - 94,541,759 (-)EnsemblGRCh38hg38GRCh38
GRCh37194,994,729 - 95,007,315 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36194,767,461 - 94,779,903 (-)NCBINCBI36Build 36hg18NCBI36
Build 34194,706,893 - 94,719,336NCBI
Celera193,249,195 - 93,261,871 (-)NCBICelera
Cytogenetic Map1p21.3NCBI
HuRef193,116,432 - 93,129,108 (-)NCBIHuRef
CHM1_1195,109,584 - 95,122,259 (-)NCBICHM1_1
T2T-CHM13v2.0194,377,216 - 94,389,797 (-)NCBIT2T-CHM13v2.0
F3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393121,517,186 - 121,528,701 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3121,517,186 - 121,528,697 (+)EnsemblGRCm39 Ensembl
GRCm383121,723,537 - 121,735,052 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3121,723,537 - 121,735,048 (+)EnsemblGRCm38mm10GRCm38
MGSCv373121,426,455 - 121,437,970 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363121,715,560 - 121,727,066 (+)NCBIMGSCv36mm8
Celera3128,097,400 - 128,112,071 (+)NCBICelera
Cytogenetic Map3G1NCBI
cM Map352.94NCBI
F3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82212,511,675 - 212,523,375 (+)NCBIGRCr8
mRatBN7.22209,827,061 - 209,838,666 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2209,826,959 - 209,838,668 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2217,490,132 - 217,501,670 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02215,397,871 - 215,409,409 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02210,239,702 - 210,251,242 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02225,310,686 - 225,322,281 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2225,310,624 - 225,322,272 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02243,348,430 - 243,360,439 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42218,371,050 - 218,382,645 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12218,334,111 - 218,345,706 (+)NCBI
Celera2202,257,415 - 202,269,039 (+)NCBICelera
Cytogenetic Map2q42NCBI
F3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955423254,189 - 264,159 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955423254,060 - 264,448 (+)NCBIChiLan1.0ChiLan1.0
F3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21132,482,788 - 132,495,423 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11131,637,687 - 131,650,209 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0197,190,381 - 97,203,076 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1195,918,359 - 95,931,050 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl195,918,502 - 95,931,050 (-)Ensemblpanpan1.1panPan2
F3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1654,709,581 - 54,720,603 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl654,708,471 - 54,720,607 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha657,418,032 - 57,428,969 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0655,085,266 - 55,096,260 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl655,083,526 - 55,096,264 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1654,766,195 - 54,777,118 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0654,750,367 - 54,761,295 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0655,203,270 - 55,214,213 (+)NCBIUU_Cfam_GSD_1.0
F3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405058104,300,058 - 104,310,937 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365374,636,667 - 4,647,916 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365374,637,028 - 4,647,915 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
F3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4122,826,644 - 122,837,666 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14122,827,018 - 122,837,673 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24134,474,466 - 134,479,707 (+)NCBISscrofa10.2Sscrofa10.2susScr3
F3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12038,726,690 - 38,738,457 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2038,726,798 - 38,739,408 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603379,312,870 - 79,325,353 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000011855   ⟹   ENSHGLP00000011727
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247423,112,801 - 3,124,301 (+)Ensembl
RefSeq Acc Id: XM_004841234   ⟹   XP_004841291
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247423,112,827 - 3,123,424 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004841291 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB01241 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000011727
RefSeq Acc Id: XP_004841291   ⟸   XM_004841234
- UniProtKB: G5AW30 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000011727   ⟸   ENSHGLT00000011855


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000008407 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000011855 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro FN3_dom UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Interferon/interleukin_rcp_dom UniProtKB/TrEMBL
  Tissue_factor UniProtKB/TrEMBL
  Type-II_Cytokine-TF_Rcpt UniProtKB/TrEMBL
KEGG Report hgl:101702267 UniProtKB/TrEMBL
NCBI Gene F3 ENTREZGENE
PANTHER INTERFERON/INTERLEUKIN RECEPTOR UniProtKB/TrEMBL
  PTHR20859:SF22 UniProtKB/TrEMBL
Pfam Interfer-bind UniProtKB/TrEMBL
  Tissue_fac UniProtKB/TrEMBL
PIRSF Tissue_factor_3 UniProtKB/TrEMBL
PRINTS TISSUEFACTOR UniProtKB/TrEMBL
Superfamily-SCOP SSF49265 UniProtKB/TrEMBL
UniProt G5AW30 ENTREZGENE, UniProtKB/TrEMBL