F3 (coagulation factor III, tissue factor) - Rat Genome Database

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Gene: F3 (coagulation factor III, tissue factor) Homo sapiens
Symbol: F3
Name: coagulation factor III, tissue factor
RGD ID: 737354
Description: Enables phospholipid binding activity and protease binding activity. Contributes to serine-type endopeptidase activity. Involved in several processes, including activation of cysteine-type endopeptidase activity involved in apoptotic process; activation of plasma proteins involved in acute inflammatory response; and positive regulation of signal transduction. Acts upstream of or within positive regulation of interleukin-8 production. Located in cell surface; collagen-containing extracellular matrix; and extracellular space. Part of serine-type peptidase complex. Implicated in B-lymphoblastic leukemia/lymphoma; COVID-19; disseminated intravascular coagulation; and von Willebrand's disease. Biomarker of several diseases, including COVID-19; diabetes mellitus (multiple); hematologic cancer (multiple); lung disease (multiple); and thrombosis (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CD142; coagulation factor 3; coagulation factor III (thromboplastin, tissue factor); FLJ17960; TF; TFA; thromboplastin; tissue factor
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: AC090539.2  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is relevant for disease process.
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl194,529,173 - 94,541,759 (-)EnsemblGRCh38hg38GRCh38
GRCh38194,529,173 - 94,541,759 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37194,994,729 - 95,007,315 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36194,767,461 - 94,779,903 (-)NCBINCBI36hg18NCBI36
Build 34194,706,893 - 94,719,336NCBI
Celera193,249,195 - 93,261,871 (-)NCBI
Cytogenetic Map1p21.3NCBI
HuRef193,116,432 - 93,129,108 (-)NCBIHuRef
CHM1_1195,109,584 - 95,122,259 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
Acute Lung Injury  (ISO)
acute lymphoblastic leukemia  (IEP)
acute myeloid leukemia  (IEP)
acute pancreatitis  (IEP)
acute promyelocytic leukemia  (EXP,IEP)
adult respiratory distress syndrome  (IEP)
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis  (IEP)
B-lymphoblastic leukemia/lymphoma  (IDA)
bile duct disease  (IEP)
Breast Neoplasms  (EXP)
Cardiac Allograft Vasculopathy  (ISO)
Cardiac Fibrosis  (IMP)
carotid artery thrombosis  (IEP)
Chemical and Drug Induced Liver Injury  (EXP)
diabetes mellitus  (IEP)
diabetic angiopathy  (IEP)
Diabetic Nephropathies  (IEP)
diabetic retinopathy  (IEP)
disseminated intravascular coagulation  (EXP,IDA,IEP,ISO)
Embolism and Thrombosis  (IEP)
Endotoxemia  (IMP,ISO)
Experimental Diabetes Mellitus  (ISO)
familial hyperlipidemia  (IEP)
Graft vs Host Disease  (IEP)
Hemorrhage  (ISO)
hypertension  (ISO)
idiopathic pulmonary fibrosis  (IEP)
Inflammation  (ISO)
Kidney Reperfusion Injury  (ISO)
liver cirrhosis  (EXP,IEP,ISO)
Liver Injury  (ISO)
Liver Reperfusion Injury  (ISO)
Metabolic Syndrome  (IEP)
myeloid neoplasm  (IEP)
myocardial infarction  (ISO)
Myocardial Ischemia  (EXP)
Neointima  (ISO)
nephrotic syndrome  (EXP)
ovarian hyperstimulation syndrome  (IEP)
Ovary Reperfusion Injury  (ISO)
Peritoneal Fibrosis  (ISO)
pre-eclampsia  (IEP)
preterm premature rupture of the membranes  (IEP)
Sepsis  (IEP,ISO)
sickle cell anemia  (IEP)
Snake Bites  (ISO)
Spontaneous Abortions  (ISO)
Systemic Inflammatory Response Syndrome  (IEP)
Thromboembolism  (IDA)
thrombophilia  (ISO)
thrombosis  (EXP,IEP)
Thrombotic Microangiopathies  (IMP)
thrombotic thrombocytopenic purpura  (EXP)
type 2 diabetes mellitus  (IEP)
Venous Thrombosis  (EXP)
Viral Myocarditis  (ISO)
von Willebrand's disease  (IDA)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP)
(R)-mevalonic acid  (EXP)
(R)-noradrenaline  (EXP)
(S)-colchicine  (ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-benzothiazole-2-thiol  (EXP)
1,4-dithiothreitol  (EXP)
1-naphthyl isothiocyanate  (EXP,ISO)
1-nitropyrene  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
5-fluorouracil  (EXP)
6-propyl-2-thiouracil  (ISO)
abiraterone  (EXP)
acetamide  (ISO)
acrylamide  (ISO)
actinomycin D  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
AM-251  (EXP)
amiodarone  (EXP,ISO)
ammonium chloride  (ISO)
amphetamine  (EXP,ISO)
anandamide  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
arachidonic acid  (EXP)
aristolochic acid  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenous acid  (EXP)
asbestos  (EXP)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (EXP)
bryostatin 1  (EXP)
bryostatin 2  (EXP)
butan-1-ol  (EXP)
cadmium dichloride  (ISO)
calciol  (ISO)
cangrelor  (EXP)
cannabidiol  (EXP)
capsazepine  (EXP)
carbon nanotube  (ISO)
carmustine  (ISO)
carvedilol  (ISO)
chloropicrin  (EXP)
chloroprene  (ISO)
chlorphenamine  (EXP)
chromium(6+)  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (ISO)
clomiphene  (EXP)
clopidogrel  (ISO)
cobalt dichloride  (EXP)
concanamycin A  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (EXP)
crizotinib  (EXP)
crocidolite asbestos  (EXP,ISO)
Cuprizon  (ISO)
curcumin  (EXP)
cycloheximide  (EXP)
cyclophosphamide  (EXP)
cypermethrin  (ISO)
cytochalasin D  (EXP)
daunorubicin  (EXP)
deoxynivalenol  (EXP)
desferrioxamine B  (EXP)
desloratadine  (EXP)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (EXP)
diazinon  (EXP)
dibenz[a,h]anthracene  (ISO)
dibenziodolium  (EXP)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
dioxygen  (ISO)
diphenhydramine  (EXP)
diuron  (ISO)
dobutamine  (EXP)
donepezil hydrochloride  (EXP)
dopamine  (EXP)
dorsomorphin  (EXP)
doxorubicin  (EXP)
enalapril  (EXP)
endosulfan  (ISO)
ethanol  (EXP,ISO)
etonogestrel  (ISO)
etoposide  (EXP)
everolimus  (EXP)
fenamidone  (ISO)
ferric ammonium citrate  (EXP)
ferroheme b  (EXP)
fluoranthene  (ISO)
fluvastatin  (EXP)
folic acid  (ISO)
fructose  (EXP)
furan  (ISO)
geranylgeraniol  (EXP)
glutathione  (EXP)
heme b  (EXP)
Hexadimethrine bromide  (ISO)
hinokiflavone  (EXP)
histamine  (EXP)
histamine phosphate  (EXP)
ibuprofen  (EXP)
indole-3-acetic acid  (EXP)
indometacin  (EXP)
irbesartan  (ISO)
isobutanol  (EXP)
ketoconazole  (EXP)
L-1,4-dithiothreitol  (EXP)
L-ascorbic acid  (EXP)
lenalidomide  (EXP)
lipopolysaccharide  (EXP,ISO)
lithium chloride  (EXP)
losartan  (EXP)
LY294002  (EXP)
mancozeb  (EXP)
medroxyprogesterone acetate  (EXP,ISO)
mepyramine  (EXP)
mercury dibromide  (EXP)
mercury dichloride  (EXP)
methamphetamine  (ISO)
Methanandamide  (EXP)
methotrexate  (EXP,ISO)
methylmercury chloride  (EXP)
mifamurtide  (EXP)
mifepristone  (EXP,ISO)
mithramycin  (EXP)
MK-2206  (EXP)
mometasone furoate  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
monocrotaline  (ISO)
N-acetyl-L-cysteine  (EXP)
N-acetylsphingosine  (EXP)
N-ethylmaleimide  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
naphthalene  (ISO)
nickel atom  (EXP)
nickel sulfate  (EXP,ISO)
nicotinamide  (EXP)
nicotine  (ISO)
nimesulide  (ISO)
nitrofen  (ISO)
notoginsenoside R1  (EXP)
ochratoxin A  (EXP,ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paclitaxel  (EXP)
palbociclib  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
phenethyl isothiocyanate  (EXP)
phenformin  (ISO)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (EXP)
phorbol 13-acetate 12-myristate  (EXP)
phosgene  (ISO)
pirinixic acid  (EXP,ISO)
primaquine  (EXP)
primidone  (EXP)
probucol  (EXP)
progesterone  (EXP,ISO)
pyrrolidine dithiocarbamate  (EXP)
quercetin  (EXP)
quercitrin  (EXP)
quinolin-8-ol  (EXP)
ranitidine  (ISO)
resveratrol  (EXP)
riddelliine  (ISO)
rivaroxaban  (ISO)
SB 203580  (EXP)
SB 431542  (EXP)
serpentine asbestos  (EXP)
silicon dioxide  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
simvastatin  (EXP,ISO)
sirolimus  (EXP,ISO)
sirtinol  (EXP)
sodium arsenite  (EXP)
splitomicin  (EXP)
staurosporine  (EXP)
streptozocin  (ISO)
succimer  (ISO)
Sudan I  (EXP)
sulfasalazine  (EXP)
sulforaphane  (EXP)
sunitinib  (EXP)
tamibarotene  (EXP)
tamoxifen  (EXP,ISO)
temozolomide  (EXP)
Temsirolimus  (EXP)
terconazole  (EXP)
tetrachloromethane  (ISO)
tibolone  (EXP)
tin(II) chloride (anhydrous)  (EXP)
tioguanine  (ISO)
titanium dioxide  (EXP,ISO)
torin 1  (EXP)
trans-caffeic acid  (ISO)
trichostatin A  (ISO)
triclosan  (EXP)
triptonide  (ISO)
valproic acid  (EXP)
vancomycin  (ISO)
vincaleukoblastine  (ISO)
vinclozolin  (ISO)
vincristine  (EXP,ISO)
vitamin E  (EXP)
WIN 55212-2  (EXP)
wortmannin  (EXP)
XL147  (ISO)
zoledronic acid  (EXP)
zotarolimus  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function


References - curated
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Additional References at PubMed
PMID:392457   PMID:1740409   PMID:2271516   PMID:2315317   PMID:2704749   PMID:2719077   PMID:2719931   PMID:2823875   PMID:3037536   PMID:3166978   PMID:3297348   PMID:3399965  
PMID:3424286   PMID:3455766   PMID:3527261   PMID:4023720   PMID:7598447   PMID:7615158   PMID:8086403   PMID:8598903   PMID:8609606   PMID:8632006   PMID:8702971   PMID:8889548  
PMID:8940045   PMID:9414278   PMID:9480775   PMID:9490681   PMID:9490735   PMID:9925787   PMID:10856975   PMID:10896200   PMID:11307801   PMID:11583305   PMID:11601848   PMID:11744662  
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PMID:12172458   PMID:12189027   PMID:12192302   PMID:12270558   PMID:12353085   PMID:12356487   PMID:12408769   PMID:12477932   PMID:12514112   PMID:12529356   PMID:12540946   PMID:12544727  
PMID:12603864   PMID:12652293   PMID:12654807   PMID:12787023   PMID:12871349   PMID:12883669   PMID:12903530   PMID:12920028   PMID:12941032   PMID:14597990   PMID:14610342   PMID:14675092  
PMID:14675093   PMID:14678810   PMID:14738565   PMID:14750502   PMID:14756558   PMID:14961150   PMID:15016732   PMID:15034795   PMID:15034796   PMID:15041276   PMID:15117736   PMID:15154603  
PMID:15161741   PMID:15182581   PMID:15213840   PMID:15213854   PMID:15242552   PMID:15252050   PMID:15304041   PMID:15328160   PMID:15467908   PMID:15489334   PMID:15494427   PMID:15522303  
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PMID:16344560   PMID:16363246   PMID:16453151   PMID:16473535   PMID:16488980   PMID:16490369   PMID:16493499   PMID:16507316   PMID:16510984   PMID:16516912   PMID:16529959   PMID:16531802  
PMID:16634740   PMID:16697385   PMID:16710414   PMID:16794185   PMID:16820938   PMID:16835245   PMID:16839353   PMID:16894464   PMID:16930953   PMID:16937466   PMID:16949034   PMID:16959886  
PMID:17008590   PMID:17060476   PMID:17066404   PMID:17137581   PMID:17157899   PMID:17196206   PMID:17200119   PMID:17200762   PMID:17200764   PMID:17234207   PMID:17237436   PMID:17314141  
PMID:17323935   PMID:17324918   PMID:17331567   PMID:17334638   PMID:17347408   PMID:17384202   PMID:17401435   PMID:17459125   PMID:17469034   PMID:17469850   PMID:17470200   PMID:17483700  
PMID:17536017   PMID:17549302   PMID:17577783   PMID:17586694   PMID:17597988   PMID:17598015   PMID:17663729   PMID:17675290   PMID:17721619   PMID:17724132   PMID:17726162   PMID:17848177  
PMID:17852460   PMID:17883594   PMID:17883595   PMID:17898544   PMID:17900273   PMID:17901245   PMID:17920661   PMID:17922809   PMID:17938822   PMID:17939398   PMID:17947506   PMID:17977694  
PMID:17982314   PMID:17991872   PMID:18000605   PMID:18005233   PMID:18019946   PMID:18023707   PMID:18029910   PMID:18031796   PMID:18091328   PMID:18180609   PMID:18217146   PMID:18278195  
PMID:18278454   PMID:18284603   PMID:18292391   PMID:18297283   PMID:18308368   PMID:18310227   PMID:18315555   PMID:18327399   PMID:18363812   PMID:18449421   PMID:18490736   PMID:18508060  
PMID:18612547   PMID:18641355   PMID:18642055   PMID:18645927   PMID:18665396   PMID:18665928   PMID:18677291   PMID:18802362   PMID:18835104   PMID:18846330   PMID:18848323   PMID:18983479  
PMID:18983492   PMID:18983503   PMID:18983524   PMID:18989544   PMID:19002040   PMID:19027114   PMID:19056482   PMID:19065458   PMID:19091315   PMID:19095643   PMID:19099647   PMID:19105796  
PMID:19132232   PMID:19149969   PMID:19167313   PMID:19167713   PMID:19168442   PMID:19203804   PMID:19219655   PMID:19234141   PMID:19249541   PMID:19276228   PMID:19290852   PMID:19322201  
PMID:19350119   PMID:19356953   PMID:19359592   PMID:19424642   PMID:19428056   PMID:19483295   PMID:19492160   PMID:19500510   PMID:19515372   PMID:19541671   PMID:19545871   PMID:19558505  
PMID:19561489   PMID:19572083   PMID:19578796   PMID:19581412   PMID:19583819   PMID:19592470   PMID:19597299   PMID:19604541   PMID:19628788   PMID:19631649   PMID:19661141   PMID:19698254  
PMID:19750223   PMID:19795460   PMID:19806259   PMID:19817993   PMID:19828697   PMID:19829668   PMID:19843576   PMID:19856410   PMID:19861441   PMID:19880163   PMID:19904262   PMID:19913121  
PMID:19914247   PMID:19923558   PMID:19954621   PMID:19958818   PMID:19966052   PMID:19995406   PMID:20034913   PMID:20061396   PMID:20062929   PMID:20103969   PMID:20113254   PMID:20133705  
PMID:20138335   PMID:20140262   PMID:20142117   PMID:20149415   PMID:20149924   PMID:20150920   PMID:20153879   PMID:20156644   PMID:20163832   PMID:20171716   PMID:20185792   PMID:20189224  
PMID:20224254   PMID:20227257   PMID:20237315   PMID:20237496   PMID:20338779   PMID:20388709   PMID:20434002   PMID:20434004   PMID:20434015   PMID:20451919   PMID:20452482   PMID:20524980  
PMID:20546120   PMID:20553947   PMID:20589316   PMID:20601186   PMID:20605795   PMID:20616308   PMID:20628086   PMID:20628259   PMID:20634491   PMID:20656331   PMID:20673868   PMID:20688968  
PMID:20708219   PMID:20708733   PMID:20810696   PMID:20830515   PMID:20846886   PMID:20930172   PMID:20933205   PMID:20978007   PMID:21042291   PMID:21059650   PMID:21091668   PMID:21129276  
PMID:21149441   PMID:21160057   PMID:21182229   PMID:21186047   PMID:21236471   PMID:21245964   PMID:21248061   PMID:21293108   PMID:21310953   PMID:21344386   PMID:21367569   PMID:21404058  
PMID:21458031   PMID:21464728   PMID:21467727   PMID:21474669   PMID:21483174   PMID:21488215   PMID:21500176   PMID:21502573   PMID:21518473   PMID:21531894   PMID:21535396   PMID:21543928  
PMID:21592524   PMID:21605334   PMID:21617868   PMID:21619686   PMID:21621407   PMID:21625939   PMID:21652710   PMID:21690060   PMID:21693061   PMID:21694469   PMID:21737126   PMID:21762960  
PMID:21800004   PMID:21868706   PMID:21873635   PMID:21934552   PMID:22022598   PMID:22066736   PMID:22076613   PMID:22099707   PMID:22115773   PMID:22119392   PMID:22156911   PMID:22178066  
PMID:22187432   PMID:22196362   PMID:22212466   PMID:22214850   PMID:22237453   PMID:22238593   PMID:22340074   PMID:22437887   PMID:22461171   PMID:22547577   PMID:22556343   PMID:22672593  
PMID:22682123   PMID:22682138   PMID:22683021   PMID:22705067   PMID:22771387   PMID:22784289   PMID:22828416   PMID:22964479   PMID:23007470   PMID:23029002   PMID:23029190   PMID:23038262  
PMID:23065128   PMID:23118232   PMID:23152142   PMID:23223577   PMID:23294934   PMID:23325480   PMID:23333304   PMID:23373413   PMID:23376485   PMID:23381943   PMID:23383108   PMID:23409769  
PMID:23434438   PMID:23490466   PMID:23524311   PMID:23539451   PMID:23578769   PMID:23585459   PMID:23604472   PMID:23621622   PMID:23623171   PMID:23640483   PMID:23666757   PMID:23754313  
PMID:23798713   PMID:23801760   PMID:23803674   PMID:24021283   PMID:24094893   PMID:24108579   PMID:24342062   PMID:24378263   PMID:24385191   PMID:24448154   PMID:24470301   PMID:24516673  
PMID:24568471   PMID:24755284   PMID:24759146   PMID:24920554   PMID:24966616   PMID:24998411   PMID:25038529   PMID:25116956   PMID:25163770   PMID:25171777   PMID:25241761   PMID:25242242  
PMID:25262106   PMID:25281742   PMID:25312727   PMID:25403348   PMID:25407675   PMID:25425620   PMID:25427791   PMID:25450387   PMID:25463083   PMID:25465717   PMID:25490770   PMID:25596265  
PMID:25631539   PMID:25653143   PMID:25665657   PMID:25683933   PMID:25823853   PMID:25864889   PMID:25881103   PMID:25903973   PMID:25923092   PMID:25931463   PMID:25963480   PMID:26025445  
PMID:26062685   PMID:26065856   PMID:26136249   PMID:26169722   PMID:26179105   PMID:26186194   PMID:26221761   PMID:26241501   PMID:26271343   PMID:26281862   PMID:26408917   PMID:26408918  
PMID:26408920   PMID:26408922   PMID:26408924   PMID:26408925   PMID:26408926   PMID:26408927   PMID:26446354   PMID:26471500   PMID:26504080   PMID:26631725   PMID:26658897   PMID:26667361  
PMID:26694616   PMID:26715508   PMID:26731648   PMID:26763081   PMID:26765308   PMID:26791271   PMID:26797521   PMID:26967531   PMID:27002259   PMID:27057091   PMID:27127202   PMID:27142573  
PMID:27207429   PMID:27260391   PMID:27311950   PMID:27348126   PMID:27427978   PMID:27562418   PMID:27592310   PMID:27599717   PMID:27629739   PMID:27685527   PMID:27721473   PMID:27766025  
PMID:27789475   PMID:27807692   PMID:27808345   PMID:27841803   PMID:27926582   PMID:28024455   PMID:28028070   PMID:28055955   PMID:28106852   PMID:28142075   PMID:28151805   PMID:28246677  
PMID:28343272   PMID:28419722   PMID:28492698   PMID:28495929   PMID:28514442   PMID:28521572   PMID:28551673   PMID:28569919   PMID:28729433   PMID:28749986   PMID:28834179   PMID:28841839  
PMID:28957360   PMID:28962834   PMID:29032977   PMID:29044292   PMID:29061995   PMID:29075790   PMID:29167396   PMID:29217135   PMID:29225295   PMID:29427323   PMID:29437288   PMID:29452445  
PMID:29477147   PMID:29571624   PMID:29658195   PMID:29715083   PMID:29724819   PMID:29787758   PMID:29789989   PMID:29949655   PMID:29976772   PMID:30113368   PMID:30278301   PMID:30408635  
PMID:30530119   PMID:30602303   PMID:30664196   PMID:30698330   PMID:30781507   PMID:31654241   PMID:31715000   PMID:31774347   PMID:31796521   PMID:32081704   PMID:32152404   PMID:32296183  
PMID:32471327   PMID:32627125   PMID:32665005   PMID:32678428   PMID:32759504   PMID:32896248   PMID:32920807   PMID:33225609   PMID:33893844   PMID:33961781   PMID:34205482  


Comparative Map Data
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl194,529,173 - 94,541,759 (-)EnsemblGRCh38hg38GRCh38
GRCh38194,529,173 - 94,541,759 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37194,994,729 - 95,007,315 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36194,767,461 - 94,779,903 (-)NCBINCBI36hg18NCBI36
Build 34194,706,893 - 94,719,336NCBI
Celera193,249,195 - 93,261,871 (-)NCBI
Cytogenetic Map1p21.3NCBI
HuRef193,116,432 - 93,129,108 (-)NCBIHuRef
CHM1_1195,109,584 - 95,122,259 (-)NCBICHM1_1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm393121,517,186 - 121,528,701 (+)NCBIGRCm39mm39
GRCm39 Ensembl3121,517,186 - 121,528,697 (+)Ensembl
GRCm383121,723,537 - 121,735,052 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3121,723,537 - 121,735,048 (+)EnsemblGRCm38mm10GRCm38
MGSCv373121,426,455 - 121,437,970 (+)NCBIGRCm37mm9NCBIm37
MGSCv363121,715,560 - 121,727,066 (+)NCBImm8
Celera3128,097,400 - 128,112,071 (+)NCBICelera
Cytogenetic Map3G1NCBI
cM Map352.94NCBI
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.22209,827,061 - 209,838,666 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl2209,826,959 - 209,838,668 (+)Ensembl
Rnor_6.02225,310,686 - 225,322,281 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2225,310,624 - 225,322,272 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02243,348,430 - 243,360,439 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42218,371,050 - 218,382,645 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12218,334,111 - 218,345,706 (+)NCBI
Celera2202,257,415 - 202,269,039 (+)NCBICelera
Cytogenetic Map2q41NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_004955423254,189 - 264,159 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955423254,060 - 264,448 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.1195,918,359 - 95,931,050 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl195,918,502 - 95,931,050 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0197,190,381 - 97,203,076 (-)NCBIMhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1654,709,581 - 54,720,603 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl654,708,471 - 54,720,607 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha657,418,032 - 57,428,969 (+)NCBI
ROS_Cfam_1.0655,085,266 - 55,096,260 (+)NCBI
UMICH_Zoey_3.1654,766,195 - 54,777,118 (+)NCBI
UNSW_CanFamBas_1.0654,750,367 - 54,761,295 (+)NCBI
UU_Cfam_GSD_1.0655,203,270 - 55,214,213 (+)NCBI
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024405058104,300,058 - 104,310,937 (-)NCBI
SpeTri2.0NW_0049365374,637,028 - 4,647,915 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl4122,826,992 - 122,837,672 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14122,827,018 - 122,837,673 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24134,474,466 - 134,479,707 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12038,726,690 - 38,738,457 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2038,726,798 - 38,739,408 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603379,312,870 - 79,325,353 (-)NCBIVero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_0046247423,112,827 - 3,123,424 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37195,001,522 - 95,001,719UniSTSGRCh37
Build 36194,774,110 - 94,774,307RGDNCBI36
Celera193,255,980 - 93,256,177RGD
Cytogenetic Map1p22-p21UniSTS
HuRef193,123,217 - 93,123,414UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37194,995,748 - 94,995,957UniSTSGRCh37
Build 36194,768,336 - 94,768,545RGDNCBI36
Celera193,250,208 - 93,250,417RGD
Cytogenetic Map1p22-p21UniSTS
HuRef193,117,445 - 93,117,654UniSTS
GeneMap99-GB4 RH Map1266.58UniSTS
GeneMap99-GB4 RH Map1265.97UniSTS
Whitehead-RH Map1272.3UniSTS
NCBI RH Map1652.0UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37194,995,764 - 94,995,862UniSTSGRCh37
Build 36194,768,352 - 94,768,450RGDNCBI36
Celera193,250,224 - 93,250,322RGD
Cytogenetic Map1p22-p21UniSTS
HuRef193,117,461 - 93,117,559UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37194,994,721 - 94,995,576UniSTSGRCh37
Build 36194,767,309 - 94,768,164RGDNCBI36
Celera193,249,184 - 93,250,039RGD
HuRef193,116,421 - 93,117,276UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37194,994,387 - 94,994,526UniSTSGRCh37
Build 36194,766,975 - 94,767,114RGDNCBI36
Celera193,248,850 - 93,248,989RGD
Cytogenetic Map1p22-p21UniSTS
HuRef193,116,087 - 93,116,226UniSTS
TNG Radiation Hybrid Map151620.0UniSTS
GeneMap99-GB4 RH Map1266.29UniSTS
NCBI RH Map1652.0UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID

Predicted Target Of
Summary Value
Count of predictions:1624
Count of miRNA genes:683
Interacting mature miRNAs:787
Transcripts:ENST00000334047, ENST00000370207, ENST00000478217, ENST00000480356
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 5 2 3 1 2 21 6 5
Medium 2152 1798 1287 220 336 59 3454 1116 3228 189 1345 1511 169 1 1204 2068 5 2
Low 280 571 413 383 441 383 897 1075 504 223 93 91 1 720 1
Below cutoff 2 614 26 21 803 21 3 5 1 5 1 5


Nucleotide Sequences
RefSeq Transcripts NG_029366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001178096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide A19048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC093117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF487337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF497569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF497570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF497571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF540377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK310918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK312638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY940729 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY940730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY940731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC011029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM769013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM981095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT019808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471097 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR541792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB203987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB499288 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J02846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J02931 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF459524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M16553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M27436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X07680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000334047   ⟹   ENSP00000334145
RefSeq Status:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl194,529,173 - 94,541,759 (-)Ensembl
RefSeq Acc Id: ENST00000370207   ⟹   ENSP00000359226
RefSeq Status:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl194,529,310 - 94,541,637 (-)Ensembl
RefSeq Acc Id: ENST00000478217
RefSeq Status:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl194,532,997 - 94,536,164 (-)Ensembl
RefSeq Acc Id: ENST00000480356
RefSeq Status:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl194,533,106 - 94,541,759 (-)Ensembl
RefSeq Acc Id: NM_001178096   ⟹   NP_001171567
RefSeq Status: REVIEWED
Human AssemblyChrPosition (strand)Source
GRCh38194,529,173 - 94,541,759 (-)NCBI
GRCh37194,994,732 - 95,007,413 (-)ENTREZGENE
HuRef193,116,432 - 93,129,108 (-)ENTREZGENE
CHM1_1195,109,584 - 95,122,259 (-)NCBI
RefSeq Acc Id: NM_001993   ⟹   NP_001984
RefSeq Status: REVIEWED
Human AssemblyChrPosition (strand)Source
GRCh38194,529,173 - 94,541,759 (-)NCBI
GRCh37194,994,732 - 95,007,413 (-)ENTREZGENE
Build 36194,767,461 - 94,779,903 (-)NCBI Archive
HuRef193,116,432 - 93,129,108 (-)ENTREZGENE
CHM1_1195,109,584 - 95,122,259 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001171567   ⟸   NM_001178096
- Peptide Label: isoform 2 precursor
- UniProtKB: P13726 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001984   ⟸   NM_001993
- Peptide Label: isoform 1 precursor
- UniProtKB: P13726 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000359226   ⟸   ENST00000370207
RefSeq Acc Id: ENSP00000334145   ⟸   ENST00000334047

RGD ID:6856278
Promoter ID:EPDNEW_H1304
Type:initiation region
Description:coagulation factor III, tissue factor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Human AssemblyChrPosition (strand)Source
GRCh38194,541,758 - 94,541,818EPDNEW
RGD ID:6785531
Promoter ID:HG_KWN:3725
SO ACC ID:SO:0000170
Tissues & Cell Lines:HeLa_S3,   Lymphoblastoid,   NB4
Transcripts:NM_001178096,   NM_001993,   OTTHUMT00000029596,   UC001DQP.1,   UC001DQQ.1,   UC001DQT.1
Human AssemblyChrPosition (strand)Source
Build 36194,779,769 - 94,780,269 (-)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1p31.1-13.3(chr1:72661709-107456880)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051825]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051825]|See cases [RCV000051825] Chr1:72661709..107456880 [GRCh38]
Chr1:73127392..107999502 [GRCh37]
Chr1:72899980..107801025 [NCBI36]
GRCh38/hg38 1p21.3(chr1:94471888-94588229)x1 copy number loss See cases [RCV000053201] Chr1:94471888..94588229 [GRCh38]
Chr1:94937444..95053785 [GRCh37]
Chr1:94710032..94826373 [NCBI36]
uncertain significance
NM_001993.4(F3):c.489G>A (p.Arg163=) single nucleotide variant Malignant melanoma [RCV000064964] Chr1:94533192 [GRCh38]
Chr1:94998748 [GRCh37]
Chr1:94771336 [NCBI36]
not provided
GRCh38/hg38 1p31.1-21.1(chr1:83457325-104273917)x3 copy number gain See cases [RCV000135654] Chr1:83457325..104273917 [GRCh38]
Chr1:83923008..104816539 [GRCh37]
Chr1:83695596..104618062 [NCBI36]
Single allele duplication Normal pregnancy [RCV000161168] Chr1:94401500..94669347 [GRCh38]
Chr1:94867056..95134903 [GRCh37]
not provided
GRCh37/hg19 1p36.12-12(chr1:20608823-120546301)x3 copy number loss not provided [RCV000762767] Chr1:20608823..120546301 [GRCh37]
likely benign
GRCh37/hg19 1p21.3(chr1:94888020-95077701)x1 copy number loss See cases [RCV000448812] Chr1:94888020..95077701 [GRCh37]
likely benign
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
GRCh37/hg19 1p22.1-11.2(chr1:93837992-121343783)x3 copy number gain See cases [RCV000512354] Chr1:93837992..121343783 [GRCh37]
GRCh37/hg19 1p21.3(chr1:95000754-95323325)x3 copy number gain not provided [RCV000684602] Chr1:95000754..95323325 [GRCh37]
uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
GRCh37/hg19 1p22.1-13.3(chr1:94054724-111671707)x3 copy number gain not provided [RCV000749068] Chr1:94054724..111671707 [GRCh37]
NM_001993.5(F3):c.160A>G (p.Ile54Val) single nucleotide variant not provided [RCV000971716] Chr1:94540309 [GRCh38]
Chr1:95005865 [GRCh37]
likely benign
NM_001993.5(F3):c.487C>T (p.Arg163Trp) single nucleotide variant not provided [RCV000880188] Chr1:94533194 [GRCh38]
Chr1:94998750 [GRCh37]
NM_001993.5(F3):c.118G>A (p.Ala40Thr) single nucleotide variant not provided [RCV000902309] Chr1:94540351 [GRCh38]
Chr1:95005907 [GRCh37]
likely benign
GRCh37/hg19 1p36.22-21.1(chr1:103343285-103455144)x3 copy number gain Global developmental delay [RCV000787285] Chr1:103343285..103455144 [GRCh37]
uncertain significance
NM_001993.5(F3):c.842G>A (p.Gly281Glu) single nucleotide variant not provided [RCV000974594] Chr1:94530506 [GRCh38]
Chr1:94996062 [GRCh37]
NM_001993.5(F3):c.278A>G (p.Asp93Gly) single nucleotide variant not provided [RCV000887781] Chr1:94536099 [GRCh38]
Chr1:95001655 [GRCh37]
NM_001993.5(F3):c.106A>G (p.Thr36Ala) single nucleotide variant not provided [RCV000889879] Chr1:94540363 [GRCh38]
Chr1:95005919 [GRCh37]
GRCh37/hg19 1p22.1-21.3(chr1:93863518-96108930)x1 copy number loss not provided [RCV001005120] Chr1:93863518..96108930 [GRCh37]
uncertain significance
NC_000001.10:g.(?_94458793)_(95538454_?)del deletion not provided [RCV001385954] Chr1:94458793..95538454 [GRCh37]

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:3541 AgrOrtholog
Ensembl Genes ENSG00000117525 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000334145 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000359226 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000334047 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000370207 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH UniProtKB/Swiss-Prot
GTEx ENSG00000117525 GTEx
Human Proteome Map F3 Human Proteome Map
InterPro FN3_dom UniProtKB/Swiss-Prot
  FN3_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Interferon/interleukin_rcp_dom UniProtKB/Swiss-Prot
  Tissue_factor UniProtKB/Swiss-Prot
  Tissue_Factor_CS UniProtKB/Swiss-Prot
KEGG Report hsa:2152 UniProtKB/Swiss-Prot
OMIM 134390 OMIM
PANTHER PTHR20859:SF22 UniProtKB/Swiss-Prot
Pfam Interfer-bind UniProtKB/Swiss-Prot
  Tissue_fac UniProtKB/Swiss-Prot
PharmGKB PA158 PharmGKB
PIRSF Tissue_factor_3 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49265 UniProtKB/Swiss-Prot
UniProt P13726 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary D3DT47 UniProtKB/Swiss-Prot
  Q6FHG2 UniProtKB/Swiss-Prot
  Q86WH4 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-19 F3  coagulation factor III, tissue factor    coagulation factor III (thromboplastin, tissue factor)  Symbol and/or name change 5135510 APPROVED