RGD Reference Report - Plasma levels of tissue factor antigen in patients with non-insulin-dependent diabetes mellitus. - Rat Genome Database

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Plasma levels of tissue factor antigen in patients with non-insulin-dependent diabetes mellitus.

Authors: Song, KS  Kim, HK 
Citation: Song KS and Kim HK, Yonsei Med J. 2004 Feb 29;45(1):38-42.
RGD ID: 2313863
Pubmed: PMID:15004866   (View Abstract at PubMed)
DOI: DOI:10.3349/ymj.2004.45.1.38   (Journal Full-text)

Patients with diabetes mellitus (DM) are associated with an increased risk of thrombosis, and are susceptible to a series of complications including nephropathy. It has also been known that plasma tissue factor (TF) antigen levels increase significantly in certain disease states. To investigate the clinical significance of an association with the various complications in patients with type 2 non-insulin-dependent DM (NIDDM), we measured the plasma levels of TF antigen in 63 patients (35 males and 28 females, mean age 60.8 yrs) with NIDDM and in 22 normal subjects (14 males and 8 females, mean age 56.0 yrs). The mean concentrations of TF were higher for patients with NIDDM (253.7 +/- 144.9 pg/ml) than in normal subjects (187.3 +/- 108.7 pg/ml with marginal statistical significance (p= 0.0530). The TF levels were higher for patients with a nephropathy than for patients without a nephropathy (p=0.0402). There was a significant positive correlation between levels of TF and BUN (r=0.84, p < 0.0001) or creatinine (r=0.93, p < 0.0001). However, TF levels were found to be similar for both groups with and without thrombosis, neuropathy, retinopathy, or infection. These results suggest that plasma TF antigen levels may be associated with nephropathy and they may reflect a renal dysfunction in NIDDM.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
F3RatDiabetic Nephropathies  ISOF3 (Homo sapiens)associated with Diabetes Mellitus more ...RGD 
F3MouseDiabetic Nephropathies  ISOF3 (Homo sapiens)associated with Diabetes Mellitus more ...RGD 
F3HumanDiabetic Nephropathies  IEP associated with Diabetes Mellitus more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
F3  (coagulation factor III, tissue factor)

Genes (Mus musculus)
F3  (coagulation factor III)

Genes (Homo sapiens)
F3  (coagulation factor III, tissue factor)


Additional Information