RGD Reference Report - Tissue factor activity in leukemia cells. Special reference to disseminated intravascular coagulation. - Rat Genome Database

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Tissue factor activity in leukemia cells. Special reference to disseminated intravascular coagulation.

Authors: Andoh, K  Kubota, T  Takada, M  Tanaka, H  Kobayashi, N  Maekawa, T 
Citation: Andoh K, etal., Cancer. 1987 Feb 15;59(4):748-54.
RGD ID: 11341675
Pubmed: PMID:3802033   (View Abstract at PubMed)

Tissue factor activity (TFA) of 10(8) leukemia cells was measured in 82 patients with acute nonlymphoid leukemia by the clotting method. The TFA bore a significant correlation to the development of disseminated intravascular coagulation (DIC) in these cases. Mean TFA value with standard deviation (SD) was 8.3 +/- 6.3 U in 48 cases with DIC, which was significantly higher than 0.3 +/- 4.2 U in 34 cases without DIC. Whereas Mean TFA in non-M3 was 0.9 +/- 6.3 U which was significantly lower than 37.2 +/- 2.3 U in M3, some non-M3 showed TFA as high as M3 and were complicated by DIC. In heparin treatment, dosage of heparin could not be controlled by either APTT or AcCT but was controlled by the extent of TFA of leukemia cells. Retrospective analysis of clinical features revealed that 97000X + 9000 units/day (X = logarithm value of TFA) of heparin is an adequate dosage for the successful treatment of DIC when TFA of leukemia cells is 0.8 U or more.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
disseminated intravascular coagulation  ISOF3 (Homo sapiens)11341675; 11341675associated with Leukemia and MyeloidRGD 
disseminated intravascular coagulation  IDA 11341675associated with Leukemia and MyeloidRGD 

Objects Annotated

Genes (Rattus norvegicus)
F3  (coagulation factor III, tissue factor)

Genes (Mus musculus)
F3  (coagulation factor III)

Genes (Homo sapiens)
F3  (coagulation factor III, tissue factor)


Additional Information