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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2587
Species: Rattus norvegicus
RGD Object: Gene
Symbol: F3
Name: coagulation factor III, tissue factor
Acc ID: CHEBI:9150
Term: simvastatin
Definition: A member of the class of hexahydronaphthalenes that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug.
Chemical ID: MESH:D019821
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
F3affects response to substanceISOF3 (Homo sapiens)6480464CTDF3 polymorphism affects the susceptibility to SimvastatinPMID:19027114
F3decreases activityISOF3 (Homo sapiens)6480464CTDSimvastatin results in decreased activity of F3 proteinPMID:10830219 PMID:17513194
F3decreases expressionISOF3 (Mus musculus)6480464CTDSimvastatin results in decreased expression of F3 mRNAPMID:12818400
F3decreases expressionISOF3 (Homo sapiens)6480464CTDSimvastatin results in decreased expression of F3; Simvastatin results in decreased expression of F3 mRNA; Simvastatin results in decreased expression of F3 proteinPMID:10830219 PMID:12753293 PMID:17513194 PMID:18031796 PMID:9081680
F3increases expressionISOF3 (Homo sapiens)6480464CTDSimvastatin results in increased expression of F3 mRNA; Simvastatin results in increased expression of F3 proteinPMID:18841289
F3multiple interactionsISOF3 (Homo sapiens)6480464CTDgeranylgeraniol inhibits the reaction [Simvastatin results in decreased expression of F3]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of F3 mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of F3]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of F3 protein]PMID:12753293 PMID:15824212 PMID:18031796
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