GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | F3 | affects response to substance | ISO | F3 (Homo sapiens) | 6480464 | CTD | F3 polymorphism affects the susceptibility to Simvastatin | PMID:19027114 | F3 | decreases activity | ISO | F3 (Homo sapiens) | 6480464 | CTD | Simvastatin results in decreased activity of F3 protein | PMID:10830219 PMID:17513194 | F3 | decreases expression | ISO | F3 (Mus musculus) | 6480464 | CTD | Simvastatin results in decreased expression of F3 mRNA | PMID:12818400 | F3 | decreases expression | ISO | F3 (Homo sapiens) | 6480464 | CTD | Simvastatin results in decreased expression of F3; Simvastatin results in decreased expression of F3 mRNA; Simvastatin results in decreased expression of F3 protein | PMID:10830219 PMID:12753293 PMID:17513194 PMID:18031796 PMID:9081680 | F3 | increases expression | ISO | F3 (Homo sapiens) | 6480464 | CTD | Simvastatin results in increased expression of F3 mRNA; Simvastatin results in increased expression of F3 protein | PMID:18841289 | F3 | multiple interactions | ISO | F3 (Homo sapiens) | 6480464 | CTD | geranylgeraniol inhibits the reaction [Simvastatin results in decreased expression of F3]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of F3 mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of F3]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of F3 protein] | PMID:12753293 PMID:15824212 PMID:18031796 | |
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