C1s (complement C1s) - Rat Genome Database

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Gene: C1s (complement C1s) Rattus norvegicus
Analyze
Symbol: C1s
Name: complement C1s
RGD ID: 619983
Description: Predicted to enable identical protein binding activity and serine-type endopeptidase activity. Involved in glial cell differentiation and response to cAMP. Located in extracellular region. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome periodontal type 2. Orthologous to human C1S (complement C1s); PARTICIPATES IN coagulation cascade pathway; complement system pathway; Staphylococcus aureus infection pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C1 esterase; complement C1s subcomponent; complement component 1 subcomponent s; complement component 1, s subcomponent; r-gsp
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Oia7
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24157,430,249 - 157,442,438 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4157,430,117 - 157,442,303 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4163,653,002 - 163,665,144 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.04159,435,909 - 159,448,049 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.04158,082,567 - 158,094,754 (-)NCBIRnor_WKY
Rnor_6.04157,143,592 - 157,155,592 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4157,143,592 - 157,155,609 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04224,162,096 - 224,174,096 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44160,736,133 - 160,748,133 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14160,981,068 - 160,993,073 (-)NCBI
Celera4146,169,963 - 146,181,341 (-)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-aminothiophenol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitroaniline  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
azoxystrobin  (ISO)
benzbromarone  (EXP)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
choline  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
D-penicillamine  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diethylstilbestrol  (EXP)
dioxygen  (EXP)
disulfiram  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
fenthion  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
genistein  (EXP)
gentamycin  (EXP)
glucose  (ISO)
hexachlorobenzene  (EXP)
indometacin  (ISO)
isotretinoin  (ISO)
L-ethionine  (EXP)
L-methionine  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
mercury dibromide  (ISO)
methimazole  (EXP)
methylmercury chloride  (ISO)
Muraglitazar  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP)
nickel sulfate  (ISO)
nicotine  (ISO)
nimesulide  (EXP)
omeprazole  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
p-toluidine  (EXP)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenylmercury acetate  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
propanal  (ISO)
pyrogallol  (ISO)
quercetin  (EXP)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sotorasib  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetradecane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trametinib  (ISO)
troglitazone  (EXP,ISO)
undecane  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
vitamin E  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Increased expression and secretion of r-Gsp protein, rat counterpart of complement C1s precursor, during cyclic AMP-induced differentiation in rat C6 glioma cells. Nakagawa M, etal., Brain Res Mol Brain Res 2002 Oct 15;106(1-2):12-21.
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
10. Molecular cloning of a cDNA encoding a serine protease homologous to complement C1s precursor from rat C6 glial cells and its expression during glial differentiation. Sakai H, etal., Gene 1998 Mar 16;209(1-2):87-94.
11. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:2387866   PMID:11527969   PMID:12788922   PMID:15489334   PMID:22516433   PMID:23376485  


Genomics

Comparative Map Data
C1s
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24157,430,249 - 157,442,438 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4157,430,117 - 157,442,303 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4163,653,002 - 163,665,144 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.04159,435,909 - 159,448,049 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.04158,082,567 - 158,094,754 (-)NCBIRnor_WKY
Rnor_6.04157,143,592 - 157,155,592 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4157,143,592 - 157,155,609 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04224,162,096 - 224,174,096 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44160,736,133 - 160,748,133 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14160,981,068 - 160,993,073 (-)NCBI
Celera4146,169,963 - 146,181,341 (-)NCBICelera
Cytogenetic Map4q42NCBI
C1S
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38127,060,718 - 7,071,032 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl126,988,259 - 7,071,032 (+)EnsemblGRCh38hg38GRCh38
GRCh37127,168,022 - 7,178,336 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36127,038,278 - 7,048,597 (+)NCBINCBI36Build 36hg18NCBI36
Celera128,790,867 - 8,801,223 (+)NCBICelera
Cytogenetic Map12p13.31NCBI
HuRef127,028,290 - 7,038,646 (+)NCBIHuRef
CHM1_1127,166,966 - 7,177,322 (+)NCBICHM1_1
T2T-CHM13v2.0127,074,188 - 7,084,511 (+)NCBIT2T-CHM13v2.0
C1s1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396124,507,303 - 124,519,340 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6124,507,304 - 124,519,318 (-)EnsemblGRCm39 Ensembl
GRCm386124,530,344 - 124,542,392 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6124,530,345 - 124,542,359 (-)EnsemblGRCm38mm10GRCm38
MGSCv376124,480,362 - 124,492,377 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366124,495,964 - 124,507,900 (-)NCBIMGSCv36mm8
Celera6132,361,770 - 132,365,592 (-)NCBICelera
Cytogenetic Map6F2NCBI
C1s
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554134,620,450 - 4,630,860 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554134,620,450 - 4,630,860 (+)NCBIChiLan1.0ChiLan1.0
C1S
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1127,107,214 - 7,117,614 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl127,106,157 - 7,117,614 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0127,191,679 - 7,202,036 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
C1S
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12737,976,196 - 37,985,846 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2737,976,197 - 37,989,575 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha278,630,918 - 8,640,567 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02738,328,637 - 38,338,284 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2738,327,536 - 38,342,200 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12738,203,588 - 38,213,240 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02738,244,607 - 38,254,261 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0278,109,060 - 8,118,714 (+)NCBIUU_Cfam_GSD_1.0
C1s
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945102,063,662 - 102,075,054 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936709731,165 - 742,686 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936709731,211 - 742,583 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
C1S
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl563,670,312 - 63,708,214 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1563,670,309 - 63,681,466 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
C1S
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1117,106,769 - 7,115,055 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl117,139,115 - 7,148,056 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
ChlSab1.1 Ensembl117,139,115 - 7,148,056 (+)NCBIChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660631,100,303 - 1,110,870 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
C1s
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248603,659,341 - 3,671,142 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248603,658,272 - 3,667,717 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in C1s
98 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:178
Count of miRNA genes:139
Interacting mature miRNAs:150
Transcripts:ENSRNOT00000016330, ENSRNOT00000056058
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4119428175157578333Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132642577167139601Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4147278504167139601Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4148090542168069246Rat
61446Coreg2Compensatory renal growth QTL 23.5kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)4148423102157580971Rat
1581574Eae20Experimental allergic encephalomyelitis QTL 207.8nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)4153031106158841762Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4155561574182687754Rat

Markers in Region
C1s  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24157,436,555 - 157,437,461 (+)MAPPERmRatBN7.2
Rnor_6.04157,149,897 - 157,150,802NCBIRnor6.0
Rnor_5.04224,168,401 - 224,169,306UniSTSRnor5.0
RGSC_v3.44160,366,950 - 160,367,086UniSTSRGSC3.4
RGSC_v3.44160,742,438 - 160,743,343UniSTSRGSC3.4
Celera4145,837,214 - 145,837,350UniSTS
Celera4146,175,646 - 146,176,551UniSTS
Cytogenetic Map4q42UniSTS
RH141407  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24157,059,101 - 157,059,317 (+)MAPPERmRatBN7.2
mRatBN7.24157,430,433 - 157,430,649 (+)MAPPERmRatBN7.2
Rnor_6.04157,143,777 - 157,143,992NCBIRnor6.0
Rnor_6.04156,728,380 - 156,728,595NCBIRnor6.0
Rnor_5.04224,162,281 - 224,162,496UniSTSRnor5.0
Rnor_5.04223,744,633 - 223,744,848UniSTSRnor5.0
RGSC_v3.44160,365,103 - 160,365,318UniSTSRGSC3.4
RGSC_v3.44160,736,318 - 160,736,533UniSTSRGSC3.4
Celera4145,835,367 - 145,835,582UniSTS
RH 3.4 Map41002.0UniSTS
Cytogenetic Map4q42UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 15 57 41 19 41 8 11 2 25 33 11 8
Low 22 70 10 8
Below cutoff 6 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000016330   ⟹   ENSRNOP00000016330
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4157,430,117 - 157,442,260 (-)Ensembl
Rnor_6.0 Ensembl4157,143,592 - 157,155,609 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000056058   ⟹   ENSRNOP00000052910
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4157,430,831 - 157,441,020 (-)Ensembl
Rnor_6.0 Ensembl4157,144,195 - 157,154,120 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000112418   ⟹   ENSRNOP00000086080
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4157,430,831 - 157,442,303 (-)Ensembl
RefSeq Acc Id: NM_138900   ⟹   NP_620255
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24157,430,249 - 157,442,438 (-)NCBI
Rnor_6.04157,143,592 - 157,155,592 (-)NCBI
Rnor_5.04224,162,096 - 224,174,096 (-)NCBI
RGSC_v3.44160,736,133 - 160,748,133 (-)RGD
Celera4146,169,963 - 146,181,341 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_620255 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH62042 (Get FASTA)   NCBI Sequence Viewer  
  BAA25797 (Get FASTA)   NCBI Sequence Viewer  
  Q6P6T1 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_620255   ⟸   NM_138900
- Peptide Label: precursor
- Sequence:
RefSeq Acc Id: ENSRNOP00000016330   ⟸   ENSRNOT00000016330
RefSeq Acc Id: ENSRNOP00000052910   ⟸   ENSRNOT00000056058
RefSeq Acc Id: ENSRNOP00000086080   ⟸   ENSRNOT00000112418
Protein Domains
CUB   EGF-like   Peptidase S1   Sushi

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6P6T1-F1-model_v2 AlphaFold Q6P6T1 1-688 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693382
Promoter ID:EPDNEW_R3907
Type:initiation region
Name:C1s_1
Description:complement C1s
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04157,155,601 - 157,155,661EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619983 AgrOrtholog
BioCyc Gene G2FUF-43092 BioCyc
Ensembl Genes ENSRNOG00000011971 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000016330 ENTREZGENE
  ENSRNOP00000016330.4 UniProtKB/TrEMBL
  ENSRNOP00000052910.5 UniProtKB/TrEMBL
  ENSRNOP00000086080.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016330 ENTREZGENE
  ENSRNOT00000016330.6 UniProtKB/TrEMBL
  ENSRNOT00000056058.5 UniProtKB/TrEMBL
  ENSRNOT00000112418.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.120.290 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5598051 IMAGE-MGC_LOAD
InterPro Complement_C1s_subcomponent UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CUB_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_S1A_C1r/C1S/mannan-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sperma_CUB_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi/SCR/CCP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi_SCR_CCP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:192262 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72298 IMAGE-MGC_LOAD
NCBI Gene 192262 ENTREZGENE
PANTHER PTHR24255:SF18 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CUB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen C1s PhenoGen
PIRSF C1r_C1s_MASP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot
  CUB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUSHI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CCP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CUB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49854 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57535 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A2W2_RAT UniProtKB/TrEMBL
  C1S_RAT UniProtKB/Swiss-Prot
  D4A1S0_RAT UniProtKB/TrEMBL
  G3V7L3_RAT UniProtKB/TrEMBL
  Q6P6T1 ENTREZGENE
UniProt Secondary O70542 UniProtKB/Swiss-Prot
  Q8R099 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-18 C1s  complement C1s  C1s  complement component 1, s subcomponent  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 C1s  complement component 1, s subcomponent      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 C1s  complement component 1, s subcomponent      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization protein is secreted into medium 632360
gene_regulation expression is induced by dibutyryl cyclic AMP 632360