C1s (complement C1s) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: C1s (complement C1s) Heterocephalus glaber
Analyze
Symbol: C1s
Name: complement C1s
RGD ID: 18935395
Description: ENCODES a protein that exhibits calcium ion binding (inferred); hydrolase activity (inferred); identical protein binding (inferred); INVOLVED IN glial cell differentiation (ortholog); response to cAMP (ortholog); ASSOCIATED WITH autoimmune disease (ortholog); autoimmune hepatitis (ortholog); Complement Component C1s Deficiency (ortholog); FOUND IN extracellular region (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Complement C1s subcomponent
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248603,659,341 - 3,671,142 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248603,658,272 - 3,667,717 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
C1s
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248603,659,341 - 3,671,142 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248603,658,272 - 3,667,717 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
C1S
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38127,060,718 - 7,071,032 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl126,988,259 - 7,071,032 (+)EnsemblGRCh38hg38GRCh38
GRCh37127,168,022 - 7,178,336 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36127,038,278 - 7,048,597 (+)NCBINCBI36Build 36hg18NCBI36
Celera128,790,867 - 8,801,223 (+)NCBICelera
Cytogenetic Map12p13.31NCBI
HuRef127,028,290 - 7,038,646 (+)NCBIHuRef
CHM1_1127,166,966 - 7,177,322 (+)NCBICHM1_1
T2T-CHM13v2.0127,074,188 - 7,084,511 (+)NCBIT2T-CHM13v2.0
C1s2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396124,601,584 - 124,613,044 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6124,601,584 - 124,613,044 (-)EnsemblGRCm39 Ensembl
GRCm386124,624,625 - 124,636,085 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6124,624,625 - 124,636,085 (-)EnsemblGRCm38mm10GRCm38
MGSCv376124,574,643 - 124,586,103 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366124,590,244 - 124,601,704 (-)NCBIMGSCv36mm8
Celera6126,305,917 - 126,317,379 (-)NCBICelera
Cytogenetic Map6F2NCBI
cM Map659.17NCBI
C1s
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84159,116,549 - 159,128,736 (-)NCBIGRCr8
mRatBN7.24157,430,249 - 157,442,438 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4157,430,117 - 157,442,303 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4163,653,002 - 163,665,144 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04159,435,909 - 159,448,049 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04158,082,567 - 158,094,754 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04157,143,592 - 157,155,592 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4157,143,592 - 157,155,609 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04224,162,096 - 224,174,096 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44160,736,133 - 160,748,133 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14160,981,068 - 160,993,073 (-)NCBI
Celera4146,169,963 - 146,181,341 (-)NCBICelera
Cytogenetic Map4q42NCBI
C1s
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554134,620,450 - 4,630,860 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554134,620,450 - 4,630,860 (+)NCBIChiLan1.0ChiLan1.0
C1S
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21012,626,244 - 12,636,744 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11212,623,083 - 12,634,100 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0127,191,679 - 7,202,036 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1127,107,214 - 7,117,614 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl127,106,157 - 7,117,614 (+)Ensemblpanpan1.1panPan2
C1S
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12737,976,196 - 37,985,846 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2737,976,197 - 37,989,575 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha278,630,918 - 8,640,567 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02738,328,637 - 38,338,284 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2738,327,536 - 38,342,200 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12738,203,588 - 38,213,240 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02738,244,607 - 38,254,261 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0278,109,060 - 8,118,714 (+)NCBIUU_Cfam_GSD_1.0
C1s
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945102,063,662 - 102,075,054 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936709731,165 - 742,686 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936709731,211 - 742,583 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
C1S
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl563,670,312 - 63,708,214 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1563,670,309 - 63,681,466 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
C1S
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1117,106,769 - 7,115,055 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl117,139,115 - 7,148,056 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
ChlSab1.1 Ensembl117,139,115 - 7,148,056 (+)NCBIChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660631,100,303 - 1,110,870 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000001871   ⟹   ENSHGLP00000001825
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248603,659,341 - 3,671,142 (+)Ensembl
RefSeq Acc Id: XM_004869483   ⟹   XP_004869540
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248603,658,272 - 3,667,717 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004869540 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB18636 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000001825
  ENSHGLP00000035110
  ENSHGLP00100020897
GenBank Protein JAN96156 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_004869540   ⟸   XM_004869483
- UniProtKB: G5CAS5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000001825   ⟸   ENSHGLT00000001871


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000001389 Ensembl, ENTREZGENE
  ENSHGLG00000038360 UniProtKB/TrEMBL
  ENSHGLG00100015407 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000001871 ENTREZGENE
  ENSHGLT00000075736 UniProtKB/TrEMBL
  ENSHGLT00100021119 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/TrEMBL
  2.60.120.290 UniProtKB/TrEMBL
  Complement Module, domain 1 UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
InterPro CUB_dom UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/TrEMBL
  Pept_S1A_C1r/C1S/mannan-bd UniProtKB/TrEMBL
  Peptidase_S1_PA UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/TrEMBL
  Sperma_CUB_dom_sf UniProtKB/TrEMBL
  Sushi/SCR/CCP_sf UniProtKB/TrEMBL
  Sushi_SCR_CCP_dom UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
KEGG Report hgl:101697979 UniProtKB/TrEMBL
NCBI Gene C1s ENTREZGENE
PANTHER COMPLEMENT COMPONENT 1, S SUBCOMPONENT-RELATED UniProtKB/TrEMBL
  PTHR24255:SF18 UniProtKB/TrEMBL
Pfam CUB UniProtKB/TrEMBL
  FXa_inhibition UniProtKB/TrEMBL
  Sushi UniProtKB/TrEMBL
  Trypsin UniProtKB/TrEMBL
PIRSF C1r_C1s_MASP UniProtKB/TrEMBL
PRINTS CHYMOTRYPSIN UniProtKB/TrEMBL
PROSITE CUB UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  SUSHI UniProtKB/TrEMBL
  TRYPSIN_DOM UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
SMART CCP UniProtKB/TrEMBL
  CUB UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  Tryp_SPc UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
  SSF49854 UniProtKB/TrEMBL
  SSF50494 UniProtKB/TrEMBL
  SSF57535 UniProtKB/TrEMBL
UniProt G5CAS5 ENTREZGENE, UniProtKB/TrEMBL