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Gene: C1S (complement C1s) Homo sapiens
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Symbol: C1S
Name: complement C1s
RGD ID: 1605130
Description: Exhibits identical protein binding activity and serine-type endopeptidase activity. Predicted to be involved in complement activation, classical pathway and regulation of complement activation. Localizes to blood microparticle. Implicated in Ehlers-Danlos syndrome.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: basic proline-rich peptide IB-1; C1 esterase; complement C1s subcomponent; complement component 1 subcomponent s; complement component 1, s subcomponent; EDSPD2; FLJ44757
Orthologs:
Mus musculus (house mouse) : C1s2 (complement component 1, s subcomponent 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : C1s (complement C1s)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : C1s (complement C1s)
Pan paniscus (bonobo/pygmy chimpanzee) : C1S (complement C1s)
Canis lupus familiaris (dog) : C1S (complement C1s)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : C1s (complement C1s)
Sus scrofa (pig) : C1S (complement C1s)
Chlorocebus sabaeus (African green monkey) : C1S (complement C1s)
Heterocephalus glaber (naked mole-rat) : C1s (complement C1s)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl126,988,259 - 7,071,032 (+)EnsemblGRCh38hg38GRCh38
GRCh38127,060,718 - 7,071,032 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37127,167,819 - 7,178,336 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36127,038,278 - 7,048,597 (+)NCBINCBI36hg18NCBI36
Celera128,790,867 - 8,801,223 (+)NCBI
Cytogenetic Map12p13.31NCBI
HuRef127,028,290 - 7,038,646 (+)NCBIHuRef
CHM1_1127,166,966 - 7,177,322 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on C1S
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1605130
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.