Ibsp (integrin-binding sialoprotein) - Rat Genome Database

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Gene: Ibsp (integrin-binding sialoprotein) Rattus norvegicus
Analyze
Symbol: Ibsp
Name: integrin-binding sialoprotein
RGD ID: 2855
Description: Predicted to enable integrin binding activity and small molecule binding activity. Involved in cell adhesion. Located in extracellular space and vesicle. Orthologous to human IBSP (integrin binding sialoprotein); PARTICIPATES IN cell-extracellular matrix signaling pathway; INTERACTS WITH (S)-nicotine; 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: bone sialoprotein 2; bone sialoprotein II; Bsp; BSP II; cell-binding sialoprotein; integrin binding sialoprotein; Integrin-binding sialoprotein (bone sialoprotein II); MGC156673
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8145,744,497 - 5,757,242 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl145,744,501 - 5,775,299 (-)EnsemblGRCr8
mRatBN7.2145,439,825 - 5,452,570 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl145,439,829 - 5,452,693 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxPNT010000191.17,456 - 18,326 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0146,702,628 - 6,715,531 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0145,392,008 - 5,404,941 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0146,801,200 - 6,813,987 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl146,801,204 - 6,813,945 (-)Ensemblrn6Rnor6.0
Rnor_5.0146,789,269 - 6,807,502 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4146,548,541 - 6,561,165 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera145,578,651 - 5,591,441 (-)NCBICelera
RGSC_v3.1146,548,544 - 6,561,169 (-)NCBI
RH 3.4 Map1489.7RGD
Cytogenetic Map14p22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (EXP)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (EXP)
17beta-estradiol  (ISO)
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
6-propyl-2-thiouracil  (EXP,ISO)
Actein  (ISO)
all-trans-retinoic acid  (ISO)
aluminium oxide  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP)
cadmium atom  (ISO)
caffeine  (EXP)
calcidiol  (ISO)
calciol  (ISO)
calcitriol  (ISO)
camptothecin  (ISO)
chlorpromazine  (EXP)
cisplatin  (EXP)
cobalt dichloride  (EXP,ISO)
daidzein  (ISO)
DDT  (EXP)
decabromodiphenyl ether  (EXP)
dexamethasone  (EXP,ISO)
diiodine  (ISO)
ethanol  (EXP,ISO)
eugenol  (ISO)
flavonoids  (EXP)
furan  (EXP)
genistein  (ISO)
geranylgeraniol  (ISO)
glycerol 2-phosphate  (EXP,ISO)
herbimycin  (EXP)
hydrogen peroxide  (EXP)
ketoconazole  (ISO)
L-ascorbic acid  (EXP,ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
lithium chloride  (ISO)
magnesium atom  (ISO)
methimazole  (EXP)
nickel atom  (ISO)
nicotine  (EXP)
nitroprusside  (ISO)
oxaliplatin  (EXP)
paraquat  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
quercetin  (EXP)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sodium chloride  (EXP)
spermine  (ISO)
tacrine  (EXP)
tamoxifen  (ISO)
telmisartan  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Telmisartan Prevents Alveolar Bone Loss by Decreasing the Expression of Osteoclasts Markers in Hypertensive Rats With Periodontal Disease. Brito VGB, etal., Front Pharmacol. 2020 Nov 11;11:579926. doi: 10.3389/fphar.2020.579926. eCollection 2020.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Matrix vesicles are carriers of bone morphogenetic proteins (BMPs), vascular endothelial growth factor (VEGF), and noncollagenous matrix proteins. Nahar NN, etal., J Bone Miner Metab. 2008;26(5):514-9. Epub 2008 Aug 30.
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. The primary structure of a cell-binding bone sialoprotein. Oldberg A, etal., J Biol Chem 1988 Dec 25;263(36):19430-2.
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Activation of bone sialoprotein gene transcription by flavonoids is mediated through an inverted CCAAT box in ROS 17/2.8 cells. Shimizu E and Ogata Y, J Cell Biochem 2002;86(1):35-44.
12. Identification of a novel response element in the rat bone sialoprotein (BSP) gene promoter that mediates constitutive and fibroblast growth factor 2-induced expression of BSP. Shimizu-Sasaki E, etal., J Biol Chem 2001 Feb 23;276(8):5459-66.
13. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:7848824   PMID:8889548   PMID:12477932   PMID:12493752   PMID:12952182   PMID:15703183   PMID:16000302   PMID:16087680   PMID:16210410   PMID:16294319   PMID:16495225   PMID:17372929  
PMID:17572166   PMID:18041732   PMID:18226471   PMID:18620053   PMID:18757743   PMID:20060443   PMID:20587945   PMID:23266625   PMID:24103036   PMID:24495337   PMID:25464126   PMID:25895664  


Genomics

Comparative Map Data
Ibsp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8145,744,497 - 5,757,242 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl145,744,501 - 5,775,299 (-)EnsemblGRCr8
mRatBN7.2145,439,825 - 5,452,570 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl145,439,829 - 5,452,693 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxPNT010000191.17,456 - 18,326 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0146,702,628 - 6,715,531 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0145,392,008 - 5,404,941 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0146,801,200 - 6,813,987 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl146,801,204 - 6,813,945 (-)Ensemblrn6Rnor6.0
Rnor_5.0146,789,269 - 6,807,502 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4146,548,541 - 6,561,165 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera145,578,651 - 5,591,441 (-)NCBICelera
RGSC_v3.1146,548,544 - 6,561,169 (-)NCBI
RH 3.4 Map1489.7RGD
Cytogenetic Map14p22NCBI
IBSP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38487,799,554 - 87,812,435 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl487,799,546 - 87,813,329 (+)Ensemblhg38GRCh38
GRCh37488,720,706 - 88,733,587 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36488,939,726 - 88,952,098 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34489,077,880 - 89,090,253NCBI
Celera486,008,963 - 86,021,864 (+)NCBICelera
Cytogenetic Map4q22.1NCBI
HuRef484,466,298 - 84,479,240 (+)NCBIHuRef
CHM1_1488,697,498 - 88,710,400 (+)NCBICHM1_1
T2T-CHM13v2.0491,125,985 - 91,138,857 (+)NCBIT2T-CHM13v2.0
Ibsp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395104,447,153 - 104,459,338 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5104,447,037 - 104,459,335 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm385104,299,287 - 104,311,472 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5104,299,171 - 104,311,469 (+)Ensemblmm10GRCm38
MGSCv375104,728,306 - 104,740,491 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365104,539,600 - 104,551,767 (+)NCBIMGSCv36mm8
Celera5101,608,398 - 101,620,486 (+)NCBICelera
Cytogenetic Map5E5NCBI
cM Map550.68NCBI
Ibsp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554742,074,659 - 2,086,289 (-)Ensembl
ChiLan1.0NW_0049554742,074,659 - 2,086,289 (-)NCBIChiLan1.0ChiLan1.0
IBSP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2385,806,206 - 85,819,449 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1486,068,641 - 86,081,881 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0480,061,960 - 80,105,560 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1490,817,072 - 90,830,021 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl490,817,072 - 90,830,021 (+)EnsemblpanPan2panpan1.1
IBSP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13211,187,188 - 11,200,860 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3211,187,160 - 11,200,846 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3230,753,404 - 30,767,085 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03211,240,790 - 11,254,453 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3211,240,716 - 11,254,466 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13211,323,638 - 11,337,299 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03211,149,296 - 11,162,980 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03228,790,260 - 28,803,929 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ibsp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244052851,896,163 - 1,905,843 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936905316,459 - 323,446 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936905316,459 - 323,446 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IBSP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8131,208,282 - 131,241,266 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.18131,208,281 - 131,222,048 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28140,438,439 - 140,452,241 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IBSP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1736,170,411 - 36,185,099 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl736,174,903 - 36,184,278 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603714,894,526 - 14,905,166 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ibsp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248724,322,330 - 4,333,080 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248724,324,812 - 4,333,080 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ibsp
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11114,357,002 - 14,366,707 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ibsp
126 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:662
Count of miRNA genes:280
Interacting mature miRNAs:351
Transcripts:ENSRNOT00000002938
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14395787821572472Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14395787824886169Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)14395787818558812Rat
7411573Bw139Body weight QTL 1394.70.001body mass (VT:0001259)body weight gain (CMO:0000420)14140068101Rat
9589814Gluco67Glucose level QTL 674.540.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14140068101Rat
724541Niddm53Non-insulin dependent diabetes mellitus QTL 530.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1439578789393298Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14395787831121464Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141415516Rat
71115Niddm15Non-insulin dependent diabetes mellitus QTL 154.8blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14111334906Rat
71117Niddm17Non-insulin dependent diabetes mellitus QTL 172.35blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14117877928Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14131893212Rat

Markers in Region
D14Arb1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2145,440,438 - 5,440,710 (+)MAPPERmRatBN7.2
Rnor_6.0146,801,814 - 6,802,085NCBIRnor6.0
Rnor_5.0146,789,883 - 6,790,154UniSTSRnor5.0
RGSC_v3.4146,549,155 - 6,549,426UniSTSRGSC3.4
RGSC_v3.4146,549,154 - 6,549,426RGDRGSC3.4
Celera145,579,265 - 5,579,536UniSTS
RGSC_v3.1146,549,154 - 6,549,426RGD
RH 3.4 Map1491.2RGD
RH 3.4 Map1491.2UniSTS
SHRSP x BN Map142.29UniSTS
SHRSP x BN Map142.29RGD
Cytogenetic Map14p22UniSTS
RH94679  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8145,744,808 - 5,744,996 (+)Marker Load Pipeline
mRatBN7.2145,440,136 - 5,440,324 (+)MAPPERmRatBN7.2
Rnor_6.0146,801,512 - 6,801,699NCBIRnor6.0
Rnor_5.0146,789,581 - 6,789,768UniSTSRnor5.0
RGSC_v3.4146,548,853 - 6,549,040UniSTSRGSC3.4
Celera145,578,963 - 5,579,150UniSTS
RH 3.4 Map1489.7UniSTS
Cytogenetic Map14p22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 10 47 131 41 40 11 21 11 4 175 95 11 113 46 89 29 8 8

Sequence


Ensembl Acc Id: ENSRNOT00000002938   ⟹   ENSRNOP00000002938
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl145,744,501 - 5,763,093 (-)Ensembl
mRatBN7.2 Ensembl145,439,829 - 5,452,693 (-)Ensembl
Rnor_6.0 Ensembl146,801,204 - 6,813,945 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105753   ⟹   ENSRNOP00000076389
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl145,744,501 - 5,775,299 (-)Ensembl
mRatBN7.2 Ensembl145,439,829 - 5,452,693 (-)Ensembl
RefSeq Acc Id: NM_012587   ⟹   NP_036719
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8145,744,497 - 5,757,242 (-)NCBI
mRatBN7.2145,439,825 - 5,452,570 (-)NCBI
Rnor_6.0146,801,200 - 6,813,945 (-)NCBI
Rnor_5.0146,789,269 - 6,807,502 (-)NCBI
RGSC_v3.4146,548,541 - 6,561,165 (-)RGD
Celera145,578,651 - 5,591,441 (-)RGD
Sequence:
RefSeq Acc Id: XM_017599076   ⟹   XP_017454565
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8145,744,499 - 5,757,233 (-)NCBI
mRatBN7.2145,439,825 - 5,452,561 (-)NCBI
Rnor_6.0146,801,200 - 6,813,967 (-)NCBI
Sequence:
RefSeq Acc Id: NP_036719   ⟸   NM_012587
- Peptide Label: precursor
- UniProtKB: A0JPM6 (UniProtKB/TrEMBL),   Q3HLN4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017454565   ⟸   XM_017599076
- Peptide Label: isoform X1
- UniProtKB: A0JPM6 (UniProtKB/TrEMBL),   Q3HLN4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000002938   ⟸   ENSRNOT00000002938
Ensembl Acc Id: ENSRNOP00000076389   ⟸   ENSRNOT00000105753

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P13839-F1-model_v2 AlphaFold P13839 1-320 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699173
Promoter ID:EPDNEW_R9698
Type:single initiation site
Name:Ibsp_1
Description:integrin-binding sialoprotein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0146,813,953 - 6,814,013EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2855 AgrOrtholog
BioCyc Gene G2FUF-16506 BioCyc
Ensembl Genes ENSRNOG00000002158 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000002938 ENTREZGENE
  ENSRNOT00000105753 ENTREZGENE
IMAGE_CLONE IMAGE:8369751 IMAGE-MGC_LOAD
InterPro BSP_II UniProtKB/Swiss-Prot
MGC_CLONE MGC:156673 IMAGE-MGC_LOAD
NCBI Gene 24477 ENTREZGENE
PANTHER BONE SIALOPROTEIN 2 UniProtKB/Swiss-Prot
  PTHR10345 UniProtKB/Swiss-Prot
Pfam BSP_II UniProtKB/Swiss-Prot
PhenoGen Ibsp PhenoGen
RatGTEx ENSRNOG00000002158 RatGTEx
TIGR TC230187
UniProt A0A8I5Y053_RAT UniProtKB/TrEMBL
  A0JPM6 ENTREZGENE, UniProtKB/TrEMBL
  A6K5S7_RAT UniProtKB/TrEMBL
  F7FLE6_RAT UniProtKB/TrEMBL
  P13839 ENTREZGENE
  Q3HLN4 ENTREZGENE, UniProtKB/TrEMBL
  SIAL_RAT UniProtKB/Swiss-Prot
UniProt Secondary P97828 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-02-09 Ibsp  integrin-binding sialoprotein  Ibsp  integrin binding sialoprotein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Ibsp  integrin binding sialoprotein      Symbol and Name status set to approved 625702 APPROVED
2002-06-10 Ibsp  integrin binding sialoprotein      Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_function binds to hydroxyapatite through polyglutamic acid sequences and mediates cell attachment through an RGD sequence 62418
gene_process may function in hydroxyapatite crystal nucleation 62418
gene_regulation transcription is enhanced by NF-YA, a CCAAT box-binding transcription factor 727390