Gabra3 (gamma-aminobutyric acid type A receptor subunit alpha 3) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Gabra3 (gamma-aminobutyric acid type A receptor subunit alpha 3) Rattus norvegicus
Analyze
Symbol: Gabra3
Name: gamma-aminobutyric acid type A receptor subunit alpha 3
RGD ID: 2648
Description: Enables GABA-A receptor activity and ligand-gated monoatomic ion channel activity. Involved in auditory behavior; chemical synaptic transmission; and response to lead ion. Is active in GABA-ergic synapse; postsynaptic specialization membrane; and presynaptic active zone membrane. Human ortholog(s) of this gene implicated in bipolar disorder and multiple sclerosis. Orthologous to human GABRA3 (gamma-aminobutyric acid type A receptor subunit alpha3); INTERACTS WITH (S)-nicotine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GABA(A) receptor subunit alpha-3; GABA-A receptor alpha-3 subunit; GABAAR subunit alpha-3; gamma-aminobutyric acid (GABA) A receptor, alpha 3; gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 3; gamma-aminobutyric acid receptor subunit alpha-3; gamma-aminobutyric acid receptor, subunit alpha 3; gamma-aminobutyric acid type A receptor alpha3 subunit; Gamma-animobutyric acid (GABA) A receptor alpha 3; Gamma-animobutyric acid (GABA) A receptor, alpha 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X155,301,979 - 155,543,870 (-)NCBIGRCr8
mRatBN7.2X150,244,745 - 150,501,566 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX150,261,607 - 150,501,559 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX152,453,314 - 152,693,260 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X155,987,523 - 156,225,950 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X153,529,101 - 153,769,048 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X152,414,332 - 152,642,607 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX152,414,615 - 152,642,531 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01148,142,971 - 148,373,374 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X158,405,509 - 158,633,501 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X158,478,941 - 158,706,933 (-)NCBI
Celera1131,236,780 - 131,471,218 (-)NCBICelera
Cytogenetic MapXq37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Presynaptic and postsynaptic GABAA receptors in rat suprachiasmatic nucleus. Belenky MA, etal., Neuroscience. 2003;118(4):909-23.
2. Neonatal development of the rat visual cortex: synaptic function of GABAA receptor alpha subunits. Bosman LW, etal., J Physiol 2002 Nov 15;545(Pt 1):169-81.
3. Setting the time course of inhibitory synaptic currents by mixing multiple GABA(A) receptor a subunit isoforms. Eyre MD, etal., J Neurosci. 2012 Apr 25;32(17):5853-67. doi: 10.1523/JNEUROSCI.6495-11.2012.
4. Association between the gamma-aminobutyric acid A3 receptor gene and multiple sclerosis. Gade-Andavolu R, etal., Arch Neurol 1998 Apr;55(4):513-6.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Auditory Training Reverses Lead (Pb)-Toxicity-Induced Changes in Sound-Azimuth Selectivity of Cortical Neurons. Liu X, etal., Cereb Cortex. 2019 Jul 22;29(8):3294-3304. doi: 10.1093/cercor/bhy199.
8. Functional expression and sites of gene transcription of a novel alpha subunit of the GABAA receptor in rat brain. Malherbe P, etal., FEBS Lett 1990 Jan 29;260(2):261-5.
9. Excess of allele1 for alpha3 subunit GABA receptor gene (GABRA3) in bipolar patients: a multicentric association study. Massat I, etal., Mol Psychiatry 2002;7(2):201-7.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Spontaneous and gamma-aminobutyric acid (GABA)-activated GABA(A) receptor channels formed by epsilon subunit-containing isoforms. Neelands TR, etal., Mol Pharmacol. 1999 Jan;55(1):168-78. doi: 10.1124/mol.55.1.168.
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Gamma-aminobutyric acid receptor (GABA(A)) subunits in rat nucleus tractus solitarii (NTS) revealed by polymerase chain reaction (PCR) and immunohistochemistry.PG - 241-57 Saha S, etal., Mol Cell Neurosci 2001 Jan;17(1):241-57.
17. Ethanol concentration-dependent alterations in gene expression during acute binge drinking in the HIV-1 transgenic rat. Sarkar S and Chang SL, Alcohol Clin Exp Res. 2013 Jul;37(7):1082-90. doi: 10.1111/acer.12077. Epub 2013 Feb 15.
18. Molecular basis of the gamma-aminobutyric acid A receptor alpha3 subunit interaction with the clustering protein gephyrin. Tretter V, etal., J Biol Chem. 2011 Oct 28;286(43):37702-11. doi: 10.1074/jbc.M111.291336. Epub 2011 Aug 31.
Additional References at PubMed
PMID:1298923   PMID:1312131   PMID:1312132   PMID:1379501   PMID:1966765   PMID:14729731   PMID:15199051   PMID:16690709   PMID:17495040   PMID:17630284   PMID:19249336   PMID:21219474  
PMID:22044189   PMID:22666188   PMID:26469128   PMID:33288547  


Genomics

Comparative Map Data
Gabra3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X155,301,979 - 155,543,870 (-)NCBIGRCr8
mRatBN7.2X150,244,745 - 150,501,566 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX150,261,607 - 150,501,559 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX152,453,314 - 152,693,260 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X155,987,523 - 156,225,950 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X153,529,101 - 153,769,048 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X152,414,332 - 152,642,607 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX152,414,615 - 152,642,531 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01148,142,971 - 148,373,374 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X158,405,509 - 158,633,501 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X158,478,941 - 158,706,933 (-)NCBI
Celera1131,236,780 - 131,471,218 (-)NCBICelera
Cytogenetic MapXq37NCBI
GABRA3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X152,166,234 - 152,451,315 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX152,166,234 - 152,451,315 (-)EnsemblGRCh38hg38GRCh38
GRCh37X151,334,706 - 151,619,787 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X151,086,290 - 151,370,487 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X151,007,096 - 151,290,398NCBI
CeleraX151,581,116 - 151,866,622 (-)NCBICelera
Cytogenetic MapXq28NCBI
HuRefX140,189,381 - 140,473,318 (-)NCBIHuRef
CHM1_1X151,210,380 - 151,494,516 (-)NCBICHM1_1
T2T-CHM13v2.0X150,432,298 - 150,717,938 (-)NCBIT2T-CHM13v2.0
Gabra3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X71,476,282 - 71,700,525 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX71,476,287 - 71,700,454 (-)EnsemblGRCm39 Ensembl
GRCm38X72,432,676 - 72,656,919 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX72,432,681 - 72,656,848 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X69,678,015 - 69,901,585 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X68,686,537 - 68,908,906 (-)NCBIMGSCv36mm8
CeleraX63,400,804 - 63,600,363 (-)NCBICelera
Cytogenetic MapXA7.3NCBI
cM MapX37.24NCBI
Gabra3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554987,672,943 - 7,904,369 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554987,672,982 - 7,904,783 (-)NCBIChiLan1.0ChiLan1.0
GABRA3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X152,229,775 - 152,490,867 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X152,233,378 - 152,494,460 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X141,739,962 - 142,001,041 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X151,697,537 - 151,956,879 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX151,697,537 - 151,878,484 (-)Ensemblpanpan1.1panPan2
GABRA3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X120,152,650 - 120,460,604 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX120,153,261 - 120,460,119 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX105,530,627 - 105,839,355 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X122,414,804 - 122,682,830 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX122,425,056 - 122,682,333 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X119,092,886 - 119,401,752 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X121,583,594 - 121,892,563 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X121,458,330 - 121,767,417 (-)NCBIUU_Cfam_GSD_1.0
Gabra3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X117,580,693 - 117,795,882 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936714548,619 - 677,411 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936714461,050 - 675,745 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GABRA3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX123,456,947 - 123,684,790 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X123,456,952 - 123,684,814 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X141,020,707 - 141,147,922 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GABRA3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X126,735,146 - 126,999,990 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX126,735,288 - 127,000,017 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606564,572,635 - 64,862,527 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gabra3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248833,477,833 - 3,710,237 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248833,478,112 - 3,710,586 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gabra3
337 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:40
Count of miRNA genes:34
Interacting mature miRNAs:39
Transcripts:ENSRNOT00000040729
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX100567703150256146Rat
634346Insul4Insulin level QTL 40blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)X126975089152453651Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X113937816152453651Rat

Markers in Region
DXWox31  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X150,255,946 - 150,256,146 (+)MAPPERmRatBN7.2
Rnor_6.0X152,409,606 - 152,409,805NCBIRnor6.0
Rnor_5.01148,137,728 - 148,137,927UniSTSRnor5.0
Celera1131,231,127 - 131,231,326UniSTS
Cytogenetic MapXq37UniSTS
AU048027  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera1131,306,251 - 131,306,529UniSTS
Cytogenetic MapXq37UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 6 47 113 48 45 21 15 21 6 138 81 93 21 59 24

Sequence


Ensembl Acc Id: ENSRNOT00000080277   ⟹   ENSRNOP00000075419
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX152,414,615 - 152,641,679 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000085037   ⟹   ENSRNOP00000070043
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX150,261,607 - 150,501,559 (-)Ensembl
Rnor_6.0 EnsemblX152,415,134 - 152,642,531 (-)Ensembl
RefSeq Acc Id: NM_017069   ⟹   NP_058765
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X155,303,928 - 155,543,870 (-)NCBI
mRatBN7.2X150,261,607 - 150,501,566 (-)NCBI
Rnor_6.0X152,415,134 - 152,642,538 (-)NCBI
Rnor_5.01148,142,971 - 148,373,374 (-)NCBI
RGSC_v3.4X158,405,509 - 158,633,501 (-)RGD
Celera1131,236,780 - 131,471,218 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017601916   ⟹   XP_017457405
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X155,301,979 - 155,543,276 (-)NCBI
mRatBN7.2X150,244,745 - 150,500,968 (-)NCBI
Rnor_6.0X152,414,332 - 152,641,700 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_058765 (Get FASTA)   NCBI Sequence Viewer  
  XP_017457405 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC42031 (Get FASTA)   NCBI Sequence Viewer  
  CAA36247 (Get FASTA)   NCBI Sequence Viewer  
  EDL82833 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000070043.2
GenBank Protein P20236 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_058765   ⟸   NM_017069
- Peptide Label: precursor
- UniProtKB: P20236 (UniProtKB/Swiss-Prot),   F1LNZ5 (UniProtKB/TrEMBL),   A0A8L2UPR9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017457405   ⟸   XM_017601916
- Peptide Label: isoform X1
- UniProtKB: P20236 (UniProtKB/Swiss-Prot),   F1LNZ5 (UniProtKB/TrEMBL),   A0A8L2UPR9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075419   ⟸   ENSRNOT00000080277
Ensembl Acc Id: ENSRNOP00000070043   ⟸   ENSRNOT00000085037
Protein Domains
Neurotransmitter-gated ion-channel ligand-binding   Neurotransmitter-gated ion-channel transmembrane

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P20236-F1-model_v2 AlphaFold P20236 1-493 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13702029
Promoter ID:EPDNEW_R12550
Type:multiple initiation site
Name:Gabra3_1
Description:gamma-aminobutyric acid type A receptor alpha3 subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X152,641,640 - 152,641,700EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2648 AgrOrtholog
BioCyc Gene G2FUF-704 BioCyc
Ensembl Genes ENSRNOG00000056558 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000085037.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.58.390 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.70.170.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GABAA/Glycine_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GABAAa_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GABBAa3_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gabra-1-6_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_chan_lig-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_chan_lig-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neuro-gated_channel_TM_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neuro_actylchol_rec UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neurotrans-gated_channel_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neurotransmitter_ion_chnl_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24947 UniProtKB/Swiss-Prot
NCBI Gene 24947 ENTREZGENE
PANTHER GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR18945 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Neur_chan_LBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_chan_memb UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gabra3 PhenoGen
PRINTS GABAARALPHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GABAARALPHA3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GABAARECEPTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NRIONCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NEUROTR_ION_CHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000056558 RatGTEx
Superfamily-SCOP SSF63712 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF90112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2UPR9 ENTREZGENE, UniProtKB/TrEMBL
  A6KSY0_RAT UniProtKB/TrEMBL
  F1LNZ5 ENTREZGENE
  GBRA3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary F1LNZ5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-12-06 Gabra3  gamma-aminobutyric acid type A receptor subunit alpha 3  Gabra3  gamma-aminobutyric acid type A receptor alpha3 subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-11 Gabra3  gamma-aminobutyric acid type A receptor alpha3 subunit  Gabra3  gamma-aminobutyric acid (GABA) A receptor, alpha 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-04 Gabra3  gamma-aminobutyric acid (GABA) A receptor, alpha 3  Gabra3  gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Gabra3  gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 3  Gabra3  gamma-aminobutyric acid receptor, subunit alpha 3  Name updated 1299863 APPROVED
2002-11-06 Gabra3  gamma-aminobutyric acid receptor, subunit alpha 3  Gabra3  Gamma-animobutyric acid (GABA) A receptor, alpha 3  Name updated 625702 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localizes to both cytoplasmic and subsynaptic sites of NTS neurons 625528
gene_expression relatively high expression in NTS 625528
gene_expression protein expression seen throughout the dorsal vagal complex and other areas of medulla (gracile, cuneate, spinal tirgeminal, olivary and reticular nuclei) with higher expression seen in hypoglossal motoneurons 625528
gene_process may mediate inhibitory GABA responses in nucleus tractus solitarii (NTS) in the brain 625528