Mocs2 (molybdenum cofactor synthesis 2) - Rat Genome Database
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Gene: Mocs2 (molybdenum cofactor synthesis 2) Rattus norvegicus
Analyze
Symbol: Mocs2
Name: molybdenum cofactor synthesis 2
RGD ID: 1359477
Description: Predicted to have identical protein binding activity and molybdopterin synthase activity. Predicted to be involved in Mo-molybdopterin cofactor biosynthetic process. Predicted to localize to cytosol; molybdopterin synthase complex; and nuclear speck. Human ortholog(s) of this gene implicated in molybdenum cofactor deficiency type B. Orthologous to human MOCS2 (molybdenum cofactor synthesis 2); PARTICIPATES IN molybdenum cofactor biosynthetic pathway; folate metabolic pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: MGC94220; MOCS2B; molybdenum cofactor synthesis protein 2 large subunit; molybdenum cofactor synthesis protein 2B; molybdopterin synthase; molybdopterin synthase catalytic subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2246,504,574 - 46,516,327 (+)NCBI
Rnor_6.0 Ensembl246,980,976 - 46,992,883 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0246,980,964 - 46,992,886 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0271,520,174 - 71,532,084 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4246,948,321 - 46,960,060 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1246,876,587 - 46,888,290 (+)NCBI
Celera242,260,839 - 42,272,490 (+)NCBICelera
Cytogenetic Map2q14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:11591653   PMID:12732628   PMID:15073332   PMID:23376485  


Genomics

Comparative Map Data
Mocs2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2246,504,574 - 46,516,327 (+)NCBI
Rnor_6.0 Ensembl246,980,976 - 46,992,883 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0246,980,964 - 46,992,886 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0271,520,174 - 71,532,084 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4246,948,321 - 46,960,060 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1246,876,587 - 46,888,290 (+)NCBI
Celera242,260,839 - 42,272,490 (+)NCBICelera
Cytogenetic Map2q14NCBI
MOCS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl553,095,679 - 53,110,063 (-)EnsemblGRCh38hg38GRCh38
GRCh38553,095,679 - 53,109,757 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37552,391,509 - 52,405,587 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36552,429,649 - 52,441,355 (-)NCBINCBI36hg18NCBI36
Build 34552,429,653 - 52,441,355NCBI
Celera549,347,470 - 49,359,176 (-)NCBI
Cytogenetic Map5q11.2NCBI
HuRef549,363,558 - 49,377,653 (-)NCBIHuRef
CHM1_1552,394,058 - 52,408,152 (-)NCBICHM1_1
Mocs2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913114,954,707 - 114,965,956 (+)NCBIGRCm39mm39
GRCm39 Ensembl13114,954,772 - 114,968,811 (+)Ensembl
GRCm3813114,818,160 - 114,829,420 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13114,818,236 - 114,832,275 (+)EnsemblGRCm38mm10GRCm38
MGSCv3713115,608,445 - 115,619,628 (+)NCBIGRCm37mm9NCBIm37
MGSCv3613115,939,164 - 115,949,607 (+)NCBImm8
Celera13119,161,937 - 119,173,119 (+)NCBICelera
Cytogenetic Map13D2.2NCBI
Mocs2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544614,295,737 - 14,307,838 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544614,295,737 - 14,305,735 (+)NCBIChiLan1.0ChiLan1.0
MOCS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1562,539,208 - 62,550,926 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl562,539,214 - 62,550,921 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0560,920,268 - 60,931,990 (+)NCBIMhudiblu_PPA_v0panPan3
MOCS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1462,153,828 - 62,164,154 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl462,153,296 - 62,185,492 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha461,928,792 - 61,939,117 (+)NCBI
ROS_Cfam_1.0462,651,866 - 62,662,174 (+)NCBI
UMICH_Zoey_3.1462,427,116 - 62,437,429 (+)NCBI
UNSW_CanFamBas_1.0462,551,658 - 62,561,990 (+)NCBI
UU_Cfam_GSD_1.0463,078,354 - 63,088,687 (+)NCBI
Mocs2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213205,369,033 - 205,380,226 (+)NCBI
SpeTri2.0NW_00493648014,302,824 - 14,313,265 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MOCS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1632,424,645 - 32,462,521 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11632,427,783 - 32,462,362 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21634,270,548 - 34,290,713 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MOCS2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1449,387,923 - 49,399,902 (-)NCBI
ChlSab1.1 Ensembl449,386,487 - 49,399,928 (-)Ensembl
Mocs2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247596,261,970 - 6,272,246 (+)NCBI

Position Markers
D5Wox6  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0246,985,503 - 46,986,121NCBIRnor6.0
Rnor_5.0271,524,701 - 71,525,319UniSTSRnor5.0
RGSC_v3.4246,952,847 - 46,953,465UniSTSRGSC3.4
Celera242,265,277 - 42,265,895UniSTS
Cytogenetic Map2q14UniSTS
RH133558  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0246,992,215 - 46,992,419NCBIRnor6.0
Rnor_5.0271,531,413 - 71,531,617UniSTSRnor5.0
RGSC_v3.4246,959,389 - 46,959,593UniSTSRGSC3.4
Celera242,271,819 - 42,272,023UniSTS
RH 3.4 Map2304.4UniSTS
Cytogenetic Map2q14UniSTS
BF404043  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0246,984,514 - 46,984,707NCBIRnor6.0
Rnor_5.0271,523,712 - 71,523,905UniSTSRnor5.0
RGSC_v3.4246,951,858 - 46,952,051UniSTSRGSC3.4
Celera242,264,288 - 42,264,481UniSTS
RH 3.4 Map2292.3UniSTS
Cytogenetic Map2q14UniSTS
AW535104  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0246,984,585 - 46,984,736NCBIRnor6.0
Rnor_5.0271,523,783 - 71,523,934UniSTSRnor5.0
RGSC_v3.4246,951,929 - 46,952,080UniSTSRGSC3.4
Celera242,264,359 - 42,264,510UniSTS
RH 3.4 Map2294.8UniSTS
Cytogenetic Map2q14UniSTS
RH139819  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0246,992,644 - 46,992,836NCBIRnor6.0
Rnor_5.0271,531,842 - 71,532,034UniSTSRnor5.0
RGSC_v3.4246,959,818 - 46,960,010UniSTSRGSC3.4
Celera242,272,248 - 42,272,440UniSTS
Cytogenetic Map2q14UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)23127638105149020Rat
9590080Insglur4Insulin/glucose ratio QTL 428.70.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)2368630848686308Rat
738012Anxrr3Anxiety related response QTL 33.8exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)2789360052893600Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)2944467949615930Rat
1578671Bmd10Bone mineral density QTL 105.4femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)2944467968866454Rat
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21055527555555275Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21423783059237830Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)216679272245624402Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21901646564016465Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22027698165276981Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22064137165641371Rat
7387318Stl32Serum triglyceride level QTL 323.20.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)22261295267612952Rat
10402051Gdil2Gastrointestinal dilation QTL 2enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)22328064775687607Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)223837491149614623Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)223837491169852800Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)223837491169852800Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)223837491169852800Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)223837491169852800Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)223837491169852800Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)223837491169852800Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)223837491218957222Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)223837491218957222Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)223837719169852670Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)223837719169852670Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)22618609783819822Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)22618609783819822Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22618609783819822Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226186097135654963Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226186097142053534Rat
1643006Pain1Pain QTL 13.630.005mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)22626799548676716Rat
12879841Cm87Cardiac mass QTL 870.026heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)227161361148295267Rat
12879842Cm88Cardiac mass QTL 880.042heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)227161361148295267Rat
12879843Am3Aortic mass QTL 30.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)227161361148295267Rat
12879844Kidm62Kidney mass QTL 620.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227161361148295267Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22776030172760301Rat
1300160Hrtrt3Heart rate QTL 33.62heart pumping trait (VT:2000009)absolute change in heart rate (CMO:0000534)22872786752507805Rat
10755434Coatc7Coat color QTL 70.04794coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23127237976272379Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23408817591101903Rat
10755436Coatc8Coat color QTL 80.02431coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23513320280133202Rat
2306903Bp336Blood pressure QTL 3360.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)236245223112175725Rat
9685065Swd6Spike wave discharge measurement QTL 65.80.01brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge rate (CMO:0001739)23899084849401197Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)240171834105089682Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)240171834105089682Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)240171834105089682Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)240171834105089682Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)240171834105089682Rat
12879863Bp402Blood pressure QTL 4020.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24106343956736627Rat
1300155Bp174Blood pressure QTL 1744.09arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)24277691662238534Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242776916169852800Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242776916195645082Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242776916217498710Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242776916217498710Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243133606217498545Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243133606217498545Rat
2293676Bmd19Bone mineral density QTL 1910.70.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)243141290114164944Rat
2293682Bmd24Bone mineral density QTL 248.90.0001femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)243141290114164944Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243141290154583160Rat
631208Bw1Body weight QTL15.09mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight as a percentage of body weight (CMO:0000654)24314978885642672Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243149788198704485Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246537589217498710Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:165
Count of miRNA genes:126
Interacting mature miRNAs:138
Transcripts:ENSRNOT00000015781
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 36 11 8
Low 5
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001007633 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001162413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017590714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017590715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017590716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC079181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO554692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM123325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000082990   ⟹   ENSRNOP00000073722
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl246,981,010 - 46,992,883 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000083668   ⟹   ENSRNOP00000069073
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl246,980,976 - 46,992,883 (+)Ensembl
RefSeq Acc Id: NM_001007633   ⟹   NP_001007634
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2246,504,588 - 46,516,327 (+)NCBI
Rnor_6.0246,980,976 - 46,992,886 (+)NCBI
Rnor_5.0271,520,174 - 71,532,084 (+)NCBI
RGSC_v3.4246,948,321 - 46,960,060 (+)RGD
Celera242,260,839 - 42,272,490 (+)RGD
Sequence:
RefSeq Acc Id: NM_001162413   ⟹   NP_001155885
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2246,504,588 - 46,516,327 (+)NCBI
Rnor_6.0246,980,976 - 46,992,886 (+)NCBI
Rnor_5.0271,520,174 - 71,532,084 (+)NCBI
RGSC_v3.4246,948,321 - 46,960,060 (+)RGD
Celera242,260,839 - 42,272,490 (+)RGD
Sequence:
RefSeq Acc Id: XM_006231985   ⟹   XP_006232047
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2246,504,608 - 46,516,327 (+)NCBI
Rnor_6.0246,981,010 - 46,992,886 (+)NCBI
Rnor_5.0271,520,174 - 71,532,084 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006231986   ⟹   XP_006232048
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2246,504,574 - 46,516,327 (+)NCBI
Rnor_6.0246,980,986 - 46,992,886 (+)NCBI
Rnor_5.0271,520,174 - 71,532,084 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017590714   ⟹   XP_017446203
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0246,981,035 - 46,992,886 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017590715   ⟹   XP_017446204
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0246,980,982 - 46,992,886 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017590716   ⟹   XP_017446205
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0246,980,964 - 46,992,886 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001007634   ⟸   NM_001007633
- Peptide Label: isoform Mocs2B
- UniProtKB: Q6AY59 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001155885   ⟸   NM_001162413
- Peptide Label: isoform Mocs2A
- UniProtKB: Q6AY59 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006232048   ⟸   XM_006231986
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006232047   ⟸   XM_006231985
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017446205   ⟸   XM_017590716
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017446204   ⟸   XM_017590715
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017446203   ⟸   XM_017590714
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000073722   ⟸   ENSRNOT00000082990
RefSeq Acc Id: ENSRNOP00000069073   ⟸   ENSRNOT00000083668

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691147
Promoter ID:EPDNEW_R1672
Type:initiation region
Name:Mocs2_1
Description:molybdenum cofactor synthesis 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0246,981,009 - 46,981,069EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
2 46983738 46983739 C A snv ACI/EurMcwi (RGD), ACI/N (MCW)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359477 AgrOrtholog
Ensembl Genes ENSRNOG00000056325 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000069073 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000073722 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000082990 UniProtKB/Swiss-Prot
  ENSRNOT00000083668 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.90.1170.40 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7130858 IMAGE-MGC_LOAD
InterPro MoaE_sf UniProtKB/Swiss-Prot
  MOCS2B_euk UniProtKB/Swiss-Prot
  Mopterin_biosynth_MoaE UniProtKB/Swiss-Prot
KEGG Report rno:294753 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94220 IMAGE-MGC_LOAD
NCBI Gene 294753 ENTREZGENE
Pfam MoaE UniProtKB/Swiss-Prot
PhenoGen Mocs2 PhenoGen
Superfamily-SCOP SSF54690 UniProtKB/Swiss-Prot
UniProt MOC2B_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Mocs2  molybdenum cofactor synthesis 2    molybdopterin synthase  Name updated 1299863 APPROVED
2005-07-29 Mocs2  molybdopterin synthase      Symbol and Name status set to provisional 70820 PROVISIONAL